Louis Collins

Louis Collins
McGill University | McGill · Department of Neurology and Neurosurgery

Ph.D.

About

788
Publications
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Publications

Publications (788)
Article
Importance: Preventive trials of anti-amyloid agents might preferably recruit persons showing earliest biologically relevant β-amyloid (Aβ) binding on positron emission tomography (PET). Objective: To investigate the timing at which Aβ-PET binding starts showing associations with other markers of Alzheimer disease. Design, setting, and particip...
Article
Full-text available
Cerebellar symptoms in multiple sclerosis (MS) are well described; however, the exact contribution of cerebellar damage to MS disability has not been fully explored. Longer-term observational periods are necessary to better understand the dynamics of pathological changes within the cerebellum and their clinical consequences. Cerebellar lobe and sin...
Article
Importance: National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD). Objective: To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at near-te...
Preprint
Parkinsons disease (PD) is a complex neurodegenerative disorder affecting regions such as the substantia nigra (SN), red nucleus (RN) and locus coeruleus (LC). Processing MRI data from patients with PD requires anatomical structural references for spatial normalization and structural segmentation. Extending our previous work [1][2], we present mult...
Article
Given that image registration is a fundamental and ubiquitous task in both clinical and research domains of the medical field, errors in registration can have serious consequences. Since such errors can mislead clinicians during image-guided therapies or bias the results of a downstream analysis, methods to estimate registration error are becoming...
Preprint
Background Finding an early biomarker of Alzheimer’s disease (AD) is essential to develop and implement early treatments. Much research has focused on using hippocampal volume to measure neurodegeneration in aging and Alzheimer’s disease (AD). However, a new method to measure hippocampal change, known as hippocampal grading, has shown enhanced pred...
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In this work, a hierarchical search algorithm is proposed to efficiently compute the distance between similar tractography streamlines. This hierarchical framework offers an upper bound and a lower bound for the point-wise distance between two streamlines, which guarantees the validity of a proximity search. The proposed streamline representation e...
Article
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The corpus callosum (CC) is the largest fiber tract in the human brain, allowing interhemispheric communication by connecting homologous areas of the two cerebral hemispheres. In adults, CC size shows a robust allometric relationship with brain size, with larger brains having larger callosa, but smaller brains having larger callosa relative to brai...
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Background: Research suggests that cerebral small vessel disease (CSVD), amyloid, and pTau contribute to age-related cognitive decline. It remains unknown how these factors relate to one another and how they jointly contribute to cognitive decline in normal aging. This project examines the association between these factors and their relationship t...
Article
Full-text available
Background Navigation systems for spinal fusion surgery rely on intraoperative computed tomography (CT) or fluoroscopy imaging. Both expose patient, surgeons and operating room staff to significant amounts of radiation. Alternative methods involving intraoperative ultrasound (iUS) imaging have recently showed promise for image-to-patient registrati...
Article
Linear registration to stereotaxic space is a common first step in many automated image-processing tools for analysis of human brain MRI scans. This step is crucial for the success of the subsequent image-processing steps. Several well-established algorithms are commonly used in the field of neuroimaging for this task, but none have a 100% success...
Preprint
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White matter hyperintensities may be one of the earliest pathological changes in aging and may potentially accelerate cognitive decline. Whether race influences WMH burden has been conflicting. The goal of this study was to examine if race differences exist in WMH burden and whether these differences are influenced by vascular factors [i.e., diabet...
Preprint
Background Increased age and cognitive impairment is associated with an increase in cerebrovascular pathology often seen as increased signal in T2-weighted and FLAIR structural MRIs and known as white matter hyperintensities (WMHs). Whether WMHs differ between healthy older adults with subjective cognitive decline (SCD+) and without subjective cogn...
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Introduction Lateral ventricles are reliable and sensitive indicators of brain atrophy and disease progression in behavioral variant frontotemporal dementia (bvFTD). Here we validate our previously developed automated tool using ventricular features (known as VentRa) for the classification of bvFTD vs a mixed cohort of neurodegenerative, vascular,...
Article
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We examined the relations of restricted and repetitive behaviors (RRB; insistence on sameness, repetitive sensory-motor, self-injurious behavior) to social skills overall and aspects that comprise social skills as measured by the VABS-II (coping skills, play/leisure time, interpersonal relationships) in 24- (n = 63) and 36-month old (n = 35), high-...
Article
Objective: Previous research has demonstrated that the amygdala is enlarged in children with autism spectrum disorder (ASD). However, the precise onset of this enlargement during infancy, how it relates to later diagnostic behaviors, whether the timing of enlargement in infancy is specific to the amygdala, and whether it is specific to ASD (or pre...
