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Lorenza Dall'Aglio

Lorenza Dall'Aglio
Massachusetts General Hospital; Harvard Medical School · Center for Genomic Medicine; Center for Precision Psychiatry

Depression & anxiety | Youth | modifiable factors for prevention | biological pathways to disorder etiology

About

14
Publications
2,262
Reads
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154
Citations
Introduction
PhD fellow conducting empirical research on the neurobiology of anxiety and depression in childhood and adolescence. Open science advocate.
Additional affiliations
January 2023 - January 2023
Harvard University
Position
  • Visiting researcher
Description
  • Neurobiology of anxiety and depression in children and adolescents
September 2018 - September 2019
King's College London
Position
  • Student
Description
  • Genetically-driven gene expression in Major Depression
November 2017 - September 2019
Erasmus MC
Position
  • Research trainee
Description
  • Maternal caregiving and offspring DNA methylation
Education
October 2019 - October 2023
Erasmus MC
Field of study
  • Neuroimaging
September 2018 - September 2019
King's College London
Field of study
  • Behavioural Genetics
August 2015 - August 2018
Erasmus University Rotterdam
Field of study
  • Psychology

Publications

Publications (14)
Article
Full-text available
Importance Physical activity may promote healthy brain development in children, but previous research was predominantly cross-sectional and included small samples, providing limited knowledge. Objective To investigate the longitudinal associations of physical activity with brain morphology changes. Design, Setting, and Participants A 4-year longi...
Article
Objective: Associations between psychiatric problems and white matter (WM) microstructure have been reported in youth. Yet, a deeper understanding of this relation has been hampered by a dearth of well-powered longitudinal studies and a lack of explicit examination of the bidirectional associations between brain and behavior. We investigated the t...
Preprint
Multivariate machine learning techniques are a promising set of tools for identifying complex brain-behavior associations. However, failure to replicate results from these methods across samples has hampered their clinical relevance. This study aimed to delineate dimensions of brain functional connectivity that are associated with child psychiatric...
Article
Full-text available
Background: Functional connectivity has been associated with psychiatric problems, both in children and adults, but inconsistencies are present across studies. Prior research has mostly focused on small clinical samples with cross-sectional designs. Methods: We adopted a longitudinal design with repeated assessments to investigate associations b...
Preprint
Full-text available
Background Functional connectivity has been associated with psychiatric problems, both in children and adults, but inconsistencies are present across studies. Prior research has mostly focused on small clinical samples with cross-sectional designs. Methods We adopted a longitudinal design with repeated assessments to investigate associations betwe...
Article
Full-text available
Background: Associations between attention-deficit/hyperactivity disorder (ADHD) and brain morphology have been reported, although with several inconsistencies. These may partly stem from confounding bias, which could distort associations and limit generalizability. We examined how associations between brain morphology and ADHD symptoms change with...
Preprint
Full-text available
Objective Associations between psychiatric problems and white matter (WM) microstructure have been reported in childhood and adolescence. Yet, a deeper understanding of this relation has been hampered by a dearth of well-powered longitudinal studies and a lack of explicit examination of the bidirectional associations between brain and behavior. We...
Preprint
Full-text available
Background: Associations between attention-deficit/hyperactivity disorder (ADHD) and brain morphology have been reported, although with several inconsistencies. These may partly stem from confounding bias, which could distort associations and limit generalizability. We examined how associations between brain morphology and ADHD symptoms change with...
Article
Full-text available
Increasingly, policies are being introduced to reward and recognise open research practices, while the adoption of such practices into research routines is being facilitated by many grassroots initiatives. However, despite this widespread endorsement and support, as well as various efforts led by early career researchers, open research is yet to be...
Article
Full-text available
Background. Experimental work in animals has shown that DNA methylation (DNAm), an epigenetic mechanism regulating gene expression, is influenced by typical variation in maternal care. While emerging research in humans supports a similar association, studies to date have been limited to candidate gene and cross-sectional approaches, with a focus on...
Preprint
Full-text available
Increasingly, policies are being introduced to reward and recognise open research practices, while the adoption of such practices into research routines is being facilitated by many grassroots initiatives. However, despite this widespread endorsement and support, open research is yet to be widely adopted, with early career researchers being the not...
Article
Full-text available
Abstract Background Major Depression (MD) is determined by a multitude of factors including genetic risk variants that regulate gene expression. Here, we examined the genetic component of gene expression in MD by performing a Transcriptome-Wide Association Study (TWAS), inferring gene expression-trait relationships from genetic, transcriptomic, and...
Preprint
Full-text available
Background Major Depression (MD) is determined by a multitude of factors including genetic risk variants which regulate gene expression (GE). Here, we examined the genetic component of GE in MD by performing a Transcriptome-Wide Association Study (TWAS), inferring GE-trait relationships from genetic, transcriptomic and phenotypic information. Meth...
Article
Full-text available
Epigenetic processes have been suggested as key mechanisms in the etiology of neurodevelopmental disorders. This systematic review summarizes the current evidence for an association between epigenetics and Autism Spectrum Disorder (ASD) and Attention/Deficit-Hyperactivity Disorder (ADHD). Six databases were searched until the 24 th of October 2017....

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