Luca Vannucci

Luca Vannucci
The Czech Academy of Sciences | AVCR · Laboratory of Immunotherapy

Doctor of Medicine

About

151
Publications
22,448
Reads
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2,891
Citations
Citations since 2016
66 Research Items
1782 Citations
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20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
Introduction
Luca Vannucci currently is head of the Laboratory of Immunotherapy of the Institute of Microbiology, Czech Academy of Sciences, and President of the Czech Immunological Society. He works in Cancer Research, Immunology and Microscopy. Running projects in his Lab are: 1) local immunity/tissue structure relationships during tumor microenvironment development; 2) use of nanoparticles in tumor microenvironment detection and therapy; 3) evaluation of natural immunomodulators e.g. beta-glucans.
Additional affiliations
December 2018 - December 2021
Czech Immunological Society
Position
  • CEO
January 2012 - November 2019
The Czech Academy of Sciences
Position
  • Head of Department
June 1999 - December 2014
The Czech Academy of Sciences
Position
  • Principal Investigator
Education
October 2001 - October 2007
Charles University in Prague
Field of study
  • Immunology
October 1988 - June 1992
University of Milan
Field of study
  • Oncology
February 1986 - July 1987
The University of Chicago Medical Center
Field of study
  • Experimental carcinogenesis (Ben May Laboratory - Prof. C.B. Huggins, Nobel Laureate)

