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Lorenzo Villa Zapata

Lorenzo Villa Zapata
Mercer University Atlanta · Pharmacy Practice

Pharmacist, PhD

About

53
Publications
4,304
Reads
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256
Citations
Introduction
Lorenzo Villa-Zapata, Ph.D., PharmD, is currently a Clinical Assistant Professor at Mercer University, College of Pharmacy. He was a Postdoctoral Fellow at Skaggs School of Pharmacy at the University of Colorado, Denver. Dr. Villa was assistant professor at the Universidad de Concepción in Chile. His research focuses on Patient Clinical Outcomes, Adherence, Predictive modeling, Health Outcomes Assessments and Pharmaceutical Care.
Additional affiliations
August 2008 - November 2015
University of Concepción
Position
  • Professor (Assistant)
August 2008 - November 2015
University of Concepción
Position
  • Professor (Assistant)
July 2002 - July 2008
Universidad Austral de Chile
Position
  • Instructor

Publications

Publications (53)
Article
Introduction: Tizanidine is primarily metabolized via cytochrome P450 (CYP) 1A2 and therefore medications that inhibit the enzyme will affect the clearance of tizanidine, leading to increased plasma concentrations of tizanidine and potentially serious adverse events. Objectives: Our aim was to study the occurrence of adverse events reported in t...
Chapter
Ineffective computerized alerts for potential Drug-Drug Interactions (DDI) is a longstanding informatics issue. Prescribing clinicians often ignore or override such alerts due to lack of context and clinical relevance, among various other reasons. In this study, we reveiwed published data on the rate of DDI alert overrides and medications involved...
Article
Full-text available
Introduction: Hydroxychloroquine can induce QT/QTc interval prolongation for some patients; however, little is known about its interactions with other QT-prolonging drugs. Objective: The purpose of this retrospective electronic health records study was to evaluate changes in the QTc interval in patients taking hydroxychloroquine with or without...
Article
Objective. To review the literature assessing student pharmacist well-being and the impact of well-being associated interventions. Findings. Of the 15 studies included, six assessed student pharmacist well-being while nine evaluated the impact of a well-being intervention. There are various approaches to assessing student pharmacist well-being. The...
Article
Full-text available
Previous economic estimates of infection with Toxoplasma gondii and chronic sequelae following infection lack sufficient data to establish the true burden of disease and its chronic sequelae. This scoping review aims to fill this gap by updating existing literature regarding the development of postinfectious sequelae following T. gondii infection....
Article
Full-text available
BACKGROUND: Tacrolimus is a first-line immunosuppressive therapy to prevent rejection and graft failure in kidney transplant recipients. Once-daily extended-release tacrolimus tablets (LCPT) have been shown to be efficacious, particularly for Hispanic and Black patient subpopulations who are rapid metabolizers, but is more costly than twice-daily i...
Article
Full-text available
Purpose To provide evidence of serum potassium changes in individuals taking angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers (ARBs) concomitantly with spironolactone compared to ACEI/ARB therapy alone. Methods PubMed, Embase, Scopus, and Web of Science were searched for studies including exposure to both spiro...
Article
Objective The pharmacy profession is shifting from transactional dispensing of medication to a more comprehensive, patient-centered model of care. Collaborative practice agreements (CPAs) extend the role of a pharmacist to initiate, monitor, modify, and discontinue drug therapies and provide other clinical services. Although collaborative practice...
Article
Aims Six prospective real-world studies of antihypertensive treatment with valsartan-centric regimens were pooled to: (1) examine the effectiveness of ∼90 days of second- or later-line valsartan treatment in hypertensive patients with known comorbidities; and (2) identify physician- and patient-related determinants associated with systolic (SBP) an...
Article
The National Health and Nutrition Examination Survey (NHANES) evaluates the epidemiology in the U.S. population of certain infectious diseases, including Toxoplasma gondii (T. gondii), a protozoan parasite. This study aims to evaluate the seroprevalence of T. gondii -IgG antibodies using NHANES data to identify risk factors related to T. gondii. Us...
Article
Objectives Valproic acid (VPA) is an anticonvulsant used in several clinical scenarios. VPA has been increasingly associated with intentional or unintentional overdose. In patients presenting with severe VPA overdose, supportive care and airway protection are cornerstones of treatment, while levocarnitine is suggested in patients with hyperammonemi...
Article
What is known and objective A framework to evaluate the impact of clinical pharmacists in intensive care units (ICUs) in Chile has not yet been established. This study evaluates the cost avoidance and cost‐benefit ratios of clinical pharmacist interventions in terms of treatment optimization in an adult ICU in southern Chile. Methods Clinical phar...
