Linlin Li

Linlin Li
Chinese Academy of Sciences | CAS · Beijing Institute of Nanoenergy and Nanosystems

PhD

About

136
Publications
32,375
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Introduction
Dr. Linlin Li is a professor and group leader at Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences. She received her Ph.D. degree in physical chemistry from the Technical Institute of Physics and Chemistry, CAS (2008). She has published over 100 original papers on Adv. Mater., J. Am. Chem. Soc., ACS Nano, Adv. Funct. Mater. etc. Details please find in : https://www.x-mol.com/groups/lilinlin
Additional affiliations
July 2008 - November 2015
Technical Institute of Physics and Chemistry
Position
  • Professor (Associate)

Publications

Publications (136)
Article
Full-text available
Multidrug resistance (MDR) is the key cause that accounts for the failure of clinical cancer chemotherapy. To address the problem, herein, we presented an alternative strategy to conquer drug-resistant breast cancer through the combinatorial delivery of Ca²⁺ channel siRNA with cytotoxic drug. Mesoporous silica nanocapsules (MSNCs) with mesoporous a...
Article
Full-text available
Nanoformulations that can respond to the specific tumor microenvironment (TME), such as a weakly acidic pH, low oxygen, and high glutathione (GSH), show promise for killing cancer cells with minimal invasiveness and high specificity. In this study, we demonstrate self-assembled copper-amino acid mercaptide nanoparticles (Cu-Cys NPs) for in situ glu...
Article
With the rapid development of wearable electronic devices, higher requirements are pushing forward the overall circuit design of variability, flexibility, and stretchability. However, power supplies and functional circuits with these characteristics are difficult to be implemented with critical challenges. Here, the use of Cu particles mixed liquid...
Article
Ultrasound (US)-triggered sonodynamic therapy (SDT) based on semiconductor nanomaterials has attracted considerable attention for cancer therapy. However, most inorganic sonosensitizers suffer from low efficiency due to the rapid recombination of electron-hole pairs. Herein, the Cu2-xO-BaTiO3 piezoelectric heterostructure was fabricated as a sonose...
Article
Recently, the development of chemodynamic therapy (CDT) offers a potential approach for fighting bacteria and treating infectious diseases, in which those CDT nanoagents can catalyze the generation of hydroxyl radicals (•OH) to destroy bacteria. In this work, to improve the efficiency of CDT, we have designed a new kind of metformin (Met)-capped tw...
Article
With the rapid development of photo-responsive nanomaterials, photo-triggered therapeutic strategies such as photothermal therapy (PTT) and photodynamic therapy (PDT) have been new alternatives to current cancer therapeutic methods. Herein, we have fabricated oxygen vacancy-engineered BaTiO3 (BTO-Ov) nanoparticles (NPs) for near-infrared (NIR) ligh...
Article
Mechanical logic and computation embedded in deployable structures are complementary to conventional digital logic schemes for autonomous sense, decision, and response in artificial intelligence and bio-robots. It is highly desired that responsive and adaptive structures can readily interact with external stimuli to implement mechanologic (e.g., wr...
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ROS production efficiencies of the nanocatalysts is highly desired for cancer therapy, but currently the ROS generation efficiency is still far from defecting the tumors. Therefore, improving their ROS generation ability is highly desirable for cancer therapy. Herein, inspired by the electrostatic preorganization effect during the catalysis of natu...
Article
Flexible and wearable electronic devices have broad applications in human–machine interaction and personal health monitoring. To meet different application scenarios, in this work, an antibacterial, antifreezing, stretchable, and self‐healing organohydrogel‐based triboelectric nanogenerator (O‐TENG) for biomechanical energy harvesting and self‐powe...
Article
Bioelectricity is an indispensable part of organisms and plays a vital role in cell modulation and tissue/organ development. The development of convenient and bio-safe electrical stimulation equipment to simulate endogenous bioelectricity for cell function modulation is of great significance for its clinical transformation. In this review, we intro...
Article
Recently, with the rational design of transition metal-containing nanoagents, chemodynamic therapy (CDT) has been developed and considered a promising method for cancer therapy through Fenton and Fenton-like reaction-induced hydroxyl radical (·OH) generation and cellular oxidative damage. However, it is still a great challenge to realize high react...
Article
The development of intelligent and wearable electronics raises an urgent requirement for stretchable, durable power sources and sensors. Especially, self-powered sensor that can work with high sensing sensitivity and stability in harsh environments is greatly desired for wilderness exploration and urgent rescue. Herein, an anti-freezing, stretch-ma...
Article
High photoinduced carriers (PC) recombination rate, low PC mobility and limited solar energy utilization rate are the three main roadblocks that severely limit the photocatalytic activity of semiconductors. In this work, we designed a plasmonic bimetallic ZnO nanorod array (Au/ZnO/Pt) with Au nanoparticles (NPs) located on top of ZnO nanorods, and...
