Lubov Atramentova

V. N. Karazin Kharkiv National University · Department of Genetics and Cytology

Aim. The aim was to compare the frequency spectra of Y chro mosome haplogroups among Ukrainians from different regions, identify atypical populations and determine their characteristics. Methods. A sample of Ukrainians (n = 1141) from 12 regions of Ukraine was investigated. DNA samples were genotyped by the SNP markers of the Y chromosome. The freq...

Background. It is generally believed that environmental and genetic factors interact with the formation of nonalcoholic fatty liver disease (NAFLD) phenotype and determine its progression. Both NAFLD and type 2 diabetes (T2D) are heterogeneous diseases with common pathogenic pathways. Adiponectin is an adipokine, which increases the sensitivity of...

We have studied the gene pools of populations with «Tatar» enthonym in three regions of Eurasia – Tatars of Crimea, Tatars of Volga region and Tatars of Siberia. About 1000 individuals of these peoples were analyzed on 50 SNP markers of Y-chromosome, the most informative tool in population genetics. Ethnoterritorial groups of Tatars were found to b...

Readable link: http://rdcu.be/kt5n High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring populatio...

Aim The aim of this study was to examine the effects of omega-3 fatty acids on novel cardiovascular risk factors in relation to +174 G>C interleukin-6 gene (IL6) single nucleotide polymorphism (SNP). Methods A total of 61 patients (M/F: 34/27; age 53.9 ± 1.2 yrs; BMI 32.68 ± 0.77 kg/m²; HbA1С 7.06 ± 0.18%; FBG 8.00 ± 0.28 mmol/L) with Type 2 diabe...

Permanent residents of Kharkiv (637 men and 856 women at the age of 45–65 years) are tested on the level of aggression and empathy. The average aggression level (41.7 points) is higher in migrants (born outside Kharkiv) than in indigenous people (36.3 points); the average empathy level is lower in migrants (3.2 points) than in indigenous people (5....

The territory of present-day Ukraine is subdivided into some regions with specific demographic and politic history. Nevertheless, the corresponding subdivision in genetic structure is not revealed in previous investigations: populations of Ukrainians under study were genetically homogeneous on SNP markers of Y chromosome. In the current investigati...

The Slavic branch of the Balto-Slavic sub-family of Indo-European languages underwent rapid divergence as a result of the spatial expansion of its speakers from Central-East Europe, in early medieval times. This expansion-mainly to East Europe and the northern Balkans-resulted in the incorporation of genetic components from numerous autochthonous p...

The diagnostic model to highlight the high-risk groups of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus by the level of retinol-binding protein-4, high molecular weight adiponectin and body mass index using discriminant analysis was developed.

Abstract Results from studying Y-chromosomal polymorphisms of Russian and Ukrainian populations are presented for Slobozhanshina, which is a contemporary border region, inhabited in the 17th–18th centuries at the “Wild Field” boundary due to migrations of both the Russians from the north and Ukrainians from the west. In general, the Ukrainian and R...

The diagnostic models to highlight the high-risk groups of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus by the level of retinol-binding protein-4, and body mass index using logistic regression and ROC-analysis are developed. By means of logistic regression risk factors for nonalcoholic fatty liver disease are identifie...

It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal...

According to the obstetric history of Yevpatoria residents of postreproductive age, the parameters of the dif- ferential fertility as components of the natural selection (index Crow) in Slavic (Russian and Ukrainian) and non-Slavic individuals have been calculated. It is shown that, in the studied population, in one generation, the index of total s...

The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and endometrial cancer. Assessing SNP285 and 309 genotypes across 25 different ethnic populations (>10.000 individuals), the incidence of...

Indicators characterizing population migration were calculated according to the marriage records of Yevpatoria (Crimea) of 1960/1961, 1985, and 1994/1995. The marital migration coefficient m in those years was 0.80, 0.75, and 0.66, the endogamy index was 0.04, 0.08, and 0.15, and the rate of marriage contingency by birthplace was 0.15, 0.16, and 0....

Background: A wide range of normal and clinically significant behavior traits, including fears, were intensively studied and heritability coefficients were obtained for many of them. A heritability value is a population-based trait, so it may significantly vary in different human populations. In the former Soviet Union, research on human behavior t...

According to the obstetric history of Yevpatoria residents of postreproductive age, the parameters of the differential fertility as components of the natural selection (index Crow) in Slavic (Russian and Ukrainian) and non-Slavic individuals have been calculated. It is shown that, in the studied population, in one generation, the index of total sel...

