Luca Boeri

Luca Boeri
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico | Policlinico Maggiore · Urology

MD
Urologist and PHD student

About

581
Publications
21,024
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2,418
Citations
Citations since 2017
512 Research Items
2383 Citations
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201720182019202020212022202302004006008001,000
201720182019202020212022202302004006008001,000

Publications

Publications (581)
Article
Full-text available
Objectives To investigate which infertile men with semen parameters above WHO reference limits at first semen analysis deserve a second semen test. Materials and methods Data from 1358 consecutive infertile men were analysed. Patients underwent two consecutive semen analyses at the same laboratory. Descriptive statistics and logistic regression mo...
Article
Full-text available
Introduction: Antegrade sclerotherapy (Tauber) effectively treats varicocele. However, fluoroscopy exposes young males to ionizing radiation. We aimed to evaluate radiation exposure and surgical outcomes after the Tauber procedure. Materials and methods: We retrospectively analysed data from 251 patients. Dose area product (DAP) and fluoroscopy tim...
Article
Background: Recurrent pregnancy loss (RPL) and unexplained infertility are the current indications to test sperm DNA fragmentation (SDF) according to the EAU Guidelines on sexual and reproductive health. Objective: To identify a novel and better performing model to diagnose primary infertile men presenting with altered SDF and to outlie its pred...
Article
Full-text available
Objective: The purposes of this multi-center study were to evaluate the rate of infection stones and to evaluate the urine cultures of patients with infection stones. Materials: Charts of adulpatients with urinary stones were reviewed and data on stone analyses and urine cultures were collected. Results: In total, 1204 renal stone formers (RSF...
Article
Full-text available
The interrelationship between male sexual desire and erectile dysfunction (ED) has been scantly investigated. Thus, we aimed at investigating the prevalence of and the predictors of unrecognised low sexual desire/interest (uLSD/I) in a cohort of men with new onset ED. Complete data from 1587 men seeking for first medical help for ED between 2010 an...
Article
Full-text available
Purpose Backflow of pathogens and endotoxins from the renal pelvis to the bloodstream is one supposed mechanism for infectious complications development after endourological stones surgery. The aim of this study is detecting to prove bacterial spread into irrigation fluid and bloodstream during percutaneous nephrolithotomy (PCNL) and to correlate t...
Article
Background: Peyronie's disease (PD) has a huge impact on patients' physical and psychological wellbeing. Objectives: To investigate whether patients' age has an impact on PD symptomatic burden at first presentation. Materials & methods: Data from 129 consecutive heterosexual patients seeking first medical attention for PD at a single andrologi...
Article
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Background: Scoring metrics to assess and compare outcomes of percutaneous nephrolithotomy (PCNL) are needed. We aim to evaluate prevalence and predictors of trifecta in a cohort of patients treated with vacuum-assisted mini-percutaneous nephrolithotomy (vmPCNL) for kidney stones. Methods: Data from 287 participants who underwent vmPCNL were ana...
Article
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Background: Antioxidants are commonly used for the treatment of idiopathic male infertility. Previous studies have shown that antioxidants are able to improve sperm quality, but little is known about their impact on sperm DNA fragmentation (SDF). Preliminary findings showed that superoxide-dismutase (SOD)-based antioxidant plus hydroxytyrosol and...
Article
Objectives Patients with low urinary tract symptoms (LUTS) frequently complain some sexual dysfunction and sometimes even episodes of bothersome urinary incontinence (UI). We aimed to assess the relationship between UI (as measured with the ICIQ-UI-SF), and sexual disfunction (as measured with the IIEF), in men presenting with LUTS at a tertiary-re...
Article
Objectives The interrelationship between sexual desire and erectile dysfunction (ED) has been variously investigated. We aimed to investigate the prevalence of and the predictors of unrecognized low sexual desire (LSD) in the real-life setting. Methods Data from 1509 men seeking first medical help for new-onset ED at a single andrology centre were...
