Lisa R Starr

• PhD
• Professor (Associate) at University of Rochester

Prior work consistently links additive genetic variation in the hypothalamic‐pituitary‐adrenal (HPA) axis—a multilocus genetic profile score (MGPS)—to depression risk in the context of stress exposure. However, despite that HPA MGPS variants were selected based on evidence that they elevate cortisol reactivity, there are surprisingly few tests of w...

Emotion differentiation (ED; the ability to distinguish discrete internal emotion states) may reflect or benefit from knowledge of linguistic labels. The present study uses natural language processing to examine how emotion vocabulary (EV; diversity of unique emotion terms within active vocabulary) relates to ED and depression in an adolescent samp...

Background: Efforts to identify risk and resilience factors for anxiety severity and course during the COVID-19 pandemic have focused primarily on demographic rather than psychological variables. Intolerance of uncertainty (IU), a transdiagnostic risk factor for anxiety, may be a particularly relevant vulnerability factor. Method: N = 641 adults wi...

Emotion differentiation (ED; the ability to distinguish discrete internal emotion states) may reflect or benefit from knowledge of linguistic labels. The present study uses natural language processing to examine how emotion vocabulary (EV; diversity of unique emotion terms within active vocabulary) relates to ED and depression in an adolescent samp...

Difficulty concentrating is an understudied cognitive phenomenon, despite its status as a diagnostic criterion for generalized anxiety disorder and contributor to clinically significant distress and impairment. Worry may constitute a cognitive mechanism by which anxiety leads to difficulty concentrating. The present study examined concurrent and pr...

Background: Efforts to identify risk and resilience factors for anxiety severity and course during the COVID-19 pandemic have focused primarily on demographic rather than psychological variables. Intolerance of uncertainty (IU), a transdiagnostic risk factor for anxiety, may be a particularly relevant vulnerability factor.Method: N = 641 adults wit...

Background: Efforts to identify risk and resilience factors for anxiety severity and course during the COVID-19 pandemic have focused primarily on demographic rather than psychological variables. Intolerance of uncertainty (IU), a transdiagnostic risk factor for anxiety, may be a particularly relevant vulnerability factor.Method: N = 641 adults wit...

Though sexual minority adolescents face a wide array of deleterious stressors, few studies have examined the role of specific types of stress exposure (i.e., chronic vs. episodic, interpersonal vs. non-interpersonal) on mental health disparities. This study utilizes a contextual threat-based assessment to (a) compare levels of stress exposure types...

Background and objectives: Increasing research underscores low positive emotion (PE) as a vital component of depression risk in adolescence. Theory also suggests that PE contributes to adaptive coping. However, it is unclear whether naturalistic experiences of emotions contribute to long-term depression risk, or whether daily PE levels equip adole...

Maladaptive emotion regulation (ER) strategies are important predictors of stress generation—the process by which individuals with certain traits are likely to experience higher levels of dependent (self-generated), but not independent (fateful), stressful life events. Positive affect (PA) dampening, the tendency to downregulate positive moods by r...

Research links life stressors, including acute, chronic, and early life stress, to the development of ruminative brooding. However, singular forms of life stress rarely occur in isolation, as adolescents typically encounter stressors that vary on important dimensions (e.g., types, timings, quantities) across development. The current study employs l...

The ability to make fine-grained distinctions between discrete negative emotions—termed negative emotion differentiation (NED)—is important for emotion regulation and psychological well-being. Posttraumatic stress disorder (PTSD) is associated with elevated trauma-related negative emotions (e.g., fear, anger, guilt, shame) and self-reported difficu...

Stress generation theory initially posited that depression elevates risk for some stressful events (i.e., dependent events) but not others (i.e., independent events). This preregistered meta-analytic review examined whether stress generation occurs transdiagnostically by examining 95 longitudinal studies with 38,228 participants (537 total effect s...

The stress generation hypothesis suggests that some individuals contribute more than others to the occurrence of dependent (self-generated), but not independent (fateful), stressful life events. This phenomenon is commonly studied in relation to psychiatric disorders, but effects are also driven by underlying psychological processes that extend bey...

Sexual minority (e.g., gay, lesbian, bisexual) people are at increased risk for suicidal thoughts and behaviors compared to their heterosexual peers. The interpersonal theory of suicide proposes that perceived burdensomeness and thwarted belongingness are central to the desire to die, and both are associated with suicidal ideation in sexual minorit...

