Lubna Iqbal

Lubna Iqbal
Pakistan Council of Scientific and Industrial Research | PCSIR · Pharmceutical research centre

PhD biochemistry

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89
Publications
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Citations
Citations since 2017
3 Research Items
387 Citations
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080

Publications

Publications (89)
Article
Full-text available
Extracts of nine plants were studied for DPPH radical scavenging and reducing abilities. Pentatropis spiralis, Calotropis procera, Helitropium curassavicum, Withania somnifera and Chenopodium album showed reducing power ranging from 34% to 146%. Suaeda fruticosa, Trianthema portulacastrum, Pluchea lanceolata and Rumex dentatus has excellent antioxi...
Article
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To treat Alzheimer's disease (AD), the available candidates are effective only against mild AD or have side effects. So, a study was planned to synthesis new candidates that may have good potential to treat AD. A series of new anthrarobin acyl derivatives (2-8) were synthesized by the reaction of anthrarobin (1) and acetic anhydride/acyl chlorides....
Article
Full-text available
The antioxidant, lipoxygenase inhibitory activities and free radical scavenging capacity of the crude extract, aqueous and some organic fractions of dry and ripe fruit of Aeglemarmelos. L were studied to understand the protective and therapeutic role for the use of the fruit as a remedy in different ailments. All the tested fractions and extracts s...
Article
Full-text available
Six Schiff bases 8–13 were synthesized by condensation of 2-aminophenol (1) with various chloro- and nitro-benzaldehydes (2–7), characterized, and evaluated for antioxidant, antibacterial, lipoxygenase, and urease inhibitory potentials. All Schiff bases except 11 showed potent antioxidant activity with IC50 values ranging between 17.2 and 33.1 μM w...
Article
Full-text available
The current study explores the antioxidant potential of anthrarobin and its synthesized derivatives determined by various methods including DPPH radical scavenging ability, reducing power and superoxide scavenging activity. Anthrarobin was acetylated with acetic anhydride in the presence of pyridine to afford anthracen-1, 10-dihydroxy-2-acetate (1)...
Article
Cashmins A ( 1 ) and B ( 2 ), two new coumarins, have been isolated from the chloroform-soluble subfraction of the methanolic extract of Sorbus cashmiriana Hedl. Both compounds showed potent antioxidant activity in different antioxidant assays.
Article
Full-text available
Schiff bases 8-13, have been synthesized by the condensation of 2-aminophenol 1 with aldehydes/kitones 2-7. Their structures were characterized by spectroscopic (1 H-NMR, IR, EI-MS) data along with elemental analysis. The target compounds were biological screened out and showed good lipoxygenase, α-glucosidase inhibition and antioxidant activities,...
Article
Full-text available
Four novel complexes of “3-(2-(2-hydroxy-3-methoxybenzylidene)hydrazono)indolin-2-one” have been synthesized with Co +2 , Ni +2 , Cu +2 and Zn +2 . Physical and analytical techniques including CHN, IR, UV-Vis, AAS, molar conductivity values and magnetic susceptibility data were used to characterize all complexes. The bis Schiff base ligand i.e. 3-(...
Article
Full-text available
Six new Copper(II) complexes with bishydrazone derived from the condensation of 5-chloro-isatin monohydrazone with different substituted benzaldehyde, have been synthesized and characterized byusing various spectroscopic and physicochemical techniques including FT-IR, EI-mass, elemental analysis,UV-Visible, magnetic susceptibility and conductivity...
Article
Full-text available
The objective of this study was to synthesize potent and/or novel inhibitors for α-chymotrypsin activity. Eighteen derivatives of N-methylphenyl-N′-(alkyl/aryl) urea (1–18) were synthesized, and their inhibitory effects on α-chymotrypsin enzyme were evaluated. Two compounds exhibited potent inhibitory activities. The most potent, N-(2-methylphenyl)...
