Ljubomir Petricevic

Ljubomir Petricevic
Medical University of Vienna | MedUni Vienna · Department of Obstetrics and Gynecology

MD

About

71
Publications
8,012
Reads
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1,446
Citations
Additional affiliations
January 2007 - present
Position
  • Probiotics in Gynaecology and Obstetrics
August 2005 - present
Medical University of Vienna
Position
  • Professor (Associate)
Education
August 2005 - October 2011
Medical University of Vienna
Field of study
  • Gynaecology and Obstetrics
October 1997 - November 2004
Medical University of Vienna
Field of study
  • Medicine

Publications

Publications (71)
Article
Full-text available
Background: Rheumatic diseases and vaginal infections both increase the risk of preterm birth. It is unclear if pregnant women with rheumatic disease are more likely to experience vaginal infections, which might potentially accumulate modifiable risk factors. Objective: In this study, we sought to evaluate the vaginal microbiota of pregnant women w...
Article
Aim The aim of this official guideline, published and coordinated by the German (DGGG), Austrian (OEGGG) and Swiss (SGGG) Societies of Gynecology and Obstetrics in collaboration with the DMykG, DDG and AGII societies, was to provide consensus-based recommendations obtained by evaluating the relevant literature for the diagnosis, treatment and manag...
Article
Full-text available
Background This study aimed to evaluate the vaginal microbiota of HIV‐positive pregnant women relative to HIV‐negative controls, and to compare their risk of vaginal dysbiosis, bacterial vaginosis, and vulvovaginal candidosis (VVC). Methods This is a nested matched case‐control study that analyzed data from women who received pregnancy care at our...
Article
Full-text available
Approximately 70-75% of women will have vulvovaginal candidosis (VVC) at least once in their lifetime. In premenopausal, pregnant, asymptomatic, and healthy women and women with acute VVC, Candida albicans is the predominant species. The diagnosis of VVC should be based on clinical symptoms and microscopic detection of pseudohyphae. Symptoms alone...
Article
Full-text available
This study aimed to evaluate the potential of oral probiotics to eradicate vaginal GBS colonization during the third trimester of pregnancy. We screened 1058 women for GBS colonization at 33-37 gestational weeks using a combination of vaginal-to-rectal swab and culture-based methods. Women who tested GBS positive were randomized to either the verum...
Article
Full-text available
The use of drugs in pregnancy always raises concerns regarding potential fetal exposure and possible adverse effects through their accumulation in fetal tissues and organs. Barusiban is an oxytocin antagonist under development for potential use as tocolytic in preterm-labor patients. It displays greater affinity for the oxytocin receptor compared t...
Article
Objective: Extended-spectrum beta-lactamase (ESBL) is a rapidly evolving enzyme that cleaves beta-lactam-containing antibiotics, forming resistance to certain types of antibiotics, such as penicillin, cephalosporins and monobactams. Colonization with ESBL-producing bacteria during pregnancy is harmful, however this topic is currently underrepresen...
Article
We aimed at assessing the evidence for an effect on vaginal dysbiosis by oral administration of a mixture of Lactobacillus strains isolated from vaginal microbiota. For this purpose, we systematically reviewed the literature for randomised clinical trials (RCTs) in which the effect of oral administration of a mixture of four Lactobacillus strains (...
Article
Background Recent research on the vaginal microbiome indicates that a combination of different microbes and their interaction are the cause of dysbiosis and the basis of a normal vaginal microbiota. Objective Summary of recent knowledge on the vaginal microbiome. Results Based on the latest studies in the literature on the vaginal microbiome, the...
Presentation
Intra-amniotic infection is a serious complication associated with preterm birth and significant perinatal and maternal morbidity. The accurate diagnosis based on clinical signs of the infection in the pregnant mother is often made at a time when the infection has generalized and septicaemia has ensued. The delayed detection of the early signs of i...
Conference Paper
