Lingyu Sun

Lingyu Sun
Southeast University (China) | SEU

About

69
Publications
10,433
Reads
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2,159
Citations
Citations since 2016
69 Research Items
2136 Citations
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800
20162017201820192020202120220200400600800

Publications

Publications (69)
Article
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Bone defects caused by trauma, tumor, or osteoarthritis remain challenging due to the lack of effective treatments in clinic. Stem cell transplantation has emerged as an alternative approach for bone repair and attracted widespread attention owing to its excellent biological activities and therapy effect. The attempts to develop this therapeutic ap...
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Natural biomaterials have been widely applied in wound treatment. Hotspots in this area are focused on reducing their immunogenicity and improving their therapeutic effect. In this work, we present a novel aquaculture derived hybrid skin patch based on acellular fish skin (AFS) and chitosan (CS) for wound healing. Such functional patch was simply c...
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Background Wound healing has become a worldwide healthcare issue. Attempts in the area focus on developing patches with the capabilities of avoiding wound infection, promoting tissue remolding, and reporting treatment status that are of great value for wound treatment. Results In this paper, we present a novel inverse opal film (IOF) patch based o...
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Structural colors have a demonstrated value in constructing various functional materials. Efforts in this area are devoted to developing stratagem for generating heterogeneous structurally colored materials with new architectures and functions. Here, inspired by icing process in nature and ice-templating technologies, we present freeze-derived hete...
Article
Mesenchymal stem cells derived‐exosomes (MSC‐exos) exhibit an intrinsic and directed efficiency for multiple diseases, while their versatile and effective delivery to the target site is still challenge. Herein, inspired by the acids and enzymes resistant property of sealing gelatin capsules, we present novel MSC‐exo‐encapsulated oral microcapsules...
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Lung‐on‐a‐chip models hold great promise for disease modeling and drug screening in the past decade. Herein, inspired by the iridescence phenomenon of soap bubbles, we present a novel biomimetic 3D microphysiological lung‐on‐a‐chip system with breathing visuality. The system with an array of pulmonary alveoli at the physiological scale was construc...
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Heart‐on‐a‐chip plays an important role in revealing the biological mechanism and developing new drugs for cardiomyopathy. Tremendous efforts have been devoted to developing heart‐on‐a‐chip systems featuring simplified fabrication, accurate imitation and microphysiological visuality. In this paper, the authors present a novel electroconductive and...
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Type 1 diabetes mellitus (T1DM) are characterized by hyperglycemia with pancreatic β cells deficiency, leading to subsequent acute and chronic complications. Effects in recent decades are the trend to develop advanced techniques for β cell culture, of which three-dimensional (3D) cell culture showed promising potentials. Herein, we generate the uni...
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Information security occupies an important position in the era of big data. Attempts to improve the security performance tend to impart them with more additional encryption strategies. Herein, inspired by the wettability feature of Stenocara beetle elytra and signal model of traffic light, a novel array of perovskite nanocrystals (PNs)‐integrated P...
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Tissue engineered scaffolds have demonstrated values in fabricating corneal equivalence. Attempts in this area tend to develop functional scaffold with physiochemical properties and structure resembling the native corneal tissue. Herein, a novel recombinant human collagen (RHC) based scaffold with ordered microstructures is presented to induce the...
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When organs, especially external organs are injured, pathogens and excessive water loss can threaten the wound healing process and cause local irreversible tissue damage. Here, novel natural κ-Carrageenan microparticles (MPs) able to deliver bioactive proteins and small molecules to the wound surface for promoted regeneration were developed using m...
Article
Oral administration route for treating inflammatory bowel disease (IBD) is one of the most convenient methods, especially for the chemical molecular drugs and biologics. Attempts to develop applicable oral administration method tend to focus on the construction of functional microcarriers through simple operations and employing innovative but acces...
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Electronic skins have received increasing attention in biomedical areas. Current efforts about electronic skins are focused on the development of multifunctional materials to improve their performance. Here, the authors propose a novel natural‐synthetic polymers composite structural color hydrogel film with high stretchability, flexibility, conduct...
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As a fundamental feature of solid surfaces, wettability is playing an increasingly important role in our daily life. Benefitting from the inspiration of biological paradigms and the development in manufacturing technology, numerous wettability materials with elaborately designed surface topology and chemical compositions have been fabricated. Based...
