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Publications (939)
Objective
Epiretinal prostheses are designed to restore vision to people blinded by photoreceptor degenerative diseases by stimulating surviving retinal ganglion cells (RGCs), which carry visual signals to the brain. However, inadvertent stimulation of RGCs at their axons can result in non-focal visual percepts, limiting the quality of artificial v...
Variation in the neural code between individuals contributes to making each person unique. Using ~100 neural population recordings from major ganglion cell types in the macaque retina, we develop an interpretable computational representation of individual variability using machine learning. This representation preserves invariances, such as asymmet...
Retinal prostheses must be able to activate cells in a selective way in order to restore high-fidelity vision. However, inadvertent activation of far-away retinal ganglion cells (RGCs) through electrical stimulation of axon bundles can produce irregular and poorly controlled percepts, limiting artificial vision. Therefore, the problem of axon bundl...
Sensory information from different modalities is processed in parallel, and then integrated in associative brain areas to improve object identification and the interpretation of sensory experiences. The Superior Colliculus (SC) is a midbrain structure that plays a critical role in integrating visual, auditory, and somatosensory input to assess sali...
The visual message conveyed by a retinal ganglion cell (RGC) is often summarized by its spatial receptive field, but in principle also depends on the responses of other RGCs and natural image statistics. This possibility was explored by linear reconstruction of natural images from responses of the four numerically-dominant macaque RGC types. Recons...
Electrical stimulation of retinal ganglion cells (RGCs), which transmit visual information to the brain, is used in retinal implants to treat blindness caused by photoreceptor degeneration. However, the performance of existing clinical implants is limited by indiscriminate stimulation of many cells and cell types. Recent work in isolated macaque re...
The functional organization of diverse retinal ganglion cell (RGC) types, which shape the visual signals transmitted to the brain, has been examined in many species. The unique spatial, temporal, and chromatic properties of the numerically dominant RGC types in macaque monkey retina are presumed to most accurately model human vision. However, the f...
The visual message conveyed by a retinal ganglion cell (RGC) is often summarized by its spatial receptive field, but in principle should also depend on other cells' responses and natural image statistics. To test this idea, linear reconstruction (decoding) of natural images was performed using combinations of responses of four high-density macaque...
Responses of sensory neurons are often modeled using a weighted combination of rectified linear subunits. Since these subunits often cannot be measured directly, a flexible method is needed to infer their properties from the responses of downstream neurons. We present a method for maximum likelihood estimation of subunits by soft-clustering spike-t...
Sound localization plays a critical role in animal survival. Three cues can be used to compute sound direction: interaural timing differences (ITDs), interaural level differences (ILDs) and the direction-dependent spectral filtering by the head and pinnae (spectral cues). Little is known about how spectral cues contribute to the neural encoding of...
Sound localization plays a critical role in animal survival. To compute the incident sound direction, the animal can use three cues: interaural timing differences (ITDs), interaural level differences (ILDs) and the direction-dependent spectral filtering of the sound by the head and pinnae (spectral cues). Compared to ITDs and ILDs, little is known...
The functions of the diverse retinal ganglion cell types in primates and the parallel visual pathways they initiate remain poorly understood. Here, unusual physiological and computational properties of the ON and OFF smooth monostratified ganglion cells are explored. Large-scale multi-electrode recordings from 48 macaque retinas revealed that these...
The visual functions of the diverse retinal ganglion cell types in the primate retina, and the parallel visual pathways they initiate, remain poorly understood. Here, the unusual physiological and computational properties of the ON and OFF smooth monostratified (SM) ganglion cells are explored. Large-scale multi-electrode recordings from 48 macaque...
Integration of rectified synaptic inputs is a widespread nonlinear motif in sensory neuroscience. We present a novel method for maximum likelihood estimation of nonlinear subunits by soft-clustering spike-triggered stimuli. Subunits estimated from parasol ganglion cells recorded in macaque retina partitioned the receptive field into compact regions...