Article
Connections among brain regions allow pathological perturbations to spread from a single source region to multiple regions. Patterns of neurodegeneration in multiple diseases, including behavioral variant of frontotemporal dementia (bvFTD), resemble the large-scale functional systems, but how bvFTD-related atrophy patterns relate to structural netw...
Preprint
Full-text available
INTRODUCTION Changes in the hippocampus are associated with both increased age and cognitive decline due to mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Most studies have examined the association between hippocampal changes and episodic memory, with many reporting a relationship between hippocampal measurements and global cognition...
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Full-text available
Introduction Lateral ventricles are reliable and sensitive indicators of brain atrophy and disease progression in behavioral variant frontotemporal dementia (bvFTD). We aimed to investigate whether an automated tool using ventricular features could improve diagnostic accuracy in bvFTD across neurodegenerative diseases. Methods Using 678 subjects -...
Article
Previous literature links maternal pregnancy-specific anxiety (PSA) with later difficulties in child emotional and social cognition as well as memory, functions closely related to the amygdala and the hippocampus. Some evidence also suggests that PSA affects child amygdalar volumes in a sex-dependent way. However, no studies investigating the assoc...
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Background Impulsivity increases the risk for obesity and weight gain. However, the precise role of impulsivity in the aetiology of overeating behavior and obesity is currently unknown. Here we examined the relationships between personality-related measures of impulsivity, Uncontrolled Eating, body mass index (BMI), and longitudinal weight changes....
Article
Long-term cognitive deficits have been observed in some children who experience an acquired demyelinating syndrome (ADS). We examined changes in cognitive functioning over the first two years following incident ADS andtested whether normalized brain and thalamic volume accounted for decline over time. Twenty-five youth (mean age 12.8 years) with AD...
Article
White matter hyperintensities (WMHs) are commonly assumed to represent non-specific cerebrovascular disease comorbid to neurodegenerative processes, rather than playing a synergistic role. We compared the impact of WMHs on grey matter (GM) atrophy and cognition in normal aging (N=571), mild cognitive impairment (MCI, N=551), Alzheimer's dementia (A...
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Full-text available
Background People with subjective cognitive decline (SCD) may be at increased risk for Alzheimer’s disease (AD). However, not all studies have observed this increased risk. This project examined whether four common methods of defining SCD yields different patterns of atrophy and future cognitive decline between cognitively normal older adults with...
Article
Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder associated with atrophy of the frontal and/or anterior temporal lobes, it is highly heterogeneous and represents about 5% of all cases of dementia and it is one of the most common causes of early‐onset dementia (Onyike and Diehl‐Schmid, 2013). FTD syndromes can be divided int...
Article
Patients in the early stages of AD dementia experience decline in their cognitive abilities at different rates. Accurately predicting the progression rate would enable the enrichment of patient populations in clinical trials. Using the early AD‐related pattern of atrophy and cognitive scores from a baseline visit, we trained a model to predict cogn...
Article
Individuals with mild cognitive impairment (MCI) have variable clinical outcomes, with a proportion converting to dementia in a short follow‐up period. Subtyping MCI subjects based on biomarker levels can provide additional insights on why some individuals progress faster, aiding clinical treatment strategy and facilitating cohort enrichment for cl...
Article
In the absence of a pathologic genetic mutation, diagnostic certainty of the behavioral variant frontotemporal dementia (bvFTD) still relies on convergence of clinical criteria and imaging findings. Using deformation‐based morphometry (DBM), we recently showed that ventricular volume can discriminate bvFTD from cognitively normal controls (CN)1. He...
Article
Accurately predicting the progression rate in patients with mild cognitive impairment and mild dementia due to AD enables enrichment of trial populations. Here, we evaluate the potential use of our prognostic model (Abstract #54217) as a screening tool for enrichment in clinical trials in early AD. Data included 312 patients with mild AD from the A...
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Full-text available
People with subjective cognitive decline (SCD) are at increased risk for developing Alzheimer’s disease (AD). SCD may thus be a very early clinical manifestations of AD. However, identifying which individuals with SCD will develop AD is difficult with current biomarker techniques. To predict whether someone with SCD will progress to AD, it is neces...
Article
Connections among brain regions allow pathological perturbations to spread from a single source node to multiple nodes. Patterns of neurodegeneration in multiple diseases, including behavioral variant of frontotemporal dementia (bvFTD), resemble the network architecture (Seeley et al., 2009, Neuron), but how bvFTD‐related atrophy patterns relate to...