Patent
Full-text available
The process for the preparation of topical analgesic cream traumatic pain involves the mixing of water based and lipid based ingredients into an appropriate quantity at suitable temperature i.e. 40°C at which the desired creamy texture is obtained. The active ingredients of this capsicum based topical analgesic cream for traumatic pains are ethanol...
Article
ABSTRACT Alpha amylase from Bacillus subtilis KIBGE HAS was partially purified by ultrafiltration and ammonium sulphate precipitation. After partial purification, the specific activity of protein increased to 2813 U/mg with 20.8 fold purification. The enzyme showed activity in the presence of chelating agent (EDTA) and protein denaturing agents lik...
Article
Full-text available
Schiff bases, 2-{[(2-hydroxyphenyl)methylidene]amino}phenol (4) and 2-{[3-4-(dimethylamino)phenyl-2-propenylidene]amino}phenol (5), have been synthesized by the condensation of 2-aminophenol (1) with 2-hydroxybenzaldehyde (2) and 4-dimethylaminocinnamaldehyde (3), respectively. They showed good lipoxygenase inhibition and antioxidant activities, as...
Article
This study was designed to explore the phytochemical screening, total phenolic contents, radical scavenging potential and urease inhibitory activities in various fractions of the aerial parts of Nepeta praetervisa. Sub-fractions (n-hexane, chloroform, ethyl acetate, n-butanol, and aqueous) were prepared from the crude methanolic extract using parti...
Patent
The process for the preparation of an analgesic cream for joints and arthritis pain involves the mixing of water based and lipid based ingredients into an appropriate quantity at suitable temperature i.e. 40°C at which the desired creamy texture is obtained. The active ingredients of analgesic cream are ethanolic extract of roots of Moringa oleifer...
Article
An efficient and facile condensation of 2-aminobenzophenone with different carbonyls yields novel Schiff bases (1-11) in the presence of dodecatungstosilicic acid / P2O5 in solvent free conditions. The products were obtained in high yield on grinding the reaction mixture for 1-3 minutes. The structures of the products were characterized using spect...
Article
ABSTRACT A new Schiff base, C19H18N4O3, (3) was prepare by condensation of 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carbaldehyde (1) and 2- hydroxybenzohydrazide (2) in the presence of conc. H2SO4. Single crystal X-ray crystallographic and spectroscopic techniques including 1H-NMR, IR, EI-MS along with elemental analysis were employed...
Article
Current study was designed to investigate antibacterial and lipoxygenase inhibitory activities of 2-[(2-methoxybenzylidene)amino]phenol derivatives. In enzyme inhibition, the lipoxygenase inhibition activity was also found to be moderate. The compounds also revealed excellent antibacterial activity in the order of S. aureus>B. subtilis>E. coli>S. t...
Article
Full-text available
Nine compounds have been isolated for the first time from Celtis africana, namely trans-N-coumaroyltyramine (1), trans-N-feruloyltyramine (2), trans-N-caffeoyltyramine (3), lauric acid (4), oleic acid (5), palmitic acid (6), lupeol (7), β-sitosterol (8) and oleanolic acid (9), respectively. Their structures have been elucidated by different spectro...
Article
Phytochemical investigation of the ethyl acetate soluble fraction of the methanol soluble extract of the roots of Daphne oleoides resulted in isolation and identification of two new isomeric biisoflavonoids characterized as 8,8"-bi-6-hydroxyorobol (1) and 8,8"-bi-6, 2'-dihydroxygenistein (2). The structures of these compounds were established by an...
Article
Full-text available
A series of 4-aryl methylidene-2-phenyl/methyl-5-(4H)-oxazolone derivatives (2-7) have been synthesized using the reported method by condensation of aldehydes with N-benzoyl / N-acetyl glycine in the presence of zinc oxide as a catalyst and acetic anhydride at room temperature in ethanol. The compounds (2-6) are new derivatives. The structures of c...