Article
Objectives The Masturbation Erection Index (MEI) has been recently validated in the setting of men presenting with erectile dysfunction (ED). We sought to analyze the correlation between MEI and the International Index for Erectile Function (IIEF) in a cross-sectional study in men with ED. Methods Data of 87 men presenting for ED at a tertiary ref...
Article
Objectives Erectile dysfunction (ED) has been demonstrated to be reasonably prevalent among young men (≤40 yr). We aimed to i) assess changes in patterns of reported ED in men ≤ 40 yr and ii) compare the sociodemographic and clinical characteristics of ED men ≤ 40 yr vs. > 40 yr of age over a 8-yr period at a single academic centre. Methods 1179 p...
Article
Objectives The Masturbation Erection Index (MEI) has been recently validated in the setting of men presenting with erectile dysfunction (ED). We sought to analyze the correlation between MEI and the International Index for Erectile Function (IIEF) in a cross-sectional study in men with ED. Methods Data of 87 men presenting for ED at a tertiary ref...
Article
Objectives High estrogens levels have been associated with higher rates of heart attacks, strokes, and prostate cancer. Moreover, hyperestrogenism is believed to be harmful to male sexuality. We aimed to investigate the impact of hyperestrogenism on sexual functioning in the real-life setting. Methods Data from 481 men seeking first medical help f...
Article
Objectives The interrelationship between sexual desire and erectile dysfunction (ED) has been variously investigated. We aimed to investigate the prevalence of and the predictors of unrecognized low sexual desire (LSD) in the real-life setting. Methods Data from 1509 men seeking first medical help for new-onset ED at a single andrology centre were...
Article
Objectives The ASCVD (Atherosclerotic Cardiovascular Disease) risk score is a validated and standardised algorithm predicting the individual 10-year risk of developing acute cardiovascular events (CVs). Patients with erectile dysfunction (ED) are at greater risk of CVs; we aimed to i) apply the ASCVD score at a homogenous cohort of men undergoing d...
Article
Objectives Laser enucleation of the prostate is associated with an invariable risk of retrograde ejaculation which could affect patient’ sexual life with negative impact on orgasmic function (OF). We investigated OF outcomes after Holmium Laser Enucleation of the Prostate (HoLEP) in patients consecutively treated at a single center. Methods The Ex...
Article
Objectives Testosterone therapy (TT) is commonly prescribed in men with androgen deficiency. TT has several common side effects. Moreover, the effect of TT on serum prostate specific antigen (PSA) levels has been a matter of debate over the last decade. We aimed to investigate the effect of TT on PSA and haematocrit levels in a cohort of men with a...
Article
Objectives Patients with low urinary tract symptoms (LUTS) frequently complain some sexual dysfunction and sometimes even episodes of bothersome urinary incontinence (UI). We aimed to assess the relationship between UI (as measured with the ICIQ-UI-SF), and sexual disfunction (as measured with the IIEF), in men presenting with LUTS at a tertiary-re...
Article
Objectives High estrogens levels have been associated with higher rates of heart attacks, strokes, and prostate cancer. Moreover, hyperestrogenism is believed to be harmful to male sexuality. We aimed to investigate the impact of hyperestrogenism on sexual functioning in the real-life setting. Methods Data from 481 men seeking first medical help f...
Article
Objectives To investigate whether patients’ age has an impact in terms of Peyronie's disease (PD) clinical characteristics at presentation. Methods Data from a group of 110 consecutive patients aged >18 and <70 years with PD and seeking first andrological attention, with a complete clinical assessment and who completed the IIEF-15 and PDQ question...
Article
Objectives Testosterone therapy (TT) is commonly prescribed in men with androgen deficiency. TT has several common side effects. Moreover, the effect of TT on serum prostate specific antigen (PSA) levels has been a matter of debate over the last decade. We aimed to investigate the effect of TT on PSA and haematocrit levels in a cohort of men with a...