Article
Full-text available
Both cortical and subcortical structures are organized into a large number of distinct areas reflecting functional and cytoarchitectonic differences. Mapping these areas is of fundamental importance to neuroscience. A central obstacle to this task is the inaccuracy associated with bringing results from individuals into a common space. The vast indi...
Article
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Background: While both cognitive and magnetic resonance imaging (MRI) data has been used to predict progression in Alzheimer's disease, heterogeneity between patients makes it challenging to predict the rate of cognitive and functional decline for individual subjects. Objective: To investigate prognostic power of MRI-based biomarkers of medial t...
Preprint
Full-text available
Background: Research suggests that cerebral small vessel disease (CSVD), amyloid, and pTau contribute to age-related cognitive decline. It remains unknown how these factors relate to one another, nor how they jointly contribute to cognitive decline in normal aging. This project examines the association between these pathologies and their relationsh...
Chapter
Full-text available
The evolution of consumer-grade hardware components (e.g., trackers, portable ultrasound probes) has opened the door for the development of low cost systems. We evaluated different low-cost tracking alternatives on the accuracy of 3D freehand ultrasound reconstruction in the context of image-guided neurosurgery. Specifically, we compared two low-co...
Chapter
In this work, a new hierarchical approach is proposed to efficiently search for similar tractography streamlines. The proposed streamline representation enables the use of binary search trees to increase the tractography clustering speed without reducing its accuracy. This hierarchical framework offers an upper bound and a lower bound for the point...
Preprint
Full-text available
Connections among brain regions allow pathological perturbations to spread from a single source region to multiple regions. Patterns of neurodegeneration in multiple diseases, including behavioral variant of frontotemporal dementia (bvFTD), resemble the large-scale functional systems, but how bvFTD-related atrophy patterns relate to structural netw...
Article
Full-text available
Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is 'BigBrain'. Here, we review recent methodological advances for the integration of BigBrain with multi-modal neuroimaging and introduce a toolbox, 'BigBrainWarp', that combines these developments. The aim of BigBrainWar...
Article
Full-text available
Standard templates are widely used in human neuroimaging processing pipelines to facilitate group-level analyses and comparisons across subjects/populations. MNI-ICBM152 template is the most commonly used standard template, representing an average of 152 healthy young adult brains. However, in patients with neurodegenerative diseases such as fronto...
Preprint
Full-text available
Linear registration to stereotaxic space is a common first step in many automated image-processing tools for analysis of human brain MRI scans. This step is crucial for the success of the subsequent image-processing steps. Several well-established algorithms are commonly used in the field of neuroimaging for this task, but none have a 100% success...
Article
Full-text available
In vivo biomarker abnormalities provide measures to monitor therapeutic interventions targeting amyloid-β pathology as well as its effects on downstream processes associated with Alzheimer’s disease pathophysiology. Here, we applied an in vivo longitudinal study design combined with imaging and cerebrospinal fluid biomarkers, mirroring those used i...
Preprint
Full-text available
Diffusely abnormal white matter (DAWM), characterised by biochemical changes of myelin in the absence of frank demyelination, has been associated with clinical progression in secondary progressive MS (SPMS). However, little is known about changes of DAWM over time and their relation to focal white matter lesions (FWML). The objectives of this work...
Article
Full-text available
Objective This study used converging methods to examine the neural substrates of cognitive ability in middle-aged and older men with well-controlled HIV infection. Methods Seventy-six HIV+ men on antiretroviral treatment completed an auditory oddball task and an inhibitory control (Simon) task while time-locked high-density EEG was acquired; 66 ha...
Article
Full-text available
The surgical treatment of injuries to the spine often requires the placement of pedicle screws. To prevent damage to nearby blood vessels and nerves, the individual vertebrae and their surrounding tissue must be precisely localized. To aid surgical planning in this context we present a clinically applicable geometric flow based method to segment th...
Article
Full-text available
To move Alzheimer Disease (AD) research forward it is essential to collect data from large cohorts, but also make such data available to the global research community. We describe the creation of an open science dataset from the PREVENT-AD (PResymptomatic EValuation of Experimental or Novel Treatments for AD) cohort, composed of cognitively unimpai...
Article
Full-text available
Beta-amyloid (Aβ) and tau proteins, the pathological hallmarks of Alzheimer's disease (AD), are believed to spread through connected regions of the brain. Combining diffusion imaging and positron emission tomography, we investigated associations between white matter microstructure specifically in bundles connecting regions where Aβ or tau accumulat...
