Luca Di Gianfrancesco

Luca Di Gianfrancesco
Istituto Oncologico Veneto

Doctor of Medicine
Urologist at Dept. of Oncological Urology of Veneto Institute of Oncology (IOV) IRCCS headquarter of Castelfranco Veneto

About

78
Publications
3,995
Reads
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223
Citations
Citations since 2017
65 Research Items
218 Citations
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Additional affiliations
October 2019 - present
Catholic University of the Sacred Heart
Position
  • PhD Student
Education
August 2013 - August 2018
October 2004 - October 2011
Catholic University of the Sacred Heart
Field of study
  • Medicine and Surgery

Publications

Publications (78)
Article
Full-text available
Introduction Holmium Laser Enucleation of the Prostate (HoLEP) represents an effective and well-established technique in the treatment of lower urinary tract symptoms (LUTS) related to benign prostatic hypertrophy (BPH). We evaluated patients with BPH and concomitant or incidentally detected prostate cancer (PCa) treated with HoLEP and the subseque...
Article
Full-text available
Background: Severe functional impairment is often considered a contraindication to intravesical therapy for nonmuscle-invasive bladder cancer (NMIBC). A tailored intravesical bacillus Calmette-Guérin (BCG) procedure was evaluated in high-risk (HR)-NMIBC patients with severe functional impairment. Materials and methods: Patients with a Katz Index...
Article
Full-text available
Despite several efforts in the search for noninvasive biomarkers to provide prognostic information for noninvasive muscle bladder cancer, none have shown significant potential. In this context, standard urinalysis is still necessary to provide many data. This method is an inexpensive, simple, and easy-to-repeat tool to follow-up patients over time....
Article
Full-text available
Purpose Hemorrhagic cystitis (HC) is a frequent complication of allogeneic hematopoietic stem-cell transplantation (HSCT). HC worsens transplant outcomes and patient wellbeing in terms of pain, hospitalization, and need for supportive care. A deeper understanding of the risk factors of HC may lead to more intensive prevention in high-risk patients....
Article
Introduction EpiCheck is a new urinary test that analyses DNA methylation biomarkers in order to identify high-risk urothelial cancer Materials and methods A prospective single centre study was performed. We analysed Epicheck results in a population of 231 patients in follow-up for non-muscle invasive bladder cancer. The primary endpoint was to ev...
Article
Full-text available
Introduction: The Italian Radical Cystectomy Registry (Registro Italiano Cistectomie - RIC) aimed to analyse outcomes of a multicenter series of patients treated with radical cystectomy (RC) for bladder cancer. Material and methods: An observational, prospective, multicenter, cohort study was performed to collect data from RC and urinary diversi...
Article
Background The management of non-muscle invasive bladder carcinoma (NMIBC) after transurethral resection of a bladder tumor consists of adjuvant intravesical therapy and strict and long surveillance with urine cytology and cystoscopy. The Bladder EpiCheck test (Nucleix Ltd) (BE) is a newly developed urinary markers based on DNA methylation changes...
Article
Full-text available
The COVID-19 pandemic continues to put a strain on the entire world population. The common features of bladder cancer (BCa) and COVID infection have been widely reported and discussion may continue regarding treatment as well. We have highlighted how COVID-19 therapy has many implications with BCa therapy, in particular with potential protective ro...
Article
Full-text available
Background: Bladder cancer (BCa) emits specific volatile organic compounds (VOCs) in the urine headspace that can be detected by an electronic nose. The diagnostic performance of an electronic nose in detecting BCa was investigated in a pilot study. Methods: A prospective, single-center, controlled, non-randomized, phase 2 study was carried out...
Article
Numerous studies showed that bladder urothelial carcinoma and upper urothelial tract carcinoma (UTUC) display clinical and genomic similarities. In order to analyze that the same panel of biomarkers used in the diagnosis of bladder urothelial carcinoma could be suitable for early detection of UTUC, we performed a retrospective study in which we ana...
Preprint
Full-text available
PURPOSE Hemorrhagic cystitis (HC) is a frequent complication during allogeneic hematopoietic stem-cell transplantation (HSCT). HC worsen transplant outcomes and patients wellbeing in terms of pain, medicalization and need for supportive care. Deeper understanding of HC risk factors may contribute to focus on more intense prevention in high risk pat...
Article