Article
Objectives To investigate whether patients’ age has an impact in terms of Peyronie's disease (PD) clinical characteristics at presentation. Methods Data from a group of 110 consecutive patients aged >18 and <70 years with PD and seeking first andrological attention, with a complete clinical assessment and who completed the IIEF-15 and PDQ question...
Article
Objective: - To i) identify a novel risk stratification for patients complaining of haemospermia; and, ii) compare its predictive ability to select high-risk patients by retrospectively validating the EAU guidelines classification. Patients and methods: - Data from 283 consecutive patients complaining of a single episode/recurrent haemospermia w...
Preprint
Full-text available
Purpose: To evaluate prevalence and predictors of trifecta in a cohort of patients treated with vacuum-assisted percutaneous nephrolithotomy (vamPCNL) for kidney stones. Methods: Data from 287 patients who underwent vamPCNL were analysed. Patient’s demographics, stones characteristics and operative data were collected. Stone-free was defined as no...
Article
Purpose: Overall, male factor infertility (MFI) accounts for up to 50% of etiologies of couple's infertility, with almost 30% of MFI cases being idiopathic in nature. Idiopathic MFI does not support a tailored treatment work-up in clinical practice. To investigate rates of and characteristics of men presenting for idiopathic versus unexplained pri...
Article
Background: Alfa-fetoprotein (AFP) is a serum glycoprotein highly produced during fetal development. While AFP synthesis drops dramatically after birth, AFP production only persists or returns under specific pathological condition OBJECTIVE: : We sought to investigate the rate of and the potential meaning of high AFP serum levels in men seeking fi...
Article
Context The benefits and harms of varicocele treatment versus observation in adult infertile males are still controversial. Objective To systematically pool the evidence on outcomes of varicocele treatment (any surgical or radiological) versus observation in adult infertile men. Evidence acquisition A systematic review and meta-analysis was condu...
Article
Surgical treatments for ischemic priapism (IP) include shunts or penile implants. Non-ischemic priapism (NIP) is usually the result of penile/perineal trauma causing an arterial fistula and embolisation may be required. We conducted a systematic review on behalf of the EAU Sexual and Reproductive health Guidelines panel to analyse the available evi...
Article
Full-text available
Background: Percutaneous nephrolithotomy (PCNL) and its miniaturized modifications are usually considered the standard surgical options for large (>20 mm) staghorn and infected stones. Moreover, PCNL is a viable alternative to retrograde intrarenal surgery (RIRS) for smaller stones (<20 mm) in the presence of anatomical malformations or inaccessib...
Preprint
Full-text available
The interrelationship between male sexual desire and erectile dysfunction (ED) has been scantly investigated. Thus, we aimed at investigating the prevalence of and the predictors of unrecognized low sexual desire/interest (uLSD/I) in a cohort of men with new onset ED. Complete data from 1509 men seeking for first medical help for ED between 2010 an...
Article
Context: The use of scrotal ultrasound (SUS) has increased the detection rate of indeterminate testicular masses. Defining radiological characteristics that identify malignancy may reduce the number of men undergoing unnecessary radical orchidectomy. Objective: To define which SUS or scrotal magnetic resonance imaging (MRI) characteristics can p...
Article
Sickle cell disease (SCD) is an inherited hemoglobin disorder characterized by the occlusion of small blood vessels by sickle-shaped red blood cells. SCD is associated with a number of complications, including ischemic priapism. While SCD accounts for at least one-third of all priapism cases, no definitive treatment strategy has been established to...
Article
Full-text available
Concomitant sexual disorders have progressively shown increased prevalence in men at first outpatient presentation. We sought to i) estimate the prevalence of unreported premature ejaculation (PE) in a homogenous cohort of 1258 men seeking first medical help for erectile dysfunction (ED) as their primary compliant; ii) compare the baseline sociodem...
