Lorena Petrusca

Lorena Petrusca
Creatis Medical Imaging Research Center · Universite de Lyon

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61
Publications
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759
Citations

Publications

Publications (61)
Article
Full-text available
In the last decade, a large number of clinical trials have been deployed using Cardiac Magnetic Resonance (CMR) to evaluate cardioprotective strategies aiming at reducing the irreversible myocardial damage at the time of reperfusion. In these studies, segmentation and quantification of myocardial infarct lesion are often performed with a commercial...
Conference Paper
Full-text available
3D fast/ultrasound imaging has emerged in the last years in research but still suffers from its poor image quality. Indeed, using plane/diverge waves does not permit to insonify the medium with sufficient energy at each point to get a good signal-to-noise ratio, contrast-to-noise-ratio or even resolution. On the other hand, coded excitation is curr...
Conference Paper
Abstract—Sparse arrays represent an alternative to fullgridded arrays in 2-D probes realization. Sparse arrays have been used in B-mode imaging tests, but not in spectral Doppler measurements yet. In this paper, we have investigated, by mean of simulations and experiments, how the use of a sparse array instead of a full-gridded 2-D array impacts on...
Article
Two-dimensional (2-D) sparse arrays, in which a few hundreds of elements are distributed on the probe surface according to an optimization procedure, represent an alternative to full 2-D arrays, including thousands of elements usually organized in a grid. Sparse arrays have already been used in B-mode imaging tests, but their application to Doppler...
Article
Full-text available
High frame rate imaging is particularly important in echocardiography for a better assessment of the cardiac function. Several studies showed that Diverging Wave Imaging (DWI) and Multi Line Transmit (MLT) are promising methods for achieving a high temporal resolution. The aim of this study was to compare MLT and compounded motion compensated (MoCo...
Article
Full-text available
Three dimensional ultrasound (3-D US) imaging methods based on 2-D array probes are increasingly investigated. However, the experimental test of new 3-D US approaches is contrasted by the need of controlling very large numbers of probe elements. Although this problem may be overcome by the use of 2-D sparse arrays, just a few experimental results h...
Article
Full-text available
A novel ultrasound (US) high-channels platform is a pre-requisite to open new frontiers in diagnostic and/or therapy by experimental implementation of innovative advanced US techniques. To date, a few systems with more than 1000 transducers permit full and simultaneous control in both transmission and receiving of all single elements of arrays. A p...
Article
Full-text available
Cardiovascular diseases and myocardium infarction are main causes of death worldwide. After acute myocardium infarction, remodeling occurs within weeks resulting from a loss of cardiomyocytes in the damaged myocardium, and subsequent changes with regional tissue organization. Imaging methods able to render the local tissue directivity would be usef...
Article
Purpose: Treatments using high-intensity focused ultrasound (HIFU) in the abdominal region remain challenging as a result of respiratory organ motion. A novel method is described here to achieve 3D motion-compensated ultrasound (US) MR-guided HIFU therapy using simultaneous ultrasound and MRI. Methods: A truly hybrid US-MR-guided HIFU method was...
Conference Paper
Full-text available
In this paper a global estimation method based on transverse oscillation to simultaneously extract wall and flow velocities at high-framerate is presented. Several carotid phantoms with various parameters were made to validate the method. All acquisitions were performed at high-framerate (7 500 images per second) using horizontal plane wave with a...
Conference Paper
Full-text available
Early detection of cardiovascular diseases can be done by assessing the dynamic properties of arteries. In this study, two phenomena related to the carotid wall motion are presented. The 2D motion estimation method employs (i) ultrafast imaging which became a world-wide use modality, (ii) transverse oscillations technics which allow improving the m...
Article
Abstract Objective: The aim of this paper is to quantitatively investigate the thermal effects generated by the pre-focal interactions of a HIFU beam with a rib cage, in the context of minimally invasive transcostal therapy of liver malignancies. Materials and methods: HIFU sonications were produced by a phased-array MR-compatible transducer on Tur...