Article
During tumorigenesis and cancer progression, tumor microenvironment (TME) is continuously remodeled and a high intertumoral heterogeneity emerges due to hypoxia, oxidative stress and acidosis, etc., Recently, modulation of TME has received increasing attention for improving cancer therapy, which can solve some critical therapeutic problems such as...
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Electrospinning (e‐spin) technique has emerged as a versatile and feasible pathway for constructing diverse polymeric fabric structures, which show potential applications in many biological and biomedical fields. Owing to the advantages of adjustable mechanics, designable structures, versatile surface multi‐functionalization, and biomimetic capabil...
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Respiratory sensing provides a simple, non-invasive, and efficient way for medical diagnosis and health monitoring, but it relies on sensors that are conformal, accurate, durable, and sustainable working. Here, a stretchable, multichannel respiratory sensor inspired by the structure of shark gill cleft is reported. The bionic shark gill structure c...
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Electromechanical interaction of cells and extracellular matrix are ubiquitous in biological systems. Understanding the fundamentals of this interaction and feedback is critical to design next‐generation electroactive tissue engineering scaffold. Herein, based on elaborately modulating the dynamic mechanical forces in cell microenvironment, the des...
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Covalent organic frameworks (COFs) as a type of porous and crystalline covalent organic polymer are built up from covalently linked and periodically arranged organic molecules. Their precise assembly, well-defined coordination network, and tunable porosity endow COFs with diverse characteristics such as low density, high crystallinity, porous struc...
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Cell sheet harvesting has recently emerged as a promising strategy for scaffold-free cell transplantation and tissue engineering. It is critical to achieve the disconnection between cell and its adherent support while maintaining the availability of cell sheet. Hence, the regulation of cell adhesion behavior often becomes the primary consideration...
Article
Nanozyme has been widely explored for tumor catalytic therapy. Nevertheless, highly efficient and specific cancer therapy with nanozyme is still challenging under the strict condition of tumor microenvironment (TME). Herein, we fabricate a bimetallic phosphide nanoparticle (CuFeP) with multiphase interfaces as a photo-enhanced cascade nanozyme for...
Article
The production of reactive oxygen species (ROS) to elicit lethal cellular oxidative damage is an attractive pathway to kill cancer cells, but it is still hindered by the low ROS production efficiency of the current methods. Herein, we design a one-dimensional (1D) π-π conjugated ferriporphyrin covalent organic framework on carbon nanotubes (COF-CNT...
Article
The formation of interfacial chemical bonding in heterostructures plays an important role in the transport of carriers. Herein, we firstly prepared ultrathin InVO4 nanosheet (Ns) with a thickness of 1.5 nm. Diethylenetriamine-modified CdSe (CdSe-DETA) nanobelts are in-situ deposited on the surface of ultrathin InVO4 Ns to build a InVO4/CdSe-DETA st...
Article
Wearable and implantable medical devices are playing more and more key roles in disease diagnosis and health management. Various biosensors and systems have been used for respiration monitoring. Among them, self-powered sensors have some special characteristics such as low-cost, easy preparation, highly designable, and diversified. The respiratory...
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Ionogels is a kind of hybrid materials composed of ionic liquids (ILs) and solid polymer network matrix, has been extensively investigated in the most recent decade. Due to the excellent mechanical properties and ionic conductivity, their promising applications in flexible stress and strain sensors have been proposed and explosively developed. In t...
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During natural tissue regeneration, tissue microenvironment and stem cell niche including cell–cell interaction, soluble factors, and extracellular matrix (ECM) provide a train of biochemical and biophysical cues for modulation of cell behaviors and tissue functions. Design of functional biomaterials to mimic the tissue/cell microenvironment have g...
Article
Low redox ability and severe photocorrosion limit the photocatalytic activity of metal sulfides. Herein, step-scheme (S-scheme) heterojunction composited by diethylenetriamine (DETA) ammoniated MnS (α-MnS) and Bi2MoO6 with Bi surface plasmon resonance (SPR) was successfully fabricated (Bi-5%M/BMO). This special electron transport structure effectiv...
Article
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Owing to their self‐renewal and differentiation ability, stem cells are conducive for repairing injured tissues, making them a promising source of seed cells for tissue engineering. The extracellular microenvironment (ECM) is under dynamic mechanical control, which is closely related to stem cell behaviors. During the design and fabrication of biom...
Article
With the explosive development of sensing systems in miniaturization, intelligence, multi-function and networking, triboelectric nanogenerator (TENG) with simple structure, low cost and self-powering characters has become an excellent candidate for mechanical sensors. However, it remains a great challenge to obtain a stable interface of electrode a...