Objective:
Epiretinal prostheses are designed to restore vision in people blinded by photoreceptor degenerative diseases, by directly activating retinal ganglion cells (RGCs) using an electrode array implanted on the retina. In present-day clinical devices, current spread from the stimulating electrode to a distant return electrode often results i...
Objective
Epiretinal prostheses are designed to restore vision in people blinded by photoreceptor degenerative diseases, by directly activating retinal ganglion cells (RGCs) using an electrode array implanted on the retina. In present-day clinical devices, current spread from the stimulating electrode to a distant return electrode often results in...
A search for W′-boson production in the W′→tb¯→qq¯′bb¯ decay channel is presented using 36.1fb⁻¹ of 13 TeV proton–proton collision data collected by the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The search is interpreted in terms of both a left-handed and a right-handed chiral W′ boson within the mass range 1–5 TeV. Identificati...
A direct search for the standard model Higgs boson decaying to a pair of charm quarks is presented. Associated production of the Higgs and Z bosons, in the decay mode ZH→ℓ+ℓ−cc¯ is studied. A data set with an integrated luminosity of 36.1 fb−1 of pp collisions at s=13TeV recorded by the ATLAS experiment at the LHC is used. The H→cc¯ signature is id...
A search is presented for photonic signatures, motivated by generalized models of gauge-mediated supersymmetry breaking. This search makes use of proton-proton collision data at s=13 TeV corresponding to an integrated luminosity of 36.1 fb−1 recorded by the ATLAS detector at the LHC, and it explores models dominated by both strong and electroweak p...
A search for the narrow structure, X(5568), reported by the D0 Collaboration in the decay sequence X→Bs0π±, Bs0→J/ψϕ, is presented. The analysis is based on a data sample recorded with the ATLAS detector at the LHC corresponding to 4.9 fb−1 of pp collisions at 7 TeV and 19.5 fb−1 at 8 TeV. No significant signal was found. Upper limits on the number...
A search for the standard model Higgs boson produced in association with a top-quark pair, tt¯H, is presented. The analysis uses 36.1 fb−1 of pp collision data at s=13 TeV collected with the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The search targets the H→bb¯ decay mode. The selected events contain either one or two electrons...
A search for the associated production of the Higgs boson with a top quark pair (tt¯H) is reported. The search is performed in multilepton final states using a data set corresponding to an integrated luminosity of 36.1 fb−1 of proton-proton collision data recorded by the ATLAS experiment at a center-of-mass energy s=13 TeV at the Large Hadron Colli...
A search for long-lived, massive particles predicted by many theories beyond the Standard Model is presented. The search targets final states with large missing transverse momentum and at least one high-mass displaced vertex with five or more tracks, and uses 32.8 fb−1 of s=13 TeVpp collision data collected by the ATLAS detector at the LHC. The obs...
A search for electroweak production of supersymmetric particles in scenarios with compressed mass spectra in final states with two low-momentum leptons and missing transverse momentum is presented. This search uses proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider in 2015–2016, corresponding to 36.1 fb−1 of in...
The dynamics of isolated-photon production in association with a jet in proton–proton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fb⁻¹. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti-kt algorith...
A measurement of the production of three isolated photons in proton–proton collisions at a centre-of-mass energy s=8 TeV is reported. The results are based on an integrated luminosity of 20.2 fb −1 collected with the ATLAS detector at the LHC. The differential cross sections are measured as functions of the transverse energy of each photon, the dif...
The modification of the production of J/ ψ, ψ(2 S) , and Υ(nS) (n= 1 , 2 , 3) in p+Pb collisions with respect to their production in pp collisions has been studied. The p+Pb and pp datasets used in this paper correspond to integrated luminosities of 28nb-1 and 25pb-1 respectively, collected in 2013 and 2015 by the ATLAS detector at the LHC, both at...
