Luciana Souto Mofatto

Luciana Souto Mofatto
University of Campinas | UNICAMP · Institute of Biology (IB)

DDS, MS, PhD

About

55
Publications
6,270
Reads
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462
Citations
Citations since 2016
43 Research Items
418 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Additional affiliations
November 2018 - December 2019
Secretaria da Educação do Estado de São Paulo
Position
  • Analista de Tecnologia da Informação
Education
January 2020 - January 2021
University of Campinas
Field of study
  • Bioinformatics
May 2014 - January 2018
University of Campinas
Field of study
  • Bioinformatics
July 2010 - March 2014
University of Campinas
Field of study
  • Bioinformatics

Publications

Publications (55)
Poster
Objectives Carcinoma ex pleomorphic adenoma (CXPA) development is considered a sequential process, with genetic mutations determining phenotypic tumor progression. In this sense, the transition from a pleomorphic adenoma (PA) to CXPA can be attributed to the acquisition of mutational events in tumor suppressor genes such as TP53. This study aims to...
Article
Full-text available
Currently, there are no evidence-based treatment options for long COVID-19, and it is known that SARS-CoV-2 can persist in part of the infected patients, especially those with immunosuppression. Since there is a robust secretion of SARS-CoV-2-specific highly-neutralizing IgA antibodies in breast milk, and because this immunoglobulin plays an essent...
Article
Full-text available
Wood-feeding termites effectively degrade plant biomass through enzymatic degradation. Despite their high efficiencies, however, individual glycoside hydrolases isolated from termites and their symbionts exhibit anomalously low effectiveness in lignocellulose degradation, suggesting hereto unknown enzymatic activities in their digestome. Herein, we...
Article
The prevalence of obesity has increased significantly worldwide. Therefore, this study aimed to evaluate the influence of obesity on the proteomic profile of periodontal ligament (PDL) tissues of rat first maxillary molars (1 M) submitted to orthodontic tooth movement (OTM). Ten Holtzman rats were distributed into two groups (n = 5): the M group (O...
Article
Background and objectives: Many studies have been conducted to better understand the molecular mechanism involved with periodontitis progression. There has been growing interest in the potential impact of obesity on periodontitis onset and progression, but the mechanisms involved remain to be elucidated. The present study was designed to determine...
Article
Cementum is a mineralized tissue that covers tooth roots and functions in the periodontal attachment complex. Cementocytes, resident cells of cellular cementum, share many characteristics with osteocytes, are mechanoresponsive cells that direct bone remodeling based on changes in loading. We hypothesized that cementocytes play a key role during ort...
Article
Full-text available
Background: Some studies have determined that the SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination with adenovirus-vectored and inactivated vaccines. Methods: We...
Article
Full-text available
Background: Mutations accrued by SARS-CoV-2 lineage P.1—first detected in Brazil in early January, 2021—include amino acid changes in the receptor-binding domain of the viral spike protein that also are reported in other variants of concern, including B.1.1.7 and B.1.351. We aimed to investigate whether isolates of wild-type P.1 lineage SARS-CoV-2...
Article
Full-text available
In this work, we evaluated the fermentative performance and metabolism modifications of a second generation (2G) industrial yeast by comparing an industrial condition during laboratory and industrial scale fermentations. Fermentations were done using industrial lignocellulosic hydrolysate and a synthetic medium containing inhibitors and analyses we...
Article
Full-text available
In this work, we evaluated the fermentative performance and metabolism modifications of a second generation (2G) industrial yeast by comparing an industrial condition during laboratory and industrial scale fermentations. Fermentations were done using industrial lignocellulosic hydrolysate and a synthetic medium containing inhibitors and analyses we...
Article
Full-text available
We documented 4 cases of severe acute respiratory syndrome coronavirus 2 reinfection by non-variant of concern strains among healthcare workers in Campinas, Brazil. We isolated infectious particles from nasopharyngeal secretions during both infection episodes. Improved and continued protection measures are necessary to mitigate the risk for reinfec...
Article
Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes which catalyze the oxidative cleavage of polysaccharides. LPMOs belonging to the family 15 in the Auxiliary Activity (AA) class from the Carbohydrate-Active Enzyme database are found widespread across the Tree of Life, including viruses, algae, oomycetes and animals. Recently,...
Preprint
Full-text available