Publications

Publications (151)
Article
Full-text available
The immune checkpoint inhibitors have revolutionized cancer immunotherapy. These inhibitors are game changers in many cancers and for many patients, sometimes show unprecedented therapeutic efficacy. However, their therapeutic efficacy is largely limited in many solid tumors where the tumor-controlled immune microenvironment prevents the immune sys...
Article
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To date, tumors, the second cause of death worldwide, are a modern medicine plight. The development of rapid, cost-effective and reliable prevention and diagnostics tools is mandatory to support clinicians and ensure patients’ adequate intervention. Pituitary tumors are a class of neoplasm, which calls for suitable and ad hoc diagnostic tools. Rece...
Article
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Ovarian teratomas are rare neoplasms in female dogs, and they are characterised by the proliferation of tissues of embryonic origin. Most teratomas are benign, but a histological diagnosis is important for clinicians. The objective of this article is to describe a benign ovarian teratoma in a dog, which was found on the street and was appearing lik...
Article
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The concept of trained immunity has become one of the most interesting and potentially commercially and clinically relevant ideas of current immunology. Trained immunity is realized by the epigenetic reprogramming of non-immunocompetent cells, primarily monocytes/macrophages and natural killer (NK) cells, and is less specific than adaptive immunity...
Article
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Andrographolide is a labdane diterpenoid isolated from Andrographis paniculata and traditionally used in Chinese and Indian medicine. Reported effects include anti-bacterial, anti-inflammatory and anti-cancer functions. Most of the studies support the hypothesis that andrographolide supplementation stimulates immune system, so the observed effects...
Article
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Continuous activation of the immune system inside a tissue can lead to remodelling of the tissue structure and creation of a specific microenvironment, such as during the tumour development. Chronic inflammation is a central player in stimulating changes that alter the tissue stroma and can lead to fibrotic evolution. In the colon mucosa, regulator...
Article
Full-text available
Continuous activation of the immune system inside a tissue can lead to remodelling of the tissue structure and creation of a specific microenvironment, such as during the tumour development. Chronic inflammation is a central player in stimulating changes that alter the tissue stroma and can lead to fibrotic evolution. In the colon mucosa, regulator...
Article
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Germ-free animals (GF) are those without a microbiome since birth. This particular biological model has become one of special interest with the growing evidence of importance of the microbiome in the life, development, adaptation, and immunity of humans and animals in the environments in which they live. Anatomical differences observed in GF compar...
Article
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Cancer, bacteria, and immunity relationships are much-debated topics in the last decade. Microbiome′s importance for metabolic and immunologic modulation of the organism adaptation and responses has become progressively evident, and models to study these relationships, especially about carcinogenesis, have acquired primary importance. The availabil...
Article
Significance There are controversial data about the protumoral role of pancreatic cancer stroma, and dissecting multiple aspects will help to develop effective tailored therapies. Interleukin-17A (IL17A) has been reported to accelerate pancreatic acinar–ductal metaplasia, be important for maintaining stem-like cancer cells, and recruit immunosuppre...
Article
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Mucosal surfaces are colonized by highly diverse commensal microbiota. Coating with secretory IgA (SIgA) promotes the survival of commensal bacteria while it inhibits the invasion by pathogens. Bacterial coating could be mediated by antigen-specific SIgA recognition, polyreactivity, and/or by the SIgA-associated glycans. In contrast to many in vitr...
Article
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TiO2 prolatenanospheroids (PNSs) may be photosensitizers (PSs), which act by catalyzation of hydroxyl radical (∙OH) formation upon light illumination. ∙OH might, in turn, contribute to killing of cancer cells. On the other hand, there is great concern about toxicity in the dark of TiO2 nanoparticles in general. In this work, we have investigated th...
Article
Hot water extract from biomass of heterotrophic mutant green alga Parachlorella kessleri HY1 (Chlorellaceae) was deproteinised, and three polysaccharidic fractions were obtained by preparative chromatography. The low-molecular fraction (1.5 × 104g mol−1) was defined mainly as branched O-2-β-xylo-(1→3)-β-galactofuranan where xylose is partially meth...
Article
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A gluten-free diet is a special type of diet intended for people with gluten intolerance. The introduction of targeted screening into the practice has improved celiac diagnosis, with an increase of newly diagnosed patients who have remained life-long dependents on a gluten-free diet. On the other hand, the gluten-free diet has also been voluntarily...
Article
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The lysyl oxidases (LOXs) are a family of enzymes deputed to cross-link collagen and elastin, shaping the structure and strength of the extracellular matrix (ECM). However, many novel “non-canonical” functions, alternative substrates, and regulatory mechanisms have been described and are being continuously elucidated. The activity of LOXs, therefor...
Conference Paper
Secretory IgA (S-IgA) contributes to protecting mucosal surfaces from pathogenic bacteria attachment. It is not clear, if S-IgA interacts with microorganisms through antigen-specific Fab moiety, or antigen-nonspecifically through remaining protein backbone or through attached mostly N-oligosaccharides. Entheropahogenic E. coli (EPEC) strain O55 ca...
