Liu Bo

• PhD
• Researcher at Nantong University

Elucidating the relationship between spin excitations and fermiology is essential for clarifying the pairing mechanism in iron-based superconductors (FeSCs). Here, we report inelastic neutron scattering results on the hole overdoped Ba 0.4 K 0.6 Fe 2 As 2 near a Lifshitz transition, where the electron pocket at M point is nearly replace by four hol...

In clinical practice, surgical removal of tumors often leaves behind small tumors and circulating tumor cells, increasing the risk of metastasis and recurrence, which seriously affects treatment outcomes. Immunotherapy activates the immune system to monitor and inhibit tumor metastasis and recurrence long‐term. However, inflammatory microenvironmen...

Radioresistance presents a substantial obstacle to achieving optimal therapeutic outcomes for breast cancer treatment. In this study, we develop a cancer cell membrane (CM) ‐ coated nanozyme system (MPPC@CM), specifically designed for radioimmunotherapy to address this issue. This innovative system involves the in situ reduction of platinum and pal...

Emerging evidence emphasizes the critical role of alternative polyadenylation (APA) in posttranscriptional regulation of genes, and APA‐associated genetic variants (apaQTLs) show particular relevance for multiple disease. However, genetic regulation of APA and its role in non‐small cell lung cancer (NSCLC) risk have not been thoroughly studied. Her...

H 2 gas sensor room temperature H 2 O resistance surface refreshing Pt-doped WO 3 film A B S T R A C T Until now, no one hydrogen sensing technology can meet all requirements of application. Hydrogen sensors working in extreme conditions are needed. Chemiresistive gas sensors own lots of merits but suffer from high relative humidity (RH). Furthermo...

Mixed lineage kinase domain-like protein (MLKL), a critical necroptosis effector, is strongly linked to inflammation, a key component of skin wound healing. However, its precise role in the wound healing process remains inadequately characterized. This study revealed sustained MLKL overexpression throughout the wound healing process, not limited to...

Tumor immune checkpoint therapy (ICT) aims to block immune escape signals between tumor and immune cells. However, low delivery efficiency of immune checkpoint inhibitors (ICIs), narrow single-target approach, and reduced responsiveness notably hinder clinical development of ICT. Here, we developed a nanoliposome-bacteria hybrid system that acts as...

Digital medical imaging, particularly pathology images, is essential for cancer diagnosis but faces challenges in direct model training due to its super-resolution nature. Although weakly supervised learning has reduced the need for manual annotations, many multiple instance learning (MIL) methods struggle to effectively capture crucial spatial rel...

Radiation induced lung injury, known as the main complication of thoracic radiation, remains to be a major resistance to tumor treatment. Based on the recent studies on radiation-induced lung injury, this review collated the possible mechanisms at the level of target cells and key pathways, corresponding prognostic models including predictors, pati...

Background The molecular basis for the disparities between primary ovarian cancer (POC) and ovarian cancer secondary to breast cancer (OCSTBC) remains poorly understood. This study aimed to explore the different characteristics between them through genomic analysis. Methods We performed differentially expressed genes (DEGs) analysis between POC (n...

Recrystallization is an important diagenetic process that widely occurs in carbonate rocks as a result of increasing temperature and pressure during burial. Exploration has revealed that carbonate rocks affected by recrystallization vary in their reservoir properties. To investigate the favorable development conditions of recrystallized carbonate r...

Radio-immunotherapy has antitumor activity but also causes toxicity, which limits its clinical application. JS-201 is a dual antibody targeting PD-1 and TGF-β signaling. We investigated the antitumour effect of JS-201 combined with radiotherapy and the effect on radiation-induced lung injury (RILI). Different tumor models were established to detect...

Breast cancer is one of the most prevalent cancers among women, with early detection playing a critical role in improving survival rates. This study introduces a novel transformer-based explainable model for breast cancer lesion segmentation (TEBLS), aimed at enhancing the accuracy and interpretability of breast cancer lesion segmentation in medica...

Radiation pneumonitis (RP) is characterized by inflammation and is associated with autophagy. However, the relationship between functional genetic variants of autophagy-related genes and radiation pneumonitis remains unknow. In this study we aimed to investigate whether genetic variants of genes involved in autophagy are associated with radiation p...

