Lucindo José Quintans-Júnior

Lucindo José Quintans-Júnior
Universidade Federal de Sergipe · Departamento de Fisiologia

PhD - Pharmacology
Full Professor - Head of Laboratory of Neuroscience and Pharmacological Assays (LANEF)

About

573
Publications
164,876
Reads
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10,355
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Introduction
Graduated in Pharmacy by the Federal University of Paraíba - UFPB (1993-1997), Master's (1998-2000) and PhD (2000-2004) in Natural Products and Bioactive Compounds (Area: PHARMACY) by UFPB. Post-doctorate in Neuroscience at the University of Iowa (UIOWA, USA) (2012-2013). Full Professor in the Department of Physiology at the Federal University of Sergipe (DFS/UFS), Brazil.
Additional affiliations
October 2012 - September 2013
University of Iowa
Position
  • PostDoc Position
September 2006 - present
Universidade Federal de Sergipe
Position
  • Professor (Associate)
January 2006 - January 2015
Universidade Federal de Sergipe
Position
  • Head of Laboratory of Neuroscience and Pharmacological Assay - LANEF

Publications

Publications (573)
Article
Coronavirus disease 2019 (COVID-19), the infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an aggressive disease that attacks the respiratory tract and has a higher fatality rate than seasonal influenza. The COVID‐19 pandemic is a global health crisis, and no specific therapy or drug has been formally...
Article
Obesity is a major public health problem, and there is increasing scientific interest in its mechanisms , as well as a search for new compounds with antioxidant and anti-inflammatory properties that can minimize the metabolic complications associated with its pathology. One potential source of these compounds is natural products; Among these, flavo...
Article
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BACKGROUND Hydroxychloroquine (HCQ) is an anti-malarial and immunomodulatory drug considered a potential candidate for drug repurposing in COVID-19 due to their in vitro antiviral activity against SARS-CoV-2. Despite the potential antiviral effects and anti-inflammatory profile, the results based on clinical studies are contradictory. Therefore, th...
Article
Objectives Considering that γ-terpinene (γ-TPN) is a monoterpene found in Cannabis oil, with high lipophilicity and limited pharmacokinetics, our objective was to evaluate whether its complexation in β-cyclodextrin (γ-TPN/β-CD) could improve its physicochemical properties and action on cancer pain, as well as verify the mechanisms of action involve...
Article
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Destacamos que a UFS obteve um resultado expressivo nesta avaliação quadrienal. Para se ter noção do impacto e avanço dos resultados em nossa pós-graduação, cerca de 51,7% dos PPGs subiram da nota 3 para 4 (portanto, estando aptos a solicitar doutorado junto à CAPES). Assim, na UFS, se todas as propostas de doutorado (APCN) forem aprovadas, teremos...
Preprint
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No último dia 02/09, a CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) publicou o tão esperado resultado preliminar da sua avaliação quadrienal. Parte integrante do Ministério da Educação (MEC), a CAPES regula e coordena toda pós-graduação brasileira. A divulgação deste resultado, que encontra-se ainda sob judice, só está sendo...
Article
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Background There is evidence that chemosensory dysfunctions, including smell and taste disorders, are common findings in patients with SARS-CoV-2 infection. However, the underlying biological mechanisms and the role of inflammatory markers are still poorly understood. Aim To investigate the inflammatory biomarkers levels in patients with COVID-19...
Article
In this household-based seroepidemiological survey, we analyzed the dynamics of SARS-CoV-2 seroprevalence during the first year of the COVID-19 pandemic in Sergipe State, Northeast Brazil, the poorest region of the country. A total of 16,547 individuals were tested using a rapid IgM-IgG antibody test and fluorescence immunoassay (FIA). Seroprevalen...
Article
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). Studies have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may induce humoral and cellular immune memory to receptor-binding domain (RBD), spike glycoprotein (S), and nucleoc...
Poster
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Os estados de Sergipe, Alagoas e Piauí são os únicos do Nordeste ainda sem Programas de Pós-Graduação (PPG) considerados de excelência, ou seja, cursos que receberam nota igual ou superior a 6 na avaliação da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). A cada 4 anos, o órgão, vinculado ao Ministério da Educação (MEC), publi...
Article
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For more than 40 years, marine microorganisms have raised great interest because of their major ecological function and their numerous applications for biotechnology and pharmacology. Particularly, Archaea represent a resource of great potential for the identification of new metabolites because of their adaptation to extreme environmental condition...
Preprint
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Purpose Peptic ulcers are lesions in the gastric and duodenal mucosa generated by an imbalance between protective factors (gastroduodenal mucus secretion, bicarbonate production, adequate blood flow) and harmful factors (excess pepsin or hydrochloric acid). Some drugs used in peptic ulcer therapy are associated with adverse effects. The aim of this...