Article
Vaccination constitutes one of the major breakthroughs in human medicine. At the same time, development of more immunogenic vaccine alternatives to using aluminum‐based adjuvants is one of the most important phases of vaccination development. Amongst different sources of carbohydrate polymers, including plants, microbes, and synthetic sources teste...
Chapter
Beneficial effects of nutrition on immunity are well-established. Lately optimal nutritional composition is playing more and more important role in prevention and therapy of various diseases including metabolic, cardiovascular, and infectious diseases. Biological effects of some of the most commonly used nutraceuticals are summarized and discussed...
Article
New sulfonamides 5/6 derived from 4-methoxyacetophenone 1 were synthesized by N-sulfonation reaction of ammonia (3)and aminopyrimidinone (4)with its sulfonyl chloride derivative 2. Sulfonamides 5 and 6 were used as precursors of two new series of chalcones 8a-f and 9a-f, which were obtained through Claisen-Schmidt condensation with aromatic aldehyd...
Article
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Cancer and cardiovascular diseases have been classified as non-communicable diseases for decades. Both diseases have characteristics of immune reactions, which are principally identical, but differing in important aspects. The aim of this communication is to highlight new approaches to immune processes involved in both types of diseases.
Article
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Glucans are part of a group of biologically active natural molecules and are steadily gaining strong attention not only as an important food supplement, but also as an immunostimulant and potential drug. This paper represents an up-to-date review of glucans (β-1,3-glucans) and their role in various immune reactions and the treatment of cancer. With...
Article
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The objective of this work was to compare the effect of selected feed mixtures on the duodenal morphology. One-hundred-four rats of the Wistar strain were divided to thirteen groups per eight rats. The experiment started in 35-day-old rats after birth and lasted for 32 days. The groups (A-M) were fed by commercial diet, 85 % wheat and 15 % oat diet...
Article
Full-text available
The objective of this work was to compare the effect of selected feed mixtures on the duodenal morphology. One-hundred-four rats of the Wistar strain were divided to thirteen groups per eight rats. The experiment started at 35-days rats after birth and lasted for 32-days. The groups (A-M) were fed; commercial diet, 85% wheat and 15% oat diet, 85% w...
Article
Accumulating evidence points to a beneficial effect of vagus nerve activity in tumor development. The vagus nerve is proposed to slow tumorigenesis because of its anti-inflammatory properties mediated through ACh and the α7nAChR. Since α7nAChRs are widely expressed by many types of immune cells we hypothesized that the vagus nerve affects the tumor...
Article
Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive cancer with a 5-year survival rate of ∼ 8%. An hallmark of PDA is the massive desmoplasia and the complex stromal-tumor interaction, regulated by a pletory of secreted factors. The role of IL-17 and T-helper 17 in cancer progression or anti-tumour immunity remain controversial. To...
Article
Full-text available
No attention is usually focused on the possible involvement of immune mechanisms, particularly of autoimmunity, on the development and progress of atherosclerosis. The pioneering work occurring almost 50 years ago was overlooked, and the idea of atherosclerosis as an autoimmune disease only started gaining traction about 10 years ago. Our review di...
Chapter
Since the half of the past century, attempts to locally treat intracranial neoplasms have grown. From pioneering interstitial seeds of various materials (radioactive, non-radioactive) with or without the application of ElectroMagnetic Field (EMF), recently new interest was elicited by the possibilities offered by the nanotechnologies. The blocking...
Article
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Hypercholesterolemia is one of primary risk factors of cardiovascular disease, together with metabolic syndrome, hypertension and diabetes. Although progress has been made, the search for novel methods of preventing and treating dyslipidemia is ongoing and current therapies for cardiovascular disease induce various side effects. β‑glucans are linea...
Article
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Correction for ‘Biodistribution of upconversion/magnetic silica-coated NaGdF 4 :Yb ³⁺ /Er ³⁺ nanoparticles in mouse models’ by Uliana Kostiv et al. , RSC Adv. , 2017, 7 , 45997–46006.
Article
Full-text available
Upconversion magnetic nanoparticles emit visible light after NIR irradiation. Gd renders them with MRI contrast. Localization of the particles is excellently visible in blood vasculature of tumor bearing mice after intravenous administration.
Article
Cells of the innate immunity infiltrating tumour tissues promote, rather than halt, cancer cell proliferation and distant spreading. Tumour-Associated Macrophages (TAMs) are abundantly present in the tumour milieu and here trigger and perpetrate a state of chronic inflammation which ultimately supports disease development and contributes to an immu...
Article
Full-text available
The effects of β-glucan in cancer are the most studied biological effects of β-glucan. From all available β-glucans, the most data are available on lentinan, mostly because it is used in clinical practice for over 20 years. Current review represent a state-of-the-art comprehensive review of knowledge obtained in last twelve years. © 2017 Luca Vannu...
Article
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Inflammatory bowel diseases (IBD) are serious health problems and are connected with increased risk of colitis-associated colorectal carcinoma (CAC). It is the most common cause of death in the patients with Crohn's disease and ulcerative colitis. In this short review, we intend to summarise some aspects of the immunological signalling networks tha...