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Publications (94)
Background: There are age- and sex-related increases in the prevalence of osteoporosis. Bone densitometry based on dual energy X-ray absorptiometry (DXA) is the gold standard for the assessment of bone mineral density (BMD). Three-dimensional (3D) analysis of the proximal femur (3D-DXA) allows discrimination between cortical and trabecular compartm...
Background: Yerba mate (YM, Ilex paraguariensis) consumption beneficially affects the bones. However, whether YM components exert their effect on bone cells directly remains elusive.Methods: We evaluated how main YM components affect osteoblastic (MC3T3-E1) and osteocytic (MLO-Y4) cells in vitro when administered separately or in an aqueous extract...
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by symmetric polyarthritis that can lead to joint deformity, disability, and osteoporosis. We aimed to evaluate whole hand and regional BMD in RA patients compared to controls. In addition, we evaluated the BMD of dominant versus non-dominant hands in healthy subjects. We inclu...
Bone is a highly dynamic tissue, and the constant actions of bone-forming and bone-resorbing cells are responsible for attaining peak bone mass, maintaining bone mass in the adults, and the subsequent bone loss with aging and menopause, as well as skeletal complications of diseases and drug side-effects. It is now accepted that the generation and a...
Introduction and aim:
T-score bone mineral density (BMD) thresholds may influence guidance for treatment in patients under glucocorticoid (GC) therapy. Different BMD thresholds have been described but there is no international consensus. The aim of this study was to find a threshold to help in treatment decision-making in the population under GC t...
Objective:
The aim of this study was to provide an evidence-based framework to guide health care professionals treating patients under glucocorticoid (GC) therapy and develop guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis (GIO) in postmenopausal women and men aged ≥50 years.
Methods:
An expert panel on bone di...
Purpose:
To evaluate the effect of teriparatide (TPTD) on bone mineral density (BMD) and bone markers under clinical practice conditions. To assess whether the results in real-life match those published in clinical trials.
Methods:
Cross-sectional study of postmenopausal women treated with TPTD for at least 12 months.
Results:
264 patients wer...
Borgobello, A., Mandolesi, M., Lovey, J.P., Cono, A.L., Brun, L., & Pierella, M.P. (2022). Análisis de experiencias de cursado en entornos virtuales de estudiantes de Psicología en tiempos de pandemia para pensar la post-pandemia. Perspectivas en Psicología, 19(2), 124-146. http://perspectivas.mdp.edu.ar/revista/index.php/pep/article/view/623
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El...
En este artículo se presentan los resultados de una investigación cuyo objetivo general fue aportar a vislumbrar las transformaciones en las experiencias estudiantiles del primer año en tiempos de virtualización forzosa. Los ejes de indagación fueron las percepciones acerca del acompañamiento recibido y la relación con docentes, las valoraciones de...
Este artículo presenta resultados referidos a las experiencias de ingresantes de la carrera de Medicina de la Facultad de Ciencias Médicas de la Universidad Nacional de Rosario (FCM-UNR) en el contexto de virtualización forzosa dada a partir del año 2020 a causa de la pandemia ocasionada por el virus SARS-CoV-2. Se utilizó como técnica de recolecci...
Pseudomyogenic hemangioendothelioma (PMH) can be a challenge for diagnosis and might be confused with other tumors, such as epithelioid sarcoma. Here we present a case and a systematic review of the literature to identify and discuss PMH treatment in primary bone involvement. A 25-year-old woman was referred for bone pain (10/10) in the left lower...
Este estudio se centra en indagar la problemática del ingreso a la universidad en el contexto de pandemia durante el año 2020. La perspectiva metodológica fue exploratoria y tuvo como técnica de recolección de datos un cuestionario digital destinado a estudiantes de primer y segundo año. Las respuestas procesadas fueron 2500. Los resultados muestra...
Heterotopic ossification (HO) is the formation of extraskeletal bone in muscle and soft tissues and could be genetic or non-genetic. The classic presentation of non-genetic HO is in young adults with a clear history of local trauma, surgery or prolonged immobilization after spinal cord and traumatic brain injuries. Genetic HO has a significant clin...
