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L.M.C.L. Laurent Fossion

L.M.C.L. Laurent Fossion
Azzeno · Urology

MD, Urologist, FeBU

About

77
Publications
10,761
Reads
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388
Citations
Introduction
L.M.C.L. Laurent Fossion currently works as urologist in AZZeno hospital. Laurent does research in Uro-Oncology. Laurent presents clinical data and quality alalyses of his own surgical database of minimal invasive uro-oncological surgery.
Additional affiliations
November 2020 - present
University-Hospital Brugmann UVC
Position
  • Head of Department
January 2008 - October 2020
Maxima Medical Center
Position
  • Urologist
Description
  • Specialized in Uro-oncology and minimal invasive surgery & robotics.
January 2015 - November 2017
Maastricht Universitair Medisch Centrum
Position
  • Consultant
Description
  • I start with the cystectomy/RARC project in MUMC in association with Dr. C. Van De Beeck and Dr. J. Van Roermund. Beside this project I will support the RALP project with Dr. J. Van Roermund.
Education
September 1992 - June 1999
KU Leuven
Field of study
  • Medical School / Medecine

Publications

Publications (77)
Article
Full-text available
Samenvatting Er is onvoldoende bekend over de middellangetermijnoverleving van niet-gemetastaseerd spierinvasieve blaaskanker (SIBC) na open (ORC) versus robotgeassisteerde (RARC) cystectomie, met of zonder neoadjuvante chemotherapie (NAC). Om de vijfjaarsoverleving na beide interventies en de invloed van NAC te onderzoeken, is een retrospectieve s...
Article
Full-text available
Objectives: To assess survival of patients with muscle-invasive bladder cancer (MIBC) who underwent radical cystectomy (RC) with or without neo-adjuvant chemotherapy (NAC) according to the pathological response at RC. Methods: 965 patients with MIBC (cT2-4aN0M0) who underwent RC with or without NAC were analyzed. Among the collected data were co...
Article
Full-text available
Background Guidelines recommend neoadjuvant chemotherapy (NAC) for the treatment of nonmetastatic muscle-invasive bladder cancer (MIBC). NAC is, however, underutilized in practice because of its associated limited overall survival (OS) benefit and significant treatment-related toxicity. We hypothesized that the absence of circulating tumour cells (...
Poster
Full-text available
Open radical cystectomy (ORC) is the gold standard for treating patients with a muscle invasive (MIBC) or high-risk non-muscle invasive bladder cancer. Nonetheless, laparoscopic radical cystectomy (LRC) provides comparable early oncologic outcomes and improved perioperative outcomes. We have implemented laparoscopic radical cystectomy in our depart...
Article
Background: Radical cystectomy with pelvic lymph node dissection is the recommended treatment in non-metastatic muscle-invasive bladder cancer (MIBC). In randomised trials, robot-assisted radical cystectomy (RARC) showed non-inferior short-term oncological outcomes compared with open radical cystectomy (ORC). Data on intermediate and long-term onc...
Article
Full-text available
Background With the increasing attention for the role of General Practitioners (GPs) after cancer treatment, it is important to better understand the involvement of GPs following prostate cancer treatment. This study investigates factors associated with GP contact during follow-up of prostate cancer survivors, such as patient, treatment and symptom...
Preprint
Full-text available
Operationeel, sept 2021 Senhance-robotgeassisteerde endoscopische extraperitoneale radicale prostatectomie Veel jaren bestond er geen alternatief voor de Da Vinci-robot, maar in 2016 werd een nieuwe robot geïntroduceerd: Senhance Surgical System. In dit artikel zullen we de voor-en nadelen van deze robotsystemen bespreken en onze ervaringen met dez...
Article
Full-text available
Operationeel, sept 2021 Senhance-robotgeassisteerde endoscopische extraperitoneale radicale prostatectomie Veel jaren bestond er geen alternatief voor de Da Vinci-robot, maar in 2016 werd een nieuwe robot geïntroduceerd: Senhance Surgical System. In dit artikel zullen we de voor-en nadelen van deze robotsystemen bespreken en onze ervaringen met dez...
Article
