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Introduction
Lucy Doos currently works at College of Medical and Dental Sciences, University of Birmingham. Lucy does research in Public Health, Health Service Research and Primary Care.
Current institution
Publications
Publications (50)
Background: Randomized controlled trials (RCTs) are the gold standard in clinical research and providing scientific evidence to improve patients' care. Blinding is a crucial measure to control a variety of potential biases when conducting RCTs. However, double blind placebo-controlled studies are methodically complex and costly. In the case of drug...
Rationale Gold standard treatment for chronic obstructive pulmonary disease (COPD) includes a supported self-management plan to enable patients to recognise and treat acute exacerbations (AECOPD). The Predict & Prevent trial was designed to provide a definitive randomised clinical trial of a personalised early warning decision support system, COPDP...
Objectives
Recent figures show that over 200 million women and girls, globally, live with the consequences of female genital mutilation (FGM). Complex debilitating physical, psychological and social problems result from the practice. Health education interventions have proven to be essential in both preventing the practice and informing support of...
Background
Multiple clinical trials demonstrate consistent but modest benefit of adjuvant extended endocrine therapy (EET) in HR + breast cancer patients. Predictive biomarkers to identify patients that benefit from EET are critical to balance modest reductions in risk against potential side effects of EET. This study compares the performance of th...
Purpose:
The Breast Cancer Index (BCI) HOXB13/IL17BR (H/I) ratio predicts benefit from extended endocrine therapy in hormone receptor-positive (HR+) early-stage breast cancer. Here we report the final analysis of the Trans-aTTom study examining BCI (H/I)'s predictive performance.
Experimental design:
BCI results were available for 2445 aTTom tri...
Background
The NHS has recognised the importance of a high quality patient safety culture in the delivery of primary health care in the rapidly evolving environment of general practice. Two tools, PC-SafeQuest and MapSaf, were developed with the intention of assessing and improving patient safety culture in this setting. Both have been made widely...
Background: Several biomarkers such as estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) and Ki67 have been implicated in the pathogenesis and/or as prognostic biomarkers of breast cancer, and are utilized to determine treatment. Given the heterogeneity of response to endocrine therapy, however, predictive biomarkers are cr...
International migration is shaping and changing urban areas as well as impacting on healthcare access and provision in Europe. To investigate how residents of superdiverse neighborhoods put together their healthcare, we conducted qualitative interviews with 76 healthcare providers and 160 residents in four European cities - Bremen, Germany; Birming...
522
Background: BCI is a validated gene expression-based assay that stratifies patients based on risk of overall (0-10y) and late (post-5y) distant recurrence (DR) and predicts likelihood of benefit from extended endocrine therapy (EET). The Trans-aTTom study established Level1B validation for BCI (H/I) to predict benefit from EET. ¹ In this update...
Background: Optimizing the duration of adjuvant endocrine therapy in patients diagnosed with early stage hormone receptor-positive (HR+) breast cancer requires improved approaches to individualize disease profile and to reduce any unnecessary treatment burden for patients. Current clinical practice guidelines recommend 10 years of adjuvant endocrin...
Objectives
To investigate the trend in the launch price of new drugs for five common health conditions.
Design
Cross-sectional study using data on new drugs launched in the UK between 1981 and 2015 for hypertension, asthma, rheumatoid arthritis, schizophrenia and colorectal cancer.
Data and sources
All drugs marketed in the UK between 1981 and 20...
This article examines the ways in which healthcare providers from a mixed economy of welfare operating in superdiverse neighbourhoods connect and innovate across the healthcare ecosystem to meet diverse and complex needs. Moving beyond a health systems approach which siloes different types of provision, we use the concept of bricolage to make visib...
Background:
Obstetric fistula is a debilitating childbearing injury that results from poorly managed obstructed labour, leading to the development of holes between the vagina and bladder and/or rectum. Effects of this injury are long-lasting, as women become incontinent and are often marginalised from their communities. Despite continuous occurren...
Background
Female Genital Mutilation/Cutting (FGM/C) is a harmful practice that violates the human rights of women and girls. Despite global efforts to restrict the practice, there have been few reports on major positive changes to the problem. Health education interventions have been successful in preventing various health conditions and promoting...
Objective:
Major gaps remain in our understanding of primary care patient safety. We describe a toolkit for measuring patient safety in family practices.
Methods:
Six tools were used in 46 practices. These tools were as follows: National Health Service Education for Scotland Trigger Tool, National Health Service Education for Scotland Medicines...