Existing research supports competing hypotheses about the link between negative emotional (NE) reactivity to daily events (e.g., hassles and uplifts) and depression. Some have suggested that depression is associated with blunted reactivity, and others have suggested that depression is associated with heightened reactivity. In this study, we tested...

Co-rumination (defined as perseverative, negatively-focused discussions about problems) has been linked to internalizing symptoms, especially following psychosocial stress. The sudden outbreak of SARS-CoV-2, the virus causing Coronavirus disease 2019 (COVID-19) during Spring 2020 may have been a common focus of co-rumination. Conceptualized within...

Rumination is correlated with diverse types of internalizing problems, but the extent to which it relates to a higher-order internalizing spectrum versus disorder-specific pathology is unclear. Using a quantitative model of the internalizing dimension, we compared the strength of transdiagnostic versus diagnosis-specific pathways from brooding—the...

In their Nature Communications paper, AlShebli et al. showed that women scientists face under-citation relative to men, and that this effect was compounded when multiple women co-authored manuscripts together. None of this is surprising; it is consistent with a wide body of research documenting pernicious systematic and structural gender biases. Wh...

Childhood adversity appears to sensitize youth to stress, increasing depression risk following stressful life events occurring throughout the lifespan. Some evidence suggests hypothalamic–pituitary–adrenal (HPA) axis-related and serotonergic genetic variation moderates this effect, in a “gene-by-environment-by-environment” interaction (G × E × E)....

Anxiety disorders, including separation anxiety disorder, selective mutism, specific phobia, social anxiety disorder, panic disorder, agoraphobia, and generalized anxiety disorder, are among the most prevalent psychological disorders in children and adolescents. Adolescence is a period characterized by numerous changes in academic, occupational, fa...

Negative emotion differentiation (NED) is the ability to precisely discern negatively-valenced emotional states. Low NED has been linked to numerous negative outcomes. However, little is known about the conditions under which individual differences in NED emerge, particularly during adolescence, a potentially important developmental stage. We exami...

Objectives Although studies support a direct association between parent and child emotion regulation, little work has considered potential mechanisms, such as family context. For example, parents who have difficulty regulating their emotions may be more likely to adopt an authoritarian parenting style, especially under high family chronic stress, a...

Research suggests that childhood adversity (CA) is associated with a wide range of repercussions, including an increased likelihood of interpersonal stress generation. This may be particularly true following interpersonal childhood adversity (ICA) and for youth with high hypothalamic-pituitary-adrenal (HPA) axis-related genetic risk. In the current...

Rumination has been conceptualized as a stable, trait-level response style involving repetitive and passive focus on the symptoms of distress and the possible causes and consequences of those symptoms. This theoretical review examines developmental risk factors of ruminative response style, incorporating a developmental psychopathology perspective....

Negative emotion differentiation (NED) refers to the ability to identify and label discrete negative emotions. Low NED has been previously linked to depression and other indices of low psychological well-being. However, this construct has rarely been explored during adolescence, a time of escalating depression risk, or examined in the context of na...

Serotonin-linked genetic risk and stressful life event (SLE) interaction research has been criticized for using single genetic variants with inconsistent replicability. A recent study showed that a multilocus genetic profile score (MGPS) capturing additive risk from five serotonin-linked polymorphisms moderated the association between major interpe...

Developmental research documents that anhedonia, or diminished interest in usual activities, is associated with a diverse array of emotional problems in childhood and adolescence. Meanwhile, official nosologies desginate anhedonia as a more specific characteristic of major depressive disorder. Using a quantitative model of the internalizing domain,...

Research exploring the mechanisms by which specific genes contribute to overall marital quality is still in its beginning stages; however, one mechanism may be the link between the oxytocin receptor gene (OXTR) and behavioral deficits relevant to social support—a critical determinant of marital quality. Using 79 different-sex married couples (N = 1...

Research suggests that genetic variants linked to hypothalamic-pituitary-adrenal (HPA)-axis functioning moderate the association between environmental stressors and depression, but examining gene–environment interactions with single polymorphisms limits power. The current study used a multilocus genetic profile score (MGPS) approach to measuring HP...

