Lucília Diogo

Lucília Diogo
Católica Medical School

PharmD, PhD

About

26
Publications
3,317
Reads
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297
Citations
Citations since 2017
4 Research Items
239 Citations
201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050
Additional affiliations
September 2008 - February 2015
Universidade NOVA de Lisboa
Position
  • Research Assistant
September 2008 - February 2015
NOVA Medical School / CEDOC
Position
  • Research Assistant
September 2008 - February 2015
NOVA Medical School / Chronic Diseases Research Center (CEDOC)
Position
  • Research Assistant

Publications

Publications (26)
Article
Background Schizophrenia is a chronic, severe and disabling brain disorder with a still poorly understood heterogeneous neurobiological and genetic background, estimated to affect 1% of the population worldwide. A series of findings have concluded that cellular inflammatory immune alterations are associated with psychopathology variation and may co...
Chapter
Previous data showed the lack of efficacy of an adrenoceptor antagonist to revert hypertension induced by chronic intermittent hypoxia (CIH). We hypothesized that, in addition to sympathetic activation, CIH may change the availability and dynamics of cysteine. Temporal variation in total cysteine and its fractions, free reduced, free oxidized and p...
Article
Efavirenz is an anti-HIV drug that presents relevant short- and long-term central nervous system adverse reactions. Its main metabolite (8-hydroxy-efavirenz) was demonstrated to be a more potent neurotoxin than efavirenz itself. This work was aimed to understand how efavirenz biotransformation to 8-hydroxy-efavirenz is related to its short- and lon...
Article
Efavirenz is a drug of choice for adults and children infected with the human immunodeficiency virus. Notably, up to 35% of patients on efavirenz suffer from mood changes. This work aimed to investigate efavirenz biotransformation into 8-hydroxy-efavirenz as an up-stream event of mood changes and to evaluate the suitability of 8-hydroxy-efavirenz b...
Article
Hypertension is associated with cerebrovascular disease, white matter lesion and cognitive deficit, both in experimental models and clinical observations. Furthermore, in non-clinical models it is shown that hippocampus is affected by hypertension and hypoxia. Herein, two distinct hypertension models were used to study neurogenic response in hippoc...
Article
Chronic intermittent hypoxia (CIH) is a feature of obstructive sleep apnea (OSA). Whereas clinical studies have demonstrated the association between OSA and insulin resistance, the molecular mechanisms behind it are still unknown. Herein we investigated the effect of mild CIH on insulin sensitivity and we evaluated the changes in insulin and HIF si...
Article
Full-text available
Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder which is associated with patient morbidity and an elevated risk of developing hypertension and cardiovascular diseases. There is ample evidence for the involvement of bone marrow (BM) cells in the pathophysiology of cardiovascular diseases but a connection between...
Article
Full-text available
Objective: This paper is aimed at identifying putative morphological changes induced in the rat's tracheal mucosa by chronic hyperbaric oxygen (HBO) treatment or chronic intermittent hypoxia (CIH). Study design: Tracheal samples were obtained from three groups of 11, 12 and 13 adult Wistar rats. The first group was submitted to 20 sessions of 10...
Article
Full-text available
Gavage is a widely performed technique for daily dosing in laboratory rodents. Although effective, gavage comprises a sequence of potentially stressful procedures for laboratory animals that may introduce bias into experimental results, especially when the drugs to be tested interfere with stress-dependent parameters. We aimed to test vehicles suit...
Article
Chronic intermittent hypoxia (CIH) and hypertension are closely related conditions. In studies performed with animal models of CIH, antihypertensive drugs were just used as pharmacological tools and the experiments were not planned to first induce hypertension and further evaluate the efficacy of drugs. We aimed to investigate in a rat model of CIH...
Article
Full-text available
Obstructive sleep apnea and hypertension are closely related diseases. The lowering effect of continuous positive airway pressure (CPAP) on blood pressure (BP) control is modest and concomitant antihypertensive therapy is still required. However, the best antihypertensive regimen for BP control in patients with OSA remains unknown. We aimed to inve...
Article
Animal models of chronic intermittent hypoxia (CIH) mimic the hypertension observed in patients with obstructive sleep apnoea. Antihypertensive drugs were applied to these animal models to address the physiological mechanism but not to revert established hypertension. We aimed to investigate the efficacy of carvedilol (CVDL), an unselective beta-bl...
Article
Full-text available
The carotid bodies (CB) are peripheral chemoreceptors that sense changes in arterial blood O2, CO2, and pH levels. Hypoxia, hypercapnia, and acidosis activate the CB, which respond by increasing the action potential frequency in their sensory nerve, the carotid sinus nerve (CSN). CSN activity is integrated in the brain stem to induce a panoply of c...
Article
Full-text available
Sleep apnea/hypopnea disorders include centrally originated diseases and obstructive sleep apnea (OSA). This last condition is renowned as a frequent secondary cause of hypertension (HT). The mechanisms involved in the pathogenesis of HT can be summarized in relation to two main pathways: sympathetic nervous system stimulation mediated mainly by ac...
Article
Full-text available
Objective(s): Twenty-four-hour ambulatory blood pressure monitoring (ABPM) seems to be the most accurate way of diagnosing hypertension in patients with obstructive sleep apnea (OSA). However, this diagnostic tool is expensive and time-consuming and is therefore not used routinely. We aimed to find baseline predictors that enable the identificatio...
Article
Sensitive skin is a subject of intense research work. However, its contours have not been defined and properly investigated so far. The aim of this work was to characterize objectively the consumers of cosmetic products, which referred skin susceptibility to several agents or conditions. Twenty-four healthy female volunteers, mean age 38.9+/-13 yea...
Article
IFSCC Magazine, 12 (2009) (2) 107–110 Reports from global markets suggest that the sensitive skin syndrome affects 50% of the population. Since there is currently no information on this condition in a small market like that in Portugal, the authors designed this descriptive cross-sectional study to characterize this syndrome in this particular cont...

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Projects

Projects (4)
Project
Mechanism underlying efavirenz neurotoxicity Factors of interindividual variability in efavirenz response