Abstract Background: Radical cystectomy with pelvic lymph node dissection is the recommended treatment in non-metastatic muscle-invasivebladder cancer (MIBC). In randomised trials, robot-assisted radical cystectomy (RARC) showed non-inferior short-term oncological out-comes compared with open radical cystectomy (ORC). Data on intermediate and long...
Article
Full-text available
Background Despite multiple studies evaluating the effectiveness of Robot-Assisted Radical Prostatectomy (RARP), there is no definitive conclusion about the added value of RARP. A retrospective cluster study was conducted to evaluate long-term sexual and urinary functioning after RARP and Laparoscopic Radical Prostatectomy (LRP) based on real-world...
Article
Background: Open radical cystectomy (ORC) is regarded as the standard treatment for muscle-invasive bladder cancer, but robot-assisted radical cystectomy (RARC) is increasingly used in practice. A recent study showed that RARC resulted in slightly fewer minor but slightly more major complications, although the difference was not statistically sign...
Article
4523 Background: International guidelines for the treatment of non-metastatic muscle-invasive bladder cancer (MIBC) recommend neoadjuvant chemotherapy (NAC), which, however, is underutilized in practice. We hypothesized that the absence of circulating tumour cells (CTCs), an established prognostic marker in MIBC, may identify patients with such a f...
Article
Background Radical cystectomy with pelvic lymph node dissection (PLND) and urinary diversion in patients with bladder cancer is known for its high risk of complications. Although open radical cystectomy (ORC) is regarded as the standard treatment, robot-assisted radical cystectomy (RARC) is increasingly used in practice, despite the fact that high-...
Article
Full-text available
Introduction: Recent technical advances have made new minimally invasive techniques possible to treat large volume (>80 ml) benign prostatic hyperplasia (BPH). The endoscopic transperitoneal adenomectomy of the prostate (ETAP) is a new minimally invasive technique developed in our centre. The aim of this study was to describe the safety, efficacy...
Article
Full-text available
Background: Cross resistance between androgen-receptor targeting therapies (ARTs) (abiraterone acetate plus prednisone [ABI+P] or enzalutamide [ENZ]) for treatment of metastatic castration-resistant prostate cancer (mCRPC) may affect responses to second ART (ART2). Objective: To establish treatment duration and prostate-specific antigen (PSA) re...
Article
Introduction and objective: definitive inclusion of RMB in SRM diagnostic algorithm remains controversial. We assessed incidence and accuracy of RMB in SRMs in the CROES Renal Mass registry and the influence of preoperative RMB on peri-operative complications after SRM nephron-sparing surgery (NSS). Methods: "ad hoc" description of incidence of...
Article
Background: Cabazitaxel has been shown to improve overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients after docetaxel in the TROPIC trial. However, trial populations may not reflect the real-world population. We compared patient characteristics and outcomes of cabazitaxel within and outside trials (standard of...
Article
Objective The objective of this study is to present the results in the first 40 patients treated with a new minimal invasive technique in the treatment of large-volume benign prostate hyperplasia: the endoscopic transvesical adenomectomy of the prostate (ETAP). Patients and Methods From 2014 to 2016 we performed the ETAP in 40 patients with large...
Article
Full-text available
We presenteren een bijzondere casus van een recidief/metastase in de nier van een primair oesofaguscarcinoom.
Article
Background: The best practice for the organization of follow-up care in oncology is under debate, due to growing numbers of cancer survivors. Understanding survivors’ preferences for follow-up care is elementary for designing patient-centred care. Based on data from prostate cancer and melanoma survivors, this study aims to identify: 1) preferences...
Article
The Henoch-Schönlein purpura (HSP) is a systemic vasculitis that mostly occurs in children. Besides the most common clinical manifestations such as palpable purpura, arthralgia, abdominal pain and renal disease, it can have urological manifestations. We report a rare case of a 2-year-old boy with the HSP who developed a testicular torsion under cor...