Full-text available
Objectives To assess if the lockdown period (March–April 2020) during the coronavirus disease-19 outbreak in Italy influenced the number, presentation, and treatment of urgent admissions to the emergency department for ureteral lithiasis, and to evaluate the same variables during the reopening phase (May–June 2020). Methods We performed a retrospe...
Article
Prostate cancer is the second most commonly diagnosed cancer in man. Since the first MRI was performed, enormous progress has been made in diagnosis, treatment, and follow up of PCa, mainly due to multiparametric prostatic MRI (mpMRI). Although mpMRI has become the best imaging tool for identifying PCa, some limitations still exist. Prostate imagin...
Article
The treatment of renal cancer has changed in the last decades with an increase in application of conservative surgery such as partial nephrectomy (PN) in order to achieve an optimal oncological outcome with the maximum preservation of renal function. The indication for PN is mandatory in case of bilateral tumors or in case of impaired renal functio...
Article
Background Atypical small acinar proliferation (ASAP) occurs in approximately 5% of prostate biopsies. Approximately 30%–40% of these patients may develop prostate cancer (PCa) within a 5-year period, often not clinically significant. Current guidelines recommend a repeat biopsy within 3–6 months after the initial diagnosis, but it seem not to be t...
Article
Background: A common limit for the widely used risk scores for preoperative assessment is the lack of information about aspects linked to frailty that may affect outcome, especially in the setting of elderly patients undergoing urologic surgery. Frailty has been recently introduced as an additional characteristic to be assessed for better identify...
Article
Introduction In cases of recurrent high-risk non–muscle-invasive bladder cancer, radical cystectomy (RC) is recommended. We compared oncologic and treatment-related outcomes of second-line conservative device-assisted therapy to RC. Patients and Methods In a retrospective cohort study, we analyzed 209 consecutive patients with recurrent bacillus C...
Article
Full-text available
The COVID-19 outbreak, in a few weeks, overloaded Italian hospitals, and the majority of medical procedures were postponed. During the pandemic, with hospital reorganization, clinical and learning activities performed by residents suffered a forced remodulation. The objective of this study is to investigate how urology training in Italy has been af...
Article
Full-text available
Introduction and objectives We aimed to evaluate how the corona virus disease of 2019 (COVID-19) outbreak influenced emergency department (ED) admissions for urolithiasis, hospitalizations and clinical management of the hospitalized Patients. Patients and methods We conducted a multicentric retrospective analysis of ED admissions in three high vol...
Article
Full-text available
Introduction: To compare the efficacy of artificial urinary sphincter (AUS) versus retrourethral transobturator sling (RTS) in men with moderate postprostatectomy urinary incontinence (PPI) using the propensity score-matching (PSM) to enhance the validity of the comparison (Canadian Task Force classification II-2). Patients and methods: Consecut...
Article
Full-text available
Introduction Complete ureteral avulsion represents a rare and fearsome complication of ureteroscopy, reported in less than 1% of cases. In literature there are few reports and different options are presented for its treatment. We present a case of a ureteral avulsion managed with ileal ureter replacement. Case presentation A 67‐year‐old man with a...
Article
Full-text available
Resumen Introducción Y Objetivos: Nuestro objetivo fue evaluar el impacto de la enfermedad del coronavirus de 2019 (COVID-19)* en los ingresos en los servicios de urgencias (SU)**, las hospitalizaciones y el manejo clínico de los pacientes con urolitiasis. Pacientes Y Métodos: Realizamos un análisis retrospectivo multicéntrico de las admisiones en...
Article
Introduction: Psychological aptitude for surgery includes all the non-technical abilities that are necessary for the surgeons. However, differently from the other careers, these skills are not considered in the selection process and their role is definitively underestimated in the field of surgery. We perform a literature review of non-technical s...
Article
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Objectives: To evaluate the neutrophil-to-lymphocyte ratio (NLR) as a prognostic factor for response of high risk non muscle invasive bladder cancer (HRNMIBC) treated with BCG therapy. Materials and methods: Between March 2010 and February 2014 in a tertiary center 100 consecutive patients with newly diagnosed HRNMIBC were retrospectively analyz...
Article