Chronic stress exposure has been shown to alter hypothalamic-pituitary-adrenal (HPA) axis functioning, which may mediate its effects on psychopathology and negative health outcomes. The nature of the chronic stress-HPA axis dysregulation is unclear and individuals likely vary in the extent to and manner in which indices of HPA axis regulation, such...

Childhood adversity (CA) is known to predict sensitization to proximal stressors. Researchers have suggested that disruptions in hypothalamus–pituitary–adrenal axis functioning may be a biological mechanism. If so, CA may predict altered associations between proximal life stress and markers of cortisol secretion. We examined whether CA moderates as...

Depressive rumination has been strongly linked to the development and maintenance of depression; however, less attention has been paid to ruminative processes in response to positive affect, and fewer have examined these processes in daily life. The current study sought to address these gaps by exploring depressive rumination and two forms of respo...

Many scholars posit that engaging in civic actions enhances mental health, yet existing evidence is limited. To address gaps in the literature and advance understanding of benefits of civic engagement from adolescence to young adulthood, we estimated a longitudinal structural model to test bidirectional associations between civic engagement (i.e.,...

Research suggests the ability to differentiate discrete emotions protects against psychopathology. Little is known about daily processes through which negative and positive emotion differentiation (NED, PED) influence depressive symptomatology. We examined NED and PED as moderators of associations between daily processes (negative/positive experien...

1 Background Anxiety and depression are commonly comorbid with each other, with anxiety often temporally preceding the development of depression. Although increasingly research has begun to investigate the role of sleep problems in depression, no study has examined insomnia as a mediator in the longitudinal relationship between anxiety and subseque...

Objective: Despite proliferation of laboratory-based studies examining reward functioning in depression, few studies have examined these processes in everyday life. We addressed this shortcoming by exploring experience and anticipation of uplifting experiences under ecologically valid conditions METHOD: One hundred fifty-seven young adults, oversa...

Biased stress appraisals critically relate to the origins and temporal course of many—perhaps most—forms of psychopathology. We hypothesized that aberrant stress appraisals are linked directly to latent internalizing and externalizing traits that, in turn, predispose to multiple disorders. A high-risk community sample of 815 adolescents underwent s...

Background: Anxiety often precedes depression. The anxiety response styles theory of comorbidity suggests anxious individuals with a tendency to ruminate or make hopeless attributions about anxiety symptoms (negative anxiety response styles [NARS]) are more vulnerable to subsequent depressive symptoms. However, this theory has never been tested in...

Studies support a link between adolescent romantic involvement and depression. Adolescent romantic relationships may increase depression risk by introducing chronic stress, and genetic vulnerability to stress reactivity/emotion dysregulation may moderate these associations. We tested genetic moderation of longitudinal associations between adolescen...

Research has linked depression to maladaptive variants of support seeking, including co-rumination (CR) and excessive reassurance seeking (ERS), which may contribute to symptom onset and maintenance. Although both CR and ERS are associated with depression, insufficient research has examined how daily behaviors and experiences interact with trait-le...

Adolescent romantic involvement is statistically normative and makes important contributions to relational development. Social anxiety is a prevalent problem in adolescents and is likely to interfere with the development of healthy romantic functioning. In the current chapter, we first review the nature of adolescent romantic relationships and thei...

Previous research supports gene-environment interactions for polymorphisms in the corticotropin hormone receptor 1 gene (CRHR1) and the serotonin transporter gene linked polymorphic region (5-HTTLPR) in predicting depression, but it has rarely considered genetic influences on stress sensitization processes, whereby early adversities (EA) increase d...

Anxiety disorders tend to precede onset of comorbid depression. Several researchers have suggested a causal role for anxiety in promoting depressive episodes, but few studies have identified specific mechanisms. The current study proposes an interpersonal model of comorbidity, where anxiety disorders disrupt interpersonal functioning, which in turn...

Transdiagnostic and disorder-specific models of intergenerational transmission of internalizing pathology – ERRATUM - Volume 44 Issue 1 - L. R. Starr, C. C. Conway, C. L. Hammen, P. A. Brennan

Background: Numerous studies have supported an association between maternal depression and child psychiatric outcomes, but few have controlled for the confounding effects of both maternal and offspring co-morbidity. Thus, it remains unclear whether the correspondence between maternal and offspring depressive and anxiety disorders is better explain...

Anxiety and depression co-occur, both at the disorder and symptom levels, and within anxiety disorders, fluctuations in daily anxious mood correspond temporally to fluctuations in depressed mood. However, little is known about the factors or conditions under which anxiety and depressive symptoms are most likely to co-occur. The current study invest...

