Lorena Deuker

The hippocampal-entorhinal region supports memory for episodic details, such as temporal relations of sequential events, and mnemonic constructions combining experiences for inferential reasoning. However, it is unclear whether hippocampal event memories reflect temporal relations derived from mnemonic constructions, event order, or elapsing time,...

Retrieval practice improves retention of information in long-term memory more than restudy, but the underlying neural mechanisms of this “Retrieval Practice Effect” (RPE) remain little understood. Therefore, we investigated the behavioral and neural differences between previously retrieved versus re-studied items at final retrieval. Thirty younger...

The hippocampal-entorhinal region supports memory for episodic details, such as temporal relations of sequential events, and mnemonic constructions combining experiences for inferential reasoning. However, it is unclear whether hippocampal event representations reflect temporal relations derived from mnemonic constructions, event order, or elapsing...

Alzheimer’s disease (AD) manifests with progressive memory loss and spatial disorientation. Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of young adults at genetic risk for AD ( APOE ε4-carriers). Because the EC harbors grid cells, a likely neural substrate of path integration (PI), we examined PI performance i...

Alzheimer's disease (AD) manifests with progressive memory loss and spatial disorientation. Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of young adults at genetic risk for AD (APOE ϵ4-carriers). Because the EC harbors grid cells, a likely neural substrate of path integration (PI), we examined PI performance in...

Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through a virtual city (Deuker et al., 2016), but the content of entorhinal mnemonic representations rem...

The concept of stimulus-specific memory traces, or engrams, suggests that the fate of individual memories can be tracked via empirically observable brain states. Recent advances in neuroscience have made it possible to discern these brain states in various ways. In animals, transgenics and optogenetics have allowed identifying distinct cell populat...

Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events encountered along a route through a virtual city (Deuker et al., 2016), but the content of entorhinal mnemonic representations rem...

Memory consolidation serves to stabilize initially fragile memory traces. Rodent studies suggest that consolidation relies on replay of previously acquired stimulus-specific activity patterns. This replay is coupled to hippocampal sharp wave-ripple (SWR) events and sleep spindles. More recently, the application of multivariate analysis methods has...

The hippocampus has long been implicated in both episodic and spatial memory, however these mnemonic functions have been traditionally investigated in separate research strands. Theoretical accounts and rodent data suggest a common mechanism for spatial and episodic memory in the hippocampus by providing an abstract and flexible representation of t...

Average absolute angular errors.DOI: http://dx.doi.org/10.7554/eLife.17089.004

Searchlight results for absolute directional coding analysis.DOI: http://dx.doi.org/10.7554/eLife.17089.009

Pattern similarity difference between 0° modulo 60° and 30° modulo 60° condition in left and right posterior medial entorhinal cortex.DOI: http://dx.doi.org/10.7554/eLife.17089.013

ELife digest Recordings of brain activity in moving rats have found neurons that fire when the rat is at specific locations. These neurons are known as grid cells because their activity produces a grid-like pattern. A separate group of neurons, called head direction cells, represents the rat’s facing direction. Functional magnetic resonance imaging...

During systems-level consolidation, mnemonic representations initially reliant on the hippocampus are thought to migrate to neocortical sites for more permanent storage, with an eminent role of sleep for facilitating this information transfer. Mechanistically, consolidation processes have been hypothesized to rely on systematic interactions between...

In an ever-changing environment, selecting appropriate responses in conflicting situations is essential for biological survival and social success and requires cognitive control, which is mediated by dorsomedial prefrontal cortex (DMPFC) and dorsolateral prefrontal cortex (DLPFC). How these brain regions communicate during conflict processing (dete...

Recent findings suggest that repetition effects interact with episodic memory processes that are putatively supported by the hippocampus. Thus, the formation or refinement of episodic memories may be related to a modulating signal from the hippocampus to the neocortex which leads to sparser or more extended stimulus representations (repetition supp...

Human functional magnetic resonance imaging (fMRI) studies have long investigated the hippocampus without differentiating between its subfields, even though theoretical models and rodent studies suggest that subfields support different and potentially even opposite functions. The CA3 region of the hippocampus has been ascribed a pivotal role both i...

Memory consolidation transforms initially labile memory traces into more stable representations. One putative mechanism for consolidation is the reactivation of memory traces after their initial encoding during subsequent sleep or waking state. However, it is still unknown whether consolidation of individual memory contents relies on reactivation o...

Conformity is an important aspect of social behavior. Two main motives have been identified: people may adapt their behavior to “play nice” despite knowing better (normative conformity) or they may accept the others' opinion as a valid source of information (informative conformity). Neuroimaging studies can help to distinguish between these two pos...

The story of our lifetime - our narrative self - is constructed from our autobiographical memories. A central claim of social psychology is that this narrative self is inherently social: When we construct our lives, we do so in a real or imagined interaction. This predicts that self-referential processes which are involved in recall of autobiograph...

List of topics. (DOCX)

Overview of all significantly activated regions when the rating of emotions is included as a regressor. Activations were thresholded at a voxel-wise threshold of pFDR<0.05 and a cluster threshold of at least 5 contiguous voxels. (DOCX)

Movement of participants during scanning. This figure shows movement parameters of all 17 participants which were finally included in the analysis of fMRI data. Each subpanel depicts the movement of one participant in the x, y, and z direction. Only subjects who moved less than the extent of one voxel (3 mm) met the inclusion criteria. (TIF)

Neural activations related to autobiographical memory and social interactions, when emotion ratings are included as additional regressors. A: Autobiographical vs. non-autobiographical memory recall (thresholded at pFDR<0.05). B: Social vs. non-social (for graphical depiction, we chose a threshold of pFWE<0.05). The results are very similar to those...

Graph theory provides many metrics of complex network organization that can be applied to analysis of brain networks derived from neuroimaging data. Here we investigated the test-retest reliability of graph metrics of functional networks derived from magnetoencephalography (MEG) data recorded in two sessions from 16 healthy volunteers who were stud...