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Traditional Chinese medicine and Chinese herbs have a demonstrated value for disease therapy and sub-health improvement. Attempts in this area tend to develop new forms to make their applications more convenient and wider. Here, we propose a novel Chinese herb microneedle (CHMN) patch by integrating the herbal extracts, Premna microphylla and Cente...
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Bioartificial liver (BAL) system has become a promising alternative to traditional liver transplantation in rescuing acute liver failure (ALF) patients. Herein, inspired by natural microstructure of hepatic lobules, we developed a novel biomimetic bioartificial liver system (BBALS) by integrating human induced pluripotent stem cell-derived hepatocy...
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Cellular mechanics plays an important role in physiological processes such as cell growth, differentiation, apoptosis and gene expression. Herein, we present a nano-imprinted structural color graphene film with anisotropic microgroove and two-dimensional (2D) photonic crystal structures for cardiomyocytes dynamic displaying. The anisotropic structu...
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Multifunctional composite flexible sensors are essential components in flexible and stretchable electronics. In this paper, we present novel mussel-inspired Janus structural color films as visually flexible electronics. The Janus composite film with a three-layer structure, which is compozed of a conductive carbon nanotube (CNT) layer, a supporting...
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Functional materials with specific wettability have broad technological implications in various fields. Herein, inspired by the rapid replenishment of Nepenthes nectaries, we present novel lubricant infused hierarchical porous surfaces with self-replenishing and self-reporting capacities. As the porous surfaces were replicated from colloidal co-ass...
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Structural color hydrogels (SCHs) have ushered in a new era for a variety of fields including sensing, display, and anti‐counterfeiting. Attempts in this area are trending to improve their functions to implement the practical values. Herein, bioinspired by chameleons, a novel multi‐responsive angle‐independent SCH is presented. The SCH consists of...
Article
Perovskite quantum dots (PQDs) are new class of optoelectronic materials, which have been widely studied for their extraordinary physical properties. Attempts to develop these materials are tending to make their fabrication much controllable and extend their values in different areas. Here, we present a novel strategy for one-step in situ synthesis...
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Wound healing is a complex physiological process that involves coordinated phases such as inflammation and neovascularization. Attempts to promote the healing process tend to construct an effective delivery system based on different drugs and materials. In this paper, we propose novel MXene-integrated microneedle patches with adenosine encapsulatio...
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Adsorption of low-density lipoprotein from plasma is vital for the treatment of dyslipidemia. Appropriate adsorbent material for efficient and selective adsorption of low-density lipoprotein is highly desired. In this work, we developed pollens-derived magnetic porous particles as adsorbents for this purpose. The natural pollen grains were modified...
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Brain organoid is a promising technique with potential applications in developmental study, drug discovery and regenerative medicine, however, its practical values are restricted by poor flexibility, and lack of near-physiological structures or functions. Here, we present a multidisciplinary strategy to engineer novel vascularized human induced plu...
Article
As a severe cardiovascular disease, acute myocardial infarction (AMI) has been attaching increasing attention and research for its high morbidity and mortality. In this paper, the novel protein microcapsules integrated hierarchical scaffold is designed for treating AMI model by using microfluidic templates. Based on advanced microfluidic electrospr...
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Cellular mechanics are of great significance in biological functions and have stimulated the development of various techniques to detect and analyze it. Here, a novel heterogeneous structural color microfiber designed for dynamic cardiac mechanics sensing is presented. The microfiber is fabricated by the programmed injection microfluidic spinning m...
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Stimuli-responsive materials have been experiencing explosive developments, which are functionally integrated with multi-signals in response to external environment variations. Here, we present a novel dual-responsive graphene hybrid structural color film as electronic skins. The film is fabricated by adding conductive reduced graphene oxide (rGO)-...
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Myocardial infarction (MI) has become a serious social burden worldwide for its high mortality. Here, we propose a novel induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs)-integrated conductive microneedle (MN) patch for treating MI. The cardiac patches are composed of drug-encapsulated MN bottom layer, parallel-aligned carbon nanotu...