Single nucleotide polymorphism +276G > T of adiponectin gene (ADIPOQ) in type 2 diabetesmellitus patients (n=544) and healthy habitants (n = 215) of Kharkiv was studied. There wereno significant differences of single nucleotide polymorphism +276 G > T frequencies for patients(pG = 0.691; pT = 0,309) and healthy subjects (pG = 0,601; pT = 0,399). Ho...

Based on data collected from urban residents by questionnaire, the basic parameters of the genetic-demographic structure of populations of the three megalopolises, i.e., Moscow, Kharkov, and Minsk, have been calculated, including the migration coefficients and their dynamics in generations, the radius of the cities migration attraction, the paramet...

The Q192R polymorphism of PON-1 gene was genotyped in 96 individuals with diabetes mellitus type 2 (T2DM) and 123 nondiabetic control individuals from Kharkiv. Allele frequencies do not differ significantly between T2DM (p Q = 0.65 and p R = 0.35) and healthy individuals (p Q = 0.70 and p R = 0.30). Genotype distribution for healthy people complies...

Polymorphism of PON-1 gene in 192 position of amino acid sequence of enzyme paraoxonase 1 was studied. For this research we have used the blood samples of 96 patients with T2DM and 123 healthy habitants of Kharkiv. Frequencies of alleles for the patients (pQ = 0,65, pR = 0,35) and the healthies (PQ = 0,70 and pR = 0,30) did not differentiate meanin...

+276G > T polymorphism in the adiponectine gene (APM1) was studied in 103 samples obtained from donors in the Kharkiv population (men/women: 64/38; 70 Ukrainian, 33 Russian). The T- and G-allele frequencies did not significantly differ between either men and women or between Russians and Ukrainians and comprised p T = 0.55 and p G = 0.45 in the gen...

Deletions in the fifth and eighth exons of FHIT gene were detected using intragenic microsatellites D3s1540 and D3s1234 in 17 males and 5 females with esophageal cancer. The patients were residents of Hebei province, China. Homozygotic deletions in the fifth and eighth exons were detected in 16 of 22 patients. Hypermethylation of the FHIT gene was...

We studied the polymorphism of gene PON-1 in 192 positions of amino acid sequence of enzyme paraoxonase 1, which is connected with isoenzymes R and Q. We analyzed 109 blood samples of habitants of Kharkiv (78 men and 31 women), 84 Ukrainians and 25 Russians. The frequency of the Q allele was p Q = 0.67, and R allele − p R = 0.33. The differences...

The study considers data on 15 STR-loci from paternity cases across Belarus districts from 2004 to the beginning of 2006 (set #1, 580 individuals) and since that to the beginning of 2007 (set #2, 530 individuals); the data majorly consist of ethnic Belarusians. No significant difference was found between the sets, as well as between the country dis...

The characteristics of the gene pools of indigenous populations of Ukraine and Belarus have been studied using 28 alleles of 10 loci of biochemical gene markers (HP, GC, TF, PI, C′3, ACP1, GLO1, PGM1, ESD, and 6-PGD). The gene pools of the Russian and Ukrainian indigenous populations of Belgorod oblast (Russia) and the indigenous populations of Ukr...

This work develops a detailed STR database from 11 population samples and samples from paternity analyses from different districts of Belarus. The combined data on 2020 individuals form a total database for the country, with the exclusion power of 99.987% based on 11 STR loci. Possible differentiation in allele frequencies between population sample...

Data from the Lugansk City Registry Office archives of 1960, 1985, 1990, and 2000 were used to calculate genetic demographic parameters characterizing marriage migration. The migration coefficients (m) in these years were 0.69, 0.54, 0.47, and 0.36; the endogamy indices were 12.1, 24.4, 30.5, and 43.2%, and the marriage contingency coefficients wit...

Records on marriages contracted in the city of Yevpatoria, Ukraine in 1960/1961, 1985, 1993, and 1994/1995 were used to determine some parameters of the city population structure. The coefficients of correlation with respect to the age of marriage in reproductive-age couples contracting marriages in these years were 0.77, 0.81, and 0.80, respective...

Records on marriages contracted in the city of Yevpatoria, Ukraine in 1960/1961, 1985, 1993, and 1994/1995 were used to determine some parameters of the city population structure. The coefficients of correlation with respect to the age of marriage in reproductive-age couples contracting marriages in these years were 0.77, 0.81, and 0.80, respective...