Background: A new SARS-CoV-2 lineage, named P.1 (20J/501Y.V3), has recently been detected in Brazil. Mutations accrued by the P.1 lineage include amino acid changes in the receptor-binding domain of the spike protein that also are reported in variants of concern in the United Kingdom (B.1.1.7) and South Africa (B.1.325). Methods: We isolated two P...
Article
Background and Objectives Dental cementum (DC) is a mineralized tissue covering tooth roots that plays a critical role in dental attachment. Differences in deciduous vs. permanent tooth DC have not been explored. We hypothesized that proteomic analysis of DC matrix would identify compositional differences in deciduous (DecDC) vs. permanent (PermDC)...
Article
Full-text available
Objective Our study aimed to clarify the differential transcriptome profile of PDL cells poised to differentiate into the O/C cell lineage. Methodology To characterize periodontal-derived cells with distinct differentiation capacities, single-cell-derived clones were isolated from adult human PDL progenitor cells and their potential to differentia...
Chapter
Full-text available
Eucalyptus é um gênero nativo da Austrália que possui como característica a alta adaptabilidade e rápido crescimento em diversas condições edafoclimáticas. Atualmente o Eucalyptus é utilizado na produção de celulose e papel devido a essas características, além de apresentar alto potencial para a produção de biocombustível de segunda geração por ter...
Chapter
Full-text available
Due to the immense complexity of plant genomes, transcriptomic analysis plays a relevant role in understanding the biological mechanism, since in addition to providing evidence of how the organism responds in a given situation, RNA sequencing can also be used to aid genomic information. The analysis can be divided into four steps: i) quality analys...
Data
Script da análise referente ao capítulo "Pipeline de Expressão diferencial em R aplicado à Arabidopsis thaliana"
Data
Projeto em R para analise estatistica de dados de clones comerciais de Eucalyptus (E. urograndis e E. urophylla) suplementados com flavonoides.
Article
Full-text available
All the transcriptome sequencing data mentioned in the original article is publicly available at the National Center of Biotechnology Information (NCBI).
Article
Background: Aggressive periodontitis (AgP), currently periodontitis grade C, presents early onset, rapid progression, and a poorly established genetic association. Thus, this study aimed to identify genetic variants associated with AgP via whole-exome sequencing (WES) through a familial screening approach. Materials and methods: WES was performe...
Article
Full-text available
Brazilian purpuric fever is a febrile hemorrhagic pediatric disease caused by Haemophilus influenzae biogroup aegyptius , a bacterium which was formerly associated with only self-limited purulent conjunctivitis. Here, we present draft genomes of strains from five Brazilian purpuric fever cases and one conjunctivitis case.
Article
The ever-increasing demand for energy, along with worldwide policies aiming sustainability, resulted in an escalation of research projects focusing on alternative routes for energy production. Among the available options, microorganism fermentation using lignocellulosic biomass as a carbon source to generate bioproducts is considered a promising te...
Article
Full-text available
As one of the most abundant constituents of the tumour microenvironment (TME), cancer-associated fibroblasts (CAF) display critical roles during tumour progression and metastasis. Multiple classes of molecules including growth factors, cytokines, proteases and extracellular matrix proteins, are produced by CAF to act as mediators of the stroma-tumo...
Article
Full-text available
Key message: We provide a transcriptional profile of coffee rust interaction and identified putative up regulated resistant genes Coffee rust disease, caused by the fungus Hemileia vastatrix, is one of the major diseases in coffee throughout the world. The use of resistant cultivars is considered to be the most effective control strategy for this...
Data
Pyrosequence and bioinformatic workflow performed in this present study. Photo from Ana Maria Costa-Leonardo.
Data
Phylogenetic tree for putative symbiotic xylanases. (A) xylanases from family GH10 and (B) xylanases from family GH11.
Data
Secretion signal predictions of CAZy and PAD enzymes identified in metatranscriptomic from worker and soldier castes of C. gestroi. The analysis was performed using C. gestroi (Method 1) and Z. nevadensis (Method 2) genomes as references, SignalP and WolF-PSORT were used for signal peptide prediction.
Data
Phylogenetic tree for putative symbiotic cellulases. (A) endo-glucanases from GH5 family and (B) exo-glucanases from GH7 family.
Data
Total unigenes identified in worker and soldier castes of Coptotermes gestroi.
Data
Total proteins identified in worker and soldier castes of Coptotermes gestroi.
Article
Full-text available
Termites are considered one of the most efficient decomposers of lignocelluloses on Earth due to their ability to produce, along with its microbial symbionts, a repertoire of carbohydrate-active enzymes (CAZymes). Recently, a set of Pro-oxidant, Antioxidant, and Detoxification enzymes (PAD) were also correlated with the metabolism of carbohydrates...
