Lisa Fleury

Swiss Federal Institute of Technology in Lausanne | EPFL · Center for Neuroprosthetics CNP

Homonymous Hemianopia (HH), a common visual impairment resulting from occipital lobe lesions, affects a significant number of stroke survivors. Intensive perceptual training can foster recovery, possibly by enhancing surviving visual pathways. This study employed cortico-cortical paired associative stimulation (ccPAS) to induce associative plastici...

BACKGROUND Cortical excitation/inhibition dynamics have been suggested as a key mechanism occurring after stroke. Their supportive or maladaptive role in the course of recovery is still not completely understood. Here, we used transcranial magnetic stimulation (TMS)-electroencephalography coupling to study cortical reactivity and intracortical GABA...

Background: Most studies on stroke have been designed to examine one deficit in isolation; yet, survivors often have multiple deficits in different domains. While the mechanisms underlying multiple-domain deficits remain poorly understood, network-theoretical methods may open new avenues of understanding. Methods: Fifty subacute stroke patients...

Background and Objectives Stroke is the leading cause of long-term disability, making the search for successful rehabilitation treatment one of the most important public health issues. A better understanding of the neural mechanisms underlying impairment and recovery and the development of associated markers is critical for tailoring treatments to...

Prism adaptation (PA) is a useful method to investigate short-term sensorimotor plasticity. Following active exposure to prisms, individuals show consistent after-effects, probing that they have adapted to the perturbation. Whether after-effects are transferable to another task or remain specific to the task performed under exposure, represents a c...

Prism Adaptation (PA) is a useful method to study the mechanisms of sensorimotor adaptation. After-effects following adaptation to the prismatic deviation constitute the probe that adaptive mechanisms occurred, and current evidence suggests an involvement of the cerebellum at this level. Whether after-effects are transferable to another task is of...

Despite recent improvements, complete motor recovery occurs in <15% of stroke patients. To improve the therapeutic outcomes, there is a strong need to tailor treatments to each individual patient. However, there is a lack of knowledge concerning the precise neuronal mechanisms underlying the degree and course of motor recovery and its individual di...

Objective Cortical excitation/inhibition dynamics have been suggested as a key mechanism occurring after stroke. Their supportive or maladaptive role in the course of recovery is still not completely understood. Here, we used TMS-EEG coupling to study cortical reactivity and intracortical GABAergic inhibition, as well as their relationship to resid...

Objectives (i) to create a shortened version of the Action Research Arm Test scale, (ii) to investigate its psychometric properties compared to the original scale and (iii) to externally validate it within an independent cohort. Design Prospective longitudinal cohort study. Settings Two University Hospitals (France, Switzerland). Participants 47...

Background Most studies on stroke have been designed to examine one deficit in isolation, yet survivors often have multiple deficits in different domains. While the mechanisms underlying multiple-domain deficits remain poorly understood, network-theoretical methods may open new avenues of understanding. Methods 50 subacute stroke patients (7±3days...

Despite recent improvements, complete motor recovery occurs in less than 15% of stroke patients. To improve the therapeutic outcomes, there is a strong need to tailor treatments to each individual patient. However, there is a lack of knowledge concerning the precise neuronal mechanisms underlying the degree and course of motor recovery and its indi...

Whether sensorimotor adaptation can be generalized from one context to other represents a crucial interest in the field of neurological rehabilitation. Nonetheless, the mechanisms underlying transfer to another task rema in un clear. Prism Ad aptation (PA) is a useful method employed both to study short-term plasticity and for rehabilitation. Neuro...

During prism adaptation (PA), active exposure to an optical shift results in sustained modifications of the sensorimotor system, which have been shown to expand to the cognitive level and serve as a rehabilitation technique for spatial cognition disorders. Several models based on evidence from clinical and neuroimaging studies offered a description...

The plasticity that characterizes our nervous system enables us to realize smooth and precise movement despite varying demands. The understanding and distinction of processes enabling to modify existing movements when facing a perturbation (adaptation) or to learn new ones (learning) represents a crucial challenge. Sensorimotor adaptation is reflec...

The sensorimotor system sets up plastic alterations to face new demands. Terms such as adaptation and learning are broadly used to describe a variety of processes underlying this aptitude. The mechanisms whereby transformations acquired to face a perturbation generalize to other situations or stay context-dependent remain weakly understood. Here, w...

Sensorimotor plasticity allows the nervous system to set up appropriate motor and sensory compensations when individuals face changing demands in a given motor task. A much-debated question in neuroscience research is the identification of processes that encompass this capacity of plasticity. Prism adaptation is the oldest experimental paradigm tha...

When individuals are exposed to a constant change of the interplay with their environment, they are able to develop compensatory alterations of visuo-motor coordination in order to counteract the perturbation. Prism adaptation (PA) is a very simple tool that has been used for several decades to investigate adaptive processes. However, the specific...

Introduction : L’hémiplégie cérébrale infantile provoque une altération du fonctionnement des membres supérieurs (MS), ce qui impacte la qualité de vie des enfants atteints au quotidien. L’évaluation de la fonction motrice des MS représente un intérêt considérable : elle permet d’orienter les décisions médicales et de quantifier les progrès réalis...