Article
Conservative and medical treatments are considered the first step in ischemic priapism (IP) management, although there is no clear evidence regarding their efficacy. We conducted a systematic review on behalf of the EAU Guidelines panel on Sexual and Reproductive health to analyse the available evidence on the efficacy and safety of conservative an...
Article
The advent of immunotherapy and targeted therapy has outstandingly improved the prognosis in subjects with melanoma. Their use is now advocated also in earlier stages as an adjuvant therapy, and some neoadjuvant clinical trials are ongoing. Consequently, survivors free of disease are increasing, as well as those exposed to these new agents. Parenth...
Article
Full-text available
In the most recent version of the ‘WHO Laboratory Manual For The Examination And Processing Of Human Semen’, the updated target population used to infer reference values included 3589 fertile subjects, representative of 12 countries and 5 continents, and 10 studies. We have critically evaluated the newly proposed distribution of semen examination r...
Article
Full-text available
Purpose To assess how accurate are urologists in predicting stone-free status (SFS) after vacuum-assisted mini-PCNL (vamPCNL) compared to computed tomography (CT) and clinical predictors of discordant SFS. Methods Data from 235 patients who underwent vamPCNL were analysed. Patient’s demographics, stones’ characteristics and operative data were rec...
Article
Background: Low-chance retrieval non-obstructive azoospermic (NOA) patients are a subpopulation of NOA patients. The objective of this study is to compare the surgical outcome of microsurgical-assisted testicular sperm extraction (M-TeSE) and combined trifocal/M-TeSE in low-chance retrieval NOA patients. Material and methods: A single-center ret...
Article
Full-text available
Purpose To validate the comprehensive complication index (CCI) for mini-percutaneous nephrolithotomy (mPCNL). Methods Data from 287 patients who underwent mPCNL were analyzed. Complications after mPCNL were classified using both the CCI and the Clavien–Dindo classification (CDC). Descriptive statistics and linear/logistic regression analyses detai...
Article
Introduction : Percutaneous microwave ablation (MWA) of renal masses (RM) is still considered experimental as opposed to established procedures such as cryoablation (CA). We aimed to compare perioperative, functional and oncological outcomes of patients with RM treated with CA and MWA. Methods : Data from 116 (69.9%) and 50 (30.1%) patients treate...
Article
Background: Male factor contributes to up to 50% of cases of couples experiencing infertility. Cannabis is one of the most commonly used recreational drugs and its effects on the reproductive system have been largely debated in the literature. Objectives: The aim of this study is to evaluate the effect of recreational cannabis use on total T (tT...
Article
Full-text available
Background: Standardized methods for reporting surgical quality have been described for all the major urological procedures apart from radical nephroureterectomy (RNU). Objective: To propose a tetrafecta criterion for assessing the quality of RNU based on a consensus panel within the Young Association of Urology (YAU) Urothelial Group, and to test...
Article
Background: Erectile dysfunction aetiology (ED) has been historically identified as organic, psychogenic, and mixed. Objectives: To stratify and compare a cohort of patients seeking medical help for ED for the first time according to the newly proposed binary classification of the EAU guidelines: "primary organic" versus "primary psychogenic"....
Article
Full-text available
Background: In 2021, the World Health Organization (WHO) has provided the latest update on processing and evaluating semen analysis. Objectives: To assess (i) the rate of discordance in semen parameters categorization across three different WHO reference values (namely WHO21, 2010 and 1999) and (ii) the clinical differences among discordant seme...
Article
Full-text available
Background In the context of established male hypogonadism, testosterone therapy (TTh) has been employed to regain physiologic levels of circulating testosterone and improve sexual function and overall quality of life. Aim To assess the risk of cardiovascular disease and mortality as time-dependent outcomes in treated vs TTh untreated hypogonadal...
