Lorena Roldán-Martín

Lorena Roldán-Martín
Autonomous University of Barcelona | UAB · Department of Chemistry

PhD Student in Bioinformatics

About

7
Publications
446
Reads
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35
Citations
Introduction
Currently working at the Department of Chemistry, Autonomous University of Barcelona. Studying a PhD in Bioinformatics, centered in Metallopeptides to gain insight into Alzheimer's Disease.

Publications

Publications (7)
Article
Full-text available
RAS oncoproteins are molecular switches associated with critical signaling pathways that regulate cell proliferation and differentiation. Mutations in the RAS family, mainly in the KRAS isoform, are responsible for some of the deadliest cancers, which has made this protein a major target in biomedical research. Here we demonstrate that a designed b...
Article
Metal ions have been found to play an important role in the formation of extracellular β-amyloid plaques, a major hallmark of Alzheimer's disease. In the present study, the conformational landscape of Aβ42 with Al(iii) and Cu(ii) has been explored using Gaussian accelerated molecular dynamics. Both metals reduce the flexibility of the peptide and e...
Article
With a large amount of research dedicated to decoding how metallic species bind to proteins, in silico methods are interesting allies for experimental procedures. To date, computational predictors mostly work by identifying the best possible sequence or structural match of the target protein with metal-binding templates. These approaches are fundam...
Article
Although largely overlooked in peptide engineering, coordination chemistry offers a new set of interactions that opens unexplored design opportunities for developing complex molecular structures. In this context, we report new artificial peptide ligands that fold into chiral helicates in the presence of labile metal ions such as Fe(II) and Co(II)....
Article
Artificial bipyridine‐containing peptide ligands encode in their sequence the stereoselective folding into chiral three‐stranded FeII or CoII peptide helicates and as kinetically inert dinuclear CoIII complexes by in‐situ oxidation. These peptide helicates selectively label DNA replication foci in functional cells. Abstract Although largely overlo...
Preprint
a> Peptide engineering has been extremely successful in creating new structures with defined properties and functions. Although generally overlooked in this context, coordination chemistry offers an additional set of interactions that opens unexplored design opportunities for developing complex molecular structures. With this in mind, we report the...
Preprint
Full-text available
div> With a large amount of research dedicated to decoding how metallic species bind to protein, in silico methods are interesting allies for experimental procedures. To date, computational predictors mostly work by identifying the best possible sequence or structural match of the target protein with metal binding templates. These approaches are f...

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