Luciano Furlanetti

Luciano Furlanetti
King's College London | KCL · Department of Basic & Clinical Neuroscience

MD, PhD, FEBNS

About

67
Publications
36,901
Reads
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592
Citations
Additional affiliations
November 2019 - December 2019
Hospices Civils de Lyon (Centre Hospitalier Universitaire de Lyon)
Position
  • Observship functional neurosurgery
May 2018 - present
King's College Hospital NHS Foundation Trust
Position
  • Fellow
Description
  • Clinical fellow 2018 - 2020. Currently external research collaborator. Full registration Specialist in Neurosurgery (GMC-UK)
August 2015 - July 2018
Universität des Saarlandes
Position
  • Facharzt für Neurochirurgie
Education
August 2018 - February 2020
King's College Hospital NHS Foundation Trust
Field of study
  • Functional Neurosurgery, Epilepsy and Neuro-oncology
October 2016 - March 2017
European Association of Neurosurgical Societies
Field of study
  • Neurosurgery
November 2014 - June 2018
University Medical Center Freiburg/ University of Saarland
Field of study
  • German Board Certification in Neurosurgery

Publications

Publications (67)
Article
Full-text available
Over the last two decades deep brain stimulation (DBS) has become a widely used therapeutic alternative for a variety of neurological and psychiatric diseases. The extensive experience in the field of movement disorders has provided valuable knowledge and has led the path to its application to other hard-to-treat conditions. Despite the recognised...
Article
Full-text available
A scientific journal’s greatest responsibility is to ensure that all contributions accepted for publications are rigorously but fairly reviewed. The Editor-in-Chief and Archives of Pediatric Neurosurgery gratefully acknowledge the qualified and regular collaboration of renowned medical doctors and scientists who kindly devoted their time to constru...
Chapter
Neurosurgery has provided an alternative option for patients with refractory psychiatric indications. Lesion procedures were the initial techniques used, but deep brain stimulation (DBS) has the advantage of relative reversibility and adjustability. This chapter sets out to delineate the current evidence for DBS use in paediatric psychiatric condit...
Chapter
Astrocytomas are the most common type of primary brain tumors in adults and children. The recently Revised fourth Edition of World Health Organization (WHO) Classification of Central Nervous System Tumors has led to a paradigm shift concerning the understanding of the natural history and management of CNS tumors, shedding light to the importance of...
Article
Full-text available
Background Central itch syndrome has been previously described in conditions such as stroke. The neurophysiology of central itch syndrome has been investigated in non-human primates but remains incompletely understood. Methods We report an observational study of a rare case of severe central itch following thalamic deep brain stimulation and postu...
Article
Cavernous malformations are vascular malformations that can occur anywhere in the central nervous system (CNS). Giant cavernous malformations (GCM) are extremely rare in adults, especially in the posterior fossa. Herein, we described a 48-year-old male who presented with vertigo and postural instability for three months. Neuroimaging revealed a 131...
Article
Full-text available
Penfield's motor homunculus describes a caricaturised yet useful representation of the map of various body parts on the pre-central cortex. We propose a supplemental map of the clinically represented areas of human body in pre-central cortex and a novel subcortical corticospinal tract map. We believe this knowledge is essential for safe surgery in...
Article
Full-text available
IntroductionDystonic opisthotonus is defined as a backward arching of the neck and trunk, which ranges in severity from mild backward jerks to life-threatening prolonged severe muscular spasms. It can be associated with generalized dystonic syndromes or, rarely, present as a form of axial truncal dystonia. The etiologies vary from idiopathic, genet...
Poster
Full-text available
Abstract Objective: The study aims to propose a supplemental map of the clinically represented areas of human body in pre-central cortex and a novel subcortical corticospinal tract map that are accurate and essential for safe surgery in patients with eloquent brain lesions. Design: It is a 5-year single-centre retrospective cohort study between 2...
Article
Full-text available
Introduction Europe was the epicentre of the COVID-19 pandemic in March 2020, with the highest number of cases and deaths between March and April. In May, the infection numbers registered a fall followed by a second new rise, not proportionally reflected by an increase in the number of deaths. We aimed to investigate the relationship between diseas...
Article
Full-text available
OBJECTIVE Deep brain stimulation (DBS) is an established treatment for pediatric dystonia. The accuracy of electrode implantation is multifactorial and remains a challenge in this age group, mainly due to smaller anatomical targets in very young patients compared to adults, and also due to anatomical abnormalities frequently associated with some et...
