Ludovic S. Live

Ludovic S. Live
Affinité Instruments

PhD Analytical Chemistry

About

27
Publications
6,513
Reads
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739
Citations
Introduction
Over the last decade, I’ve climbed the highest level of education, contributed to a startup’s successful fundraising round of more than $20 million, navigated the complexities of developing and delivering strategic programs for the largest province in Canada and co-founded a company to bring brilliant discoveries to market. "I can accept failure, everyone fails at something. But I can't accept not trying." - Michael Jordan
Additional affiliations
November 2017 - present
Affinité Instruments
Position
  • Chief Operating Officer
January 2016 - November 2017
Government of Ontario, Canada
Position
  • Consultant
January 2015 - May 2015
Université de Montréal
Position
  • Consultant
Education
September 2007
Longwood Medical
Field of study
  • TCSPC workshop
August 2007
Robert Giffard
Field of study
  • Neurophotonic school

Publications

Publications (27)
Article
Full-text available
We report on the development of surface plasmon resonance (SPR) sensors and matching ELISAs for the detection of nucleocapsid and spike antibodies specific against the novel coronavirus 2019 (SARS-CoV-2) in human serum, plasma and dried blood spots (DBS). When exposed to SARS-CoV-2 or a vaccine against SARS-CoV-2, the immune system responds by expr...
Preprint
We report on the development of surface plasmon resonance (SPR) sensors and matching ELISAs for the detection of nucleocapsid and spike antibodies specific against the novel coronavirus 2019 (SARS-CoV-2) in human serum, plasma and dried blood spots (DBS). When exposed to SARS-CoV-2 or a vaccine against SARS-CoV-2, the immune system responds by expr...
Preprint
Full-text available
We report a surface plasmon resonance (SPR) sensor detecting nucleocapsid antibodies specific against the novel coronavirus 2019 (SARS-CoV-2) in undiluted human serum. When exposed to SARS-CoV-2, the immune system responds by expressing antibodies at levels that can be detected and monitored to identify the patient population immunized against SARD...
Preprint
Full-text available
We report a surface plasmon resonance (SPR) sensor detecting nucleocapsid antibodies specific against the novel coronavirus 2019 (SARS-CoV-2) in undiluted human serum. When exposed to SARS-CoV-2, the immune system responds by expressing antibodies at levels that can be detected and monitored to identify the patient population immunized against SARD...
Patent
Full-text available
There is disclosed a method for fabricating a plasmonic structure for use in a surface plasmon resonance sensor, comprising: coating a surface of an optically clear substrate with a monolayer of microspheres forming a sphere mask; etching the sphere mask to produce an array of microholes; depositing an adsorption layer on the etched sphere mask and...
Article
Full-text available
Electronic readout of markers of disease provides compelling simplicity, sensitivity and specificity in the detection of small panels of biomarkers in clinical samples; however, the most important emerging tests for disease, such as infectious disease speciation and antibiotic-resistance profiling, will need to interrogate samples for many dozens o...
Article
We describe a simple electrochemical immunoassay for HIV antibody detection that localizes capture and detection reagents in close proximity to a microsensor. Antigenic peptides from HIV-1 gp41 or HIV-2 gp36 were covalently attached to a SU-8 substrate that also presented a template for the deposition of three-dimensional microsensors. The detectio...
Article
Full-text available
The debate is still ongoing on the optimal mode of interrogation for surface plasmon resonance (SPR) sensors. Comparative studies previously demonstrated that nanoparticles exhibiting a localized SPR (LSPR) have superior sensitivity to molecular adsorption processes while thin Au film-based propagating SPR is more sensitive to bulk refractive index...
Article
Full-text available
The presence of microhole arrays in thin Au films is suited for the excitation of localized and propagating surface plasmon (SP) modes. Conditions can be established to excite a resonance between the localized and propagating SP modes, which further enhanced the local electromagnetic (EM) field. The co-excitation of localized and propagating SP mod...
Article
The plasmonic properties of metallic nanoparticles and macroscopic Au film have been thoroughly investigated for the development of biosensors based on surface plasmon resonance (SPR). Nanoparticle based localized surface plasmon resonance (LSPR) is a technique extremely sensitive to molecular adsorbate, whilst conventional SPR based on the Kretsch...
Article
Micro-patterned thin films interrogated in the Kretschmann configuration of SPR could extend the detection range to lower concentrations and small biomolecules due to a greater sensitivity. This was achieved with the same instrumentation and analysis methodologies developed for SPR with continuous films. The plasmonic properties of micro-patterned...
Article
Metallic thin films patterned with micrometer size triangle or hole arrays present plasmonic properties when excited in the Kretschmann configuration, that are improved in comparison to conventional thin film surface plasmon resonance (SPR). These optical properties can be tuned by varying the physical aspects of the microplasmonic structures. Tria...
Article
Full-text available
Since the last decade, nanohole arrays have emerged from an interesting optical phenomenon to the development of applications in photophysical studies, photovoltaics and as a sensing template for chemical and biological analyses. Numerous methodologies have been designed to manufacture nanohole arrays, including the use of focus ion beam milling, s...
Chapter
Full-text available
The plasmonic nature of discontinuous thin films with micro-patterned structures such as triangles and hole arrays present distinct optical properties with a Kretschmann surface plasmon resonance (SPR) instrument. Au microstructures were prepared with a modified nanospheres lithography (NSL) method using 3.2 μm spheres which gives 1.8 μm triangles...
Article
The optical properties of Au triangles with 700 and 950 nm and 1.8 mu m edge length and of microhole arrays with a 3 mu m periodicity show a strong absorption peak highly sensitive to refractive index with excitation in the Kretschmann configuration of surface plasmon resonance (SPR). This absorption peak is due to a SPR phenomenon only present wit...
Conference Paper
This proceeding summarizes the optical properties of plasmonic structures from nanoscale to macroscale. Of particular interest, Au triangles and hole arrays of near micron size exhibit concomitantly surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) optical properties in the Vis-NIR region, resulting in excellent optical...
Article
Wavelength interrogation surface plasmon resonance (SPR) spectroscopy using a dove prism combines a simple and inexpensive optical design with high-resolution refractive index monitoring and biosensing. A BK7 dove prism inverts an optical image with a total internal reflection angle of 72.8 degrees , an angle active in SPR. Hence, a unique system c...
Article
In this letter, we demonstrate that Au triangles between approximately 200 nm and 1.5 mu m are transitioning from a predominantly localized surface plasmon resonance (LSPR) character to a regime where both LSPR and a short-range SPR mode are concomitantly present. The Au triangles are active in LSPR between approximately lambda = 700 nm for the sma...
Article
Full-text available
This paper reports the development of spherical Ag@SiO2 nanocomposites in which fluorescein isothiocyanate molecules have been incorporated using a silane coupling agent and a straightforward microemulsion-based synthesis procedure. The photophysical characteristics of core-shell and coreless nanostructures with similar silica shell thickness and f...

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