Article
Full-text available
It has been suggested that there are histological and functional distinctions between the periodontal ligament (PDL) of deciduous (DecPDL) and permanent (PermPDL) teeth. Thus, we hypothesized that DecPDL and PermPDL display differences in the constitutive expression of genes/proteins involved with PDL homeostasis. Primary PDL cell cultures were obt...
Data
Spectrum count report and statisctical results of all identified proteins per sample (n = 3 DecPDL and n = 3 PermPDL). Fold change and p-values defined by the beta-binomial test are shown. (XLSX)
Article
Full-text available
Background Drought is a widespread limiting factor in coffee plants. It affects plant development, fruit production, bean development and consequently beverage quality. Genetic diversity for drought tolerance exists within the coffee genus. However, the molecular mechanisms underlying the adaptation of coffee plants to drought are largely unknown....
Poster
Full-text available
The search for renewable and sustainable energy products has increased recently, in order to substitute scarce and pollutant sources from petroleum oil and coal. Green Chemistry is the development of new chemical products that do not cause damages in the environment. One example of Green Chemistry is the bioproduct derived from microorganism’s ferm...
Article
Full-text available
The bioethanol production system used in Brazil is based on the fermentation of sucrose from sugarcane feedstock by highly adapted strains of the yeast Saccharomyces cerevisiae. Bacterial contaminants present in the distillery environment often produce yeast-bacteria cellular co-aggregation particles that resemble yeast-yeast cell adhesion (floccul...
Article
Full-text available
Ruby is a dynamic interpreted, open source, object-oriented programming language with an elegant syntax and a focus on simplicity and productivity. One factor that may hinder the dissemination of Ruby, among academic and technological communities, is that it does not contain built in methods for statistical analysis and graph creation. Statistical...
Article
Ruby is a dynamic interpreted, open source, object-oriented programming language with an elegant syntax and a focus on simplicity and productivity. One factor that may hinder the dissemination of Ruby, among academic and technological communities, is that it does not contain built in methods for statistical analysis and graph creation. Statistical...
Conference Paper
Full-text available
The bioethanol production system used in Brazil is based on the alcoholic fermentation of sucrose derived from sugarcane feedstock by highly adapted strains of the yeast Saccharomyces cerevisiae. PE-2 and CAT-1 are the most productive and widely adopted S. cerevisiae strains used by distilleries in Brazil. Due to no sterile condition at industrial...
Conference Paper
Full-text available
Objective: DNA methylation is an epigenetic change that regulates the gene expression during embryonic development and cellular differentiation in eukaryotes. It is characterized by a post-replication modification that often appears in the cytosine dinucleotide sequence 5'-CG-3' in eukaryotic cells. Cytosine methylation can be related to mutations...
Conference Paper
Objective: DNA methylation is known to play an important role in regulating gene expression during biological development and tissue differentiation in eukaryotes. Events of DNA methylation or demethylation in specific regions of genome can drive activation or silencing of genes and these can contribute to the multistage process of cell malignant t...
Conference Paper
Full-text available
Genome assemblies are not free of errors and the quality of assembly depends largely on the sequencing platforms, software and the organism. In the biology point of view, they are susceptible to several errors and difficulties, such as the presence of duplicated sequences (repeats), polyploidy and heterozygosity. Most of the computer applications h...
Article
Full-text available
The formation of an ordered enamel organic extracellular matrix (EOECM) seems to be a crucial step for the proper formation of the enamel mineral phase. The ordered supramolecular structure of the EOECM in the secretory stage can be analyzed using polarizing microscopy, as it is strongly birefringent. Excessive fluoride (F) ingestion during tooth d...
Article
Full-text available
Carbonic anhydrase VI is a secreted enzyme that catalyzes the hydration of carbon hydroxide in saliva and other body fluids. This enzyme has been implicated in taste and gastrointestinal dysfunctions, tooth erosion, and caries. The purpose of this study was to analyze the allele and genotype distribution of three polymorphisms in the coding sequenc...
Article
Full-text available
Carbonic anhydrase VI is a secreted enzyme that catalyzes the hydration of carbon hydroxide in saliva and other body fluids. This enzyme has been implicated in taste and gastrointestinal dysfunctions, tooth erosion, and caries. The purpose of this study was to analyze the allele and genotype distribution of three polymorphisms in the coding sequenc...

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