Lorenzo Zamboni

Lorenzo Zamboni
Azienda Ospedaliera Universitaria Integrata Verona · Division of Addiction Medicine

PsyD and PhD Student

About

42
Publications
9,347
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163
Citations

Publications

Publications (42)
Article
Full-text available
Cytisine is considered to be the oldest medication for smoking cessation and has been used for this purpose in some Eastern/Central European and Central Asian countries for over 50 years. Several sources points towards cytisine's efficacy and effectiveness; it's well tolerated when taken at the recommended dose, and adverse events reported in trial...
Article
Full-text available
Cognitive behavioral therapy (CBT) is the most successful protocol in gambling disorder (GD) treatment. However, it presents some weaknesses, especially concerning relapse prevention (RP). RP is one of the most important therapeutic steps, aiming at managing cravings and to avoid future relapse increasing perceived self-efficacy. Encouraging result...
Article
Full-text available
IntroductionSince the 1990s there has been evidence of the significant role Flumazenil (FLU) has in benzodiazepines (BZD) detoxes. The Verona Detox approach has been developed for high dose BZD and Z-drug detoxification via continuous subcutaneous infusion of FLU, a selective BZD receptor antagonist acting on the BZD subunit of the GABA-A receptor....
Article
Full-text available
Benzodiazepines (BZDs) represent one of the most widely used groups of pharmaceuticals, but if used for long periods of time they are associated with dependence and an increased risk of harmful effects. High-dose (HD) BZD dependence is a specific substance use disorder associated with a poor quality of life. It is especially important to pinpoint d...
Article
The use of benzodiazepines among athletes is a new and growing phenomenon according to the recent case reports published. Therefore, there is an urgent need to identify if there is rationale for the use of benzodiazepines and its effects on exercise. This review aims to provide an overview of the effects of benzodiazepine in exercise among healthy...
Article
Full-text available
Substance use disorders (SUDs) are characterized by a recurrent and maladaptive use of drugs and/or alcohol. Cognitive behavioral therapies (CBTs) comprise different types of interventions: traditional CBT and the more recent “third wave” behavior therapies, such as acceptance and commitment therapy (ACT), dialectical behavior therapy (DBT), mindfu...
Article
Full-text available
We have read the article by Istvan and colleagues, which recently appeared on your Journal, 1 with great interest. Among doctors, the use of zolpidem has been driven by the still-widespread false belief that, since zolpidem is not chemically a benzodiazepine, it cannot lead to addiction and tolerance. Indeed, it took almost 30 years from when the d...
Article
Full-text available
Young adults exhibit greater sensitivity than adults to nicotine reinforcement, and Attention Deficit Hyperactivity Disorder (ADHD) increases the risk for early-onset smoking. We investigated the correlation between ADHD Self-Report Scale (ASRS) scores and smoking, evaluated the prevalence of ADHD symptomatology (not diagnoses) in smokers and non-s...
Article
Full-text available
An effective approach in the treatment of benzodiazepine (BZD) overdosing and detoxification is flumazenil (FLU). Studies in chronic users who discontinued BZD in a clinical setting suggested that multiple slow bolus infusions of FLU reduce BZD withdrawal symptoms. The aim of this study was to confirm FLU efficacy for reducing BZD withdrawal syndro...
Article
Full-text available
Background: The COVID-19 pandemic and control measures may have had an impact on unpleasant emotions experimented during the lockdown (LD). This may have increased the number of hours spent online and could have impacted the quality of the enacted behavior, in terms of loss of control of Internet use. In this online survey, we were interested in me...
Article
Full-text available
Background The COVID-19 pandemic and control measures may have had an impact on unpleasant emotions experimented during the lockdown (LD). This may have increased the number of hours spent online and could have impacted the quality of the enacted behavior, in terms of loss of control of Internet use. In this online survey, we were interested in mea...
Preprint
Full-text available
The use of zolpidem has been driven by the still-widespread false belief among doctors that, since zolpidem is chemically not a benzodiazepine, it cannot lead to addiction and tolerance. We would like to contribute to better highlight certain characteristics of zolpidem and its potential as a substance of abuse due to the fact that our operating un...
Article
Full-text available
The considerable prominence of internet addiction (IA) in adolescence is at least partly explained by the limited knowledge thus far available on this complex phenomenon. In discussing IA, it is necessary to be aware that this is a construct for which there is still no clear definition in the literature. Nonetheless, its important clinical implicat...
Article
Background: Intravenous misuse and attention-deficit/hyperactivity disorder (ADHD) are common in patients under opioid maintenance treatment (OMT), who often misuse benzodiazepine (BZD). Objectives: To explore the rate of adult ADHD among patients under OMT in Italy and whether screening positive for adult ADHD is associated with OMT and BZD mis...
Article
Full-text available
It is widely recognised that benzodiazepine abuse can potentially induce addiction. Benzodiazepine addiction among athletes is a new and growing phenomenon that we are encountering among our patients. We describe a case of lormetazepam addiction in a female competitive marathon runner. A 30‐year‐old female elite athlete developed lormetazepam addic...
Article
Full-text available
Opioid maintenance treatment (OMT) is the most widespread therapy for both females and males opioid addicts. While many studies have evaluated the OMT impact on men’s sexuality, the data collected about the change in women’s sexual functioning is still limited despite the fact that it is now well-known that opioids - both endogenous and exogenous -...
Article
Full-text available