Article
Purpose: In industrialized countries, air pollutants levels have been monitored closely for environmental and research issues. Using Italian data, we aimed to investigate the association between air pollutants levels and semen parameters in a cohort of non-Finnish white-European men presenting for couple's infertility. Materials and methods: Com...
Article
Full-text available
A range of drugs have a direct role in triggering ischaemic priapism. We aimed at identifying: a) which medications are associated with most priapism-reports; and, b) within these medications, comparing their potential to elicit priapism through a disproportionality analysis. The FDA Adverse Event Reporting System (FAERS) database was queried to id...
Article
Full-text available
A limited number of studies have described patients on finasteride showing findings which were consistent with Peyronie’s disease (PD). We aimed to detect a pharmacovigilance signal of possible association between finasteride and PD-related clinical features. The Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database was...
Article
Introduction The routine use of dynamic duplex ultrasound of the penis (DDUP) to detect vasculogenic erectile dysfunction (V-ED) has been questioned because of a related patient’ discomfort and costs issues. Objective to investigate clinical factors which could guide the physician in selecting candidates for DDUP in routine practice. Methods Data...
Article
Introduction High serum estrogens levels have been associated with higher rates of heart attacks, strokes, and prostate cancer. Moreover, hyperestrogenism is believed to be harmful to male sexuality. Objectives We aimed to investigate the prevalence of and the impact of hyperestrogenism on sexual functioning in a cohort of men seeking medical atte...
Article
Introduction Peyronie's disease is a benign condition involving the tunica albuginea of the corpora cavernosa of the penis. Objectives To investigate whether patients’ age has an impact in terms of Peyronie's disease (PD) clinical characteristics at presentation. Methods Data from a group of 110 consecutive patients aged >18 and <70 years with PD...
Article
Introduction The Sexual and Reproductive Health guidelines of the European Association of Urology (EAU) suggest stratifying patients complaining of haemospermia into low versus high-risk categories for treatable aetiologies. Objective To validate EAU guidelines in a homogeneous cohort of men with haemospermia and to identify a novel and better per...
Article
Introduction Patients with low urinary tract symptoms (LUTS) frequently complain some sexual dysfunction and sometimes even episodes of bothersome urinary incontinence (UI). Objective We aimed to assess the relationship between UI (as measured with the ICIQ-UI-SF), and sexual disfunction (as measured with the IIEF), in men presenting with LUTS at...
Article
Introduction There is a current lack of effective conservative treatments for Peyronie Disease (PD). Surgery represents an effective treatment, despite being associated with bothering complications, including erectile dysfunction (ED). Objective We investigated patients wish of being operated for PD at a single center. Methods Data were prospecti...
Article
Introduction Erectile dysfunction (ED) is defined according to three different aetiological groups: organic, psychogenic and mixed. As most cases have mixed aetiology, EAU guidelines suggests using the terms "primary organic" or "primary psychogenic". Objectives We aimed to stratify a homogenous cohort of patients seeking medical help for ED for t...
Article
Introduction The interrelationship between male sexual desire and erectile dysfunction (ED) has been variously investigated. Objectives We aimed to investigate the prevalence of and the predictors of unrecognized low sexual desire (LSD) in a cohort of men seeking medical help for new onset ED in the real-life setting. Methods Data from 1509 men s...
Article
Full-text available
Introduction, The aim of this systematic review was to evaluate the current evidence for the effectiveness of ginseng, Rutin and Moringa for treating erectile dysfunction. Methods, A broad search of the Scopus, PubMed, Cochrane and Web of Science databases was performed in complicance with the Preferred Reporting Items for Systematic Reviews and Me...
Article
Full-text available
Topical anaesthetics are considered a first-line therapy option in men with premature ejaculation (PE). A cross-sectional retrospective analysis was performed to evaluate the real-life use of the eutectic mixture of prilocaine/lidocaine spray (FORTACIN™) in a cohort of 198 white-European men who had been consecutively and prospectively seen at a si...