Lucas Engelhardt

Objectives: Early detection of pseudarthrosis is crucial to be able to initiate countermeasures in due time. Existing scoring systems for risk of non-unions lack precision due to subjective interpretation, variability among surgeons [1] and non-consideration of load bearing patterns, potentially leading to misdiagnosis or delayed treatment. We pro...

Bone healing simulations utilizing the concept of mechanobiologically-driven tissue differentiation for predicting the effect of fracture treatment are well established concepts in computational biomechanics. Making this technology fit for clinical use has been a long-term goal that has yet to be realized. Early adopters in clinical use cases have...

Background: The healing potential of a fracture is determined by mechanical and biological factors. Simulation-based workflows can help assess these factors to assist in predicting non-unions. The aim of this study was the introduction of two use cases for a novel patient-specific simulation workflow based on clinically available information. Metho...

Fracture healing is a complex process that involves numerous biological and mechanical factors. Understanding this process is crucial for healthcare professionals involved in the treatment and management of fractures, but also, for students pursuing careers in fields such as medicine, physical therapy, and biomechanics. Learning about fracture heal...

As non-unions are still common, a predictive assessment of healing complications could enable immediate intervention before negative impacts for the patient occur. The aim of this pilot study was to predict consolidation with the help of a numerical simulation model. A total of 32 simulations of patients with closed diaphyseal femoral shaft fractur...

Fragestellung: Trotz aller Fortschritte in der Frakturversorgung beträgt das Risiko einer ausbleibenden vollständigen Konsolidierung bei der Behandlung von Frakturen 1,9-4,9%. Eine prädiktive Einschätzung des Risikos für das Auftreten von Heilungskomplikationen oder die Ausbildung von Pseudarthro-sen könnte ein frühzeitiges Eingreifen ermöglichen,...

Trotz aller Fortschritte beträgt das Risiko einer ausbleibenden Konsolidierung bei der Behandlung von Frakturen 1,9-4,9 %. Eine prädiktive Einschätzung des Risikos von Komplikationen könnte ein frühzeitiges Eingreifen ermöglichen, bevor Patienten negativ betroffen sind. Ziel dieser Studie ist die erstmalig klinische Anwendung eines Simulationsmodel...

Currently, fracture-healing simulations are primarily applied to diaphyseal fractures. In order to simulate metaphyseal fracture healing, we extended the previously developed and tested computational model for diaphyseal fractures [1] to metaphyseal fractures [2]. Up to now, the investigations were analyzed in 2D rotational symmetric geometries. Re...

Regarding the prevention of injuries and rehabilitation of the human hand, musculoskeletal simulations using an inverse dynamics approach allow for insights of the muscle recruitment and thus acting forces on the hand. Currently, several hand models from various research groups are in use, which are mainly validated by the comparison of numerical a...

As shown in [1] and recent presentations [2,3], we developed a new detailed hand model for the AnyBody Modelling System [4]. This model not only includes the possibility of a patient specification but also has been validated by moment arm studies [1,2] and EMG [3]. The aim of this work was to apply the new detailed hand model to a specific hand gri...

Simulating diaphyseal fracture healing via numerical models has been investigated for a long time. It is apparent from in vivo studies that metaphyseal fracture healing should follow similar biomechanical rules although the speed and healing pattern might differ. To investigate this hypothesis, a pre-existing, well-established diaphyseal fracture h...

The AnyBody Modeling System™ (AMS) is a musculoskeletal software simulation solution using inverse dynamics analysis. It enables the determination of muscle and joint forces for a given bodily motion. The recording of the individual movement and the transfer into the AMS is a complex and protracted process. Researches indicated that the contactless...

Musculoskeletal research questions regarding the prevention or rehabilitation of the hand can be addressed using inverse dynamics simulations when experiments are not possible. To date, no complete human hand model implemented in a holistic human body model has been fully developed. The aim of this work was to develop, implement, and validate a ful...

The present work deals with a specific step of a fracture healing simulation (see e.g. [1], [2]). In this step, the given concentration distribution of a biological tissue, such as bone, is smoothed (i.e. smeared over the three-dimensional healing domain). The current implementa-tion of this smoothing operation in the form of a matrix-vector multip...

The AnyBody™ Modelling System (AMS) is an universally used musculoskeletal simulation software using inverse dynamics. Until now, no complete human hand model is realized in the AMS. Considering other musculoskeletal hand models [1], no validation based on dynamic movements has been investigated yet. The aim of this work is to implement a full deta...

Currently, fracture-healing simulations are primarily applied to diaphyseal fractures. In order to simulate metaphyseal fracture healing, we extend the previously developed and tested computational model by Simon et al. [1]. As this model is a continuum (i.e. organ-level) model of fracture healing, the complex trabecular structure is not required b...

The AnyBody™ Modeling System (AMS) [1], is an universally used musculoskeletal simulation software using inverse dynamics. Until now, no complete human hand model is known in the AMS. Also considering other musculoskeletal software platforms, just one detailed entire hand model is recently published [2] but is only based on one subject. The aim of...

Die menschliche Hand ist ein hochkomplexes Greiforgan, welches aus 27 Knochen und 39 aktiven Muskeln besteht [1]. Dies führt dazu, dass beim Greifen die Bestimmung von spezifischen Muskelkräften nicht trivial ist. Hierbei kann das vorgestellte invers-dynamische Model, dass mit Hilfe des Anybody™-Modelling-Systems [2] entwickelt wurde, helfen.

The human hand is a highly developed and sophisticated grasping organ containing 27 bones with 36 articulations and 39 active muscles [1] contributing to a wide range of movements, (19 degrees of freedom) while possessing sensitive haptic properties. This makes the human hand an extremely complex system, where the determination of specific muscle f...

Purpose: Aerosol particle deposition in the human nasal cavity is of high interest in particular for intranasal central nervous system (CNS) drug delivery via the olfactory cleft. The objective of this study was the development and comparison of a numerical and experimental model to investigate various parameters for olfactory particle deposition...

In a running research project in cooperation with the University of Applied Science Biberach, an intranasal aerosol application for drugs, treating neurodegenerative diseases, should be optimized by the help of computational fluid and particle dynamics (CFPD) simulation. For the treatment it is essential that a high ratio of particles reach the olf...

In a running research project in cooperation with the University of Applied Science Biberach, an intranasal aerosol application for drugs, treating neurodegenerative diseases, should be optimized by the help of computational fluid dynamics (CFD). For the treatment it is essential that a high ratio of particles reach the olfactory epithelium, which...

In this project, the heat and flow transfer characteristics of a pin-fin heat exchanger were analyzed using a three dimensional finite element based numerical model. Simulations were conducted based on low Reynolds number and fully developed laminar airflow through an array of circular pin-fins. A computational fluid dynamic (CFD)-solution is estab...