Lisa B Sheeber

Oregon Research Institute | ORI

Background: Adolescence and early adulthood are pivotal stages for the onset of mental health disorders and the development of health behaviors. Digital behavioral activation (BA) interventions, with or without coaching support, hold promise for addressing risk factors for both mental and physical health problems by offering scalable approaches to...

Maternal depressive symptoms are associated with elevations in harsh parenting behavior, including criticism, negative affect, and hostile or coercive behavior, and these behaviors contribute to associations between maternal depressive symptomatology and child functioning. We used multilevel survival analysis to examine social–cognitive processes a...

BACKGROUND Adolescence and early adulthood are pivotal stages for the onset of mental health disorders and the development of health behaviors. Digital behavioral activation (BA) interventions, with or without coaching support, hold promise for addressing risk factors for both mental and physical health problems by offering scalable approaches to e...

Background Adolescence and early adulthood are pivotal stages for the onset of mental health disorders and the development of health behaviors. Digital behavioral activation interventions, with or without coaching support, hold promise for addressing risk factors for both mental and physical health problems by offering scalable approaches to expand...

Personalized prediction is a machine learning approach that predicts a person's future observations based on their past labeled observations and is typically used for sequential tasks, e.g., to predict daily mood ratings. When making personalized predictions, a model can combine two types of trends: (a) trends shared across people, i.e., person-gen...

Parenting styles associated with maternal depression are a risk factor for adolescent psychopathology, and maternal attributional styles may be a key mechanism in this relationship. Mother-adolescent dyads (N = 180; 96 male; ages 10-15) completed in-person interactions and then the mothers participated in a video-mediated recall procedure to assess...

Background/aims: This study examined how mothers with and without depression differ in neural activation in response to adolescents' affective faces. Secondly, it examined the extent to which these neural activation patterns are related to observed positive and aggressive parenting behavior. Methods: Mothers with and without depression (based on...

Depression affects neural processing of emotional stimuli, and could, therefore, impact parent-child interactions. However, the neural processes with how mothers with depression process their adolescents’ affective interpersonal signals, and how this relates to mothers’ parenting behavior, are poorly understood. Mothers with and without depression...

This paper studies the hypothesis that not all modalities are always needed to predict affective states. We explore this hypothesis in the context of recognizing three affective states that have shown a relation to a future onset of depression: positive, aggressive, and dysphoric. In particular, we investigate three important modalities for face-to...

Depression presents risks that are profound and intergenerational, yet research on the association of depression with the physiological processes that might be associated with impaired mental and physical health has only recently been contextualized within the family environment. Participants in this multi-method case–control study were 180 mother-...

BACKGROUND Postpartum depression interferes with maternal engagement in interventions shown to be effective in improving infant social-emotional and communication outcomes. There is an absence of integrated interventions with demonstrated effectiveness in both reducing maternal depression and promoting parent-mediated practices that optimize infant...

Background Postpartum depression interferes with maternal engagement in interventions that are effective in improving infant social-emotional and social-communication outcomes. There is an absence of integrated interventions with demonstrated effectiveness in both reducing maternal depression and promoting parent-mediated practices that optimize in...

Background Internet cognitive behavioural therapy (iCBT) is a viable delivery format of CBT for depression. However, iCBT programmes include training in a wide array of cognitive and behavioural skills via different delivery methods, and it remains unclear which of these components are more efficacious and for whom. Methods We did a systematic revi...

Importance Personalized treatment choices would increase the effectiveness of internet-based cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in interventions that better suit them. Objective To provide personalized estimates of short-term and long-term relative efficacy of guided and unguided iCBT for depressi...

Mothers in the United States (U.S.) who are of non-dominant culture and socioeconomically disadvantaged experience depression during postpartum at a rate 3 to 4 times higher than mothers in the general population, but these mothers are least likely to receive services for improving mood. Little research has focused on recruiting these mothers into...

Background A substantial body of research has emerged suggesting that depression is strongly linked to poor physical health outcomes, which may be partly due to increased allostatic load across stress response systems. Interestingly, health risks associated with depression are also borne by the offspring of depressed persons. Our aim was to simulta...

Objective: Determine how depressed mothers and their adolescent offspring differ in affective and autonomic reactivity during positive and negative parent-adolescent interactions.Methods: In this multi-method case-control study of 180 mother-adolescent dyads (50% mothers depressed, 50% mothers non-depressed) we collected self-reported positive and...

Peers become increasingly important during adolescence, with emerging gender differences in peer relationships associated with distinct behavioral and emotional outcomes. Males tend to socialize in larger peer groups with competitive interactions, whereas females engage in longer bouts of dyadic interaction with more intimacy. To examine gender dif...

Importance: Most prior research examining the impact of maternal depression on offspring has been limited in the following ways: 1) focused only on families with young (i.e., prepubescent) children, 2) constrained within one domain (e.g., psychological, behavioral, or biological), and 3) lacked simultaneous investigation of the impact maternal depr...