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Blood purification by adsorption of excessive biomolecules is vital for maintaining human health. Here, inspired by kidney self‐purification, which removes a number of biomolecules with different sizes simultaneously, hierarchical molecular‐imprinted inverse opal particles integrated with a herringbone microfluidic chip for efficient biomolecules c...
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Significance Inspired by the wettability structure of Stenocara beetle and adhesion ability of mussel, we present an innovative MXene-integrated PhC array for multichannel bioinformation coding. The bioinspired hydrophilic–hydrophobic surfaces can selectively capture colloidal droplets to form PhC arrays; while the mussel’s byssus-mimicked DA catec...
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Microneedles are providing an emerging strategy for promoting wound healing. Attempts to develop this technology tend to impart them with additional functions. Herein, inspired by the claws of eagles, we present a liquid metal (LM)-encapsulated microneedle patch by employing a top-down multiple-mold-guided photolithography method for incisional wou...
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As simulators of organisms in Nature, soft robots have been developed over the past few decades. In particular, biohybrid robots constructed by integrating living cells with soft materials demonstrate the unique advantage of simulating the construction and functions of human tissues or organs, thus attracting extensive attention and research intere...
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Microneedles have attracted increasing interest among various medical fields due to their painless, noninvasive, and efficient way of drug delivery. However, practical applications of these microneedles in different epidermal locations and environments are still restricted by their low adhesion and poor antimicrobial activity. Here, inspired by the...
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Fiber-shaped supercapacitors are considered to be one of the most promising power source candidates in flexible electronics for their light weight, high flexibility and wearability. Here, inspired by natural silkworms spinning and their hierarchical fiber structure, we present a multi-channel co-flow microfluidic strategy for one-step spinning of m...
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Oxygen carriers are attracting extensive interest in biomedical researches and clinical applications such as wound healing, alternative blood transfusion and acute trauma treatment. Great efforts have been devoted to the generation of oxygen carriers with special functions and properties to meet specific demands. Here, we present black phosphorus (...
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Functional materials with specific wettability surfaces are valuable for many areas. Extensive applications for superwettbility have led to demand for integrating devices with flexible and multi-functional. Here, inspired by the super-adhesive of mussels and the hierarchical structures of mosquitos’ compound eyes, we proposed a new method to constr...
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Significance Droplet manipulation has received great attention and research for its potential applications in various fields. Wettability surfaces, especially tunable wettability surfaces, are efficient way to manipulate the pinning and sliding of droplets. However, these surfaces only demonstrate uniform wettability control behavior and thus were...
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Biological soft robots have attracted extensive attention and research because of their superiority in executing designed biomedical missions compared with conventional robots. Here, inspired by the crawling mechanism of snakes and caterpillars, a novel biological soft robot composed of asymmetric claws, a carbon nanotube (CNT)‐induced myocardial t...
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Patch plays an important role in clinical medicine for its broad applications in tissue repair and regeneration. Here, inspired by the diverse adhesion, anti-adhesion, and responsive structural color phenomena in biological interfaces, we present a hybrid hydrogel film with an adhesive polydopamine (PDA) layer and an anti-adhesive poly(ethylene gly...
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Heart‐on‐a‐chip based on microfluidic platform can simulate the structure and reveal the function of heart at the micrometer level, compensating the gap between organism and experiments in vitro. In this paper, a novel heart‐on‐a‐chip system integrated with reduced graphene oxide (rGO) hybrid anisotropic structural color film is designed for cardia...
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Structural color materials have been studied for decades because of their fascinating properties. Effects in this area are the trend to develop functional structural color materials with new components, structures, or morphologies for different applications. In this study, we found that the coassembled graphene oxide (GO) and colloid nanoparticles...
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Ferrofluids, also known as ferromagnetic particle suspensions, are materials with an excellent magnetic response, which have attracted increasing interest in both industrial production and scientific research areas. Because of their outstanding features, such as rapid magnetic reaction, flexible flowability, as well as tunable optical and thermal p...
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Owing to the unique features of angle independence and wide-angle display, non-iridescent materials have attracted increasing interest in coating, decoration, and anti-counterfeiting. However, there are still some defects that limit their applications, such as relatively pale colors and suboptimal stability. Inspired by mussels' super-adhesivity an...