Programmed cell death protein-1 (PD-1) inhibitors plus chemotherapy have been the standard of care in the first-line treatment of advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma; however, the survival benefits are modest in patients with low programmed death ligand 1 (PD-L1) expression. Here we investigated the efficacy and saf...

Traditional limb kinematic analysis relies on manual goniometer measurements. With computer vision advancements, integrating RGB cameras can minimize manual labor. Although deep learning-based cameras aim to offer the same ease as manual goniometers, previous approaches have prioritized accuracy over efficiency and cost on PC-based devices. Neverth...

As a form of clean energy, hydrogen (H 2 ) offers significant potential to mitigate the effects of global warming caused by fossil fuels. The development of high-performance H 2 gas sensors is...

As a clean and sustainable energy storage technology, zinc-air batteries (ZABs) offer significant potential for future applications. However, the development of efficient, stable, and cost-effective non-precious metal catalysts for the...

This phase 2/3 trial (NCT04856787) assessed the efficacy and safety of SHR-1701, a bifunctional protein targeting PD-L1 and TGF-β, in combination with BP102 (a bevacizumab biosimilar) and XELOX (capecitabine plus oxaliplatin) as a first-line treatment for unresectable metastatic colorectal cancer (mCRC). In this phase 2 study, a total of 62 patient...

In recent years, photocatalytic materials with a nanofiber-like morphology have garnered a surge of academic attention due to their distinctive properties, including an expansive specific surface area, a considerable high aspect ratio, a pronounced resistance to agglomeration, superior electron survivability, and robust surface activity. Consequent...

Cuproptosis is an emerging mode of programmed cell death for tumor suppression but sometimes gets resisted by tumor cells resist under specific mechanisms. Inhibiting copper transporter ATPase (ATP7A) was found to disrupt copper ion homeostasis, thereby enhancing the effect of cuproptosis and eventually inhibiting tumor invasion and metastasis. In...

Lung adenocarcinoma (LUAD) is the major subtype of lung cancer. The poor prognosis of LUAD patients is attributed primarily to metastasis. ADAMTS16 is a crucial member of the ADAMTS family and is involved in tumor progression. However, its role and regulatory mechanism in LUAD remain unexplored. In this study, ADAMTS16 was identified as a crucial o...

A Dirac quantum spin liquid hosts Dirac spinons, which are low-energy fractionalized neutral quasiparticles with spin 1/2 that obey the Dirac equation. Recent studies have revealed cone spin continuum in YCu$_3$(OD)$_6$Br$_2$[Br$_{x}$(OD)$_{1-x}$], consistent with the convolution of two Dirac spinons. In this work, we further studied spin excitatio...

The density peak clustering (DPC) algorithm identifies patterns in high-dimensional data and obtains robust outcomes across diverse data types with minimal hyperparameters. However, DPC may produce inaccurate pattern sizes in multi-dimensional datasets and exhibit poor performance in recognizing similar patterns. To solve these issues, we propose t...

Background Short term results of the change of center of rotation (COR) after Bryan cervical disc replacement (CDR) have been reported. However, there is a lack of long-term studies focusing on the COR and its influences on facet joint degeneration. Objective To evaluate the long-term clinical and radiographic results of Bryan CDR, and to explore...

Clear cell renal cell carcinoma (ccRCC) is tightly associated with VHL (von Hippel-Lindau tumor suppressor) mutation and dysregulated angiogenesis. Accumulating evidence indicates that antiangiogenic treatment abolishing tumor angiogenesis can achieve longer disease-free survival in patients with ccRCC. Atractylenolide I (ATL-I) is one of the main...

As a promising gene therapy strategy, controllable small molecule‐mRNA covalent modification in tumor cells could be initiated by singlet oxygen (¹O2) to complete the modification process. However, in vivo generation of ¹O2 is usually dependent on excitation of external light, and the limited light penetration of tissues greatly interferes the deve...

Species with different genetic backgrounds exhibit distinct metabolic traits. Nine beef cattle were selected for the experiment to study changes in serum metabolic phenotypes, rumen microbiota diversity, and composition in beef cattle from different genetic backgrounds. Three groups were Chinese Simmental (S group), Simmental×Chinese Holstein (SH g...

A novel and highly efficient photocatalyst of a AgBiO3/BiOCl heterojunction has been developed via a facile water bath and in situ precipitation method. The photocatalytic activities of the catalysts were investigated by the degradation of ciprofloxacin (CIP) under visible-light irradiation (>420 nm). The experiment results revealed that the photoc...

