Lone Hummelshoj

Lone Hummelshoj
World Endometriosis Research Foundation (WERF)

About

66
Publications
25,691
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6,724
Citations
Citations since 2017
14 Research Items
4259 Citations
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20172018201920202021202220230200400600800
20172018201920202021202220230200400600800

Publications

Publications (66)
Article
Introduction: Due to diagnostic challenges, normalization of symptoms and an overall lack of awareness among both patients and physicians, endometriosis is an underdiagnosed disease. This can result in delayed treatment and potentially worsening of the disease. Despite initiatives, such as patients' support organizations and specialized endometrio...
Article
Full-text available
Endometriosis affects 10% of women worldwide and is one of the most common causes of chronic pelvic pain and infertility. However, causal mechanisms of this disease remain unknown due to its heterogeneous presentation. In order to successfully study its phenotypic variation, large sample sizes are needed. Pooling of data across sites is not always...
Article
Postoperative pain management is still insufficient, leading to major deficits, including patient suffering, impaired surgical recovery, long-term opioid intake, and post-surgical chronic pain. Yet, identifying the best treatment options refers to a heterogeneous outcome assessment in clinical trials, not reflecting relevant pain-related aspects af...
Article
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Endometriosis (ENDO) and interstitial cystitis/bladder pain syndrome (IC/BPS) are chronic pain conditions for which better treatments are urgently needed. Development of new therapies with proven clinical benefit has been slow. We have conducted a review of existing preclinical in vivo models for ENDO and IC/BPS in rodents, discussed to what extent...
Article
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Background Endometriosis (where endometrial-like tissue is found outside the uterus) affects ~ 176 million women worldwide and can lead to debilitating pelvic pain. Three subtypes of endometriosis exist, with ~ 80% of women having superficial peritoneal endometriosis (SPE). Endometriosis is diagnosed by laparoscopy and, if SPE is found, gynaecologi...
Article
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COVID-19 has led to new obstacles in the care for women with endometriosis. With many centers around the globe temporarily ceasing outpatient appointments, diagnostic imaging for non-acute pelvic pain, surgery for endometriosis, and fertility treatments, endometriosis sufferers may feel particularly vulnerable and that resultant stress and anxiety...
Preprint
Full-text available
The COVID-19 pandemic poses several important questions for healthcare providers on how best to deliver endometriosis care with these restrictions. Herein, we present clinical guidance on the management of endometriosis during the COVID-19 pandemic. This Commentary is endorsed by the World Endometriosis Society (WES) and the International Federat...
Article
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STUDY QUESTION How should surgery for endometriosis be performed? SUMMARY ANSWER This document provides recommendations covering technical aspects of different methods of surgery for deep endometriosis in women of reproductive age. WHAT IS KNOWN ALREADY Endometriosis is highly prevalent and often associated with severe symptoms. Yet compared to e...
Article
Full-text available
Endometriosis is a potentially life altering, oestrogen‐dependent, condition, which is associated with chronic pelvic pain. It affects an estimated 176 million women worldwide, making it as common as diabetes mellitus (DM).
Article
Background Clinical management of endometriomas, prior to starting treatment with assisted reproductive technologies (ART), has since long been a matter of debate. Whereas cystectomy has been advocated in the past, recently more evidence has emerged on the potential negative effect of surgery on ovarian reserve. Parallel to this, prolonged downregu...
Article
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Study question What does this document on the surgical treatment of endometriosis jointly prepared by the European Society for Gynaecological Endoscopy (ESGE), ESHRE, and the World Endometriosis Society (WES) provide? Summary answer This document provides recommendations covering technical aspects of different methods of surgery for endometriomas...
Article
Full-text available
STUDY QUESTION What does this document on the surgical treatment of endometriosis jointly prepared by the European Society for Gynaecological Endoscopy (ESGE), ESHRE, and the World Endometriosis Society (WES) provide? SUMMARY ANSWER This document provides recommendations covering technical aspects of different methods of surgery for endometriomas...
Chapter
Endometriosis is a heterogeneous condition in terms of surgical characterization of the disease and nonsurgical symptomatic and non-symptomatic characteristics of the woman. Many centers across the world conduct research into endometriosis independently from each other, using different standard operating protocols (SOPs) for collection of biologica...
Article
The painful symptoms of endometriosis were described as early as 1690 (1), yet more than 300 years later there is still no definitive treatment or prevention for a disease, which affects an estimated 6-10% of reproductive-aged women (2). This equates to 176 million women worldwide (3), whose lives are burdened daily by pain and/or subfertility. Thi...
Article
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Introduction Endometriosis is a common gynaecological disease characterised by pain and subfertility. Randomised controlled trials evaluating treatments for endometriosis have reported many different outcomes and outcome measures. This variation restricts effective data synthesis limiting the usefulness of research to inform clinical practice. To a...
Article
Study question: What is the global consensus on the classification of endometriosis that considers the views of women with endometriosis? Summary answer: We have produced an international consensus statement on the classification of endometriosis through systematic appraisal of evidence and a consensus process that included representatives of na...
Article
Introduction: The objective of this review was to evaluate the published literature on epidemiologic risk factors for epithelial ovarian cancer among women with a diagnosis of endometriosis. Material and methods: A systematic literature search was conducted in PubMed and Scopus. Studies comparing epidemiologic risk factors of epithelial ovarian...
