Ludovico Gennaro Cobuccio

• Doctor of Medicine
• Resident Physician at Lausanne University Hospital

Primary health systems in resource-constrained settings suffer from human resource shortages, low quality care, and diagnostic uncertainty, resulting in over-reliance on antibiotics, increasing risks of antimicrobial resistance. Digital clinical decision support algorithms (CDSAs) help healthcare workers adhere to clinical guidelines and improve pr...

Background Despite the proven positive effects of clinical decision support systems (CDSSs) on general practitioners’ (GPs’) performance and patient management, their adoption remains slow. Several factors have been proposed to explain GPs' reluctance to adopt these tools. This study hypothesizes that the influence of CDSSs on patient-physician int...

Aims of the study Despite proven positive effects on general practitioners’ (GPs) performance and on the management of patients and treatments, adoption of clinical decision support systems (CDSSs) is slow. Several elements have been put forward to explain this reluctance of GPs to adopt these tools. We hypothesise that their influence on patient-p...

Clinical Decision Support Systems (CDSS) have the potential to improve and standardise care with probabilistic guidance. However, many CDSS deploy static, generic rule-based logic, resulting in inequitably distributed accuracy and inconsistent performance in evolving clinical environments. Data-driven models could resolve this issue by updating pre...

Background: Identifying the causes of Acute Undifferentiated Febrile Illness(AUFI) is key to improve the management of returning travellers with fever. We evaluated a BioFire®FilmArray® prototype panel of multiplex nucleic acid amplification tests(NAAT) targeting different relevant pathogens in travellers returning with fever. Methods: Prospecti...

Electronic clinical decision support algorithms (CDSAs) have been developed to address high childhood mortality and inappropriate antibiotic prescription by helping clinicians adhere to guidelines. Previously identified challenges of CDSAs include their limited scope, usability, and outdated clinical content. To address these challenges we develope...

Background: Blastocystis sp. is a worldwide-distributed protist colonizing the guts of humans and a great variety of animals. It is unclear whether it is just a commensal or an infectious parasite that prompts eradication.The main objective of this study was to evaluate the usefulness of metronidazole in patients with gastrointestinal symptoms har...

Electronic clinical decision support algorithms (CDSAs) have been developed to address high childhood mortality and inappropriate antibiotic prescription by helping clinicians adhere to guidelines. Previously identified challenges of CDSAs include its limited scope, usability, and outdated clinical algorithms. To address these challenges we develop...

Background Clinical Decision Support Systems (CDSS) have the potential to improve and standardise care with probabilistic guidance. However, many CDSS deploy static, generic rule-based logic, resulting in inequitably distributed accuracy and inconsistent performance in evolving clinical environments. Data-driven models could resolve this issue by u...

Background Diagnosis of undifferentiated non-malaria fevers (NMF) in returning travellers is a great challenge. Currently, there is no consensus about the use of empirical antibiotics in returning travellers with undifferentiated non-malaria fevers (NMF). Although studies in endemic areas showed that a wide range of pathogens implicated in undiffer...

Background Etiological diagnosis of febrile illnesses in returning travelers is a great challenge, particularly when presenting with no focal symptoms (acute undifferentiated febrile illnesses (AUFI)), but is crucial to guide clinical decisions and public health policies. In this study, we describe the frequencies and predictors of the main causes...

Background: Although tick-borne pathogens have been reported as an important cause of imported fever, the incidence of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), in travelers is unknown. Methods: We conducted a prospective cohort study to investigate the aetiologies of fever in returning travelers (Nove...

When travelling to a tropical country, the tourist can be exposed to different pathogens that can cause symptoms after a long period of latency. The physician should be informed about the geographical distribution of these diseases (schistosomiasis, Chagas disease, strongyloidiasis), the situations in which an exposure can occur and the presentatio...

Issues of professionalism and professional identity formation, particularly amongst young doctors, have been the object of increasing attention. This is explained in part by the evolution of the hospital environment (specialization, shorter stays), as well as by the prevalence of physician burnout and suicide. In this context, the CHUV implemented...

Head and neck focal manifestations of Salmonella infections : Case report and Review of the literature