Full-text available
Background In case of high grade non-muscle invasive bladder cancer (HG-NMIBC), intravesical BCG represents the first-line treatment; despite the “gold” standard therapy, up to 50% of patients relapse, needing radical cystectomy. Hence, alternative therapeutic strategies have been developed. The aim of the study was to evaluate a first-line salvage...
Article
Full-text available
Background Mitomycin C (MMC) is widely used, but the optimal dose and schedule have not been established. Objective To evaluate the ablative power and patient safety of a short-term intensive schedule of intravesical MMC in patients with recurrent non–muscle-invasive bladder cancer (NMIBC). Design, setting, and participants This was a prospective,...
Article
Full-text available
Introduction To determine in a large population of community‐dwelling incontinent patients the accuracy and determinants of pad count as measure of urinary incontinence (UI), using data from a multicentre 48‐hour pad test study. Materials and methods Incontinent subjects provided with absorbent products from 01/2012 to 03/2016 volunteered to perfo...
Article
Objectives: To evaluate the efficacy and safety of a tailored endovesical immunotherapy protocol with biweekly BCG for elderly Patients with high risk non muscle invasive bladder cancer (HG-NMIBC). Materials and methods: We retrospectively evaluated data from 200 patients older than 80 years newly diagnosed with HG-NMIBC: 100 (group 1) with mult...
Article
Mitomycin C (MMC) as an intravesical chemotherapeutic agent is a well-known option for treatment of nonmuscle invasive bladder cancer (NMIBC) recurrence; it is probably the most commonly used agent given its low rate of side effects and its efficacy. Both the American Urologic Association (AUA) and European Association of Urology (EAU) consider MMC...
Article
Background: To evaluate the difference at different steps of follow-up of the postoperative quality of life (QoL) in patients who had undergone radical cystectomy and ileal orthotopic neobladder derivation. Patients and methods: A multicentric, cross-qualitative study was performed in 5 Italian centers of reference for the treatment of bladder c...
Article
The narrow band imaging (NBI) is a new technology introduced to complement the traditional endoscopy in order to enhance the detection of nonmuscle-invasive bladder cancer and, consequently, to improve the management of the disease. In this review, we considered the most important studies about the use of NBI in the diagnosis and treatment of bladd...
Article
The occult urothelial cancerTransitional cell carcinoma (TCC) is the tumor that most frequently affects the urinary tract. The most common location is at the level of the bladder; the diagnosis is based, as per the follow-up, on urine cytology, endoscopic, and radiological examinations. Urine cytologic study is an important noninvasive tool used in...
Article
Full-text available
Transitional cell carcinoma (TCC) is the tumor that most frequently affects the urinary tract. The most common location is at the level of the bladder; the diagnosis is based, as per the follow-up, on urine cytology, endoscopic, and radiological examinations. Urine cytologic study is an important noninvasive tool used in the diagnosis and follow-up...
Article
Full-text available
Hem-o-Lok clips (Weck Surgical Instruments, Teleflex Medical, Durham, North Carolina, USA) are widely used in robot-assisted laparoscopic radical prostatectomy because of their easy application and secure clamping. To date, there have been some reports of their migration into the urinary tract, causing urethral erosion, bladder neck contractures or...
Article
Bladder cancer represents the second most common neoplasm of the urinary tract and the fourth in general among all the neoplastic pathologies for the male gender; in females, it is the eighth most frequent among all cancers. At the initial diagnosis, 70% of bladder tumors are non-muscle invasive. Treatment of this stage is multimodal, both surgical...
Article
Non-muscle-invasive bladder cancer is a common urinary malignancy whose management is a challenge: strong evidence supports the use of passive intravesical chemotherapy in the management of this tumor. Despite current guidelines, the treatment is suboptimal as illustrated by the high risk of recurrence and progression. Bacillus Calmette-Guérin (BCG...
Article
Full-text available
Purpose: Patients with non-muscle invasive bladder cancer recurrence after 2 induction courses of BCG are eligible for radical cystectomy. So, in the last years research to discover new drugs for the management of non-muscle invasive bladder cancer recurrence after failure of first and second line therapy is ongoing. In accordance to the results o...

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