Background: Asymptomatic vaginal infections during early pregnancy have been shown to increase the risk of preterm delivery (PTD). In particular, bacterial vaginosis (BV) and recurrent vulvovaginal candidosis have been associated with poor obstetric outcomes among affected women [1,2]. In the present study, we now analyzed the obstetric outcomes of...
Article
Full-text available
Bacterial vaginosis (BV) is characterised by a depletion of lactobacilli in favour of an overgrowth of anaerobic bacteria. It is associated with increased risk for urogenital infections and abortion. In this study we assessed the effect of a yoghurt drink containing Lactobacillus strains on BV. The strains had been isolated from healthy pregnant wo...
Article
Full-text available
Background: Due to chemotherapy and estrogen deprivation therapy, genitourinary syndrome of menopause is a common condition in breast cancer patients. We aimed to determine the effect of an orally administered Lactobacillus preparation on the vaginal microbiota in breast cancer patients. Methods: Postmenopausal breast cancer patients receiving c...
Article
Full-text available
PurposeVaginal colonization with Candida species (spp.) during pregnancy has been associated with impaired pregnancy outcomes. There is a reduction in spontaneous preterm birth among women with recurrent asymptomatic colonization of Candida who were treated with clotrimazole. This study aimed to evaluate the impact of the trimester of vulvovaginal...
Article
Mycoplasmata have been linked to pregnancy complications and neonatal risk. While formerly a limited number of species could be discovered by cultures, molecular biology nowadays discovers both lower quantities and more diverse species, making us realize that mycoplasmata are ubiquitous in the vaginal milieu and do not always pose a danger for preg...
Article
IntroductionVaginal infection is a major causative factor of preterm delivery. The present study was performed to evaluate the effect of asymptomatic vagi- nal colonization with Candida albicans at early gestation on pregnancy out- come. Material and methods. From 2005 to 2014, a total of 8447 women with singleton pregnancies between 10+0 and 16+0...
Article
Full-text available
Background Vaginal infections are a risk factor for preterm delivery. In this study, we sought to evaluate the vaginal flora of pregnant women receiving opioid maintenance therapy (OMT) in comparison to non-dependent, non-maintained controls. MethodsA total of 3763 women with singleton pregnancies who underwent routine screening for asymptomatic va...
Article
Full-text available
Pregnant women with gestational diabetes mellitus (GDM) are reported to be at increased risk for infections of the genital tract. This study aimed to compare the prevalence of asymptomatic bacterial vaginosis (BV) and Candida colonization at early gestation between pregnant women with and without diabetic conditions during pregnancy. We included da...
Article
Full-text available
Background Poor obstetrical outcomes are associated with imbalances in the vaginal flora. The present study evaluated the role of vaginal Lactobacillus species in women with intermediate vaginal flora with regard to obstetrical outcomes. Methods We retrospectively analysed data from all women with singleton pregnancies who had undergone routine sc...
Article
Vaginal infection is a major causative factor of preterm delivery. The present study was performed to evaluate the effect of asymptomatic vaginal colonization with Candida albicans at early gestation on pregnancy outcome. From 2005 to 2014, a total of 8447 women with singleton pregnancies between 10(+0) and 16(+0) gestational weeks were routinely s...
Article
Vaginal infection in early pregnancy is associated with preterm birth. This study evaluates long-term results after integrating an antenatal screen-and-treat program for asymptomatic vaginal infections into routine pregnancy care. We retrospectively analyzed data of all women with singleton high-risk pregnancies delivering at our tertiary referral...
Article
Background: Premature birth represents a serious problem in modern obstetrics. Infections play a substantial role in the occurrence of premature birth. Objective: This article presents a summary of recent knowledge from the current literature on the pathogens responsible for premature birth and their mechanisms. Results : In a review of the literat...