A detailed study of multiparticle azimuthal correlations is presented using pp data at s=5.02 and 13 TeV, and p+Pb data at sNN=5.02 TeV, recorded with the ATLAS detector at the CERN Large Hadron Collider. The azimuthal correlations are probed using four-particle cumulants cn{4} and flow coefficients vn{4}=(−cn{4})1/4 for n=2 and 3, with the goal of...
Measurements of ZZ production in the ℓ+ℓ−ℓ′+ℓ′− channel in proton–proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented. The data correspond to 36.1 fb−1 of collisions collected by the ATLAS experiment in 2015 and 2016. Here ℓ and ℓ′ stand for electrons or muons. Integrated and differential ZZ→ℓ+ℓ−ℓ′+ℓ′− cross...
A search is presented for the direct pair production of the stop, the supersymmetric partner of the top quark, that decays through an R-parity-violating coupling to a final state with two leptons and two jets, at least one of which is identified as a b-jet. The data set corresponds to an integrated luminosity of 36.1 fb−1 of proton-proton collision...
A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fb⁻¹ of proton–proton collision data at s=13TeV collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle X is assumed to decay to a pair of light quarks, and the fully hadronic final state XH...
A search for an invisibly decaying Higgs boson or dark matter candidates produced in association with a leptonically decaying Z boson in proton–proton collisions at s=13 TeV is presented. This search uses 36.1 fb −1 of data collected by the ATLAS experiment at the Large Hadron Collider. No significant deviation from the expectation of the Standard...
Bose-Einstein correlations between identified charged pions are measured for p+Pb collisions at sNN=5.02TeV using data recorded by the ATLAS detector at the CERN Large Hadron Collider corresponding to a total integrated luminosity of 28nb−1. Pions are identified using ionization energy loss measured in the pixel detector. Two-particle correlation f...
The results of a search for squarks and gluinos in final states with an isolated electron or muon, multiple jets and large missing transverse momentum using proton-proton collision data at a center-of-mass energy of s=13 TeV are presented. The data set used was recorded during 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider and c...
A search for dark matter in association with a Higgs boson decaying to two photons is presented. This study is based on data collected with the ATLAS detector, corresponding to an integrated luminosity of 36.1 fb−1 of proton-proton collisions at the LHC at a center-of-mass energy of 13 TeV in 2015 and 2016. No significant excess over the expected b...
The analysis of the momentum difference between charged hadrons in high-energy proton-proton collisions is performed in order to study coherent particle production. The observed correlation pattern agrees with a model of a helical QCD string fragmenting into a chain of ground-state hadrons. A threshold momentum difference in the production of adjac...
Simultaneous electrical stimulation and recording using multi-electrode arrays can provide a valuable technique for studying circuit connectivity and engineering neural interfaces. However, interpreting these measurements is challenging because the spike sorting process (identifying and segregating action potentials arising from different neurons)...
Supplemental mathematical details.
(PDF)
Stimulation artifact details.
A. Raw artifact traces at the smallest amplitude of stimulation (0.1 μA), considered an estimate of μ, the switching artifact. B. Raw artifact traces at 0.99 μA of stimulus. C. Difference. Notice that the main text refers to this already mean-subtracted artifact. D.
Left: Raw artifact at all different stimuli for a non...
Distribution of EI strength on the stimulating electrode among spike events, both for somatic and axonal (distant) stimulation.
For somatic stimulation inset corresponds to a zoom to smallest voltages. For EI peak strengths smaller than 10μV spike is not observed (based on manual analysis).
(EPS)
Latency distribution.
Population based estimates of the mean (top) and standard deviation (bottom) of spike latency, as a function of probability of spiking (left) and stimulus amplitude (right). This supports the observation that when activation is reached (high probability of spike) variability of latencies reaches its minimum.
(EPS)
Population results(log scale) including the mean-of-traces estimator proposed in [20] and our simplified estimator.
These results complement Fig 6A, by reporting differences by type of estimator, and also by reporting total errors.