Article
Full-text available
Objective: To compare outcome of laparoscopic radical cystectomy (LRC) with ileal conduit in 22 elderly (≥75 years.) versus 51 younger (< 75 years.) patients. Materials and methods: Analysis of prospectively gathered data of a single institution LRC only series was performed. Selection bias for LRC versus non-surgical treatments was assessed wit...
Article
Objectives: To assess temporal trends in radical cystectomy (RC) and pelvic lymph node dissection (PLND) and the effect of centralization of care in the Netherlands between 2006 and 2012. Patients and methods: This nationwide population-based study included 3524 patients from the Netherlands Cancer Registry who underwent RC as the primary treatm...
Article
Full-text available
Met de komst van de minimaal invasieve (inclusief de robotgeassisteerde) technieken in de urologie is er de afgelopen jaren veel veranderd, met name op oncologisch chirurgisch gebied. Bij de chirurgische behandeling van BPH lijken deze technieken vooralsnog maar weinig toepassing te vinden. In dit artikel presenteren wij een nieuwe, minimaal invasi...
Research
Full-text available
We report on our Positive Surgical Margin -data in EERPE for prostate cancer and compare our results with those known in the Benelux.
Article
Purpose: Aim of this study is to analyze patients with early progression after laparoscopic radical cystectomy (LRC) in a large cohort by the ESUT. More specifically, we focus on patients with favorable pathology (≤pT2;N0;R0) who developed an unexpected recurrence and analyze possible causes for such early recurrences, discussing the surgical tech...
Poster
Full-text available
Introductie In de periode 2005-2012 vond in Nederland circa 3% van de cystectomiën voor blaaskanker laparoscopisch plaats. De enorme kostenlast van de blaaskankerzorg dwingt echter technologische ontwikkelingen, zoals de laparoscopische radicale cystectomie (LRC), kritisch te evalueren ten aanzien van kwaliteitsverbetering en kosteneffectiviteit. W...
Conference Paper
Full-text available
Objective: The oncologic outcome after radical prostatectomy is negatively influenced by positive surgical margins (PSM), as it increases the risk of disease recurrence. Analysis of the incidence of PSM could contribute in improving the surgical treatment of prostate cancer. To stimulate more transparency in this topic, we studied our own populatio...
Article
Full-text available
Introduction: Additional insight in the occurrence and number of positive surgical margins (PSM) and the potential consequences is needed, since earlier studies show divergent results. This study aims at investigating the effect of the presence and number of PSM on oncological outcomes. Methods: Retrospective population-based cohort study includ...
Article
Full-text available
To analyze postoperative complications after laparoscopic radical cystectomy (LRC) and evaluate its risk factors in a large prospective cohort built by the ESUT across European centers involved in minimally invasive urology in the last decade. Patients were prospectively enrolled, and data were retrospectively analyzed. Only oncologic cases were in...
Article
Full-text available
Laparoscopic radical cystectomy in a non-academic center by a single surgeon in 94 cases Introduction: This article reports the results of laparoscopic radical cystectomy (LRC) in 94 patients with bilateral pelvic lymph node dissection by a single surgeon and compares these with the international literature. Method: From September 2006 until Octobe...
Article
The aim of the study was to evaluate the effect of positive surgical margins (PSM) on health-related quality of life and illness perception after radical prostatectomy in patients with prostate cancer.Methods Of all patients with prostate cancer diagnosed between 2006 and 2009 in 7 participating hospitals in the Eindhoven region of the Netherlands...
Article
Objective To report long-term outcomes of laparoscopic radical cystectomy (LRC) in a multi-centric European cohort, and explore feasibility and safety of the procedure.Patients and Methods This study was coordinated by EAU-section of Uro-technology (ESUT) with nine centers enrolling 503 patients undergoing LRC for bladder cancer prospectively betwe...