Article
The dichloromethane-methanol (1:1) soluble part of Calopogonium mucunoides (Fabaceae) resulted in the isolation of 10 isoflavones (4'-O-methylalpinumisoflavone, 4'-O-methylderrone, alpinumisoflavone, daidzeine, Calopogonium isoflavone A, atalantoflavone, 2',4',5',7-tetramethoxyisoflavone, 7-O-methylcuneantin, cabreuvin and 7-O-methylpseudobaptigeni...
Article
Full-text available
Three biologically active new Schiff bases, 2-[(3-hydroxybenzylidene)amino]phenol 5, 2-[(4-hydroxybenzylidene)amino]phenol 6 and 4-[(2-hydroxyphenylimino)methyl]benzene-1,3-diol 7, were synthesized by the reaction of 2-aminophenol 1 with three different hydroxyl-benzaldehydes 2–4. They were characterized by spectroscopic analysis (IR, 1H NMR, EI-MS...
Article
Ophiamides A (1) and B (2), two new sphingolipids have been isolated from the n-hexane subfraction of the MeOH extract of the whole plant of Heliotropium ophioglossum along with glycerol monopalmitate (3) and β-sitosterol 3-O-β-D: -glucoside (4) reported for the first time from this species. Their structures were elucidated by spectroscopic techniq...
Article
Full-text available
In continuation of our search for new secondary metabolites from African Erythrina species, E. mildbraedii of Cameroon was investigated. As a result of this study, a new flavanone (mildbone, 1) and a new chalcone (mildbenone, 2) have been obtained and characterized by spectroscopic means. Both the compounds exhibited significant antioxidant and mod...
Article
The discovery and development of a new drug is a complex process, full of hidden obstacles. In order to respond to the great variety of therapeutic needs and comply national and international regulatory requirements, multidisciplinary approach must be followed. In vertebrates, serine protease inhibitors have tremendous contribution in phagocytosis,...
Article
Full-text available
The concentration of monosodium glutamate (MSG) was evaluated in ten samples of formulated spices in Pakistan. The samples were analyzed by modified HPLC method after water extraction and derivatization of MSG by dinitrofluorobenzene (DNFB), using reversed phase C18 column, mobile phase was consisted of methanol: water (1:1) followed by UV detectio...
Article
New bergenin derivatives, bergecins A and B (1 and 2, resp.), have been isolated from the AcOEt-soluble fraction of Bergenia stracheyi, along with bergenin (3), and their structures were elucidated on the basis of (1) H- and (13) C-NMR spectra, and by COSY, HMQC, and HMBC experiments. Compound 2 showed potent inhibitory potential against the enzyme...
Article
Full-text available
In oder to discover potentially active antibacterial compounds, three Schiff bases: 2- [(4-methoxybenzylidene)-amino]phenol (5), 2-[(3,4-dimethoxybenzylidene)-amino] phenol (6), 2-[(3,4,5-trimethoxybenzylidene)-amino]phenol (7), were synthesized by the condensation of 2-aminophenol (1) with aldehydes (2-4) in methanol along with H2SO4. The synthesi...
Article
Full-text available
The object of this study is to determine the antioxidant activity of extracts from Glycyrrhiza glabra roots. The parent extract is methanolic extract while its sub fractions were prepared in ethyl acetate, chloroform, and n-butanol. The method based on scavenging activity and reduction capability of 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH). Ur...
Article
The antioxidant potential as well as tyrosinase inhibitory activity of citrus fruit waste were determined. Fruit peels of 4 species of genus citrus viz. Citrus sinensis (Malta), C. reticulate (Orange), C. paradisi (Grape fruit) and C. aurantifolia (Lemon), were analyzed for these bio-reactive properties. Six different fractions of crude extracts of...
Article
During the search for bioactive constituents from different parts of Aegle marmelos (Rutaceae), the ethanol soluble portion of fresh unripe fruits yielded two known amides named aegeline (1) and 2-O-methyl aegeline (2), and five known coumarins named xanthotoxol (3), alloimperatorin (4), marmesin (5), marmin (6), 7'-O-methylmarmin (7). Structures o...