Article
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Hyptis martiusii Benth. also known as "cidreira brava", has some activities verified in the literature, such as antiulcerogenic, antimicrobial and antiedematogenic. This study aimed to verify the anti-inflammatory and antinociceptive effect of the leaves essential oil. For the evaluation of the anti-inflammatory activity of OEHM (100 mg/kg/p.o.), m...
Article
UV radiation can cause damages, such as erythema, skin photoaging, and carcinogenesis. The adoption of protective measures against sun exposure is essential to prevent these damages, and the interest in using natural substances as an alternative for photoprotection is growing. Thus, hesperetin with antioxidant, anti-inflammatory, and anticancer pro...
Article
Chagas disease and Human African trypanosomiasis (HAT) are caused by Trypanosoma cruzi, T. brucei rhodesiense or T. b. gambiense parasites, respectively; while Leishmania is caused by parasites from the Leishmania genus. In recent years, many efforts have been addressed to develop inhibitors against these parasites, especially nitro-containing deri...
Article
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Na última semana a Universidade Federal de Sergipe (UFS) foi destaque nacional pela qualidade do trabalho e das atividades científicas que desenvolve. A UFS foi listada entre as 3 melhores universidade do Brasil pelo ranking World University Rankings 2022, publicado pela revista britânica Times Higher Education (THE), pertencente ao grupo editorial...
Article
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Recentemente foi anunciado o novo ranking global das universidades elaborado pelo Webometrics Ranking of Universities (https://www.webometrics.info/en/Latin_America), uma iniciativa do grupo de pesquisa espanhol Cybermetrics Lab, que desde meados dos anos 1990 tem realizado classificações periódicas de instituições de ensino superior. Atualmente o...
Article
Valencene (VLN) is a sesquiterpene found in juices and essential oils of citrus species such as Cyperus rotundus. Considering the evidence that this species has anti-inflammatory effects, the present study aims to evaluate the anti-inflammatory activity of VLN in vivo and in silico. Swiss mice (n = 6) were orally treated according to their treatmen...
Article
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Background: Efflux pumps are transmembrane proteins that expel drugs out of a bacterial cell contributing to microorganism drug resistance. Several studies addressing the use of natural products with medicinal properties have intensified given the above. Thus, the aim of the present study was to investigate the antibacterial activity and the O-eug...
Article
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Parkinson’s disease (PD) is identified by the loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc), and is correlated to aggregates of proteins such as α-synuclein, Lewy’s bodies. Although the PD etiology remains poorly understood, evidence suggests a main role of oxidative stress on this process. Lippia grata Schauer, known as...
Article
Inflammatory arthritis is the most prevalent chronic inflammatory disease worldwide. The pathology of the disease is characterized by increased inflammation and oxidative stress, which leads to chronic pain and functional loss in the joints. Conventional anti-arthritic drugs used to relieve pain and other arthritic symptoms often cause severe side...
Article
Background: Neuroprotection in traumatic brain injury (TBI) is an unmet medical need. Objective: We evaluated two agents, aglepristone (progesterone receptor antagonist) and N-salicyloyltryptamine (STP) (activator of Maxi-K channel in GH3 cells), for neuroprotection in Feeney's weight drop model of TBI. Material and methods: Forty-eight male W...
Article
Background: Knee osteoarthritis (OA) is characterized by a progressive degeneration of cartilage and menisci, leading to pain and locomotor disability. Here, we aimed to assess the effect of an exercise protocol and the oral use of non-hydrolyzed collagen (UC-II) on the functionality and quality of life of women with knee OA. Material and methods...
Article
INTRODUÇÃO: A dor lombar é considerada o problema musculoesquelético mais prevalente e oneroso na maior parte dos países. A instabilidade lombar é apontada como causa primária e secundária desse tipo de dor. Dentre os métodos de tratamento, vem ganhando destaque as técnicas de reforço muscular, portanto é nesse contexto que se encaixa a Estabilizaç...
Article
Full-text available
Introduction: Osteoarthritis is a disease characterized by progressive wear and tear of the joint, with the knee being the most affected region. These patients have reduced mobility and mobility, among other symptoms. Thus, it is necessary to know the variables that influence the ability to walk. Objective: To analyze how much the gait capacity,...
Article
Astrocytes are the most abundant cell type in the human central nervous system, and they play an important role in the regulation of neuronal physiology. In neurological disorders, astrocyte disintegration leads to the release of glial fibrillary acidic protein (GFAP) from tissue into the bloodstream. Elevated serum levels of GFAP can serve as bloo...
Article
A dengue é uma doença infecciosa causada por um vírus transmitido pelo mosquito Aedes aegypti e tem um grande potencial geográfico, principalmente em regiões tropicais e subtropicais. O presente estudo constitui-se de um protocolo de revisão de escopo e tem como objetivo identificar e caracterizar as substâncias fitoquímicas com maior potencial lar...