Preprint
Full-text available
A bstract Neuroimaging stands to benefit from emerging ultrahigh-resolution histological atlases of the human brain; the first of which is “BigBrain”. Ongoing research aims to characterise regional differentiation of cytoarchitecture with BigBrain and to optimise registration of BigBrain with standard neuroimaging templates. Together, this work pav...
Preprint
Full-text available
Background People with subjective cognitive decline (SCD) may be at increased risk for Alzheimer’s disease (AD). However, not all studies have observed this increased risk. Inconsistencies may be related to different methods used to define SCD. The current project examined whether four methods of defining SCD (applied to the same sample) results in...
Preprint
Full-text available
Introduction: White matter hyperintensities (WMHs) as seen on T2w and FLAIR scans represent small-vessel disease related changes in the brain. WMHs are associated with cognitive decline in the normal aging population in general and more specifically in patients with neurodegenerative diseases. In this study, we assessed the different spatial patter...
Article
Full-text available
Objective: At the broadest level, self-regulation refers to a range of separate, but inter-related, processes (e.g., working memory, inhibition, emotion regulation) central for the regulation of cognition, emotion and behaviour that contribute to a plethora of health and mental health outcomes. Self-regulation skills develop rapidly in early childh...
Article
Introduction Structural brain imaging is paramount for the diagnosis of behavioural variant of frontotemporal dementia (bvFTD), but it has low sensitivity leading to erroneous or late diagnosis. Methods A total of 515 subjects from two different bvFTD cohorts (training and independent validation cohorts) were used to perform voxel-wise morphometri...
Preprint
Full-text available
INTRODUCTION: Lateral ventricles are reliable and sensitive indicators of brain atrophy and disease progression in behavioral variant frontotemporal dementia (bvFTD). We aimed to investigate whether an automated tool using ventricular features could improve diagnostic accuracy in bvFTD across neurodegenerative diseases. METHODS: Using 678 subjects...
Article
Full-text available
Background: With the growing incidence of patients receiving surgical treatment for spinal metastatic tumours, there is a need for developing cost-efficient and radiation-free alternatives for spinal interventions. In this paper, we evaluate the capabilities and limitations of an image-guided neurosurgery (IGNS) system that uses intraoperative ult...
Article
Full-text available
Neuronavigation using pre-operative imaging data for neurosurgical guidance is a ubiquitous tool for the planning and resection of oncologic brain disease. These systems are rendered unreliable when brain shift invalidates the patient-image registration. Our previous review in 2015, Brain shift in neuronavigation of brain tumours: A review offered...
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Full-text available
With the recent developments in machine learning and modern graphics processing units (GPUs), there is a marked shift in the way intra-operative ultrasound (iUS) images can be processed and presented during surgery. Real-time processing of images to highlight important anatomical structures combined with in-situ display, has the potential to greatl...
Preprint
Full-text available
INTRODUCTION: Heterogeneity in the progression of Alzheimer's disease makes it challenging to predict the rate of cognitive and functional decline for individual patients. Tools for short-term prediction could help enrich clinical trial designs and focus prevention strategies on the most at-risk patients. METHOD: We built a prognostic model using b...
Article
Background Animal brain tumor models can be useful educational tools for the training of neurosurgical residents in risk-free environments. MRI technologies have not been employed utilizing these models to quantitate tumor, normal grey and white matter and total tissue removal during complex neurosurgical procedures. This pilot study was carried ou...
Preprint
Full-text available
Standard anatomical templates are widely used in human neuroimaging processing pipelines to facilitate group level analyses and comparisons across different subjects and populations. The MNI-ICBM152 template is the most commonly used standard template, representing an average of 152 healthy young adult brains. However, in patients with neurodegener...
Article
Full-text available
Autism Spectrum Disorder (ASD) is a phenotypically and etiologically heterogeneous developmental disorder typically diagnosed around 4 years of age. The development of biomarkers to help in earlier, presymptomatic diagnosis could facilitate earlier identification and therefore earlier intervention and may lead to better outcomes, as well as providi...
Preprint
Full-text available
Objective This study used converging methods to define the structural and functional characteristics of the neural substrates underlying variation in cognitive ability in older men with well-controlled HIV infection. Methods Seventy-six HIV+ men treated with combination antiretrovirals completed attention and inhibitory control tasks tapping diffe...
Article
Full-text available
Introduction: Cognitive decline in Alzheimer's disease is associated with amyloid beta (Aβ) accumulation, neurodegeneration, and cerebral small vessel disease, but the temporal relationships among these factors is not well established. Methods: Data included white matter hyperintensity (WMH) load, gray matter (GM) atrophy and Alzheimer's Disease...