Article
Two new lupene-type triterpenes, sorbicins A and B, have been isolated from the chloroform-soluble fraction of the MeOH extract from the whole plant of Sorbus cashmiriana, and their structures were elucidated by spectroscopic techniques including 2D NMR. Both compounds displayed urease and α-chymotrypsin inhibitory potential.
Article
Full-text available
Two new C-glycosylflavonoids celtisides A (1) and B (2) have been isolated from n-butanol-soluble fraction of Celtis africana, along with five known C-glycosylflavonoids vitexin (3), orientin (4), isoswertiajaponin (5), isoswertisin (6), and 2″-O-rhamnosyl vitexin (7) reported for the first time from this species. Their structures were assigned fro...
Patent
The process for the preparation of weight reducing dietary composition in powder form comprises of sifted soy meal, rice powder, skimmed milk, roasted at 75-100°C for 1-5 hrs and then mixed with agar agar, xanthan Gum, sorbitol, sodium cyclamate, saccharin, Vitamin C, Vitamin A&D, flavor and Sodium Benzoate in a rotary mixer till homogeneity before...
Article
Full-text available
Asphorodin (1), a new diglycoside, has been isolated from the ethyl acetate-soluble fraction of Asphodelus tenuifolius. It showed significant inhibitory activity against the enzyme lipoxygenase in a concentration-dependent manner. The Lineweaver-Burk and Dixon plots indicated that the nature of inhibition was non-competitive.
Article
Full-text available
Galinsosides A (1) and B (2), new flavanone glucosides together with two known flavanones, 7,3',4'-trihydroxyflavanone (3) and 3,5,7,3',4'-pentahydroxyflavanone (4) have been isolated from an ethyl acetate- soluble fraction of Galinsoga parviflora. Their structures were assigned on the basis of spectral studies. Compound 1 showed significant antiox...
Article
Conferin (1), a new isoflavone, has been isolated from the ethyl acetate soluble fraction of Caragana conferta Benth. along with seven known compounds, namely biochanin A (2), p-hydroxybenzoic acid (3), 3,5-dimethoxybenzoic acid (4), ursolic acid (5), erythrodiol (6), pinoresinol (7), and syringresinol (8), reported for the first time from this spe...
Article
Compounds 1-3, new flavonoid glucosides have been isolated from the ethyl acetate soluble fractions of Marrubium anisodon, along with apigenin 4′-0-β-D-glucopyranoside 4, kaempferol 3-0-β-D-glucopyranoside 5 and β-sitosterol 3-0-β-D-glucopyranoside 6, respectively. Their structures were assigned from 1H- and 13C-NMR spectra, DEPT and by COSY, HMQC,...
Article
Full-text available
A series of tetraketones has been synthesized by way of a one pot synthesis and screened for inhibitory activity against the enzyme lipoxygenase. An efficient and high yielding one pot synthesis to tetraketones [2-22] has been developed by way of tetraethyl ammonium bromide (Et4N+Br-) mediated condensation of cyclohexane-1, 3-dione [1] with a varie...
Article
Full-text available
A new lignan rhamnoside, racemiside (1), has been isolated from the ethyl acetate-soluble fraction of Cotoneaster racemiflora, along with scopoletin (2), 7,8-dimethoxy-6-hydroxycoumarin (3), 3,3',4'-tri-O-methylellagic acid (4), and cereotagloperoxide (5), reported for the first time from this species. All of them showed profound antioxidative acti...
Article
Full-text available
Mutiniside (1), new phenolic glucoside, and the flavonoidal glucoside cephacoside (2) have been isolated from the n-BuOH soluble fraction, along with lupeol (3), beta-sitosterol (4), stigmasterol (5), methyl-4-hydroxybenzoate (6), taraxacin (7), ursolic acid (8), and beta-sitosterol-3-O-beta-D-glucopyranoside (9), have been isolated from the EtOAc...