Data from marriage records from registry office archives of 1960, 1985, 1990, and 2000 have been used to calculate the genetic demographic parameters of the Lugansk city population. The population is mostly Ukrainian and Russian. In the years studied, Ukrainians accounted for 49.4, 44.0, 44.6, and 48.7% of the population and Russians, for 46.3, 52....

It has been proposed that the Delta32 mutation in the chemokine receptor gene, inducing resistance to HIV-1 and, probably, to other virus infections, has undergone selection in historical times. The frequency of this mutant allele has changed rapidly both in time (during the last two millennia) and in space (across Eurasia). We compiled a global da...

Data from marriage records of the city of Belgorod for 1960, 1985, and 1995 have been used to determine some parameters of population structure in this city. The coefficients of correlation with respect to age of marriage between spouses in the couples contracting marriages in these years were 0.74, 0.62, and 0.80, respectively. Women of reproducti...

Data from marriage records of the city of Belgorod for 1960, 1985, and 1995 have been used to calculate parameters characterizing migration in the Belgorod population. The marriage migration coefficients (m) in these years were 0.83, 0.68, and 0.58, respectively, and the endogamy indices were 0.05, 0.13, and 0.22, respectively. The marriage converg...

Ukrainians account for 85 and 91% of the populations of the city of Khmel'nitskii and the town of Starokonstantinov (Khmel'nitskii oblast, western Ukraine), respectively, and for 97% of the rural population of the Khmel'nitskii oblast. The proportions of Russians in the urban and rural populations of the Khmel'nitskii oblast are 7-10 and 1%, respec...

The probability to develop lung cancer before 80 years of age is 1.67 and 0.18% for the male and female populations of Kharkov, respectively; the probability to develop large-intestine cancer is 0.92 and 0.49%, respectively. The correlation coefficient (r) of the age of manifestation (AM) of cancer in parent-offspring pairs is 0.47. These correlati...

ANOVA designs for estimating heritabilities of fecundity traits in Hirudo medicinalis including batch size, the number of juveniles per cocoon, and juvenile weight. Accounting for reproduction mode of this species, different types of kinship were identified, which were taken into account in the ANOVA designs: juveniles from one batch and one cocoon...

ANOVA designs for estimating heritabilities of fecundity traits inHirudo medicinalis including batch size, the number of juveniles per cocoon, and juvenile weight. Accounting for reproduction mode of this species, different types of kinship were identified, which were taken into account in the ANOVA designs: juveniles from one batch and one cocoon...

The probability to develop lung cancer before 80 years of age is 1.67 and 0.18% for the male and female populations of Kharkov, respectively; the probability to develop large-intestine cancer is 0.92 and 0.49%, respectively. The correlation coefficient (r) of the age of manifestation (AM) of cancer in parent–offspring pairs is 0.47. These correlati...

Analysis of data on the birthplaces and ethnicity of persons who contracted marriages in the city of Donetsk in 1960, 1985, and 1992 demonstrated that the proportions of Russians and Ukrainians (the dominant ethnic groups among Donetsk residents) in the migration flow increased. The trend towards formation of ethnically disperse groups from the cit...

Analysis of the birthplace and ethnicity of males and females contracting marriages in the city of Poltava in 1960, 1985, and 1995 revealed a trend towards return of Ukrainians from various regions of the former Soviet Union to their places of origin. In the migration flow, Russians were gradually substituted by Ukrainians, and the total proportion...

Analysis of data on the birthplaces and ethnicity of persons who contracted marriages in the city of Donetsk in 1960, 1985, and 1992 demonstrated that the proportions of Russians and Ukrainians (the dominant ethnic groups among Donetsk residents) in the migration flow increased. The trend towards formation of ethnically disperse groups from the cit...

Analysis of the birthplaces and ethnicity of males and females contracting marriages in the city of Poltava in 1960, 1985, and 1995 revealed a trend towards return of Ukrainians from various regions of the former Soviet Union to their places of origin. In the migration flow, Russians were gradually substituted by Ukrainians, and the total proportio...

Marriage records were used to study the dynamics of the migration flow into the population of Kharkov in 1960-1993. The decrease in the migration rate was accompanied by changes in the ethnic composition of the migrants. The entire migration flow from the republics of the Baltic region consisted of Russians and Ukrainians. The increase in the migra...

Marriage records were used to study the dynamics of the migration flow into the population of Kharkov in 1960–1993. The decrease in the migration rate was accompanied by changes in the ethnic composition of the migrants. The entire migration flow from the republics of the Baltic region consisted of Russians and Ukrainians. The increase in the migra...