Article
Osteoarthritis (OA) is a degenerative joint disease that occurs when there is a change in the mechanical and biological properties of the articular cartilage and the subchondral bone; The condition is more prevalent in women than in men. Pequi oil (PO), which is extracted from the fruits of the pequi tree (Caryocar coriaceum Wittm), is widely used...
Article
This study investigated the dynamics of hospitalizations and in-hospital deaths from COVID-19 throughout the pandemic in Northeast Brazil, a region with the worst socioeconomic indicators in the country. A total of 141,445 cases, 8,213 hospital admissions and 1,644 in-hospital deaths from COVID-19 were registered from 14 March 2020 to 5 February 20...
Article
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d-limonene (D-LIM) is a monoterpene found mainly in the essential oil of citrus fruits. Cardiovascular effects of D-LIM alone have been extensively demonstrated. Despite possessing important pharmacological effects, its chemical properties prevent its clinical application. This study aimed to produce and characterize hydroxypropyl-β-cyclodextrin (H...
Article
Background Cancer is a group of diseases characterized by abnormal cell growth and proliferation. Natural products are a potentially important source for bioactive phytochemicals in the management of cancer, which regulate a broad range of biological events via the modulation of interleukins (ILs), pro- and anti-inflammatory modulators, and other c...
Article
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Although chemotherapy-induced peripheral neuropathy is one of the main medical complaints of cancer patients, there are currently no specific drugs for the effective treatment. In this respect, α-terpineol (TP) seems to be a potential candidate for this purpose, since it has several pharmacological properties that can be improved by nanosytems. The...
Article
Background SARS-CoV-2 infection can lead to the abnormal induction of cytokines and a dysregulated hyperinflammatory state that is implicated in disease severity and risk of death. There are several molecules present in blood associated with immune cellular response, inflammation, and oxidative stress that could be used as severity markers in respi...
Article
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Cardiovascular diseases have high morbidity and mortality rates, and their treatment is not effective in reducing the damage caused by myocardial infarction (MI). This study aimed to investigate whether nerolidol (NRD), a sesquiterpene alcohol, could attenuate MI in an isoproterenol-treated rat model. MI was induced by the administration of two dos...
Article
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Coronavirus disease 2019 (COVID-19) is a potentially fatal disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that preferentially infects the respiratory tract. Bradykinin (BK) is a hypotensive substance that recently emerged as one of the mechanisms to explain COVID-19-related complications. Concerning this, in this...
Article
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Leishmaniasis and Chagas disease are neglected tropical diseases with relevance and public interest. Currently, the search for antiparasitic agents from medicinal plants has been the target of great research. Croton rhamnifolioides Pax. & K. Hoffm is known in popular medicine as “quebra-faca” or “caatinga-branca” and is used to treat stomachache, v...
Article
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THE FRANCO-BRAZILIAN NETWORK ON NATURAL PRODUCTS (FB2NP): A NEW NETWORK PROMOTING COOPERATION AND EXCHANGES IN NATURAL PRODUCTS RESEARCH
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Background The Erythroxylaceae family is known worldwide for its species that contain compounds with a marked positive effect on physical performance, such as ephedrine and coca. E. mucronatum is a species of this family found in several parts of South America, mainly in the northern and northeastern regions of Brazil, used by natives to improve st...
Article
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Hymenaea martiana is a species popularly known in Northeastern Brazil as "jatobá" and used in folk medicine to treat pain and inflammation. The aim of this work was to evaluate the antinociceptive and anti-inflammatory activity of H. martiana. In the present study, we carried out an investigation about the effects of the crude ethanolic extract (Hm...
Article
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We investigated the seroprevalence of SARS-CoV-2 antibodies in individuals working in radio and television stations (TV) in Sergipe state, Northeast Brazil. This cross-sectional study was conducted from December 1 to December 20, 2020, a period which was considered as the beginning of the second wave of COVID-19 in the state. One hundred and thirte...
Article
Background Chronic orofacial pain is a serious public health problem with a prevalence of 7-11% in the population. This disorder has different etiologies and characteristics that make pharmacological treatment difficult. Natural products have been shown to be a promising source of treatments for the management of chronic pain, as an example the ter...
Article
Background : The traditional information of Acalypha alnifolia is captivate towards its therapeutic efficacy against diabetes along with the scientific confirmation were leads to an instinct to extract phytocompounds and to evaluate antidiabetic-molecular mechanism. Methods : Column chromatographic compound isolation were adopted to extract the pu...
Article
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Chrysin is a bioactive flavonoid found in pollens, passion flowers, honey, royal jelly, and propolis, which is commonly used as an ingredient in natural food supplements and is primarily responsible for their pharmacological properties. A transparent chrysin-loaded microemulsion (CS-ME) prepared through a ternary phase diagram was evaluated for use...