Article
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The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/progn...
Article
To what extent are outcome measures in endometriosis-related quality of life studies influenced by the setting in which patient recruitment is performed? Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies. Most studies on quality of life in women with endometriosis are conducted in tertiary care cen...
Article
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Objective To harmonize the collection of nonsurgical clinical and epidemiologic data relevant to endometriosis research, allowing large-scale collaboration. Design An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries on five continents. Setting In 2013, two workshops followed by...
Article
Objective To harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of fluid biospecimens relevant to endometriosis. Design An international collaboration involving 34 clinical/academic centers and 3 industry collaborators from 16 countries on 5 continents. Setting I...
Article
Full-text available
Objective To harmonize standard operating procedures (SOPs) and standardize the recording of associated data for collection, processing, and storage of human tissues relevant to endometriosis. Design An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries on five continents. Setting...
Article
Full-text available
Objective: To standardize the recording of surgical phenotypic information on endometriosis and related sample collections obtained at laparoscopy, allowing large-scale collaborative research into the condition. Design: An international collaboration involving 34 clinical/academic centers and three industry collaborators from 16 countries. Setting:...
Article
Full-text available
It is a truth universally acknowledged that the main symptoms of endometriosis are pelvic pain and, to a lesser extent, infertility and fatigue.1 ,2 These symptoms affect an estimated 176 million women worldwide.3 What is less frequently acknowledged, however, are the different types of pains associated with symptomatic endometriosis, a disease wh...
Article
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STUDY QUESTION To what extent do the management of endometriosis and the symptoms that remain after treatment affect the quality of life in women with the disease?
Article
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Study question: Is there a global consensus on the management of endometriosis that considers the views of women with endometriosis? Summary answer: It was possible to produce an international consensus statement on the current management of endometriosis through engagement of representatives of national and international, medical and non-medica...
Article
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The association of pain and endometriosis was recognized with the first definitive published reports of this disorder. Unfortunately, the precise etiologies and pathways leading to nociception and pain symptoms in endometriosis remain poorly understood, and as a result, effective therapeutic interventions are lacking with consequent profound effect...
Article
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To generate and validate symptom-based models to predict endometriosis among symptomatic women prior to undergoing their first laparoscopy. Prospective, observational, two-phase study, in which women completed a 25-item questionnaire prior to surgery. Nineteen hospitals in 13 countries. Symptomatic women (n = 1,396) scheduled for laparoscopy withou...
Article
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This study aimed to calculate costs and health-related quality of life of women with endometriosis-associated symptoms treated in referral centres. A prospective, multi-centre, questionnaire-based survey measured costs and quality of life in ambulatory care and in 12 tertiary care centres in 10 countries. The study enrolled women with a diagnosis o...
Article
Introduction Randomized controlled trials have shown laparoscopic removal of endometriosis to be advantageous in improving fertility outcomes for women with minimal-mild disease. There are limited data available on fertility outcomes following surgery for stage 3 and 4 endometriosis. Materials and Methods In this retrospective study at a tertiary...
Article
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The role of sex steroid hormones in reproductive function in women is well established. However, in the last two decades it has been shown that receptors for estrogens, progesterone and androgens are expressed in non reproductive tissue /organs (bone, brain, cardiovascular system) playing a role in their function. Therefore, it is critical to evalu...
Article
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To assess the impact of endometriosis on health-related quality of life (HRQoL) and work productivity. Multicenter cross-sectional study with prospective recruitment. Sixteen clinical centers in ten countries. A total of 1,418 premenopausal women, aged 18-45 years, without a previous surgical diagnosis of endometriosis, having laparoscopy to invest...
Article
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The EndoCost study aims to calculate the costs of endometriosis from a societal perspective. This multicentre, prevalence-based cost-of-illness analysis aggregates data on endometriosis costs and quality of life from a prospective hospital questionnaire and from both retrospective and prospective patient questionnaires. The EndoCost study comprises...
Article
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OBJECTIVE: To assess the impact of endometriosis on health-related quality of life (HRQoL) and work productivity. DESIGN: Multicenter cross-sectional study with prospective recruitment. SETTING: Sixteen clinical centers in ten countries. PATIENT(S): A total of 1,418 premenopausal women, aged 18-45 years, without a previous surgical diagnosis of end...
Article
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Introduction: Degradation of basement membrane (BM) is reported to be involved in the metastatic process of cancers. BM components, collagen four (COLIV) and laminin, have also been shown to be aberrantly expressed in the benign metastatic disease of endometriosis. Cytokeratin 5/6 (Ck5/6) and podocalyxin-like protein (PODXL) have been proposed as m...
Article