Opioid maintenance treatment (OMT) is the most widespread therapy for both females and males opioid addicts. While many studies have evaluated the OMT impact on men's sexuality, the data collected about the change in women's sexual functioning is still limited despite the fact that it is now well-known that opioids-both endogenous and exogenous-aff...
Article
Objective: The relationship between cigarette smoking, psychiatric symptoms/psychological distress in subjects maintained with methadone or buprenorphine was studied. Methods: 1049 subjects with a diagnosis of heroin use disorder were enrolled. The Symptom Checklist-90-Revised (SCL-90-R) and the General Health Questionnaire-12 (GHQ-12) were admi...
Article
Full-text available
Addiction is accompanied by attentional biases (AB), wherein drug-related cues grab attention independently of their perceptual salience. AB have emerged in different flavours depending on the experimental approach, and their clinical relevance is still debated. In chronic smokers we sought evidence for dissociable attention abnormalities that may...
Article
Background: The act of intravenous misuse is common in patients under opioid maintenance treatment (OMT), but information on associated factors is still limited. Objectives: To explore factors associated with (a) intravenous OMT misuse, (b) repeated misuse, (c) emergency room (ER) admission, (d) misuse of different OMT types and (e) concurrent benz...
Book
Manuale sulle dipendenze patologiche, il tema della addiction trattato a 360°. La versione ebook consultabile gratuitamente. https://play.google.com/store/books/details/In_Sostanza_Manuale_sulle_dipendenze_patologiche?id=5xJhDwAAQBAJ&hl=en_US
Article
Pubblicato sulla rivista "Tabaccologia". Premio SITAB "G. Invernizzi" 2018 (La ricerca in Tabaccologia): 3° premio per la ricerca: "Fumo, ergo gioco e bevo: pregiudizio o dato di realtà? Relazione tra fumo di sigaretta, gioco d'azzardo e consumo di alcolici nella popolazione adolescenziale". XIV Congresso Nazionale, Firenze - 8-9 novembre 2018.
Article
Pubblicato su "Dal fare al dire", rivista italiana di formazione e confronto sulle patologie di dipendenza
Article
Full-text available
Background Erectile dysfunction (ED) is common among men on opioid replacement therapy (ORT), but most previous studies exploring its prevalence and determinants yielded contrasting findings. Moreover, the impact of ED on patients’ quality of life (QoL) has been seldom explored. Objective To explore the prevalence and determinants of ED in men on...
Data
Dataset of the study. The dataset of the study with demographic and clinical data of the patients. (XLS)
Article
Il presente studio ha avuto l'obbiettivo di valutare l'impatto della Terapia di Mantenimento con Oppioidi (OMT) nelle donne e la sua correlazione con la salute sessuale e la qualità della vita. Sono state reclutate donne volontarie in OMT da almeno tre mesi e sono stati raccolti dati epidemiologici e relativi alla loro anamnesi tossicologica; sono...
Article
Background and objectives: Adult attention-deficit/hyperactivity disorder (ADHD) is frequent in patients with substance use disorders (SUD), but information on its prevalence in high-dose benzodiazepine (BZD) dependence is lacking. We estimated the prevalence of adult ADHD in a group of treatment-seeking high-dose BZD dependent patients according...
Article
Full-text available
Abstract Background. The association linking nicotine addiction with depression is known, described and clinically significant. Tobacco addiction has much in common with the dependence on illegal drugs, but it results significantly a more lethal factor. When compared with the general population, patients with depression smoke two times more, and a...
Article
Aims: Gender and psychiatric comorbidity seem to influence patients' inter-individual response to Opioid Substitution Treatments (OST) in Opioid Use Disorder (OUD) management. The aim of the study was to assess psychopathological dimensions in an Italian sample of OUD individuals entering a methadone/buprenorphine maintenance program; secondary, w...
Article
Attention Deficit Hyperactivity Disorder (ADHD) is a risk for substance use disorders. The aim of this study was to investigate the association between adult ADHD symptoms, opioid use disorder, life dysfunction and co-occurring psychiatric symptoms. 1057 heroin dependent patients on opioid substitution treatment participated in the survey. All pati...
Article
OBJECTIVES: To evaluate prevalence and severity of constipation and quality of life (QoL) in a cohort of opioid-addicted patients treated with opioid substitution treatments (OST). METHODS: A total of 1057 heroin-dependent patients treated with methadone or buprenorphine were enrolled in a multicenter observational study. Constipation was assessed...
Article
Full-text available
Quality of life (QoL) is an important measure to verify the effectiveness of therapy in substance use disorders (SUD). In this cross-sectional, multicenter study QoL has been measured in 1057 heroin dependents attending SerDs (“Servizi per le Dipendenze”, Italian National Health System Services for Addictions) and has been correlated with demograph...
Book
Full-text available
Il libro descrive la fisiopatologia del dolore, i farmaci del dolore, il loro corretto uso, i rischi di dipendenza ed abuso. Ampio spazio viene dedicato al trattamento dell'iperalgesia oppioide.
Article
Full-text available
Riassunto Introduzione. Il tabagismo è notoriamente una patologia tra-scurata a livello medico, nonostante la sua alta prevalenza di morbilità e di mortalità. Ciò è ancor più vero se consideriamo le popolazioni marginali, come i pazienti con disturbo da uso di sostanze. Obiettivi. Valutare la prevalenza di fumo e lo " smoking status " negli eroinom...
Article
Full-text available
Riassunto Introduzione. Il tabagismo è notoriamente una patologia tra- scurata a livello medico, nonostante la sua alta prevalenza di morbilità e di mortalità. Ciò è ancor più vero se consideriamo le popolazioni marginali, come i pazienti con disturbo da uso di sostanze. Obiettivi. Valutare la prevalenza di fumo e lo “smoking status” negli eroinoma...

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Projects

Projects (5)
Project
This research project aims to investigate the drugs abuse (e.g. benzodiazepines), drugs interactions (pharmacokinetics and pharmacogenetics methodology) and possible strategy solutions to manage addiction issue (e.g. exercise).