Background: Colorectal cancer (CRC) remains a significant global health challenge, often characterized by late-stage metastasis and poor prognosis. The Runt-related transcription factor 1 (RUNX1) plays a dual role as both an oncogene and a tumor suppressor in various cancers, including CRC. However, the specific regulatory mechanisms of RUNX1 in CR...

Accurate tumor detection is crucial for the early discovery and subsequent treatment of small neoplastic foci. Molecular imaging, which combines non-invasiveness, high specificity, and strong sensitivity, excels in diagnosing early...

Background It has been demonstrated that aberrant androgen receptor (AR) signaling contributes to the pathogenesis of prostate cancer (PCa). To date, the most efficacious strategy for the treatment of PCa remains to target the AR signaling axis. However, numerous PCa patients still face the issue of overtreatment or undertreatment. The establishmen...

Quantum spin liquids represent exotic states of spin systems characterized by long-range entanglement and emergent fractionalized quasiparticles. It is generally believed that disorder is hostile to quantum spin liquids. In our study, we investigated the magnetic properties of a kagome system, YCu3(OH)6[(ClxBr1−x)3−y(OH)y]. Within this system, some...

Background A successful immune response against tumors depends on various cellular processes. Hence, there is an urgent need to construct a proficient nanoplatform for immunotherapy that can concurrently regulate the activities of various cells participating in the immune process. We have developed zeolitic imidazolate framework-8 (ZIF-8) formula,...

As a promising gene therapy strategy, controllable small molecule‐mRNA covalent modification in tumor cells could be initiated by singlet oxygen (1O2) to complete the modification process. However, in vivo generation of 1O2 is usually dependent on excitation of external light, and the limited light penetration of tissues greatly interferes the deve...

Hepatitis E virus (HEV) is a foodborne zoonotic pathogen that is supposed to be one of the most common causes of acute viral hepatitis. However, HEV infection has been recently associated with a wide spectrum of extrahepatic manifestations, particularly neurological disorders. Previous studies have shown that HEV is able to cross the blood–brain ba...

Immune cell infiltration and tumor-related immune molecules play key roles in tumorigenesis and tumor progression. The influence of immune interactions on the molecular characteristics and prognosis of clear cell renal cell carcinoma (ccRCC) remains unclear. A machine learning algorithm was applied to the transcriptome data from The Cancer Genome A...

Accumulating evidence supports the concept that DNA damage response targeted therapies can improve antitumor immune response by increasing the immunogenicity of tumor cells and improving the tumor immune microenvironment. Ataxia telangiectasia mutated (ATM) is a core component of the DNA repair system. Although the ATM gene has a significant mutati...

Immune checkpoint inhibitors, particularly PD-1/PD-L1 blockades, have been approved for unresectable hepatocellular carcinoma (HCC). However, high resistance rates still limit their efficacy, highlighting the urgent need to understand the underlying mechanisms and develop strategies for overcoming the resistance. In this study, tankyrasel binding p...

Graphitic carbon nitride (g-C3N4) has been extensively investigated over the past decade for its potential utilizations in photocatalytic energy generation and pollutant degradation. To better meeting the requirements for practical utilizations, it is crucial to address the issue of poor charge separation properties in g-C3N4, which origin from the...

The pseudokinase mixed lineage kinase domain-like protein (MLKL) acts as a crucial effector in the necroptosis pathway. It is widely recognized that MLKL-dependent necrosis is closely related to inflammation in wound healing, which contributes to detrimental pathologies. In present study, transcriptome sequencing data indicate sustained overexpress...

e14549 Background: Combined immunotherapy has become the preferred treatment for HCC. However, it faces challenges: possible serious adverse reactions, the low objective response rate, and the median overall survival is about 20 months, which is far from meeting the clinical treatment needs. There is still a lack of effective predictive biomarkers...

e16191 Background: The rising elderly population worldwide has led to an increase in cases of liver cancer among individuals aged ≥65 years. With the advancement of medical treatments, the management of unresectable hepatocellular carcinoma (uHCC) now predominantly involves immunotherapy combination therapy. However, existing data in elderly patien...