Article
Sonodynamic therapy is considered as a minimally invasive method for pathogen elimination and cancer therapy with high spatial and temporal accuracy. However, sonosensitizers with good biocompatibility and high efficiency are still urgently needed. Herein, we have developed a piezoelectric nanocomposite, barium titanate (BaTiO3, BTO) nanocubes with...
Article
With high catalytic activity and stability, nanozymes have huge advantage in generating or eliminating the reactive oxygen species (ROS) due to their intrinsic enzyme-mimicking abilities, therefore attracting wide attention in ROS-related disease therapy. To better design nanozyme-based platforms for ROS-related biological application, we firstly i...
Article
Metal and amino acid (AA), as two kinds of entities, have been widely involved in biomaterials and nanomedicines. Recently, the marriage of them has developed new nanoformulations, amino acid-metal coordinated nanomaterials (AMCNs), which show great biomedical application potential in cancer therapy, antibacterial applications, biomedical imaging,...
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Triboelectric nanogenerator (TENG) can convert mechanical energy into electricity via the coupling of triboelectrification and electrostatic induction. Due to its advantages of flexible, lightweight, high energy conversion efficiency and shape‐adaptive ability, implantable and wearable TENG have shown great potentials in biomedical field for biomec...
Article
As one of the most important intracellular antioxidants and redox balance regulators, glutathione (GSH) plays a vital role in cell growth and proliferation, drug detoxification and free radical scavenging. In cancer cells, GSH concentration is several folds higher than that in normal cells. In this decade, with the rapid development of nanotechnolo...
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Ocean wave energy is one of the most promising clean and renewable energy sources, so developing effective methods to collect such ‘random’ and ultra-low frequency energy is indispensable. The invention of triboelectric nanogenerators (TENGs) provides new prospects for large-scale blue energy harvesting. In this work, a new spherical TENG based on...
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Piezotronic and plasmonic effects are effective strategies to improve photocatalytic performance. Combining these two effects in one photocatalytic heterostructure is intriguing, but has yet to be reported. Here, a hybrid ternary structure ((silver‐silver sulfide)/barium titanate (Ag‐Ag2S)/BaTiO3) is introduced, where the synergistic exciton–plasmo...
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Along with the boost of drugs’ exploitation, drug delivery has been a common concern among researchers and patients. As an emerging strategy, the micro- and nano-needle (MNN) is a single or an array of micro/nanoneedles, and promises to be a robust technology for efficient, noninvasive and convenient drug delivery. Compared with the conventional in...
Article
Electroporation is an effective approach for drug and gene delivery, but still limited by its low throughput and severe cell damage. Herein, with a self-powered triboelectric nanogenerator (TENG) as the power source, we demonstrated a high-throughput electroporation system based on the design of biocompatible and flexible polypyrrole (PPy) microfoa...
Article
Wind is one of the most important sources of green energy, but the current technology for harvesting wind energy is only effective when the wind speed is beyond 3.5–4.0 m s−1. This is mainly due to the limitation that the electromagnetic generator works best at high frequency. This means that light breezes cannot reach the wind velocity threshold o...
Article
In recent years, triboelectric nanogenerator (TENG) has been proven to be an effective and simple solution for self-powered wearable sensing, and a wide variety of materials and methods have been applied to TENG based sensors. In this study, an ultrathin fiber film with nanoporous brain-like structure (BUF) was obtained by cold-pressing the electro...
Article
Current photocatalytic semiconductors often have low catalytic performance due to limited light utilization and fast charge carrier recombination. Formation of Schottky junction between semiconductors and plasmonic metals can broaden the light absorption and facilitate the photon‐generated carriers separation. To further amplify the catalytic perfo...
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Rapid technological development and population growth are responsible for a series of imminent environmental problems and an ineluctable energy crisis. The application of semiconductor nanomaterials in photocatalysis or photoelectrocatalysis (PEC) for either the degradation of contaminants in the environment or the generation of hydrogen as clean f...
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Reactive species (RS), mainly including reactive oxygen species (ROS) and reactive nitrogen species (RNS), are indispensable in a wide variety of biological processes. RS often have elevated levels in cancer...
Article
Multidrug resistance (MDR) is the key cause that accounts for the failure of clinical cancer chemotherapy. To address the problem, herein, we presented an alternative strategy to conquer drug-resistant breast cancer through the combinatorial delivery of Ca2+ channel siRNA with cytotoxic drugs. Mesoporous silica nanocapsules (MSNCs) with mesoporous...
Article
Although CdS has been proven to be one of the best photocatalysts in visible light region, its photocorrosion characteristics and toxicity prohibit its practical applications in photocatalytic hydrogen generation and photodegradation of organic pollutants in waste water. In addition, the photocatalytic efficiency of single phase CdS nanostructure i...