Article
Samenvatting Introductie: Doel van dit onderzoek is een analyse presenteren van onze ervaring met de endoscopische extraperitoneale radicale prostatectomie (EERPE). Methode: Retrospectieve analyse van de eerste 218 EERPE-procedures. Resultaten: Tussen de eerste en laatste 109 patiënten daalde de mediane operatieduur van 285 min. (range 180-430)...
Article
Purpose: To assess direct healthcare costs for open radical cystectomy (ORC) vs laparoscopic radical cystectomy (LRC) with ileal conduit. Patients and methods: A series of 44 and 42 patients undergoing ORC and LRC with ileal conduit were retrospectively analyzed at a single institution from January 2005 to January 2012. The ORC and LRC procedure...
Article
Full-text available
Introduction: We report the oncological outcome after laparoscopic radical cystectomy (LRC) and standard laparoscopic pelvic lymph node dissection (PLND) without neoadjuvant or adjuvant therapy in the treatment of bladder cancer with a median follow-up of 32 months. Materials and methods: From September 2006 to January 2011, 40 consecutive patie...
Conference Paper
Full-text available
Introduction Laparoscopic and robot assisted pyeloplasty have been shown to be as efficacious as the gold standard open technique in the treatment of ureteropelvic junction stenosis. This study shows the results of laparoscopic pyeloplasty in a non-academic centre. Methods The results of transperitoneal laparoscopic dismembered pyeloplasty (LP) w...
Article
Introduction Despite current use of MRI for lymph node staging in patients with prostate cancer (PCa), extended pelvic lymph node dissection (ePLND) is still the gold standard. Lymph node staging is mandatory in patients with intermediate and high risk prostate cancer (EAU guidelines) when treatment with curative intention is chosen. The presence o...
Article
Full-text available
We describe an 80-year-old female with a left ureteroileal fistula and simultaneously a right ureteroiliac fistula. Her history highlights the predisposing factors of radiation, major surgery in the region, and presence of bilateral double-J-stents. She was successfully treated with an endovascular approach after being initially misdiagnosed. There...
Article
Full-text available
Synchronous renal cell carcinoma in patients with colorectal carcinoma is reported in various percentages ranging from 0.03 up to 4.85% (Halak et al. (2000), Capra et al. (2003)). When surgical treatment is indicated usually two separate operations are planned for resection. In open surgery, in such cases simultaneous resection is recommended if po...
Conference Paper
Full-text available
Doel Het blaascarcinoom is een relatief veelvoorkomende vorm van kanker. Voor resectabele spierinvasieve blaastumoren en snel recidiverende niet-spierinvasieve, hooggradige blaastumoren is een radicale cyst(oprostat)ectomie de gouden standaard behandeling. De voordelen van de laparoscopie heeft zich reeds bij vele urologisch oncologische ingrepen b...
Poster
Full-text available
Current opinion on criteria for lymphadenectomy in localized prostate cancer.
Article
The feasiility of performing a laparoscopic partial nephrectomy (LPN) has been improved thanks to multiple innovations. The current technique in our institute is reported. The LPN was performed in 39 patients: in 32 transperitoneally and in 7 extraperitoneally. Median blood loss encompassed 330 ml. The median warm ischemia lasted 26 minutes. In 3 p...
Article
Full-text available
Inleiding Het niercelcarcinoom (NCC) is de derde meest voorko-mende urologische tumor en vertegenwoordigt 3% van alle kwaadaardige gezwellen bij de volwassenen (1). De klassieke triade van symptomen is slechts aan-wezig bij 14% van de patiënten en daaraan heeft het NCC zijn naam als "silent killer" te danken (2). Recente studies tonen aan dat een N...
Article
Experience of the use of the Holmium: Yttrium-Aluminium-Garnet (Ho:YAG) laser in children has been limited. However, the Ho:YAG laser has been in clinical use in urology for several years but has mainly been used for the treatment of renal stones and benign prostatic hyperplasia. Due to its unique combination of vaporization and coagulation, the Ho...

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