The use of fluoride (F) for therapeutic purposes is controversial and its toxicity is a health problem. The aim of this study was to evaluate the effect of F on endochondral ossification in growing rats. Twenty-four rats of 21 days were divided into 4 groups which received 0, 20, 40 or 80 μmol F/100 g body weight/day for 30 days, through an orogast...
Recently, a new consensus of the European Working Group on Sarcopenia in Older People (EWSOP2) recommended new cut-off points for the diagnosis of sarcopenia. The aim of the present manuscript was to assess the prevalence of sarcopenia in postmenopausal women and its relationship with bone mineral density, falls and fragility fractures according to...
Introducción: niveles bajos de 25(OH)D se asocian a un deterioro de la función de las células beta, resistencia a la insulina y riesgo incrementado de diabetes mellitus tipo 2 (DM2). Por otra parte, la mayoría de los estudios reporta un incremento en el riesgo de fractura de cadera en DM2, pero los datos son contradictorios respecto de las fractura...
Rheumatoid arthritis (RA) patients had a higher risk of developing low bone mineral density (BMD) or osteoporosis. RA patients on classic disease-modifying antirheumatic drug (c-DMARD) therapy showed significantly lower BMD than controls, while no significant differences in most parameters were found between RA patients receiving biological disease...
Background:
Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to joint deformity and disability, as well as muscle involvement. Sarcopenia is characterized by a progressive age-related loss of muscle mass and strength.
Aim:
The aim of this study was to evaluate the prevalence of sarcopenia and possible contributing factors ass...
Wnt/β-catenin signaling is important for skeletal development and health. Eleven heterozygous gain-of-function missense mutations within the first β-propeller of low-density lipoprotein receptor-related protein 5 (LRP5) are known to cause the autosomal dominant disorder called high bone mass (HBM). In 2019, the HBM phenotype was identified in two A...
The osteoderms of Glyptodon reticulatus that do not belong to the cephalic shield, dorsal cuirass, or caudal tube are very variable morphologically. Their histological structure is also variable. Some lack a cancellous bone core, unlike those from the dorsal cuirass. One presents a few large cavities, whereas another is finely cancellous. Some pres...
Introduction:
Community-acquired pneumonia (CAP) is the infectious disease with the highest number of deaths worldwide. Several studies have shown an association between vitamin D deficiency and increases susceptibility to respiratory tract infections.
Objective:
The aim of this study was to evaluate the serum 25-hydroxyvitamin D (25OHD) levels...
Previous studies have demonstrated a negative correlation between intestinal alkaline phosphatase (IAP) activity and calcium (Ca) absorption in the gut, as IAP acts as a protective mechanism inhibiting high Ca entry into enterocytes, preventing Ca overload. Here we evaluated Ca absorption and bone properties in knockout mice (KO) completely devoid...
La Asociación Argentina de Osteología y Metabolismo Mineral (AAOMM) es una sociedad científica compuesta por profesionales de diversas áreas, dedicados al estudios de los procesos biológicos relacionados al metabolismo del tejido óseo y de los órganos con los cuales tiene relación. AAOMM fue fundada en la ciudad de Rosario en el año 1983 y desde en...
Fig. S1 Deletion of Cx43 does not affect Ob‐6 cells but leads to caspase3‐mediated apoptosis in MLO‐Y4 osteocytic cells.
Data S1 Methods.
Fig. S2 HMGB1 levels are not altered systemically with aging or in osteocytic Cx43‐defient mice.
Tanto el ranelato de estroncio (RSr) como el denosumab (Dmab) son eficaces en el tra-tamiento de la osteoporosis (OP) posmeno-páusica (PM). El efecto de cada fármaco por separado sobre la densidad mineral ósea (DMO) ha sido estudiado recientemente. Con ambas drogas se observó, al año de trata-miento, un aumento significativo de la DMO en columna lu...
Skeletal aging results in apoptosis of osteocytes, cells embedded in bone that control the generation/function of bone forming and resorbing cells. Aging also decreases connexin43 (Cx43) expression in bone; and osteocytic Cx43 deletion partially mimics the skeletal phenotype of old mice. Particularly, aging and Cx43 deletion increase osteocyte apop...
The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 4...
The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 4...