Article
The biomineralized bacterial magnetic nanoparticles (BMPs) have been widely studied for biomedical applications with their magnetic properties and a layer of biomembrane. Herein, BMPs were firstly used for magnetically targeted photothermal cancer therapy in vivo. A self-build C-shaped bipolar permanent magnet was used for magnetic targeting though...
Article
TiO2/TiN core/shell NBs are successfully synthesized, and used as the highly efficient photocatalytic H2 evolution catalysts (120 µmol/h/g) from the methanol solution. The TiN shell plays dual roles by extending...
Article
Full-text available
To meet the growing demands in flexible and wearable electronics, various sensors have been designed for detecting and monitoring the physical quantity changes. However, most of these sensors can only detect one certain kind of physical quantity based on a single mechanism. In this paper, we have fabricated a multifunctional sensor made from carbon...
Article
Bacteria induced infectious diseases have threated the lives and health of millions people each year. Nanosized titanium dioxide (TiO2) have been developed for photodynamic bacterial killing with minimal drug resistance, but the efficiency was restricted by their large band gap, limited light-absorption region, and rapid electron-hole recombination...
Chapter
Gold nanoparticles (AuNPs) have promising biomedical applications due to their unique optical properties. The sizes, morphologies, and structures of AuNPs can be precisely controlled to regulate surface plasma resonance (SPR) peak position. Moreover, Au has a high atomic number, high absorption coefficient, and strong X-ray absorption coefficient,...
Article
Bointerface mediated physical cues have been found to be able to guide stem cells to differentiate into specific cell lineages. In this study, nanostructured MoS2 biointerface was fabricated by assembling few-layer MoS2 nanoflakes onto substrate using a facile hydrothermal method. Its effects on proliferation, adhesion and osteogenic differentiatio...
Article
A new kind of magnetic gelatin-encapsulated nanoassembly was fabricated as a multifunctional drug delivery system (DDS) with pH, redox, and enzyme stimuli-responsive drug release for cancer theranostics. Cystamine-modified gelatin was used to encapsulate doxorubicin (Dox) as an anticancer drug and Fe3O4 as the magnetic resonance imaging (MRI) contr...
Article
Generally, carbon or graphite fibers (GFs) are used as the supporting materials for the preparation of flexible supercapacitors (SCs) by assembling various electrochemically active nanomaterials on them. A facile and rapid electrochemical oxidation method with a voltage of 3 V in a mixed H2SO4-HNO3 solution for 2–15 min is proposed to active contin...
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Nanoparticles have been widely researched for delivering drugs into tumor tissue for increase of therapeutic effect and decrease of drug toxicity. Passive targeting via enhanced permeation and retention (EPR) effect and active targeting with conjugation of targeting ligands are considered as two mostly used targeting strategies for nanoparticles ta...
Article
Titanium foam (TiF) as a kind of implantable biomaterials has good mechanical properties and three-dimension (3D) micro-porous structure, which has potential applications in bone tissue engineering. However, their clinical application is technically restricted by their bio-inert property with limited cross-interaction with biological microenvironme...
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TiO2 is one of the most extensively investigated materials owing to its unique properties and many promising applications. The properties of TiO2 are highly dependent on its microstructure and feature size. Here, we report a strategy of synthesis the hierarchical porous TiO2 with two distinguishable levels of ligament size, which consists of both m...
Article
Physical cues from nanostructured biomaterials have been shown to possess regulating effects on stem cell fate. In this study, nanostructured molybdenum disulfide (MoS2) thin films (MTFs) are prepared by assembling MoS2 nanosheets on a flat substrate. These films are used as a new biocompatible platform for promoting neural stem cell (NSC) differen...
Article
Ferromagnetic nanoparticles (Fe3O4 NPs) have been proven to have the intrinsic peroxidase-like activity. This property has been used for analyte detection, tumor tissue visualization, and cancer therapy, etc. However, the effect of particle structure and morphology on its peroxidase-like activity has been rarely reported. In this work, we fabricate...
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Full-text available
Terbium-aspartic acid (Tb-Asp) nanocrystals with chirality-dependent tunable fluorescent properties can be synthesized through a facile synthesis method through the coordination between Tb and Asp. Asp with different chirality (dextrorotation/D and levogyration/L) changes the stability of coordination center following fluorescent absorption/emissio...
Article
Nanostructured TiO2 materials with a controlled morphology and structure have drawn considerable attention to both fundamental research and practical applications owing to their unique characteristics. Herein, a novel, facile, and one-step hydrothermal approach was developed to synthesize urchin-like anatase TiO2 hierarchical nanostructures assembl...