Article
Magnetic resonance-guided high-intensity focused ultrasound is considered to be a promising treatment for localized cancer in abdominal organs such as liver, pancreas, or kidney. Abdominal motion, anatomical arrangement, and required sustained sonication are the main challenges. MR acquisition consisted of thermometry performed with segmented gradi...
Article
Dear editor,We would like to thank Dr. Denys for his insightful comments and to the Editorial Board of this Journal for offering us the opportunity to communicate a reply letter. We aim here to evaluate, comprehensively and concisely, what we believe to be essential issues concerning the use of HFJV as a motion suppression technique for abdominal a...
Article
With the availability of new and more accurate tumour treatment modalities such as high-intensity focused ultrasound or proton therapy, accurate target location prediction has become a key issue. Various approaches for diverse application scenarios have been proposed over the last decade. Whereas external surrogate markers such as a breathing belt...
Article
Full-text available
Magnetic resonance-guided high intensity focused ultrasound (MRgHIFU) is a noninvasive method for thermal ablation, which exploits the capabilities of magnetic resonance imaging (MRI) for excellent visualization of the target and for near real-time thermometry. Oncological quality of ablation may be obtained by volumetric sonication under automatic...
Article
Full-text available
Objective. To demonstrate the technical feasibility and the potential interest of using a digital optical camera inside the MR magnet bore for monitoring the breathing cycle and subsequently gating the PRFS MR thermometry, MR-ARFI measurement, and MRgHIFU sonication in the upper abdomen. Materials and Methods. A digital camera was reengineered to...
Article
Full-text available
Magnetic Resonance-guided High Intensity Focused Ultrasound (MRgHIFU) is a hybrid technology that aims to offer non-invasive thermal ablation of targeted tumors or other pathological tissues. Acoustic aberrations and non-linear wave propagating effects may shift the focal point significantly away from the prescribed (or, theoretical) position. It i...
Article
Full-text available
Extracorporeal high-intensity focused ultrasound (HIFU) is a minimally invasive therapy considered with increased interest for the ablation of small tumors in deeply located organs while sparing surrounding critical tissues. A multitude of preclinical and clinical studies have showed the feasibility of the method; however, concurrently they showed...
Article
Magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU, or MRgFUS) is a hybrid technology that was developed to provide efficient and tolerable thermal ablation of targeted tumors or other pathologic tissues, while preserving the normal surrounding structures. Fast 3-D ablation strategies are feasible with the newly available phased-a...
Article
Objectives: The combination of ultrasound (US) and magnetic resonance imaging (MRI) may provide a complementary description of the investigated anatomy, together with improved guidance and assessment of image-guided therapies. The aim of the present study was to integrate a clinical setup for simultaneous US and magnetic resonance (MR) acquisition...
Article
Objectives: The treatment of liver cancer is a major public health issue because the liver is a frequent site for both primary and secondary tumors. Rib heating represents a major obstacle for the application of extracorporeal focused ultrasound to liver ablation. Magnetic resonance (MR)-guided external shielding of acoustic obstacles (eg, the rib...
Article
Full-text available
MR acoustic radiation force imaging (ARFI) is an elegant adjunct to MR-guided high intensity focused ultrasound for treatment planning and optimization, permitting in situ assessment of the focusing and targeting quality. The thermal effect of high intensity focused ultrasound pulses associated with ARFI measurements is recommended to be monitored...
Article
High intensity focused ultrasound (HIFU) under MRI guidance may provide minimally invasive treatment for localized prostate cancer. In this study, ex vivo and in vivo experiments were performed using a prostate-dedicated endorectal phased array (16 circular elements arranged on a truncated spherical cap of radius 60 mm) and a translation-rotation m...
Article
Full-text available
Magnetic resonance imaging (MRI) and ultrasonography have been used simultaneously in this ex vivo study for the image-guidance of high intensity focused ultrasound (HIFU) treatment in moving tissue. A ventilator-driven balloon produced periodic and non-rigid (i.e. breathing-like) motion patterns in phantoms. MR-compatible ultrasound (US) imaging e...