Dairy products are the main source of calcium (Ca), but the loss of the consumption habit contributes to low consumption in adulthood, which leads to osteoporosis and increased fracture risk. Domestic use of kefir is straightforward and the eggshell is a natural discarded source of Ca. This paper proposes the development of an enriched Ca reduced l...
Yerba mate (Ilex paraguariensis) consumption is common in Argentina and other South American countries. Like coffee and tea, yerba mate contains xanthines and polyphenols. It has been reported that caffeine consumption has a negative impact on bone mineral den sity (BMD) while tea has been shown to have a protective effect. On the other hand, in po...
Yerba mate (Ilex paraguariensis) is a xanthine-containing beverage, which is also rich in caffeine. Because caffeine has a negative impact on bone mineral density (BMD) mainly associated with low calcium (Ca) diets, there would be expected a negative effect of yerba mate on bone. In this study, Sprague-Dawley rats were used and randomly assigned in...
Zoledronic acid (ZA) is the bisphosphonate of highest antiresorptive potency used in the treatment of osteoporosis. Its effects on trabecular bone are clear; on the other hand, its effects on cortical bone are controversial and poorly understood. The aim of this work was to study the effects of ZA on trabecular and cortical bone in ovariectomized (...
Resumen El ácido zoledrónico (AZ) es el bifosfona-to de mayor potencia antirresortiva utilizado para el tratamiento de la osteoporosis. Sus efectos sobre el hueso trabecular son claros; contrariamente, sus efectos sobre el hueso cortical son motivo de controversia y poco conocidos. El objetivo de este trabajo fue es-tudiar los efectos del AZ sobre...
The aim of this study was to evaluate the effect of strontium ranelate (SrR) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of SrR in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study inc...
ScopeIntestinal alkaline phosphatase is a brush border enzyme that is stimulated by calcium. Inhibition of intestinal alkaline phosphatase increases intestinal calcium absorption. We hypothesized that intestinal alkaline phosphatase acts as a minute-to-minute regulatory mechanism of calcium entry. The aim of this study was to evaluate the mechanism...
Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease with high prevalence of osteoporosis. Previous evidence indicates an association between vitamin D deficiency and autoimmune diseases. The aim of this study was to evaluate serum 25 hydroxyvitamin D [25(OH)D] levels, bone mineral density (BMD) and disease activity in RA...
This paper describes a novel methodology for the simultaneous estimation of bone formation (BF) and resorption (BR) in rats using fluoride as a nonradioactive bone-seeker ion. The pharmacokinetics of flouride have been extensively studied in rats; its constants have all been characterized. This knowledge was the cornerstone for the underlying mathe...
Objective:
Osteoporosis is the consequence of an imbalance in bone remodeling caused by excessive resorption or inappropriate bone formation. This paper proposes a sequential treatment with monofluorophosphate (MFP) and zoledronic acid (Z), together with changes in the calcium content in the diet.
Method:
Seven-week-old female Sprague Dawley rat...
The osteocyte network is crucial for the response of bone to mechanical force. Within this network, connexin43 (Cx43) is thought to mediate the communication of osteocytes and osteoblasts among themselves and the exchange of small molecules with the extracellular milieu. Despite recent advances in understanding Cx43 role for the response of bone ce...
Aim:
Taken into consideration that the deficiency of calcium (Ca) in the diet is a common problem, the aim of this work was to study the chicken eggshell as Ca source at home. It was evaluated: (1) different mechanisms to process eggshells and find an easy way to determine the required amount of Ca at home and; (2) the flavor and the texture for e...
La absorción varía a lo largo de la vida: lactancia (55-60%); adolescencia (35-40%); adulto (30%). A partir la adultez la eficiencia de absorción declina casi 0.2% por año, con un porcentaje adicional del 2% en la menopausia.La suplementación con calcio es necesaria en ciertas etapas de la vida, estados metabólicos o enfermedades. La utilización de...
El fluoruro de sodio (NaF) y el monofluorofosfato de sodio (MFP) son compuestos que generan fluoruro, siendo capaces de aumentar la diferenciación y proliferación de precursores osteoblásticos. El NaF ha demostrado incrementar la densidad mineral ósea de la cadera y la columna vertebral, aunque todavía existen controversias en relación con la calid...