Article
The brainstem is defined as the portion of the neural axis between the diencephalon and the cervical spinal cord. Brainstem gliomas (BSGs) can occur anywhere within this region and account for 10% to 15% of primary pediatric intracranial tumors. The development of neuroimaging allied to the refinement of surgical tools, such as improved magnificati...
Article
Purpose: The subthalamic nucleus (STN) and globus pallidus internus (GPi) targets for deep brain stimulation (DBS) can be defined by atlas coordinates or direct visualisation of the target on MRI. The aim of this study was to evaluate geometric differences between atlas-based targeting and MRI-guided direct targeting. Methods: One-hundred-nine Park...
Article
Full-text available
A scientific journal’s greatest responsibility is to ensure that all contributions accepted for publications are rigorously but fairly reviewed. The Editor-in-Chief and Archives of Pediatric Neurosurgery gratefully acknowledge the qualified and regular collaboration of renowned medical doctors and scientists who kindly devoted their time to constru...
Article
Full-text available
Introduction: Deep brain stimulation (DBS) surgery is an established treatment for movement disorders. Advances in neuroimaging techniques have resulted in improved targeting accuracy that may improve clinical outcomes. This study aimed to evaluate the safety and feasibility of using the Medtronic O-arm device for the acquisition of intraoperative...
Article
Full-text available
OBJECTIVES Coronavirus disease (COVID-19) is a potentially severe respiratory illness that has threatened humanity globally. The pediatric neurosurgery practice differs from that of adults in that it treats children in various stages of physical and psychological development and contemplates diseases that do not exist in other areas. The aim of thi...
Preprint
Full-text available
Introduction: Penfield’s motor homunculus describes a caricaturised yet useful representation of the map of various body parts on the pre-central cortex. We propose a supplemental map of the clinically represented areas of human body in pre-central cortex and a novel subcortical corticospinal tract map that are accurate and essential for safe surge...
Article
Full-text available
Introduction Neurosurgery has provided an alternative option for patients with refractory psychiatric indications. Lesion procedures were the initial techniques used, but deep brain stimulation (DBS) has the advantage of relative reversibility and adjustability. This review sets out to delineate the current evidence for DBS use in psychiatric condi...
Conference Paper
Full-text available
Objective: This study aimed to evaluate the safety and feasibility of using the Medtronic O-arm device for the acquisition of intraoperative stereotactic imaging, targeting, and localization of DBS electrodes compared with standard stereotactic MRI or CT. The outcomes evaluated included targeting accuracy, total surgical time, length of time of acq...
Article
Full-text available
Dystonia secondary to cerebral infarcts presents months to years after the initial insult, is usually unilateral and causes significant morbidity. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is established as the most frequent target in the management of the dystonic symptoms. We report our experience with subthalamic nucleus...
Article
Full-text available
Introduction: Hydrocephalus is the most common neurosurgical condition among children worldwide and shunt diversion of the cerebral-spinal fluid (CSF) has been widely available. The aim of the present study was to perform a systematic review on types and models of shunt devices available and critically evaluate scientific evidence in favor of the u...
Article
Background Lesch–Nyhan syndrome (LNS) is a rare genetic disorder characterized by a deficiency of hypoxanthine‐guanine phosphoribosyltransferase enzyme. It manifests during infancy with compulsive self‐mutilation behavior associated with disabling generalized dystonia and dyskinesia. Clinical management of these patients poses an enormous challenge...
Article
Background Lesions within the primary motor cortex (M1) and the corticospinal tract (CST) represent a significant surgical challenge with a delicate functional trade-off that should be integrated in the overall patient-centered treatment plan. Methods Patients with lesions within the M1 and CST with preoperative cortical and subcortical mapping (na...
Article
Full-text available
Much controversy remains on the current management of Chiari I deformity (CID) in children, with many clinical, surgical and ethic-legal implications. The Brazilian Society of Pediatric Neurosurgery (SBNPed, in the Portuguese acronym) has put together a panel of experts to analyze updated published data on the medical literature about this matter a...
Article
Full-text available
Introduction: Deep brain stimulation (DBS) is an established treatment for movement disorders. We have previously shown that in our practice, the majority of adult patients prefer fixed-life implantable pulse generators (IPG), although rechargeable batteries are increasingly used. The aim of this study was to evaluate patients’ long-term satisfacti...