Article
Background Warfarin use can trigger the occurrence of bleeding independently or as a result of a drug–drug interaction when used in combination with nonsteroidal anti-inflammatory drugs (NSAIDs). Objectives This article examines the risk of bleeding in individuals exposed to concomitant warfarin and NSAID compared with those taking warfarin alone (...
Article
Objectives To (1) evaluate the use of the PPCP by licensed pharmacists through a simulated patient activity; and (2) describe pharmacists’ awareness and perceptions of the Pharmacists’ Patient Care Process (PPCP) in the state of Arizona. Design Interviews were conducted to elicit pharmacists’ perceptions and awareness of the PPCP. A simulated pati...
Article
Full-text available
IntroductionColchicine is currently approved for the treatment of gout and familial Mediterranean fever, among other conditions. Clarithromycin, a strong inhibitor of CYP3A4 and P-glycoprotein, dramatically increases colchicine’s half-life, augmenting the risk of a life-threatening adverse reaction when used inadvertently with colchicine.Objectives...
Article
Phenytoin is widely used in neurocritical patients. Owing to its high pharmacokinetic variability and narrow therapeutic range, plasma level-guided dosing has become the standard. Bayesian prediction (BP) is considered the most flexible and precise pharmacokinetic strategy among several options. A retrospective study of BP dosage adjustment in 20 p...
Article
Full-text available
Objective: The majority of patients who receive antihypertensive treatment do not achieve adequate blood pressure (BP) outcomes. Adherence to antihypertensive therapy contributes to adequate control of BP and is a substantial reason for therapeutic success. This study aims to evaluate the role of clinical pharmacists in improving patient adherence...
Article
Background: To strengthen the burden estimates for chronic sequelae of foodborne illness, we conducted a scoping review of the current literature for common foodborne pathogens and their associated sequelae. We aim to describe the current literature and gaps in knowledge of chronic sequelae associated with common foodborne illnesses. Methods: A co...
Article
Twenty-five type 2 diabetic volunteer patients (mean age 62 years) were recruited in a quasi-experimental study without a control group to evaluate the effects of Bauhinia forficata Link tea on lipid profiles. Participants drank the tea of 0.4% B. forficata in 200 mL of water twice a day for 3 months. The clinical parameters evaluated were choleste...
Article
Objectives: To assess and compare the prevalence of prescribing of potentially inappropriate medications (PIMs) identified using the Beers and STOPP criteria; and to determine the clinical variables related with the prescription of PIMs in older adults. Methods: An observational study of 250 patients aged 65 years or older was conducted in a lar...
Article
Full-text available
Abstract Purpose Predictive models allow clinicians to identify higher- and lower-risk patients and make targeted treatment decisions. Microalbuminuria (MA) is a condition whose presence is understood to be an early marker for cardiovascular disease. The aims of this study were to develop a patient data-driven predictive model and a risk-score asse...
Article
Full-text available
Background: Non-adherence to prescribed treatment is a principle cause of treatment failure in patients with chronic diseases, such as type 2 diabetes mellitus (T2DM) and hypertension. Improved patient monitoring and education have been shown to improve adherence and clinical outcomes. Objective: This study evaluates the impact of a pharmacother...
Article
Full-text available
Metronidazole is the antibiotic of choice for the management of infections caused by anaerobes. Its administration requires multiple daily doses causing increased medication errors. Due to its high post-antibiotic effect and rapid concentration-dependent bactericidal activity, administration of this antibiotic in an extended dosing interval would a...
Article
Full-text available
Tuberculosis (TB) remains a major global and national problem. In Chile the incidence rate has remained at 13 per 100,000 inhabitants for several years without tendency to the expected decline that would allow their elimination by 2020. As a low prevalence country, TB cases have been concentrated in risk groups, reaching 33% in 2013, and this propo...
Article
Full-text available
Patient adherence is often not monitored because existing methods of evaluating adherence are either burdensome or do not accurately predict treatment outcomes. To examine whether two simple, single-item physician-administered measures of patient adherence to antihypertensive medication are predictive of blood pressure outcomes. Retrospective datab...
Article
Background There are many barriers that prevent persons with mental health disorders from achieving remission, including medication nonadherence. Research on the impact of pharmacist-led patient medication education groups on patient attitudes, knowledge and adherence is limited. Objective To evaluate the reliability and validity of the Medication...