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Introduction The potential of an embryo generated in vitro to implant and develop to live birth following intrauterine transfer will be affected by a number of factors, most notably the age of the woman at the time of oocyte collection. In order to quantify the relative contributions to the age related decline in success rates of failure to implant...
Article
Women with endometriosis have a substantial increase in risk of deep dyspareunia with respect to the general female population of corresponding age. This symptom has personal and intimate implications, including unfavorable emotional impact in partners. Deep dyspareunia caused by endometriosis can be viewed as an originally visceral type of pain se...
Article
With the steadily increasing volume of endometriosis articles, and titles and abstracts readily available online, there is a growing risk that references are cited without the full articles having been read by the author(s) or by referees. Too often the titles and statements in abstracts are not supported by data in the published articles. Therefor...
Article
Introduction Endometriosis is known to influence quality of life, but little is known about its personal and societal impact across the world. We designed the Global Study of Women's Health (GSWH), a multicentre study of women attending for their first laparoscopic investigation to examine the global impact of endometriosis and associated symptoms....
Article
Full-text available
Endometriosis affects an estimated 176 million women worldwide during the prime years of their lives. Yet many clinical questions remain unanswered, treatment failures are common, and there is little investment in investigating disease mechanisms. The World Endometriosis Research Foundation (WERF) has been created to provide a global platform where...
Article
Objective: To assess the impact of endometriosis on health-related quality of life (HRQoL) and work productivity. Design: Multicenter cross-sectional study with prospective recruitment. Setting: Sixteen clinical centers in ten countries. Patient(s): A total of 1,418 premenopausal women, aged 18–45 years, without a previous surgical diagnosis of end...
Article
Objective: To assess the impact of endometriosis on health-related quality of life (HRQoL) and work productivity. Design: Multicenter cross-sectional study with prospective recruitment. Setting: Sixteen clinical centers in ten countries. Patient(s): A total of 1,418 premenopausal women, aged 18–45 years, without a previous surgical diagnosis of end...
Article
Previous studies have elucidated the negative impact of endometriosis on life, but the patient selection may have contributed to a skewed picture. The aim of this study was to investigate longitudinally the consequences of the disease in women diagnosed with endometriosis 15 years ago. Retrospective descriptive. Trondheim 2007. One hundred thirty w...
Article
Full-text available
In response to the pressing need for more efficacious and safer therapeutics for endometriosis, there have been numerous reports in the last decade of positive results from animal and in vitro studies of various compounds as potential therapeutics for endometriosis. A handful of these have undergone phase II/III clinical trials. Since the announcem...
Article
Full-text available
Introduction: Endometriosis can be difficult to diagnose clinically and models that use symptoms to predict whether the disease is present or not are based on limited patient populations. Endometriosis also influences health-related quality of life, but little is known about its impact across the world. We therefore initiated two integrated multic...
Article
Full-text available
Introduction: Endometriosis can be difficult to diagnose clinically and models that use symptoms to predict whether the disease is present or not are based on limited patient populations. Endometriosis also influences health-related quality of life, but little is known about its impact across the world. We therefore initiated two integrated multi-c...
Article
Started at the grassroot level, increased awareness and investment in research has resulted in unprecedented recognition of endometriosis by the European Parliament, taken up by the Italian Senate in a 5-year action plan. This offers welcome assurance to the scientific community.
Article
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This article aims to provide a systematic review of estimates and methodology of studies quantifying the costs of endometriosis. Included studies were cost-of-illness analyses quantifying the economic impact of endometriosis and cost analyses calculating diagnostic and treatment costs of endometriosis. Annual healthcare costs and costs of productiv...
Article
Full-text available
Centres/networks of excellence are the only way forward to ensure that women with endometriosis receive consistent, evidence-based care, ensuring excellence, continuity of care, multi-disciplinarity, research, training and cost-effectiveness. Clinical excellence should be achieved by proper training, adherence to evidence-based guidelines, quality...
Article
The 9th World Congress on Endometriosis brought together world leaders in the field of endometriosis to address a wide range of topics from molecular cell biology to QoL. It was evident that there continues to be a worldwide lack of awareness of endometriosis among women and, more frighteningly, among nonspecialist clinicians. There also remains a...
Article
Full-text available
The objective was to develop recommendations for the diagnosis and treatment of endometriosis and its associated symptoms. A working group was convened comprised of practising gynaecologists and experts in evidence-based medicine from Europe, as well as an endometriosis self-help group representative. After reviewing existing evidence-based guideli...
Article
Endometriosis is surrounded by taboos, myths, delayed diagnosis, hit and miss treatments, and a lack of awareness, overlaid on the many symptoms that embody a disease we know too little about and which has no known cure. Society continues to be unable to address taboo subjects such as: pain, menstruation, infertility, and compromised sexuality and...
Article
Centres/networks of excellence are the only way forward to ensure that women with endometriosis receive consistent, evidence-based care, ensuring excellence, continuity of care, multi-disciplinarity, research, training and cost-effectiveness. Clinical excellence should be achieved by proper training, adherence to evidence-based guidelines, quality...

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