Previous research demonstrates that carriers of the short allele of the serotonin transporter gene (5-HTTLPR) show both greater susceptibility to depression in response to stressful life events and higher rates of generation of stressful events in response to depression. The current study examines relational security (i.e., self-reported beliefs ab...

The current research proposes that certain anxiety response styles (specifically, responding to anxiety symptoms with rumination or hopeless cognitions) may increase risk of depressive symptoms, contributing to anxiety-depression comorbidity. We delineate preliminary evidence for this model in three studies. In Study 1, controlling for anxiety resp...

The current study examines longitudinal associations between light and heavy sexual experiences and psychiatric symptoms in African American adolescent girls receiving mental health care. Research supports bidirectional associations between adolescent romantic and sexual behaviors and depression and other mental health problems, but this finding ha...

Research suggests that a polymorphism in the promoter region of the serotonin transporter promoter (5-HTTLPR) interacts with stressful life events to predict depressive onset, with short (s) allele presence associated with greater susceptibility to stressors. However, this research has not considered that depressed individuals often actively genera...

Research has linked adolescent romantic and sexual activities to depressive symptoms. The current study examines whether such activities are uniquely linked to depressive symptoms versus symptoms of other disorders (including anxiety, externalizing, and eating disorders), and whether co-occurring symptoms more precisely account for the association...

Two studies examined associations between social networking and depressive symptoms among youth. In Study 1, 384 participants (68% female; mean age = 20.22 years, SD = 2.90) were surveyed. In Study 2, 334 participants (62% female; M age = 19.44 years, SD = 2.05) were surveyed initially and 3 weeks later. Results indicated that depressive symptoms w...

Research suggests that anxiety disorders tend to temporally precede depressive disorders, a finding potentially relevant to understanding comorbidity. The current study used diary methods to determine whether daily anxious mood also temporally precedes daily depressed mood. 55 participants with generalized anxiety disorder (GAD) and history of depr...

Because the ability to flexibly experience and appropriately express emotions across a range of developmentally relevant contexts is crucial to adaptive functioning, we examined how adolescent attachment security may be related to more functional emotional behavior during a relationship promoting interaction task. Data were collected from 74 early...

Davila, J., La Greca, A. M., Starr, L. R., & Landoll, R. (2010). Anxiety disorders in adolescence. In J. G. Beck (Ed.), Interpersonal processes in anxiety disorders. Washington, D.C.: American Psychological Association.

Co-rumination, or excessive discussion of problems within friendships, has been associated with internalizing symptoms and is especially prevalent among adolescent girls. Eighty-three early adolescent girls participated in a prospective study further examining this construct. Co-rumination was positively correlated with depressive symptoms and posi...

This article presents preliminary psychometric data on the reliability and validity of the newly developed Romantic Competence Interview (RCI). The RCI is an interviewer-assessed measure designed to assess competence among adolescents regardless of romantic relationship status. Eighty-three early adolescent girls (m age=13.45 years) recruited from...

Davila, J. & Starr, L.R. (2009). Reassurance seeking. In Harry T. Reis & Susan Sprecher (Eds.), Encyclopedia of Human Relationships. Thousand Oaks, CA: Sage.

Building on evidence that romantic experiences are associated with depressive symptoms in adolescence, we examined their bidirectional association, as well as the role of sexual activity and parent-adolescent stress in their association. Data were collected from 71 early adolescent girls (M age 13.45 years; SD=0.68) and their primary caregiver init...

Coyne's (1976a, 1976b) interactional theory of depression predicts positive associations between excessive reassurance seeking (ERS) and both depression and interpersonal rejection. A growing body of research has supported the ERS model, but this work has yet to be systematically reviewed. A meta-analysis of 38 studies (N = 6,973) revealed an aggre...

Research on psychosocial correlates of depression and social anxiety often has not accounted for their comorbidity. Differentiating correlates of depression and social anxiety may inform the development of comorbidity models. Building on research linking both disorders to interpersonal dysfunction, this study examined interpersonal correlates of de...

Davila, J., Stroud, C. B., & Starr, L. R. (2008). Depression in couples and families. In I. Gotlib & C. Hammen (Eds.), Handbook of Depression (2nd Ed). New York: Guilford Press.