Article
Full-text available
Comparative effectiveness research (CER) is a helpful approach to improve health outcomes by developing and disseminating evidence-based information to patients, clinicians, and other decision makers about the most effective interventions. To (a) identify the factors necessary to increase the use of the Agency for Healthcare Research and Quality's...
Article
Objectives: Hypertension is a common chronic disease and risk factor for many other conditions. Despite effective treatments, few patients achieve recommended blood pressure targets. Among the variables related with poor antihypertensive outcomes, patient adherence appears to be especially influential. Adherence assessment should fit seamlessly int...
Article
Apixaban is a direct inhibitor of factor Xa, and is a potential alternative for the treatment of acute venous thromboembolism. This study sought to evaluate the efficacy and safety of apixaban versus enoxaparin. A systematic search of the literature for randomized controlled trials of apixaban thromboprophylaxis versus enoxaparin was conducted usin...
Article
The authors used pooled data from 6 valsartan-related studies including 3983 adherent and 10,663 nonadherent patients to evaluate blood pressure (BP) outcomes in both groups after 90 days of treatment, applying hierarchical linear and logistic regression to identify determinants of BP outcomes. The principal findings were that: (1) BP outcomes were...
Article
SUMMARY: BACKGROUND: Comparative effectiveness research (CER) is a helpful approach to improve health outcomes by developing and disseminating evidence-based information to patients, clinicians, and other decision makers about the most effective interventions. OBJECTIVES: To (a) identify the factors necessary to increase the use of the Agency for...
Article
Full-text available
The aim of this study was analyze the use of restricted antibiotics by patients hospitalized between 2004 and 2008 in Guillermo Grant Benavente Hospital in Concepcion. Also we attempted to identify possible correlations between antibiotic consumption and patterns of bacterial susceptibility. We performed a retrospective observational study that qua...
Article
The aim of this study was analyze the use of restricted antibiotics by patients hospitalized between 2004 and 2008 in Guillermo Grant Benavente Hospital in Concepcion. Also we attempted to identify possible correlations between antibiotic consumption and patterns of bacterial susceptibility. We performed a retrospective observational study that qua...
Article
OBJECTIVES: To assess economic and clinical characteristics of severe comorbidities during inpatient hospitalizations in persons with HIV/AIDS. METHODS: The Agency for Healthcare Research and Quality (AHRQ) Healthcare Cost and Utilization Project (H-CUP) Nationwide Inpatient Sample (NIS) was used in this retrospective database study spanning 2005-2...
Article
Full-text available
The scarcity of resources within both industrialized and developing nations has catalyzed the adoption of more formalized approaches to support decisionmaking, particularly within healthcare. In many instances, however, the unique aspects present within developing countries may not permit the direct translation of pharmacoeconomic guidelines or rec...
Article
OBJECTIVES: In this study, we seek to measure the association between physicianrated adherence to antihypertensive treatment and blood pressure outcomes. Prior to the study, we hypothesized that systolic and diastolic blood pressure outcomes were also related with patient and physician variables. Therefore, we also seek to determine the impact of t...
Article
Full-text available
A pharmaceutical care program for dyslipidemic patients was designed, implemented, and assessed. The study was conducted during 32 weeks, at three Primary Health Care Centers. One hundred and forty two patients were selected. These patients were randomly assigned to intervention or control groups. Intervention group patients received care twice a m...
Article
Full-text available
Self-medication refers to using drugs which have not been prescribed, recommended or controlled by a licensed health care specialist. Marketing, in Chile only admitted for over-the-counter medications, influences the practice of self-medication and extends it to prescription drugs. Thus, a complex self-medication process is started, due to reuse of...
Article
The different therapeutic schedules used for the prescription of digoxin have little theoretical support. To measure digoxin plasma levels in patients using four different prescription schedules. Four groups of patients were studied. Group I corresponded to 56 patients taking digoxin 0.25 mg/day, from Monday to Friday. Group II corresponded to 30 p...
Article
Background. The different therapeutic schedules used for the prescription of digoxin have little theoretical support. Aim. To measure digoxin plasma levels in patients using four different prescription schedules. Patients and methods: Four groups of patients were studied. Group I corresponded to 56 patients taking digoxin 0.25 mg/day, from Monday t...

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