Article
Full-text available
Background Lesions within the corticospinal tract (CST) represent significant surgical challenge with a delicate functional trade-off that should be integrated in the overall patient-centred treatment plan. Methods Patients with lesions within the CST with preoperative cortical and subcortical mapping (nTMS and tractography), intraoperative mappin...
Poster
Full-text available
First case series of cortical and subcortical stimulation of the cortex and subcortical region leading to stimulation and contraction of intercostal muscles during intraoperative mapping and neuromonitoring for brain tumour resection.
Article
Full-text available
Objective The effectiveness of decompressive craniectomy (DC) in the context of neurocritical care in adult patients has been recently under debate. The aim of our study was to evaluate the impact of decompressive craniectomy in severe traumatic brain injury (TBI) in children, focusing on short and long-term neurological and neuropsychological outc...
Article
Full-text available
Introduction: Neuroendoscopy is particularly useful as an adjunct in the treatment of hydrocephalus. CSF physiology differs among neonates, children and adults leading to different and conflicting results in the treatment of hydrocephalus using neuroendoscopy. The aim of our study was to review the literature regarding to analyze predictive clinica...
Poster
Full-text available
Prospective Cohort Study and Technical Report. Patients with suspected metastatic lesions within the motor cortex considered not suitable for radiosurgery were included. Preoperative MRI for neuronavigation, navigated transcranial magnetic stimulation (nTMS), pre-operative DTI Tractography, intraoperative neuromonitoring and demographic/clinical va...
Article
Full-text available
Introduction Head injury is a significant economic, social, and medical problem in developing countries and remains one of the leading causes of pediatric morbidity and mortality. The association of traumatic brain injury and coagulopathy in children is linked with an increase in mortality and poor functional outcomes. However, its impact on long-t...
Article
Background: Clinical trials of supra-lateral medial forebrain bundle (MFB) Deep Brain Stimulation (DBS) in treatment resistant major depressive patients have shown rapid and long-term benefits. Objective/hypothesis: The study used Flinders Sensitive Line (FSL) rats with previously identified depressive-like phenotype to assess the range of behav...
Article
Full-text available
Restorative therapy concepts, such as cell based therapies aim to restitute impaired neurotransmission in neurodegenerative diseases. New strategies to enhance grafted cell survival and integration are still needed to improve functional recovery. Anodal direct current stimulation (DCS) promotes neuronal activity and secretion of the trophic factor...
Thesis
Depression along with anxiety disorders is the most prevalent psychiatric illness worldwide, with a prevalence ranging from 3-7%. It has been reported that the disease relapses in about the half of these patients, becoming chronic and resistant to treatment by up to 20% of them. Due to often hospitalizations, absenteeism and disability, depression...
Article
Full-text available
DBS of the medial forebrain bundle (MFB) has been investigated clinically in major depressive disorder patients with rapid and long-term reduction of symptoms. In the context of chronic bilateral high frequency deep brain stimulation (DBS) of the MFB, the current study looked at the impact of lesioning the ascending dopaminergic pathway at the leve...
Article
Full-text available
Preclinical and clinical evidence suggests that depression might be associated with a dysfunction in the reward/motivation circuitry. Deep Brain stimulation (DBS) of the supero-lateral branch of the medial forebrain bundle (MFB) has been shown in a recent clinical trial to provide a prompt and consistent improvement of depressive symptoms in treatm...
Article
The aim of this study was to analyze the impact of deep brain stimulation (DBS) of the posteromedial hypothalamus (pHyp) on seizure frequency in patients with drug-resistant epilepsy (DRE) associated with intractable aggressive behavior (IAB). Data were collected retrospectively from nine patients, who received bilateral stereotactic pHyp-DBS for t...
Article
Clinical trials have recently shown that Deep Brain Stimulation (DBS) can be applied to treat psychiatric disorders (e.g. Parkinson's disease, depression or obsessive compulsive disorders (OCD)). However, the underlying mechanisms of these disorders, as well as the influence of electrical stimulation remain not fully understood. We present a hybrid...
Article
Full-text available
Holmes tremor (HT) is a difficult-to-treat, very disabling symptomatic condition which characteristically appears weeks to years after a brain lesion. It features a unique combination of rest, action, and postural tremors. Pharmacotherapy is mostly not effective. Chronic deep brain stimulation (DBS) of ventralis intermedius nucleus (Vim) of thalamu...