Background The soft-tissue tension is closely associated with postoperative hip dislocation in patients undergoing total hip arthroplasty (THA), especially for those patients with neurological disorders and insufficient muscle tension. The aim of this study is to explore the effect of limb lengthening on the incidence of complications following THA...

Species with different genetic backgrounds exhibit distinct metabolic traits. Nine beef cattle were selected for the experiment to study changes in serum metabolic phenotypes, rumen microbiota diversity, and composition in beef cattle from different genetic backgrounds. Three groups were Chinese Simmental (S group), Simmental×Chinese Holstein (SH g...

The sluggish kinetics of the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) significantly impede the broader implementation of Zn-air batteries (ZABs), underscoring the necessity for advanced high-efficiency materials to catalyze these electrochemical processes. Recent advancements have highlighted the potential of transiti...

Customizable and number‐tunable enzyme delivery nanocarriers will be useful in tumor therapy. Herein, a phage vehicle, T4‐Lox‐DNA‐Fe (TLDF), which adeptly modulates enzyme numbers using phage display technology to remodel the tumor microenvironment (TME) is presented. Regarding the demand for lactic acid in tumors, each phage is engineered to displ...

High-performance H 2 gas sensors based on monolayer 2D metal oxide-MoO 3 doped with Pt/Rh has been predicted. With a binding energy of −5.262 eV/−5.877 eV, the substitutional doping of Pt/Rh for Mo is a stable doping. After adsorbing O 2 in air, the band gap of Pt/Rh-MoO 3 decreases by 0.62 eV/0.51 eV due to the appearance of the impurity levels an...

Nanomaterials, including ZIF‐8 nanoparticles (NPs), are shown to be effective antimicrobial agents against Methicillin‐resistant Staphylococcus aureus(MRSA). However, the antibiofilm properties and mechanisms of ZIF‐8 NPs remain uncertain. In this study, ZIF‐8 NPs are prepared using the room temperature solution reaction method and characterized. B...

Backgroud Accumulating evidence supports the concept that DNA damage response (DDR) targeted therapies can improve antitumor immune response by increasing the immunogenicity of tumor cells and improving the tumor immune microenvironment. Ataxia telangiectasia mutated (ATM) is a core component of the DNA repair system. Although ATM gene has a signif...

Runt-related transcription factors (RUNX) are a family of transcription factors that are essential for normal and malignant hematopoietic processes. Their most widely recognized role in malignancy is to promote the occurrence and development of acute myeloid leukemia. However, it is worth noting that during the last decade, studies of RUNX proteins...

The development of low-cost and efficient cathode catalysts is crucial for the advancement of fuel cells, as the oxygen reduction reaction (ORR) on the cathode is constrained by expensive commercial Pt/C catalysts and a significant energy barrier. Metal-organic frameworks (MOFs) are considered excellent precursors for synthesizing carbon nanomateri...

Objective In hip disease patients, pain and movement restrictions might cause changes in bone strength and increase the likelihood of falls, finally leading to hip fracture. The aim of this study was to identify the incidence of, characteristics of and risk factors for hip fracture in patients with existing hip disease. Methods This was a retrospe...

Although antiprogrammed death 1 antibody plus chemotherapy has recently been approved for first-line esophageal squamous cell carcinoma (ESCC), antiprogrammed death-ligand 1 antibody may offer another combination option in this setting. In this multicenter, randomized, double-blinded phase 3 trial a total of 540 adults (aged 18–75 years) with unres...

A significant hurdle in current deep-sea microbial research remains the inability to capture these microbes in their natural habitat. Optical tweezers, with their non-contact, low-damage, and highly precise capabilities, present an ideal solution for capturing and manipulating microorganisms in liquid environments, showing promise in capturing deep...

Purpose To study the role of mitochondrial metabolism and obtain novel biomarkers in immunotherapy for non-small cell lung cancer (NSCLC). Methods We collected the 188 genes involved in mitochondrial metabolism(MMGs) from the MSIGDB project and then quantified the activity of mitochondrial metabolism. All the NSCLC patients were divided into C1 an...

A facile Z-scheme AgCl/BiOCl heterojunction photocatalyst with oxygen vacancies was fabricated by a water-bath method. The structural, morphological, optical and electronic properties of as-synthesized samples were systematically characterized. The oxygen vacancies were confirmed by EPR, which could optimize the band-gap of the AgCl/BiOCl heterojun...