Identifying the neural correlates of positive interactions between friendship dyads may provide insights into mechanisms associated with adolescent social development. Forty-eight 14- to 18-year old typically developing adolescents were video-recorded discussing a shared positive event with a close friend and subsequently viewed clips during an fMR...

Objective: The importance of parenting in influencing mental health outcomes, particularly depression, during childhood and adolescence is well known. However, the mechanisms are unclear. Emotion processing impairments in children are believed to be influenced by negative parenting behaviors and fundamental to depression. As such, investigating th...

The ways parents socialize their adolescents to cope with anxiety (i.e. coping socialization) may be instrumental in the development of threat processing and coping responses. Coping socialization may be important for anxious adolescents, as they show altered neural threat processing and over‐reliance on disengaged coping (e.g., avoidance and distr...

This study evaluated the putative mediating mechanisms of an Internet-facilitated cognitive-behavioral therapy (CBT) intervention for depression tailored to economically disadvantaged mothers of preschool-age children. The CBT mediators were tested across two previously published randomized controlled trials which included the same measures of beha...

The majority of studies using observational coding systems for family interaction data derive scales describing family members’ behaviors based on rational/theoretical approaches. This study explored an empirical approach to identifying the component structure of parent–child observational data that incorporated the affective context of the interac...

Adolescents are notorious for engaging in risky, reward-motivated behavior, and this behavior occurs most often in response to social reward, typically in the form of peer contexts involving intense positive affect. A combination of greater neural and behavioral sensitivity to peer positive affect may characterize adolescents who are especially lik...

Meta-emotion philosophy refers to an organized set of thoughts, reactions and feelings about one's emotions and the emotions of others (Gottman, Katz, & Hooven, 1997). This study investigated the prospective relationship between family meta-emotion processes and adolescent-onset Major Depressive Disorder (MDD). Adolescents (N = 198, mean age 12.5 y...

Purpose: Previous research has shown that longer duration of breastfeeding is associated with less risk of obesity in childhood and adolescence. However, although putative physiological mechanisms have been proposed, less work has focused on psychosocial or environmental factors, including socioeconomic status (SES) and stressful family environmen...

The prevalence of depression rises steeply during adolescence. Family processes have been identified as one of the important factors that contribute to affect (dys)regulation during adolescence. In this study, we explored the affect expressed by mothers, fathers, and adolescents during a problem-solving interaction and investigated whether the patt...

In threatening environments, the short (S) allele of 5-HTTLPR is proposed to augment risk for depression. However, it is unknown whether 5-HTTLPR variation increases risk for depression in environments of deprivation, lacking positive or nurturant features. Two independent longitudinal studies (n = 681 and 176, respectively) examined whether 5-HTTL...

Markov modeling presents an attractive analytical framework for researchers who are interested in state-switching processes occurring within a person, dyad, family, group, or other system over time. Markov modeling is flexible and can be used with various types of data to study observed or latent state-switching processes, and can include subject-s...

This systematic review and meta-analysis examined the efficacy of adolescent cognitive–behavioral sleep interventions. Searches of PubMed, PsycINFO, CENTRAL, EMBASE, and MEDLINE were performed from inception to May 1, 2016, supplemented with manual screening. Nine trials were selected (n = 357, mean age = 14.97 years; female = 61.74%). Main outcome...

Objective: The parent-adolescent relationship is an important predictor of adolescent mental health, especially depressive disorders. This relationship is constructed in the context of maturing emotion neurobiology and could help shape such neurobiology in ways that are important for current and future mental health. Amygdala resting-state functio...

Objective: This study utilized a novel multisystem approach to investigate the effect of observed parental behavior on the relationship between biological mechanisms associated with disease processes (i.e., autonomic physiology and immune response) among their adolescent children. Method: Thirty-three adolescents (23 males), aged 11-13, and thei...

Importance The negative effects of socioeconomic disadvantage on lifelong functioning are pronounced, with some evidence suggesting that these effects are mediated by changes in brain development. To our knowledge, no research has investigated whether parenting might buffer these negative effects. Objective To establish whether positive parenting...

Technology advances increasingly allow for access to remotely delivered interventions designed to promote early parenting practices that protect against child maltreatment. Among low-income families, at somewhat elevated risk for child maltreatment, there is some evidence that parents do engage in and benefit from remote-coaching interventions. How...

Objective: Family environments have an effect on physical health during adolescence, and a possible underlying mechanism is inflammation. However, little is known about the association between observed parenting behaviors and immune system functioning. The current study examined whether positive and negative emotional parental behaviors observed d...

Adolescent Sympathetic Activity and Salivary C-Reactive Protein: The Effects of Parental Behavior

Objective: Evaluate an Internet-facilitated cognitive-behavioral treatment intervention for depression, tailored to economically disadvantaged mothers of young children. Method: Economically disadvantaged mothers (N = 266) of preschool aged children, who reported elevated levels of depressive symptoms, were randomized to either the 8-session, In...