Article
Full-text available
Objective: High frequency deep brain stimulation (DBS) for treatment-resistant major depressive disorder is an investigational therapeutic option offering some patients a long-lasting control of the disease. Recently, bilateral DBS of the supero-lateral branch of the medial forebrain bundle (MFB) rapidly and dramatically reduced depressive symptoms...
Article
Full-text available
Subthalamic nucleus (STN) high-frequency stimulation (HFS) is a routine treatment in Parkinson's disease (PD), with confirmed long-term benefits. An alternative, but still experimental, treatment is cell replacement and restorative therapy based on transplanted dopaminergic neurons. The current experiment evaluated the potential synergy between neu...
Article
Modulating neuronal activity by electrical stimulation has expanded from the realm of motor indications into the field of psychiatric disorders in the past 10 years. The medial forebrain bundle (MFB), with a seminal role in motor, reward orientated and affect regulation behaviors, and its afferent and efferent loci, have been targeted in several DB...
Article
Full-text available
Objective: This study aims to evaluate the impact of gross total resection of giant supratentorial brain tumors (GSBT) on survival and neurological outcome in a consecutive single-center pediatric series. Methods: Clinical data of 23 patients under 18 years of age operated with GSBT (≥5 cm in diameter) were reviewed to determine epidemiological...
Article
Full-text available
Subthalamic nucleus (STN) modulation is currently the gold standard in the treatment of Parkinson's disease (PD) cases refractory to medication. Cell transplantation is a tissue-restorative approach and is a promising strategy in the treatment of PD. One of the obstacles to overcome in cell therapy is the poor dopaminergic cell survival. Our experi...
Data
Subthalamic nucleus (STN) modulation is currently the gold standard in the treatment of Parkinson's disease (PD) cases refrac-tory to medication. Cell transplantation is a tissue-restorative approach and is a promising strategy in the treatment of PD. One of the obstacles to overcome in cell therapy is the poor dopaminergic cell survival. Our exper...
Article
Full-text available
Purpose: Intrastriatal neural transplantation using multiple grafts is an experimental approach to the treatment of Huntington's disease (HD). Brain atrophy makes stereotactic plans in these patients a tedious procedure with a risk of suboptimal spatial distribution of the grafts in transplantation procedures. Here we present a self-developed soft...
Article
Full-text available
Objective: The treatment of hydrocephalus in children with endoscopic third ventriculostomy (ETV) has particular features and is associated with different success rates (SR). The aim of this study was to identify putative factors that could influence the outcome of ETV in children. Methods: Clinical data of 114 consecutive patients under 18 year...
Article
Full-text available
Objective: Neuroendoscopic surgery in children has particular features and is associated with different success rates (SR). The aim of this study was to identify putative factors that could influence the outcome in pediatric patients. Methods: Clinical data of 177 patients under 18 years of age submitted to 200 consecutive neuroendoscopic proced...
Article
Objective: To describe an atypical clinical and radiological presentation of a brainstem epidermoid cyst in a child and to provide a review of the medical literature on brainstem epidermoid cysts in children. Material and method: Review of medical records and operative notes of an unusual case of a patient with a brainstem epidermoid cyst. MEDLI...
Article
Full-text available
The goal of this study was to determine the epidemiology, clinical presentation, associated factors, pathological features, and treatment outcome of pediatric meningiomas in a single-center institution. Clinical data of 15 patients under 18 years of age operated on for meningiomas from January 1994 to December 2010 were reviewed. The study group in...
Article
Full-text available
Cavernous hemangioma (CH) is a sporadic vascular malformation occurring either as an autosomal dominant condition or as a well-known complication of radiation exposure. Medulloblastoma is a primitive neuroectodermal tumor common in children and currently treated with surgical resection, chemotherapy, and radiotherapy. Neurofibromatosis is the most...
Article
Full-text available
Total scalp avulsion is a devastating injury in clinical practice. It often occurs in female adults, being rare in children. The standard treatment for scalp avulsion is microsurgical replantation, when feasible. Coverage becomes a major problem when replantation fails or is contraindicated, resulting in significant morbidity and requiring multiple...
Article
To present our experience with penetrating cardiac injuries. We have retrospectively reviewed the records of 70 victims of penetrating cardiac injuries. A logistic regression has been performed in order to determine the association between death and clinical predictors. Penetrating injuries consisted of 43 stab wounds (61.4%) and 27 (38.6%) gunshot...