Conference Paper
We propose an unconventional approach for transferring of information between multi-modal images. It exploits the temporal commonality of multi-modal images acquired from the same organ during free-breathing. Strikingly there is no need for capturing the same region by the modalities. The method is based on extracting a low-dimensional description...
Article
Full-text available
Proton resonance frequency shift (PRFS) MR thermometry (MRT) is the generally preferred method for monitoring thermal ablation, typically implemented with gradient-echo (GRE) sequences. Standard PRFS MRT is based on the subtraction of a temporal reference phase map and is, therefore, intrinsically sensitive to tissue motion (including deformation)...
Article
Full-text available
A novel architecture for a phased-array high intensity focused ultrasound (HIFU) device was investigated, aiming to increase the capabilities of electronic steering without reducing the size of the elementary emitters. The principal medical application expected to benefit from these developments is the time-effective sonication of large tumours in...
Chapter
Magnetic resonance (MR) imaging and ultrasound (US) imaging are complementary and synergetic noninvasive imaging modalities. US imaging is practically free of geometric distortion and provides high temporal resolution and direct visualization of acoustic obstacles. MR imaging offers excellent tissue contrast and a confirmed method for near-real-tim...
Article
Full-text available
We propose an unconventional approach for transferring of information between multi-modal images. It exploits the temporal commonality of multi-modal images acquired from the same organ during free-breathing. Strikingly there is no need for capturing the same region by the modalities. The method is based on extracting a low-dimensional description...
Article
The study investigates a new sonication strategy with high-intensity focused ultrasound (HIFU), aiming for improvement of the original Ablatherm procedure in the prostate cancer treatment. The currently implemented and clinically used method (defined as reference) uses a single-element transducer, operated with 60% duty cycle. To implement the nove...
Article
Endocavitary high intensity contact ultrasound (HICU) may offer interesting therapeutic potential for fighting localized cancer in esophageal or rectal wall. On-line MR guidance of the thermotherapy permits both excellent targeting of the pathological volume and accurate preoperatory monitoring of the temperature elevation. In this article, the aut...
Article
Real-time image-guided extracorporeal high intensity focused ultrasound (HIFU) has been suggested for minimally invasive treatment of valvular dysfunction in the saphenous vein. Local application of heat on the perimeter of the valve zone was previously reported to induce a partial shrinkage of the collagen, which may correct valvular function. In...
Article
A sector-switching method that increases the HIFU sequence duty-cycle and reduces the equivalent treatment time was tested in vitro. The MR-compatible HIFU device used consisted of 2 symmetric sectors arranged on a truncated spherical cap (focus = 45 mm, long diameter = 57.5 mm, short diameter = 35 mm). A MR-compatible, 2D positioning system provid...
Article
A novel High Intensity Focused Ultrasound (HIFU) probe has been designed for minimally‐invasive treatment of valvular dysfunction in the saphenous vein, which is known to be the cause of superficial venous insufficiency (SVI) and varicose veins. Treating SVI with HIFU is possible, since venous tissue undergoes localized partial shrinkage when subje...
Article
A new high intensity focused ultrasound (HIFU) probe has been designed and tested by using MRI. The probe is intended to be used by physicians to correct valvular dysfunction in the saphenous vein, which is known to be the cause of superficial venous insufficiency (SVI) and varicose veins. Treating SVI with HIFU is possible, since venous tissue und...
Article
Full-text available
KEYWORDS: total amino acids, yoghurt, food, ID-GC/MS. Stable isotopes provide an useful tools for a variety of studies, offering the ideal internal standards in quantitative information. Isotopic dilution gas chromatography-mass spectrometry (ID-GC/MS) is the techniques used for quantitative analysis of compounds labelled with stable isotopes. The...

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Projects

Projects (5)
Project
This project is centred on 3D+t ultrasound imaging and all possible development offer by this advanced imaging platform: sparse probe design, flow quantification, advanced volumetric beamforming, motion compensation and new applications.