Lucas Oliveira Maia

Lucas Oliveira Maia
Universidade Federal do Rio Grande do Norte | IIP · Brain Institute

PhD

About

28
Publications
14,535
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141
Citations
Introduction
Biologist, with a Master's in Psychobiology and a PhD in Medical Sciences. Researcher in psychopharmacology and mental health, studying the therapeutic effects of psychoactive plants/substances in psychiatric disorders. Participates in pre-clinical, clinical, and epidemiological studies, using quantitative and qualitative methods.
Additional affiliations
March 2016 - April 2020
University of Campinas
Position
  • PhD Student
February 2013 - January 2016
Universidade Federal de São Paulo
Position
  • Research Associate

Publications

Publications (28)
Article
Full-text available
Objectives: Given the challenges arising from the poor effectiveness of therapies for Cannabis-related disorders, the most commonly used illicit drug in the world, this paper aims to review the present knowledge about the neuroanatomic, biomolecular and cellular substrate of the endocannabinoid system, describing the mechanisms of cannabinoid-depen...
Article
Full-text available
Diseases that threaten life raise existential questions that can be a source of psychological distress. Studies with psychedelics demonstrate therapeutic effects for anxiety and depression associated with life-threatening illnesses. Ayahuasca has been proposed as a possible therapeutic agent in the treatment of psychiatric disorders. Preliminary st...
Article
Full-text available
Background Global opioid consumption increased multifold post-2000, disproportionately in high-income countries, with severe mortality/morbidity consequences. Latin America features comparatively low opioid availability; Brazil, the region’s most populous country, makes an interesting case study concerning opioid use/harms. In this comprehensive ov...
Chapter
This chapter aimed to provide an overview of the large number of hallucinogens of natural origin. Following a literature review, the following hallucinogens were selected for a detailed description that considered their essential chemical groups: indoleamines (N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine, bufotenine, psilocybin, and ibo...
Article
Full-text available
Unlabelled: Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle. Objective: The objective of this paper is to assess the effects on sleep of acute systemic administration of CBD. Method: Adult male Wistar rats were randomly distributed into four groups...
Preprint
Full-text available
The psychedelic brew ayahuasca is increasingly being investigated for its therapeutic potential. To review and summarize data available on ayahuasca research using animal models, we systematically searched five databases (PubMed, Web of Science, EMBASE, LILACS and PsycInfo) for peer-reviewed studies in English, Portuguese or Spanish up to July 2022...
Article
Full-text available
RationaleStream of thought describes the nature of the mind when it is freely roaming, a mental state that is continuous and highly dynamic as in mind-wandering or free association. Classic serotonergic psychedelics are known to profoundly impact perception, cognition and language, yet their influence on the stream of thought remains largely unexpl...
Article
Full-text available
Rationale Smoking-related disease is a major problem globally. Effective smoking cessation treatments are however limited. Increasing evidence suggests that psychedelics have potential as treatments for substance use disorders and may therefore prove an option in aiding smoking cessation. Objectives To establish which factors predict smoking cessa...
Article
Full-text available
Rationale The growing prevalence of psychostimulant (including amphetamine) use and associated health harms, with limited treatment options, present a global challenge. There is an increasing availability and medical applications of cannabinoids, and growing interest in their therapeutic potential for addictive disorders. Objectives The objective...
Article
Full-text available
Background: Preliminary evidence suggests that long-term ayahuasca use is associated with better psychosocial outcomes and less drug use; however, available data on the association between ayahuasca intake frequency and psychosocial outcomes is limited. Objectives: We sought to characterize and investigate the association of regular ayahuasca use,...
Article
Full-text available
Data on cannabis use patterns and health outcome indicators for Brazil are limited. We undertook a cross-sectional internet-based survey assessing socio-demographics, cannabis use frequency, other drug use, quality-of-life (QOL), affective states (i.e. anxiety and depression), and cannabis use disorder among adult respondents in Brazil. A multinomi...
Article
Psychedelics acutely impair cognitive functions, but these impairments decline with growing experiences with psychedelics and microdoses may even exert opposing effects. Given the recent evidence that psychedelics induce neuroplasticity, this explorative study aimed at investigating the potential of psychedelics to sub-acutely change cognition. For...
Article
Background: Controversy surrounds psychedelics and their potential to boost creativity. To date, psychedelic studies lack a uniform conceptualization of creativity and methodologically rigorous designs. Aims: This study aimed at addressing previous issues by examining the effects of lysergic acid diethylamide (LSD) on creativity using multimodal...
Article
Context People affected by serious illness usually experience suffering in its various dimensions, not only in the physical but also in the psychosocial and spiritual aspects. The interest in psychedelic-assisted therapies as a potential new therapeutic modality has increased since evidence suggests a significant impact of their use on the outcomes...
Article
Ethnopharmacological relevance Ayahuasca, a psychoactive beverage prepared from Banisteriopsis caapi and Psychotria viridis, is originally used by Amazon-based indigenous and mestizo groups for medicinal and ritualistic purposes. Nowadays, ayahuasca is used in religious and shamanic contexts worldwide, and preliminary evidence from preclinical and...
Article
Full-text available
Cocaine use entails severe health-and social-related harms globally. Treatment options for cocaine dependence are highly limited. Benefits of cannabinoids for addiction have been documented , making it opportune to examine existing data on the possible outcomes associated with cannabinoids and cocaine co-use. We conducted a systematic scoping revie...
Thesis
Full-text available
Introdução: Doenças graves levantam questões existenciais que podem ser fonte de sofrimento psicológico e prejudicar o tratamento. Estudos com substâncias psicodélicas demonstram efeitos terapêuticos para ansiedade e depressão associadas a doenças físicas graves, principalmente câncer. Evidências indicam que a ayahuasca – uma bebida psicoativa de o...
Article
Full-text available
The aim of the study was to investigate the effects of an extract from the leaves of Cheiloclinium cognatum mainly comprising triterpenes and friedelanes on the reproductive system of adult male rats in order to determine its potential contraceptive actions. The animals were distributed in two groups (n = 10/group): animals treated daily for 35 day...
Article
Full-text available
Background and Objectives Studies have highlighted psychosocial factors associated with drug use among adolescents. Association of specific psychiatric comorbidity with substance use has not been properly established in Brazil. This study aimed to investigate alcohol, tobacco, and marijuana use by 15-18-year-old high school Brazilian students and t...
Chapter
This chapter aimed to provide an overview of the large number of hallucinogens of natural origin. Following a literature review, the following hallucinogens were selected for a detailed description that considered their essential chemical groups: indoleamines (N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine, bufotenine, psilocybin, and ibo...
Article
Full-text available
Background & objectives: Sleep restriction is a common feature of modern lifestyle and its effects can be extended to pregnancy. Several neurobehavioural consequences of sleep restriction during pregnancy have been reported, among which stand out perinatal depression and maternal fatigue, however, its effects over mother-infant relationship warrant...
Book
Full-text available
Anais do "Simpósio Internacional: Por uma Agência Brasileira da Cannabis Medicinal?", evento realizado em maio de 2010 pelo Centro Brasileiro de Informações sobre Drogas Psicotrópicas (CEBRID), na Universidade Federal de São Paulo (UNIFESP).
Article
This study investigated the effects of organophosphate exposure on the male reproductive system of mice submitted to chronic sleep loss condition. Adult Swiss mice were distributed into 4 groups: control; methamidophos (MTP); sleep restriction (SR); and MTP+SR. The dose of methamidophos was 0.002 mgkg(-1)day(-1) (half of the Acceptable Daily Intake...

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