Livia Naszalyi Nagy

Livia Naszalyi Nagy
CEVA · R&D

PhD

About

34
Publications
2,969
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299
Citations
Citations since 2016
8 Research Items
213 Citations
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040
2016201720182019202020212022010203040

Publications

Publications (34)
Article
Model experiments under laboratory conditions were carried out to assess the accumulation tendency of Zr from a silica-zirconia core-shell nanoparticles, synthesised for the assay. Acute exposition tests were conducted with Daphnia magna and Danio rerio and the accumulation tendency of the nano and the molecular form was compared. Significant eleva...
Article
Full-text available
jats:p>The development of delivery systems for the immobilization of nucleic acid cargo molecules is of prime importance due to the need for safe administration of DNA or RNA type of antigens and adjuvants in vaccines. Nanoparticles (NP) in the size range of 20–200 nm have attractive properties as vaccine carriers because they achieve passive targe...
Article
[email protected] [email protected] oxide nanoparticles of approx. 50 nm diameter were developed in view of an application as a novel carrier with adjuvant activities for cancer vaccines. To this end, the aim was to cover the surface of the nanocarrier by potent single stranded DNA (ssDNA) type immune stimulators used in cancer vaccination. Prior t...
Article
This paper describes the preparation of gallium-68 (68Ga) isotope labeled porous zirconia (ZrO2) nanoparticle (NP) platform of nearly 100 nm diameter and its first pharmacokinetic and biodistribution evaluation accomplished with a microPET/CT (μPet/CT) imaging system. Objectives of the investigations were to provide a nanoparticle platform which c...
Article
Full-text available
Radiation-induced bystander effects refer to the induction of biological changes in cells not directly hit by radiation implying that the number of cells affected by radiation is larger than the actual number of irradiated cells. Recent in vitro studies suggest the role of extracellular vesicles (EVs) in mediating radiation-induced bystander signal...
Article
The development of tissue specific magnetic resonance imaging (MRI) contrast agents (CAs) is very desirable to achieve high contrast ratio combined with excellent anatomical details. To this end, we introduce a highly effective manganese(II) containing silica material, with the aim to shorten the longitudinal (T1) relaxation time. The microporous s...
Article
Silicaatzirconiaatpoly(malic acid) nanocarriers of 110 nm mean diameter were designed, synthesized and characterized for the targeted delivery of diagnostic and therapeutic 99mTc to folate-overexpressing tumors. An important achievement was that a multifunctional l-(-)-malic-acid-based copolymer was formed in situ at the surface of the inorganic co...
Article
Full-text available
The present article describes the preparation of β-emitter lutetium-177-labeled zirconia colloid and its preliminary physicochemical and biological evaluation of suitability for local radionuclide therapy. The new 177Lu-labeled therapeutic radiopharmaceutical candidate was based on the synthesis mode of a previously described zirconia nanoparticle...
Article
Full-text available
Porous, fluorescent zirconia particles of nearly 380 nm diameter were prepared without template molecules or labeling dyes. The porous structure is the result of aggregation-induced particle formation. The inherent fluorescence is assigned to coordinatively unsaturated Zr4+ ions at the sol-gel derived ZrO2 surface. After physico-chemical characteri...
Article
A new method was developed for the preparation of highly monodisperse isotopically enriched Si-29 silica nanoparticles (29Si-silica NPs) with the purpose of using them as spikes for isotope dilution mass spectrometry (IDMS) quantification of silica NPs with natural isotopic distribution. Si-29 tetraethyl orthosilicate (29Si-TEOS), the silica precur...
Conference Paper
AIMS A new biocompatible and biodegradable complex nanocarrier was designed, synthesized and labelled with Tc-99m to be studied as a potential new SPECT or SPECT/CT imaging agent and as a potential theranostic nanosystem for diagnosis and therapy of early stage tumours. In this study we examined the conditions of radiolabelling and preclinical appl...
Article
Full-text available
Novel pathways of the synthesis of photoluminescent gold quantum clusters (AuQCs) using biomolecules as reactants provide biocompatible products for biological imaging techniques. In order to rationalize the rules for the preparation of red-emitting AuQCs in aqueous phase using proteins or peptides, the role of different organic structural units wa...
Article
The thermotropic and structural effects of low molecular weight poly(malic acid) (PMLA) on fully hydrated multilamellar dipalmitoylphosphatidylcholine (DPPC)-water systems were investigated using differential scanning calorimetry (DSC), small-angle X-ray scattering (SAXS), and freeze-fracture transmission electron microscopy (FFTEM). Systems of 20w...
Article
A new, simple, and "green" method was developed for the surface modification of 20nm diameter Stöber silica particles with 3-aminopropyl(diethoxy)methylsilane in ethanol. The bulk polycondensation of the reagent was inhibited and the stability of the sol preserved by adding a small amount of glacial acetic acid after appropriate reaction time. Cent...
Article
Multifunctional Langmuir-Blodgett (LB) films were fabricated on the surface of glass substrates using sol-gel derived ZnO and SiO2 particles. ZnO particles of 6 and 110 nm diameter were synthesized according to the methods of Meulenkamp and Seelig et al. (Meulenkamp, E. A. J. Phys. Chem. B 1998, 102, 5566; Seelig, E. W.; Tang, B.; Yamilov, A.; Cao,...
Article
Sol–gel-derived mesoporous layers consisting in a packing of SiO2/ZnO core–shell nanoparticles were prepared. Porous texture characterization and permeation experiments on the resulting membrane show its adequacy for ultrafiltration applications. This membrane exhibits both photocatalytic and H2S chemisorption properties related to the presence of...
Article
European Materials Research Society Fall Meeting Symposium D, 15-19 Septembre 2008, Varsovie (Pologne)
Article
A method is presented for the simulation of transmittance spectra of graded-index dielectric layers deposited on a transparent substrate of finite thickness, and the simulation process is applied to films of silica and zinc oxide nanoparticles. The method is based on the optical admittance by solving its differential equation for an appropriate ref...
Article
ZnO alcosols were synthesized by wet colloid chemical route. The particle diameters were found to be in the range of 3–6 nm studied by small angle X-ray scattering, transmission electron microscopy and UV–Vis spectroscopy.Mono- and multilayered films were prepared by Langmuir–Blodgett (LB) technique on fused silica and silicon supports. The films w...
Article
20th Conference of the European Colloid and Interface Society, Budapest, Hongrie, 17-22 Septembre 2006
Article
20th Conference of the European Colloid and Interface Society", Budapest, Hongrie, 17-22 Septembre 2006
Chapter
Multifunctional Langmuir–Blodgett films were prepared using sol–gel derived ZnO and silica nanoparticles synthesized by the procedure of Seelig etal.[1] and Stöber etal.[2], respectively. High inherent porosity was observed for ZnO particles (30–40%) by pycnometry, scanning angle reflectometry, N2 adsorption–desorption and ellipsometric porosimetry...
Article
Eljárásokat fejlesztettünk ki nanostrukturált, anorganikus (SiO2, ZnO, TiO2) vékonyrétegek különböző anyagú (fém, szilícium, üveg, kvarc) hordozók felületén történő előállítására. Tanulmányoztuk ezeknek a bevonatoknak optikai, fotokatalitikus, valamint nedvesedési tulajdonságait. Igazoltuk, hogy a vékonyrétegek multifunkcionalitása a szerkezet és ö...

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