Connexin 43 (Cx43) mediates osteocyte communication with other cells and with the extracellular milieu and regulates osteoblastic cell signaling and gene expression. We now report that mice lacking Cx43 in osteoblasts/osteocytes or only in osteocytes (Cx43(ΔOt) mice) exhibit increased osteocyte apoptosis, endocortical resorption, and periosteal bon...
The aim of this work was to evaluate the effect of fluoride (F) on oxygen consumption (VO2) in rats and how it might affect the respiratory chain and the levels of reactive oxygen species (ROS). Eighteen Sprague-Dawley rats were divided into three groups: Control, NaF20, and NaF40, which received 0, 20, and 40 μmol F/100 g bw/day for 30 days, respe...
Calcium is essential in nutrition. Its absorption varies along the life cycle: infancy 55-60%, adolescence 35-40%, aduthood30%).In adulthood absorption efficiency declines by 0.2% per year, with an additional 2% at menopause. Supplementation with tablets has a cost and needs patients' adherence to treatment. The market offers a wide variety of prod...
Sodium fluoride (NaF) and sodium monofluorophosphate (MFP) are compounds that generate fluoride, being able to increase differentiation and proliferation of osteoblast. It has been demonstrated that NaF increases bone mineral density at the level of hip and spine, although there are still controversies regarding the quality of bone. The aim of this...
Aim: Taken into consideration that the deficiency of calcium (Ca) in the diet is a common problem, the aim of this work was to study the chicken eggshell as Ca source at home. It was evaluated: (1) different mechanisms to process eggshells and find an easy way to determine the required amount of Ca at home and; (2) the flavor and the texture for eg...
Intestinal alkaline phosphatase (IAP) is a brush-border phosphomonoesterase. Its location suggests an involvement in the uptake of nutrients, but its role has not yet been defined. IAP expression parallels that of other proteins involved in Ca absorption under vitamin D stimulation. Experiments carried out in vitro with purified IAP have demonstrat...
dp er os+1.5μg/kg/w sc. Eight rats were sham operated. Histomorphometric and histopathological studies were performed on tibias obtained after 30 days of treatment. OVX decreased trabecular bone (%BV/TV), and Z prevented and raised it (Sham: 35.3±4.7, control: 21.5±1.5*, MFP: 17.1±1.0*, Z: 64.3±3.5*, MFP±Z: 52.2±3.2*, * p<0.05 vs sham, mean±SE, ANO...
Sodium fluoride (NaF) and sodium monofluorophosphate (MFP) are drugs used to increase bone mass. They have been considered equivalent but the results of the treatments were not always coincident. Most studies have been carried out in osteoporotic women or ovariectomized rats pointing to the result in bone mass rather than at the mechanism of action...
Intestinal alkaline phosphatase (IAP) is an enzyme of the brush border of the enterocyte. The activity of IAP biphasically depends on calcium. Although calcium increases IAP activity, when calcium is higher than 20 mmole/L, IAP activity decreases and the amount of an aggregated form increases. The reversibility of the effect of calcium and the aggr...
Glucocorticoid-induced osteoporosis (GIO) is the second cause of osteoporosis after postmenopausal osteoporosis, and the most common form of secondary osteoporosis. About 0.2-0.5% of the population use glucocorticoids. Vertebral fracture may occur in as many as 30-50% of patients receiving chronic glucocorticoid therapy. Glucocorticoids have multip...
Two fractions of rat intestinal alkaline phosphatase (IAP) were detected by Western blot: 168 +/- 6 and 475 +/- 45 kDa. The low molecular weight fraction constitutes 43% of the isolated proteins exhibiting 82% of the enzymatic activity, and a heavier fraction constitutes 57% of the isolated proteins and has 18% of the enzymatic activity. Calcium pr...
Intestinale Resorption von Dinatriummonofluorphosphat bei Ratten bei gleichzeitiger Verabreichung von Kalzium
In der vorliegenden Arbeit wird über die Verbesserung der intestinalen Resorption und Bioverfügbarkeit von Monofluorphosphat (Dinatriummonofluorphosphat, CAS 10163-15-2, MFP) durch gleichzeitige Verabreichung von Calcium (Calciumchlorid, CA...
