Lucas Smith

Lazar Clinic Group · LCG Greece non-profit research

In 1992, our esteemed colleagues Alan Breier, Orlando Davis, Robert Buchanan, Samuel J. Listwak, Courtney Holmes, David Pickar, and David S. Goldstein published a seminal scientific paper titled “Effects of Alprazolam on Pituitary-Adrenal and Catecholaminergic Responses to Metabolic Stress in Humans.” In it, they described with high accuracy the ef...

Since H63D syndrome was first described, the authors of this paper systematically investigated for the first time to what extent the adrenal glands, as an integral part of the HPA and SAM axes, are also affected by damage caused by non-transferrin bound iron (NTBI), a hallmark of H63D syndrome. Due to the rarity of the H63D syndrome, the representa...

Update 2.7 We report the case of a patient who suffers from hypotransferrinemia due to a genetic defect, subsequently suffers organ damage due to non-transferrin bound iron (NTBI) and develops a paradoxical reaction of glucose metabolism as a result of treatment with corticosteroids. To our knowledge, this is the first description of such an effect...

We report the case of a patient who suffers from hypotransferrinemia due to a genetic defect, subsequently suffers organ damage due to non-transferrin bound iron (NTBI) and develops a paradoxical reaction of glucose metabolism as a result of treatment with corticosteroids. To our knowledge, this is the first description of such an effect in the med...

After the short-term administration of 20mg/d prednisolone (orally) in a previously non-steroid-treated patient with iron storage disease, the steroid, which is omnipresent in clinical practice, led to paradoxical foudroyant symptoms, but above all to a reduction of 80% in the extreme narcoleptic symptomatology, not however in the cataplectic compo...

A minority of neurologists is convinced that the disease “dementia praecox” first described by Emil Kraepelin in 1899 is still valid and its annexation by psychoanalysis and later by psychiatry has caused severe damage. The psychoanalytic extremist Eugen Bleuler had successfully annexed all conceivable mental conditions for Freud’s couch therapy an...

The number of diagnoses of mental illness has been increasing for years, especially in the wealthy industrialized nations. What continues to be overlooked is the massive influence of the lobby of the psychotherapeutic "industry", which has long and steadily earned good money from hastily misdiagnosed patients. However, this can be a matter of moder...

Evidence-based medicine has shown for many years that homozygous mutations of the HFE gene H63D are by no means negligible. Not only can it cause, usually after a second hit, rather mild classical hemochromatosis, but it can also cause numerous other disorders of iron metabolism, such as hypotransferrinemia, changes in binding capacity, and others....

King-Kopetzky syndrome (KKS) is a poorly understood neurological disorder which makes it difficult to understand spoken language even though the patient has a normal hearing threshold. There has long been debate about how best to treat patients with King-Kopetzky syndrome. We decided to investigate the effect of hearing aids in this group of patien...

Evidence-based medicine has shown for many years that homozygous mutations of the HFE gene H63D are by no means negligible. Not only can it cause, usually after a second hit, rather mild classical hemochromatosis, but it can also cause numerous other disorders of iron metabolism, such as hypotransferrinemia, changes in binding capacity, and others....

The number of diagnoses of mental illness has been increasing for years, especially in the wealthy industrialized nations. What continues to be overlooked is the massive influence of the lobby of the psychotherapeutic “industry”, which has long and steadily earned good money from hastily misdiagnosed patients. However, this can be a matter of moder...

Aspirin is one of the most widely used medicines in the world and has been on the market for over a century. Therefore, it is surprising that little solid research has been done regarding the effects of aspirin on the liver. If anything, you can find a few studies from the 1970s. At that time, aspirin was described as damaging to the liver by quite...

Aspirin is one of the most widely used medicines in the world and has been on the market for over a century. Therefore, it is surprising that little solid research has been done regarding the effects of aspirin on the liver. If anything, you can find a few studies from the 1970s. At that time, aspirin was described as damaging to the liver by quite...

A confused public questions whether painkillers and antipyretics have a negative effect in the context of vaccination against Sars-CoV-2. The honest answer is that there is no scientific consensus on this. So what should be communicated to patients in a primary care setting?

Patients suffering from H63D syndrome have a significant incidence of narcolepsy with cataplexy as a symptom. Previous studies have shown that the presence of narcolepsy with cataplexy in the context of H63D syndrome is a surrogate marker for structural brain damage. Now, the aim was to clarify which measures best protect affected patients with cat...

In a study on the prevention of injury in patients with H63D syndrome and cataplexy, statistical analysis revealed an unexpected but clinically highly significant finding. Apparently, in this patient population, an inverse correlation exists between the severity of tic symptomatology on the one hand and narcolepsy with cataplexy on the other hand,...

Patients suffering from H63D syndrome have a significant incidence of narcolepsy with cataplexy as a symptom. Previous studies have shown that the presence of narcolepsy with cataplexy in the context of H63D syndrome is a surrogate marker for structural brain damage. Now, the aim was to clarify which measures best protect affected patients with cat...

A confused public questions whether painkillers and antipyretics have a negative effect in the context of vaccination against Sars-CoV-2. The honest answer is that there is no scientific consensus on this. So what should be communicated to patients in a primary care setting?

In a study on the prevention of injury in patients with H63D syndrome and cataplexy, statistical analysis revealed an unexpected but clinically highly significant finding. Apparently, in this patient population, an inverse correlation exists between the severity of tic symptomatology on the one hand and narcolepsy with cataplexy on the other hand,...

Patients suffering from H63D syndrome have a significant incidence of narcolepsy with cataplexy as a symptom. Previous studies have shown that the presence of narcolepsy with cataplexy in the context of H63D syndrome is a surrogate marker for structural brain damage. Now, the aim was to clarify which measures best protect affected patients with cat...

H63D syndrome is a serious and clinically progressive disorder of iron metabolism caused by non-transferrin-bound iron (NTBI). In 2019, after scientists from around the world joined together to form the H63D Syndrome Research Consortium (a non-profit entity), a consensus paper “H63D Syndrome” was adopted at a meeting in Oslo in December 2019. With...