Lucky H Sekhon

• BSc, MD
• Fellow at Icahn School of Medicine at Mount Sinai

Objective: Utilization of fertility preservation treatments has increased since the American Society for Reproductive Medicine lifted the "experimental" label for oocyte cryopreservation in 2012. This study characterizes changes in insurance coverage, clinical outcomes, and live birth probabilities over a span of a decade (2012-2022) in patients wh...

Objective: To assess whether open and minimally invasive myomectomy are associated with changes in postoperative ovarian reserve as measured by serum anti-müllerian hormone (AMH) level. Methods: This prospective cohort study included patients who were undergoing open abdominal myomectomy that used a tourniquet or minimally invasive (robot-assist...

PurposeTo understand the clinical factors associated with embryo survival after vitrification in a cohort of human blastocysts screened by preimplantation genetic testing for aneuploidy (PGT-A).Methods Patient demographic, embryo, and cycle characteristics associated with failed euploid blastocyst survival were compared in a cohort of women (n = 61...

Objective The current study aimed to evaluate perinatal outcomes from transfers of euploid embryos that required trophectoderm (TE) biopsy on day 7 due to delayed cavitation. Design Retrospective study Materials and Methods This study included euploid embryos that underwent IVF and preimplantation genetic testing for aneuploidy (PGT-A) from 2011 to...

Objective Recent studies have demonstrated that extended culture of blastocysts to day 7 leads to satisfactory pregnancy outcomes in patients with slow-growing embryos.1,2 However, even when confirmed to be euploid by preimplantation genetic testing for aneuploidy (PGT-A), day 7 embryos have lower rates of implantation, clinical pregnancy, and live...

This chapter provides the indications, procedures, complications management, and follow‐up of the fertility preservation. To preserve fertility in women with genetic conditions associated with: accelerated or premature ovarian failure and cancer predisposition. To preserve fertility in women before they undergo surgery that may affect their ovarian...

To assess clinical outcomes of females diagnosed with Inflammatory Bowel Disease (IBD) and infertility, which underwent in vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy. (PGT-A). Retrospective cohort study comparing clinical outcomes of patients with Inflammatory bowel disease who underwent IVF with PGT-A with a subs...

Study question:Do women with baseline hyperandrogenemia have differential ovarian response, oocyte maturation, and/or embryo quality as compared to normoandrogenemic women? Summary answer: Despite greater ovarian reserve, hyperandrogenemic patients had similar oocyte yield, blastulation, and aneuploidy compared to normoandrogenemic women. Hyperandr...

Study question: Does endometrial biopsy (EMB) and chronic endometritis (CE) screening offer clinical utility in patients following euploid embryo implantation failure? Summary answer: Patients, regardless of endometrial biopsy findings, have similar IVF outcomes on a subsequent treatment cycle as compared with patients who do not undergo endometria...

Objective: To investigate whether the duration of estrogen administration before euploid embryo transfer affects clinical outcome. Design: Retrospective cohort study. Setting: Private, academic fertility center. Patient(s): Patients (n = 1,439) undergoing autologous freeze-only in vitro fertilization with preimplantation genetic testing (PGT...

Research question: Does the composite morphology score or a particular developmental component (expansion stage, inner cell mass [ICM] or trophectoderm [TE]) of euploid blastocysts undergoing single frozen embryo transfer (FET) impact ongoing pregnancy/live birth (OP/LB) rates? Design: Retrospective cohort study including a total of 2236 embryos...

Study objective: Data are limited regarding optimal timing between operative hysteroscopy and embryo transfer (ET). This study aimed to assess whether the time interval from operative hysteroscopy to ET affects implantation and clinical pregnancy rates. Design: Retrospective cohort study (Canadian Task Force classification II-2). Setting: Priv...

Study question: What clinical factors are associated with optimal cryopreserved oocyte survival, fertilization, embryo culture, and transfer outcomes? Summary answer: The outcome of autologous oocyte vitrification-warming cycles is optimized in younger patients who undergo transfer of blastocyst-stage embryos.

Study question: Is reproductive outcome compromised in patients with IBD who undergo IVF with transfer of single euploid blastocyst? Study design, size, duration: This was a retrospective cohort study of patients who underwent IVF with preimplantation genetic testing and subsequent euploid single embryo transfer (SET) of a vitrified-warmed blastocy...

Research question: Does vitrification and warming affect live birth rate, infant birth weight and timing of delivery? Design: Retrospective, cohort study comparing outcomes of donor oocyte recipient fresh (n = 25) versus vitrified (n = 86) euploid blastocyst transfers; donor oocyte recipient singleton live births from fresh (n = 100) versus vitr...

Transfer of a single euploid embryo results in high implantation and low miscarriage rates as well as decreases the risk of multiple gestations. In some cycles, not a single euploid embryo is produced. This study aimed to compare the relative importance of factors contributing to the development of at least one euploid embryo.

Objective Controlled ovarian hyperstimulation (COH) promotes multifollicular growth, increasing the chance of obtaining euploid embryos that will successfully implant. Whether aneuploidy is increased from COH with exogenous gonadotropins interfering with natural selection of dominant follicles is a concern. This study evaluates the association betw...