Article
Alpha-terpineol (TPN) is one of the major components of the resin obtained from Protium heptaphyllum. This plant has been utilized as medicine by Brazilian indigenous tribes to treat cardiovascular diseases. Scientific reports have shown that the TPN possesses vasorelaxant and antihypertensive effects. This study was conducted to assess the cardiop...
Article
Although we have at our disposal relatively low-cost drugs that can be prescribed for the treatment of malaria, the prevalence of resistant strains of the causative parasite has required the...
Article
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Passiflora nitida Kunth, an Amazonian Passiflora species, is little studied, although the specie’s high biological potential. Herein the plant’s pharmacognostic characterization, extract production, antioxidant potential evaluation, and application of this extract in cosmetic products is reported. The physical chemical parameters analyzed were part...
Article
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Abstract This study evaluated the ability of resistance training (RT) of moderate intensity to promote vascular changes in insulin-induced vasodilation in healthy animals. Wistar rats were divided into two groups: control (CON) and trained (eight weeks of training, performing 3 sets with 10 repetitions at 60% of maximum intensity). Forty-eight hour...
Book
Anais do Simpósio Brasileiro de Farmacognosia - XIII SBFgnosia https://www.even3.com.br/anais/sbfgnosia/ Apresentação O Simpósio Brasileiro de Farmacognosia teve o objetivo de mostrar a importância dessa área no contexto da Farmacognosia atual e das Ciências Farmacêutica, interagindo com a inovação e transferência de tecnologias. Com início no a...
Article
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Semana passada foi publicada em um dos mais prestigiados jornais científicos do mundo, a revista Science, uma Letter (uma espécie de carta ao editor) capitaneada por pesquisadores brasileiros, intitulada “SOBREVIVENDO COMO UM JOVEM PESQUISADOR NO BRASIL” (O artigo original pode ser acessado em: https://www.science.org/doi/10.1126/science.abm8160),...
Article
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Patients without access to medicines often resort to the judicial system. However, no systematic review has discussed the quality of studies and the factors that may influence the access to medicines from judicialization. This study aimed to characterize the quality of research on access to judicialized medicines and their influence on public polic...
Article
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Even with the current advances that have been made in regard to COVID-19, such as a better understanding of the disease and the steady growth in the number of vaccinated individuals, it remains a challenge for humanity. Dealing with the disease in prison settings has been particularly difficult. This study sought to discover whether in-person visit...
Article
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Phytol (PHY), a constituent of chlorophyll, has some pharmacological properties such as an-tioxidant, anti-inflammatory, anxiolytic, antide-pressant, and antihyperalgesic effects. Compounds like this one have a high potential to develop neuroprotective action. Repeated administration of reserpine (RES) in rodents induces motor impairments and has b...
Article
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Introdução: Em contraste com o grande número de estudos relacionados aos fatores de risco para adquirir infecção pelo Papilomavírus humano (HPV) em mulheres, pouco se conhece acerca desses fatores em homens. Objetivo: Determinar a prevalência de lesões epiteliais penianas induzidas pelo HPV em homens parceiros de mulheres com lesões cervicais induz...
Article
Full-text available
Background and purpose: Miller Fisher syndrome (MFS) is a subtype of Guillain-Barré syndrome characterized by the triad of ophthalmoparesis, areflexia, and ataxia. Although cases of MFS have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, no studies have synthesized the clinical characteristics of patie...
Article
Full-text available
Background: Fibromyalgia syndrome (FMS) is an extra-articular rheumatologic disease with an estimated prevalence of 2–4%, whose etiology and pathogenesis are still unknown. Oxidative stress is an imbalance between products of oxidation and antioxidant defenses and plays a critical role in the etiopathogenesis of FMS. Lidocaine is a local anesthetic...
Article
Full-text available
Objetivos A pandemia da COVID-19, doença causada pelo coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), já ultrapassou 200 milhões de casos no mundo e mais de 4 milhões de óbitos. Os indivíduos podem apresentar-se assintomático, com sintomas leves ou graves associados às infecções do trato respiratório. Pacientes com COVID-19 apresen...
Article
Background: Saponins are glycosides which, after acid hydrolysis, liberate sugar(s) and an aglycone (sapogenin) which can be triterpenoid or steroidal in nature. Steroidal saponins and sapogenins have attracted significant attention as important natural anti-inflammatory compounds capable of acting on the activity of several inflammatory cytokines...
Article
Full-text available
Introdução: Em contraste com o grande número de estudos relacionados aos fatores de risco para adquirir infecção pelo Papilomavírus humano (HPV) em mulheres, pouco se conhece acerca desses fatores em homens. Objetivo: Determinar a prevalência de lesões epiteliais penianas induzidas pelo HPV em homens parceiros de mulheres com lesões cervicais induz...