(EPS)
Comparison of simplified and kernel-based estimator in the analysis of perturbations to real data.
These results complement Fig 6B, by reporting false positive and negative rates at different conditions for trial subsampling (top), amplitude subsampling (middle) and noise injection (bottom). Only for single electrode stimulation. Notice that for tr...
The linear superposition of artifacts provides a reasonable phenomenological model for two electrode stimulation.
Observations are based on a single retinal preparation (TTX). A) example of observed linearity: A1-A2) artifacts for single electrode stimulation at two different stimulating electrodes with same strength (3.1 μ A) and opposite polariti...
Experimental procedures.
(PDF)
These proceedings provide an overview of the new results obtained with the ATLAS detector at the LHC, which were presented in the Quark Matter 2017 conference. These results were covered by twelve parallel talks, one flash talk and eleven posters. These proceedings group these results into five areas: initial state, jet quenching, quarkonium produc...
Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a b¯b pair with the ATLAS detector using 36.1 fb−1 of pp collisions at a center-of-mass energy of 13 TeV at the LHC. The ob...
Ultra-peripheral heavy ion collisions provide a unique opportunity to study the parton distributions in the colliding nuclei via the measurement of photo-nuclear jet production. An analysis of jet production in ultra-peripheral Pb+Pb collisions at √sNN = 5.02 TeV performed using data collected with the ATLAS detector in 2015 is described. The data...
Simultaneous electrical stimulation and recording using multi-electrode arrays can provide a valuable technique for studying circuit connectivity and engineering neural interfaces. However, interpreting these measurements is challenging because the spike sorting process (identifying and segregating action potentials arising from different neurons)...
Jet energy scale measurements and their systematic uncertainties are reported for jets measured with the ATLAS detector using proton-proton collision data with a center-of-mass energy of s=13 TeV, corresponding to an integrated luminosity of 3.2 fb−1 collected during 2015 at the LHC. Jets are reconstructed from energy deposits forming topological c...
Dijet events are studied in the proton-proton collision data set recorded at s=13 TeV with the ATLAS detector at the Large Hadron Collider in 2015 and 2016, corresponding to integrated luminosities of 3.5 fb−1 and 33.5 fb−1 respectively. Invariant mass and angular distributions are compared to background predictions and no significant deviation is...
The rejection of forward jets originating from additional proton–proton interactions (pile-up) is crucial for a variety of physics analyses at the LHC, including Standard Model measurements and searches for physics beyond the Standard Model. The identification of such jets is challenging due to the lack of track and vertex information in the pseudo...
Light-by-light scattering (γ γ → γ γ ) is a quantum-mechanical process that is forbidden in the classical theory of electrodynamics. This reaction is accessible at the Large Hadron Collider thanks to the large electromagnetic field strengths generated by ultra-relativistic colliding lead ions. Using 480 µb −1 of lead–lead collision data recorded at...
A search for the dimuon decay of the Higgs boson was performed using data corresponding to an integrated luminosity of 36.1 fb−1 collected with the ATLAS detector in pp collisions at √s=13 TeV at the Large Hadron Collider. No significant excess is observed above the expected background. The observed (expected) upper limit on the cross section times...
ATLAS measurements of two-particle correlations are presented for √s=5.02 and 13 TeV pp collisions and for √sNN=5.02 TeV p+Pb collisions at the LHC. The correlation functions are measured as a function of relative azimuthal angle Δϕ, and pseudorapidity separation Δη, using charged particles detected within the pseudorapidity interval |η|<2.5. Azimu...
The superior colliculus (SC) receives direct input from the retina and integrates it with information about sound, touch, and state of the animal that is relayed from other parts of the brain to initiate specific behavioral outcomes. The superficial SC layers (sSC) contain cells that respond to visual stimuli, whereas the deep SC layers (dSC) conta...