Objective
To describe and classify health technologies predicted in forecasting studies.
Design and methods
A portrait describing health technologies predicted in 15 forecasting studies published between 1986 and 2010 that were identified in a previous systematic review. Health technologies are classified according to their type, purpose and clini...
The aim of our review is to identify the reconstruction technique that has a superior functional outcome and decreased number of complications for the anterior cruciate ligament (ACL). We have divided our review into 2 sections.
Our primary question evaluates the functional results and complications of autografts compared to allografts for ACL re...
INTRODUCTION
Rapid technological innovation is leading to new health technologies and interventions becoming available to healthcare markets at increasing speed; these often cost more than current alternatives and significantly affect the cost of healthcare services and delivery (1). Identifying future technologies supports service preparedness, lo...
Background: Previous studies on the frequency and nature of safety problems and harm in general practices are based on information supplied by health professionals, and scarce attention has been paid to patients themselves.
Aim: To examine patients´ perceptions and experiences of patient safety in Primary Care in England.
Design and Setting: Cross-...
Objectives
Forecasting can support rational decision-making around the introduction and use of emerging health technologies and prevent investment in technologies that have limited long-term potential. However, forecasting methods need to be credible. We performed a systematic search to identify the methods used in forecasting studies to predict fu...
Objectives:
To determine the accuracy of pharmaceutical companies' predictions of drug licensing timeframes for their products in late stage clinical development.
Methods:
We compared predicted licensing dates provided to the National Institute for Health Research Horizon Scanning Research and Intelligence Centre by pharmaceutical companies agai...
Context: Patient safety in primary care lags behind secondary care in terms of research/ measurement and quality improvement work. There are tools available to explore and potentially improve patient safety in primary care. As part of the Patient Safety Toolkit project, a toolkit comprising a selection of these tools was piloted in UK general pract...
Background: New health technologies are constantly in development and provide an increasing challenge to healthcare systems. The accurate prediction of significant health technologies helps health services to support their development or be better prepared for their adoption and diffusion. Although there is a vast literature speculating on future t...
Background: Providing timely information on new drugs is crucial to enable decision-makers to plan future allocation of resources and facilitate appropriate adoption. The optimal timing for the provision of information depends on the accuracy of predictions of launch in the health system.
Objectives: To determine how accurate pharmaceutical compani...
A systematic review was conducted of outcome measures used in treatment trials for older adolescents and adults with autism spectrum disorders (ASDs). Of 818 titles only 30 articles (19 of which involved pharmacological treatments) were identified that met inclusion criteria (sample size > 5; mean age of group > 15 years; mean IQ > 30; ASD diagnosi...
Background:
Older populations often suffer from multimorbidity and guidelines for each condition are often associated with recommended drug therapy management. Yet, how different and specific multimorbidity is associated with number and type of multi-drug therapies in general populations is unknown.
Aim:
The aim of this systematic review was to...
Objective We aimed to quantify the short-term effect of non-steroidal anti-inflammatory drugs (NSAIDs), aspirin and paracetamol analgesia dose prescribing on estimated glomerular filtration rate (eGFR) decline in the general practice population.
Design A population-based longitudinal clinical data linkage cohort study.
Setting Two large general pra...
Background
Care for patients with multimorbidity represents a major challenge not only for patients and carers but to health-care systems. Hospital discharge transition is a critical point at which challenges for multimorbidity may amplify.Objectives
The main objective of the study was to explore the experiences of heart failure (HF) and chronic ob...
How multimorbidity and socio-economic factors influence healthcare costs is unknown. Geo-demographic profiling system, Mosaic, which adds to socio-economic factors, provides the potential for an investigation of the relationship with multimorbidity, and their influence on healthcare costs.
Using chronic obstructive pulmonary disease (COPD) and chro...
Background:
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely regarded as one risk factor, which influences chronic kidney disease (CKD) progression. However, previous literature reviews have not quantified the risk in moderate to severe CKD patients.
Objective:
To estimate the strength of association between chronic NSAID use and CKD pr...
There is now considerable evidence that witnessing domestic violence can have adverse consequences for children. Our aim is to present the socio-demographic correlates of children witnessing domestic violence and its association with childhood mental disorders. The biographic, socio-demographic and socio-economic characteristics of 7865 children an...
Most children experience some degree of fear during their development. Specific fears are considered as an appropriate response provided that they are proportionate to the intensity of the perceived threat. Our aim is to present the prevalence of specific fears among children in the Great Britain, their socio-demographic correlates, in particular t...