Article
Full-text available
Objective: A series of tetraketones has been synthesized by way of a one pot access and screened for inhibitory activity against the enzyme lipoxygenase. Method: An efficient and high yielding one pot approach to tetraketones [222] has been developed by way of tetraethyl ammonium bromide (Et4N+Br¯) mediated condensation of cyclohexane-1,3-dione [1...
Article
Full-text available
Phytochemical investigation of the chloroform soluble fraction of the methanolic extract of Cotoneaster racemiflora resulted in the isolation of two new aromatic esters named cotonoates A (1) and B (2) along with the known compound methyl 3,4-dihydroxy-5-methoxybenzoate (3). The structures of the new compounds have been assigned on the basis of spe...
Data
Study of various brands of regular and medicated toothpastes of the local markets of Lahore and Karachi for the presence of steroids revealed the presence of synthetic steroids in medicated toothpastes only while all common, popular brands were devoid of steroids with a few exceptions.
Article
A new steroid leucisterol (1) and a new peroxy acid urticic acid (2) along with methoxybenzyl benzoate (3), 4-hydroxy benzoic acid (4), beta-sitosterol (5), and ursolic acid (6), have been isolated from the chloroform soluble fraction of the whole plant of Leucas urticifolia. Their structures were elucidated on the basis of nuclear magnetic resonan...
Article
Full-text available
The main objective of this study was to prepare pancreatin in liquid and powder form and to determine its amylase activity in crude homogenate of animal tissue. Different conditions were optimized for estimation of maximal activity including pH, temperature and substrate concentration. The optimum pH was found to be 6.8. The enzyme was optimally ac...
Article
A mild and efficient route to tetraketones (2-22) has been developed by way of tetraethyl ammonium bromide (Et(4)N(+)Br(- )) mediated condensation of dimedone (5,5-dimethylcyclohexane-1,3-dione, 1) with a variety of aldehydes. All these compounds showed significant lipoxygenase inhibitory activity and moderate to strong antioxidant potential. Compo...
Article
Full-text available
Study of various brands of regular and medicated toothpastes of the local markets of Lahore and Karachi for the presence of steroids revealed the presence of synthetic steroids in medicated toothpastes only while all common, popular brands were devoid of steroids with a few exceptions.
Article
Salsolins A (1) and B (2), the new triterpenes, have been isolated from the chloroform soluble fraction of Salsola baryosma along with 2alpha,3beta,23,24-tetrahydroxyurs-12-en-28-oic acid (3) reported for the first time from this species. Their structures have been assigned from 1H and 13C NMR spectra, DEPT and by 2D COSY, NOESY, HMQC and HMBC expe...
Article
Full-text available
The new triterpenoidal and flavonone glycosides atriplisides A and B have been isolated from the ethyl acetate fraction of the whole plant of Perovskia atriplicifolia. Their structures were elucidated on the basis of spectroscopic data, especially 2D NMR techniques including 1 H-COSY, HMQC, HMBC, and NOESY.
Article
Full-text available
Three tetraketones namely 4-methoxyphenyl-2,2′-methylenebis-(5,5- dimethylcyclohexane-1,3-dione) (1), 2-chlorophenyl-2,2′-methylenebis-(5,5- dimethylcyclohexane-1,3-dione) (2) and 4-N,N-dimethylaminophenyl-2,2′- methylenebis-(5,5-dimethylcyclohexane-1,3-dione) (3) have been screened for their antioxidant potentials using 1,1-diphenyl-2-picrylhydraz...
Article
Full-text available
New flavonoidal glucosides leufolins A (1) and B (2), have been isolated from the ethyl acetate soluble fraction of the whole plants of Leucas urticifolia. Their structures were elucidated on the basis of extensive analysis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Both of these compounds exhibited significant inhibitory potentia...
Article
Full-text available
Different isolated strains of Leuconostoc mesenteroides produce dextran compared with that of L. mesenteroides NRRL B-512 F. Among nine newly isolated strains, strains PCSIR-4 and PCSIR-9 produced dextran of different quality. Using these two newly isolated strains, the development of dextran coincided closely with the disappearance of sucrose. The...