Inclusive isolated-photon production in pp collisions at a centre-of-mass energy of 13 TeV is studied with the ATLAS detector at the LHC using a data set with an integrated luminosity of 3.2 fb−1. The cross section is measured as a function of the photon transverse energy above 125 GeV in different regions of photon pseudorapidity. Next-to-leading-...
This paper describes the implementation and performance of a particle flow algorithm applied to 20.2 fb −1−1 of ATLAS data from 8 TeV proton–proton collisions in Run 1 of the LHC. The algorithm removes calorimeter energy deposits due to charged hadrons from consideration during jet reconstruction, instead using measurements of their momenta from th...
Two-particle pseudorapidity correlations are measured in sNN=2.76TeVPb+Pb, sNN=5.02TeVp+Pb, and s=13TeVpp collisions at the Large Hadron Collider (LHC), with total integrated luminosities of approximately 7μb-1, 28 nb-1, and 65 nb-1, respectively. The correlation function CN(η1,η2) is measured as a function of event multiplicity using charged parti...
Multi-particle cumulants and corresponding Fourier harmonics are measured for azimuthal angle distributions of charged particles in pppp collisions at s√s = 5.02 and 13 TeV and in pp + Pb collisions at sNN−−−√sNN = 5.02 TeV, and compared to the results obtained for low-multiplicity Pb + PbPb + Pb collisions at sNN−−−√sNN = 2.76 TeV. These measureme...
Measurements of the production cross section of a ZZ boson in association with jets in proton–proton collisions at s√=13s=13 TeV are presented, using data corresponding to an integrated luminosity of 3.16 fb −1−1 collected by the ATLAS experiment at the CERN Large Hadron Collider in 2015. Inclusive and differential cross sections are measured for e...
High-precision measurements by the ATLAS Collaboration are presented of inclusive W+→ℓ+νW+→ℓ+ν , W−→ℓ−ν¯W−→ℓ−ν¯ and Z/γ∗→ℓℓZ/γ∗→ℓℓ ( ℓ=e,μℓ=e,μ ) Drell–Yan production cross sections at the LHC. The data were collected in proton–proton collisions at s√=7TeVs=7TeV with an integrated luminosity of 4.6fb−14.6fb−1 . Differential W+W+ and W−W− cross sect...
A measurement of the production cross section for two isolated photons in proton-proton collisions at a center-of-mass energy of s=8 TeV is presented. The results are based on an integrated luminosity of 20.2 fb-1 recorded by the ATLAS detector at the Large Hadron Collider. The measurement considers photons with pseudorapidities satisfying |ηγ|<1.3...
Epiretinal prostheses for treating blindness activate axon bundles, causing large, arc-shaped visual percepts that limit the quality of artificial vision. Improving the function of epiretinal prostheses therefore requires understanding and avoiding axon bundle activation. This paper introduces a method to detect axon bundle activation based on its...
Measurements of jet activity in top-quark pair events produced in proton–proton collisions are presented, using 3.2 fb−1 of pp collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS experiment at the Large Hadron Collider. Events are chosen by requiring an oppositecharge eμ pair and two b-tagged jets in the final state. The norm...
Measurements of jet activity in top-quark pair events produced in proton–proton collisions are presented, using 3.2 fb−1−1 of pp collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS experiment at the Large Hadron Collider. Events are chosen by requiring an opposite-charge eμeμ pair and two b-tagged jets in the final state. The...
This paper describes the algorithms for the reconstruction and identification of electrons in the central region of the ATLAS detector at the Large Hadron Collider (LHC). These algorithms were used for all ATLAS results with electrons in the final state that are based on the 2012 pp collision data produced by the LHC at s√ = 8 TeV. The efficiency o...
Ratios of top-quark pair to Z-boson cross sections measured from protonproton collisions at the LHC centre-of-mass energies of √ s = 13 TeV, 8 TeV, and 7 TeV are presented by the ATLAS Collaboration. Single ratios, at a given √ s for the two processes and at different √ s for each process, as well as double ratios of the two processes at different...