This study utilized a multi-method approach (self-reported affect, observed behavior, and psychophysiology) to investigate differences between clinically depressed and non-depressed adolescents across three different affective interaction contexts with their parents. 152 adolescents (52 males, 14-18 y.o.), and their parents, participated in a labor...

Parenting plays a multifaceted role in adolescent development. In this article, we review studies based on an observational assessment of affective parenting behaviors collected as part of the longitudinal Orygen Adolescent Development Study and explore three ways that parenting may predict adolescent-onset depression. Specifically, we review findi...

Background: Almost nothing is known about the potential negative effects of Internet-based psychological treatments for depression. This study aims at investigating deterioration and its moderators within randomized trials on Internet-based guided self-help for adult depression, using an individual patient data meta-analyses (IPDMA) approach. Met...

Limited attention has been directed toward the influence of non-abusive parenting behaviour on brain structure in adolescents. It has been suggested that environmental influences during this period are likely to impact the way that the brain develops over time. The aim of this study was to investigate the association between aggressive and positive...

Psychopathology characteristics of the sample. (DOCX)

Inter-scanner reliability analysis. Proportion of male and female participants for whom ROI thickness increased (green), decreased (blue) or did not change (red) based on the inter-scanner reliability analysis. (DOCX)

S1 Methods and Results provides more detailed information about methods (family interaction coding and MRI processing, including analysis of inter-scanner effects) and results (more comprehensive information about associations between maternal behaviors and adolescent outcomes). (DOC)

Average SD (mm) for each ROI based on individuals scanned at both sites for reliability analysis. (DOCX)

Anxious youth exhibit heightened emotional reactivity, particularly to social-evaluative threat, such as peer evaluation and feedback, compared to non-anxious youth. Moreover, normative developmental changes during the transition into adolescence may exacerbate emotional reactivity to peer negative events, particularly for anxious youth. Therefore,...

This is a comprehensive, up-to-date and evidence-based review of women's mental health. It starts by considering the social and cultural contexts of women's lives today before addressing how developmental aspects pertain to mental health, exploring biological, evolutionary and psychosocial parameters. The heart of the book contains a series of chap...

Background: Childhood anxiety is associated with low levels of parental autonomy granting and child perceived control, elevated child emotional reactivity and deficits in child emotion regulation. In early childhood, low levels of parental autonomy granting are thought to decrease child perceived control, which in turn leads to increases in child...

A single imaging gene-environment (IGxE) framework that is able to simultaneously model genetic, neurobiological, and environmental influences on psychopathology outcomes is needed to improve understanding of how complex interrelationships between allelic variation, differences in neuroanatomy or neuroactivity, and environmental experience affect r...

This study examined parental emotion socialization processes associated with adolescent unipolar depressive disorder. Adolescent participants (N 5 107; 42 boys) were selected either to meet criteria for current unipolar depressive disorder or to be psychologically healthy as defined by no lifetime history of psychopathology or mental health treatme...

Affective family processes are associated with the development of depression during adolescence. However, empirical description of these processes is generally based on examining affect at the individual or dyadic level. The purpose of this study was to examine triadic patterns of affect during parent-adolescent interactions in families with or wit...

Adversity early in life can disrupt the functioning of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes and increase risk for negative health outcomes. The interplay between these axes and the environment is complex, and understanding needs to be advanced by the investigation of the multiple hormonal relationships underlyi...

Earlier use of tobacco in adolescence is associated with numerous adverse outcomes later in life. Although a number of studies have linked individual differences in affective functioning to adolescent smoking, these have relied primarily on self-report measures, and the contribution of different dimensions of affect to the onset of tobacco use duri...

The pituitary gland is integral in mediating the stress-response via its role in hypothalamic-pituitary-adrenal (HPA) axis function. Pituitary gland volume (PGV) is altered in stress-related psychopathology, and one study to date has shown stress to be associated with age-related PGV change during adolescence. The current study investigated the eff...

The focus on parental stress in the literature on inmate family contact builds on the broader literature on the impact of imprisonment on the mental health of prisoners and the direct consequences of such on their family members. This work points to the ways in which requisite coping strategies developed in response to stressors that are specific t...

In this paper, we investigate the problem of detecting depression from recordings of subjects' speech using speech processing and machine learning. There has been considerable interest in this problem in recent years due to the potential for developing objective assessments from real-world behaviors, which may provide valuable supplementary clinica...

Objective: The objective of this study was to evaluate the participation rates and factors associated with nonparticipation among mothers living in low-income households who were invited to join a parent-education and-support research program delivered via the Internet with professional support. Methods: Four hundred and seventy-seven mothers of in...

Nearly 2 million children in the United States have a parent in prison. The circumstances related to this situation place them at increased risk for behavioral and emotional disorders. The process of reunification between mother and child after release is a stressful and emotional one. A pilot study was conducted to develop and test a new program,...