Article
IntroductionBased on Lactobacillus species co-colonizing the vagina and rectum, it has been hypothesized that the rectum may be an important reservoir for vaginal colonization by lactobacilli. There are no data on this issue in male-to-female transsexual women.AimWe undertook this observational study to characterize the Lactobacillus species presen...
Article
Full-text available
The presence of an abnormal vaginal microflora in early pregnancy is a risk factor for preterm delivery. There is no investigation on vaginal flora dominated by lactic acid bacteria and possible association with preterm delivery. We assessed the dominant vaginal Lactobacillus species in healthy pregnant women in early pregnancy in relation to pregn...
Article
During the last years, the application of probiotics in gynaecological clinical practice has gained increasing relevance regarding therapy and prevention. This trend has also provoked the need for having tailored pharmaceutical preparations containing powerful microbial strains with defined properties. For the development of such preparations, seve...
Article
Full-text available
There is a general opinion that penile skin lined neovagina of transsexual women is not able to support the growth of lactobacilli. This study was undertaken to prove if lactobacilli strains could survive in neovagina and to characterise the most dominant Lactobacillus species. Sixty three male-to-female transsexual women without abnormal vaginal d...
Article
Lactobacilli have been found in the neovagina of very low numbers of transsexual women. We undertook this study to determine whether an orally administered preparation of four lactobacilli strains exerts some measurable effect on the neovaginal microflora of female transsexuals. 60 male to female transsexual women with penile linked neovagina were...
Article
Objective: This study was undertaken to characterize the Lactobacillus spp. dominating the vaginal microbiota of healthy postmenopausal women and to determine the possible influence of rectal lactobacilli. Methods: Sixty postmenopausal women aged 55-65 years without clinical signs of vaginal infection not receiving hormone replacement therapy we...
Article
Perioperative antibiotic prophylaxis during elective cesarean delivery at term to reduce postoperative maternal infectious morbidity is generally used but may not be effective on the basis of the available data. Also, the optimal timing of prophylactic antibiotic administration is unclear. To compare the effectiveness of cefazolin administered befo...
Article
To investigate the hypothesis that the rectum may be an important reservoir for vaginal colonisation by Lactobacillus species. We included 60 pregnant women aged 18-35 years and 80 postmenopausal women aged 55-65 years in this cross-sectional observational study. Participants had to be without clinical signs of vaginal infection and without hormone...
Article
We determined the association between short-term neonatal morbidities, such as bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH), and Ureaplasma spp. in amniotic fluid, placental and amniotic membrane of preterm infants. This study enrolled 257 patients who were born by cesarean section at <34 weeks' gestation. Patients were di...
Article
To assess whether a simple screen-and-treat strategy in pregnancy, previously tested in a randomised controlled study, also effectively lowers the rate of preterm delivery under real-life conditions. In a retrospective cohort study, data were enrolled of 2986 women with singleton pregnancies presenting for routine antenatal care between 11 and 24 w...
Article
Fragestellung: Ureaplasmen sind die meist isolierte Keime aus der Vagina. Diese Keime gelangen uber den Gebarmutterhals in den Bereich zwischen Plazenta und Chorio-Amnionmembrane, und konnten nach Angaben einiger Autoren fur vorzeitige Wehen oder vorzeitigen Blasensprung verantwortlich sein. Der Mechanismus einer vorzeitigen Beendigung der Schwange...
Article
To evaluate the efficacy of additional topical Lactobacillus casei rhamnosus (Lcr35) subsequent to antibiotic treatment of bacterial vaginosis (BV) to restore the normal vaginal flora. Single-centre, randomised, observerblinded study. Population-based study in Vienna over 1 year. 190 women were enrolled in the study. Women with Nugent scores betwee...
Article