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Barcodes have been widely used in biomolecular multiplexed screening and diagnosis, but higher throughput is still a challenge. In this work, we developed a kind of molybdenum disulfide (MoS2) encapsulated photonic crystal (PhC) barcodes as a fluorescence biosensor with binary optical encoding strategy for different microRNA (miRNA) detection. Thro...
Article
Significance Efficient droplet manipulation has been widely studied and used in various applications, including water treatment, chemical and biological analysis, etc. However, most of the approaches for droplet manipulation still face many challenges such as external energy dependence, single-directional droplets handling, and nonrecyclability. In...
Article
Colloidal crystals are of great interest to researchers because of their excellent optical properties and broad applications in barcodes, sensors, displays, drug delivery, and other fields. Therefore, the preparation of high quality colloidal crystals in large quantities with high speed is worth investigating. After decades of development, microflu...
Article
Slippery liquid-infused porous surfaces (SLIPs), especially capable of tunable and smart response to the external stimuli, play important roles in the field of intelligent transportation, microreactors, self-cleaning, anti-icing, and beyond. Herein, a novel electric-tunable wettability of paraffin-infused porous colloidal crystal films (PIPCCFs) is...
Article
Nanomedicine, with its advantages of rapid diagnosis, high sensitivity and high accuracy, has aroused extensive interest of researchers, as the cornerstone of nanomedicine, nanomaterials achieve extra attention and rapid development. Among nanomaterials, quantum dots stand out due to their long fluorescence lifetime and excellent antiphotobleaching...
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As nanomaterials (NMs) possess attractive physicochemical properties that are strongly related to their specific sizes and morphologies, they are becoming one of the most desirable components in the fields of drug delivery, biosensing, bioimaging, and tissue engineering. By choosing an appropriate methodology that allows for accurate control over t...
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Inspired by helical or spiral veins, which endow plants with excellent flexibility and elasticity to withstand storms, we present novel hollow microsprings with ionic liquid encapsulation for flexible and stretchable electronics. The microsprings were generated by using a coaxial capillary microfluidic device to consecutively spin poly(vinylidene f...
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Microneedle (MN) arrays have demonstrated value for cosmetics, diagnosis, transdermal drug delivery, and other biomedical areas. Much effort has been devoted to developing simple stratagem for creating versatile moldings and generating functional MN arrays. Here, inspired by the serrated microstructure of mantises’ forelegs, we present a novel serr...
Article
The ultrasensitive detection of multiple nucleic acids has great significance in a broad range of medical fields since nucleic acid samples are usually of small volumes and highly diluted. Herein, we present a novel magnetic photonic crystal (PhC) barcode-integrated condensing-enriched superhydrophobic platform for the ultrasensitive multiple miRNA...
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Structural color materials with the property of angle-independence have attracted increasing interest in recent years because of their applications in various research fields. In this paper, inspired by the anisotropic lattice microstructure of the Parides sesostris butterfly, we present a novel angle-independent structural material by simply dopin...
Article
In this paper, novel antibacterial porous microcarriers with a pathological state responsive switch were developed to promote wound healing. The porous microcarrier includes an inverse opal scaffold generated by a temperature-responsive hydrogel that deforms according to different temperatures, and a biodegradable sodium alginate hydrogel used as a...
Article
Biohybrid actuators composed of living tissues and artificial materials have attracted increasing interest in recent years because of their extraordinary function of dynamically sensing and interacting with complex bioelectrical signals. Here, a novel biohybrid actuator with self-driven actuation and self-reported feedback is designed based on an a...
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In article number 1803551, Zhiyang Li, Xuehao Wang, Yuanjin Zhao, and co‐workers present mussel‐inspired photonic crystal (PhC) barcodes with graphene oxide (GO) encapsulation for multiplex miRNA detection. The GO‐based hybridization chain reaction strategy realizes low abundance and high sensitivity miRNA quantification. At the same time, multiple...
Article
Multiplexed microRNA (miRNA) quantification has a demonstrated value in clinical diagnosis. In this paper, novel mussel‐inspired photonic crystal (PhC) barcodes with graphene oxide (GO) encapsulation for multiplexed miRNA detection are presented. Using the excellent adhesion capability of polydopamine, the dispersed GO particles can be immobilized...