A set of selection measures for increasing reproduction efficiency in Hirudo medicinalis has been developed. The optimal values of reproductive traits corresponding to the highest progeny number were determined and recommended. The probability of correlated selection response in traits "number of threads in a cocoon" and "weight of threads" was est...

A set of selection measures for increasing reproduction efficiency in Hirudo medicinalis has been developed. The optimal values of reproductive traits corresponding to the highest progeny number were determined and recommended. The probability of correlated selection response in traits number of juveniles in a cocoon and weight of juveniles was est...

The phenotype variability and inheritance of reproductive traits were investigated in the medicinal leech. Distribution parameters were determined for the following traits: batch size (X = 4.3 +/- 0.2, sigma = 1.7, CV = 40%, As = 0.23 +/- 0.25, Ex = 0.19 +/- 0.51), number of juveniles in a cocoon (X = 10.9 +/- 0.3, sigma = 4.6, CV = 42%, As = 0.31...

The phenotype variability and inheritance of reproductive traits were investigated in the medicinal leech. Distribution parameters were determined for the following traits: batch size (X = 4.3 0.2, = 1.7, CV = 40%, As = 0.23 0.25, Ex = 0.19 0.51), number of juveniles in a cocoon ( X= 10.9 0.3, = 4.6, CV = 42%, As = 0.31 0.15, Ex = 0.23 0.30), and j...

The genetic determination of insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus and thyroid gland diseases (TGD) was carried out using clinical-genealogical data on 229 patients with IDDM, 275 patient with NIDDM, 247 patients with TGD and their relatives. Results of component decomposition showed the role of genetic factor...

Analysis of records of the marriages that were contracted in the city of Donetsk revealed that, between 1960 and 1992, the marriage rate in the city decreased from 14.8 to 4.7 per 1000 people, the migration rate (m) decreased from 0.71 to 0.34, and the endogamy index increased from 0.123 to 0.458. Between 1960 and 1985, outbreeding in the Donetsk p...

Analysis of records of the marriages that were contracted in the city of Poltava revealed an increase in outbreeding between 1960 and 1985 in the Poltava population. This was expressed in increased ethnic diversity, proportion of interethnic marriages, migration range, and the parent-offspring and average marital distances, whereas the proportion o...

Analysis of records of the marriages that were contracted in the city of Poltava revealed an increase in outbreeding between 1960 and 1985 in the Poltava population. This was expressed in increased ethnic diversity, proportion of interethnic marriages, migration range, and the parent-offspring and average marital distances, whereas the proportion o...

The characteristics of marriages contracted in 1993 in two districts of the city of Khar'kov were studied. The age, education, occupation, ethnicity, and birthplace of the spouses were recorded. The genetic demographic parameters of the marriage structure were compared to the results of a similar study performed in 1985. It was found that since 198...

The characteristics of marriages contracted in 1993 in two districts of the city of Kharkov, Ukraine were studied. The age, education, occupation, ethnicity, and birthplace of the spouses were recorded. The genetic demographic parameters of the marriage structure were compared to the results of a similar study performed in 1985. It was found that s...

The pedigrees of 484 patients suffering from diabetes mellitus have been investigated. It was found that the ratio of genes inducing insulin-dependent and insulin-independent diabetes mellitus differs in the groups of patients with different forms of disease.

It was detected that the migration coefficient of Poltava's population increased from m = 0.68 in 1960 to 0.71 in 1985. The coefficient of coincidence of married pairs in nationality and origin decreased from K = 0.152 and K = 0.055 to K = 0.119 and K = 0.043 and increased from K = 0.085 to 0.095 according to their occupation. Potential selection i...

A study of the Kharkov population revealed the effect of parent exogamy for liability of the progeny to diabetes mellitus that was more pronounced in sons than in daughters. Minimum genetic effect on the formation of diabetes mellitus concerns the group of reduced exogamy. In type I diabetes mellitus, the maximum genetic effect concerns the group o...

The similarity of hereditary load in the women, suffering from alcoholism and drug addiction has been determined. The degree of parents exogamy has no influence on daughters resistance to alcoholism and drug addiction. The sick women with loaded pedigree have higher probability to form concordant couple than unloaded ones.

Positive assortative mating for birthplace and nationality has been revealed by means of sample analysis of couples married in two districts of Kharkov in 1960 and 1985. The contingency coefficient measuring the association between birth places of husband and wife was K = 0.15 in one district in 1960 and K = 0.18 in the other, these values being K...