The purpose of this randomized, double-blind, placebo-controlled study was to evaluate the influence of the orally administered probiotic strains Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the quality of the vaginal flora in postmenopausal women. Postmenopausal women with Nugent scores between 4 and 6 in initial vaginal swab, w...
Article
This study was undertaken to characterise the dominant species of Lactobacillus colonising the vagina of healthy pregnant women, to examine some of their phenotypic and genotypic properties, and to gain a better understanding of the potential role of species, which might be associated with infection-free status. A prospective descriptive cohort stu...
Article
The purpose of this investigation was to determine the cost-saving potential of a simple screen-and-treat program for vaginal infection, which has previously been shown to lead to a reduction of 50% in the rate of preterm births. To determine the potential cost savings, we compared the direct costs of preterm delivery of infants with a birth weight...
Article
The purpose of this study was to evaluate the prevalence of microbial invasion of the amniotic cavity at the time of preterm cesarean delivery for therapy-resistant preterm labor or preterm premature rupture of membranes, which are events that commonly are induced by infection, and to compare this group of patients with a group of patients who unde...
Article
Full-text available
Objetivo: Evaluar si un programa de tamizaje durante el embarazo reduce la tasa de partos prematuros en una población general de gestantes. Diseño: Estudio multicéntrico, prospectivo, aleatorio y controlado. Lugar: Clínicas prenatales no establecidas en hospitales. Material y métodos: Se realizó una coloración de Grama 4.429 gestantes durante sus c...
Article
The association between elevated interleukin (IL)-8 concentrations in amniotic fluid and preterm delivery is well described. Little consideration has been given to the impact of different groups of microorganisms within the amniotic cavity on IL-8 concentration. We collected amniotic fluid, placental tissue and amniotic membranes during preterm ces...
Article
Full-text available
To evaluate whether a screening strategy in pregnancy lowers the rate of preterm delivery in a general population of pregnant women. Multicentre, prospective, randomised controlled trial. Non-hospital based antenatal clinics. 4429 pregnant women presenting for their routine prenatal visits early in the second trimester were screened by Gram stain f...
Article
Full-text available
This prospective comparative study evaluated a DNA hybridization test (Affirm VPIII) as an alternative to Gram stain for the diagnosis of bacterial vaginosis. We examined vaginal smears from 1,725 pregnant women between the 12th and 36th weeks of gestation with clinical signs of vaginal infection. The DNA hybridization test compared well with Gram...
Article
Fragestellung Da ein eindeutiger Zusammenhang zwischen Frühgeburt und Infektion nachgewiesen werden konnte, wird in zahlreichen Studien in der Schwangerschaft ein Screening und eine Behandlung von vaginalen Infektionen gefordert. Ziel dieser Studie ist es, im Rahmen einer lokalen Multizenteruntersuchung nachzuweisen, ob ein einfaches Infektionsscre...
Article
Einleitung Zervixinsuffizienz mit nachfolgend prolabierender Fruchtblase führt fast immer zu einer Frühgeburt. Insgesamt stellt dieses Symptom ab der 20. Schwangerschaftswoche einen Schwerpunkt an jedem perinatalen Zentrum dar. Ziel unserer Studie war es, retrospektiv zu analysieren, welche Methode der Therapie bei einer bereits prolabierten Frucht...
Article
Fragestellung Die vulvovaginale Pilzinfektion ist eine der häufigsten Infektionen des äußeren weiblichen Genitaltrakts. In einer lokalen Untersuchung gingen wir der Frage nach, welche der derzeit angewandten Arznei- und Therapieformen von Patientinnen bei vulvovaginaler Pilzinfektion bevorzugt werden. Methode Bei 1400 Frauen wurde mittels Frageboge...
Article
In der vorliegenden Arbeit berichten wir über vier Fälle von schwangeren Patientinnen mit Muttermundbefund und vorgewölbter Fruchtblase, welcher sich unter konservativem Management zu einer stehenden Zervix rückbildete. Insgesamt ließen sich die Schwangerschaften deutlich verlängern, in einem der berichteten Fälle um 10 Wochen. Summary In this pape...

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