Lingyan Feng

• PhD
• Shanghai University

MXene, a two‐dimensional nanomaterial, has metal conductivity, high electronegativity, functionalized with surface groups, which make it widely applicable in catalysis and biosensing. However, studies on the principle of enhanced electrochemiluminescence (ECL) by MXene composites and the improvement of their performance in catalyzing the ECL reacti...

Nanozymes with multienzyme‐like activity have sparked significant interest in anti‐tumor therapy via responding to the tumor microenvironment (TME). However, the consequent induction of protective autophagy substantially compromises the therapeutic efficacy. Here, a targeted nanozyme system (Fe‐Arg‐CDs@ZIF‐8/HAD, FZH) is shown, which enhances syner...

This study develops a highly sensitive chiroptical sensor for detecting Hg ²⁺ and I ⁻ ions through the co-assembly of G-quartet nanofibers and N–S-CDs.

Safety concerns arising from bacteria present a significant threat to human health, underscoring the pressing need for the exploration of novel antimicrobial materials. Nanozymes, as a new type of nanoscale material, have attracted widespread attention for antibacterial applications owing to their ability to mimic the catalytic activity of natural...

The family of MAX phases and their two‐dimensional derivative MXenes attract significant attention due to their unparalleled properties. Synthesis of MAX phases and MXene from biomass sources is important to expand their biology‐related applications, while it remains a challenge. The present work explores the possibility to synthesize MAX phases an...

Alkali‐metal doped perovskite oxides have emerged as promising materials due to their unique properties and broad applications in various fields, including photovoltaics and catalysis. Understanding the complex interplay between alkali metal doping, structural modifications, and their impact on performance remains a crucial challenge. In this study...

Zeolitic imidazole frameworks (ZIFs), which combine the favorable characteristics of tunable porosity, controlled structure, and facile functionalization, are explored as a novel class of nanocarriers for biomedical applications. In this study, different ZIF materials are investigated, including ZIF‐8, ZIF‐67, ZIF‐90, ZIF‐92, and ZIF‐108, with the...

The increasing bacterial resistance highlights the necessity of developing superior antibacterial materials. Metal‐doped carbon dots (CDs), a crucial branch of carbon‐based nanozymes, exhibit efficient antibacterial properties using the reactive oxygen species (ROS) effect. In this study, iron‐doped carbon dots (Fe‐CDs) are synthesized with high pe...

Identifying efficient electrocatalysts for oxygen evolution reaction (OER) is vital for sustainable energy. This study focuses on efficient spinel OER electrocatalysts. We utilize a covalent competition-based interpretable machine learning process,...

Circularly polarized luminescent (CPL) materials have garnered significant interest due to their potential applications in chiral functional devices. Synthesizing CPL materials with a high dissymmetry factor (g lum ) remains a significant challenge. Inspired by efficient machine learning (ML) applications in scientific research, we demonstrate ML‐b...

Accurate determination of serotonin (ST) provides insight into neurological processes and enables applications in clinical diagnostics of brain diseases. Herein, we present an electrochemical aptasensor based on truncated DNA aptamers and a polyethylene glycol (PEG) molecule-functionalized sensing interface for highly sensitive and selective ST det...

In data-driven materials design where the target materials have limited data, the transfer machine learning from large known source materials, becomes a demanding strategy especially across different crystal structures. In this work, we proposed a deep transfer learning approach to predict thermodynamically stable perovskite oxides based on a large...

Porphyrin (TMPyP) functionalized carbon quantum dots (CQDs-TMPyP), a novel and efficient carbon nanocomposite material, were developed as a novel luminescent material, which could be very useful for the sensitive detection of copper ions in the Cu2+ quenching luminescence of functionalized carbon quantum dots. Therefore, we constructed a sensitive...

Chiral carbon dots (CDs) are a novel luminescent zero‐dimensional carbon‐based nanomaterial with chirality. They not only have the advantages of good biocompatibility, multi‐color‐emission, easy functionalization, but also exhibits highly symmetrical chiral optical characteristics, which broadens their applicability to enantioselectivity of some ch...

We found that the complexes of nucleotides and terbium (III) had circularly polarized luminescence (CPL). The CPL of GMP/Tb/Ag coordination polymer nanoparticles (CPNs) was converted by magnetic field and pH....

An artificial tongue for the discrimination of different metal ions based on fluorescent carbon dots (C-dots) and meso-tetrakis(4-(N-methylpyridiumyl))porphyrin (TMPyP) was developed in this manuscript. Fluorescence resonance energy transfer (FRET) between C-dots and TMPyP was applied for the sensor array consisting of C-dots, TMPyP and a C-dot–TMP...

Carbon dots (CDs) due to their excellent photostability, good biocompatibility and multicolor fluorescence, have been preferentially selected as luminescent fluorophores and co-assembled with various chiral host templates in recent years. The as-prepared composites exhibit marvellous circularly polarized luminescence (CPL) activity and show promisi...

Chiral materials related to circularly polarized luminescence (CPL) make up a rapidly developing new field that has broad application prospects in optoelectronic devices, selective recognition, biomedicine, and other fields. Biofunctional chiral materials are also attracting increasing attention because of their unique biocompatibility, chiral reco...

An innovative strategy for circularly polarized luminescence (CPL) of carbon dots (CDs) has been developed: The achiral CDs displayed contrary supramolecular chirality and opposite CPL in two different bi‐solvent systems, which are due to the formation of self‐assembled helical nanostructures with two diverse assembly modes (P and M) in aggregate s...

Over the last few decades, biosensors have made significant advances in detecting non-invasive biomarkers of disease-related body fluid substances with high sensitivity, high accuracy, low cost and ease in operation. Among various two-dimensional (2D) materials, MXenes have attracted widespread interest due to their unique surface properties, as we...

Chiral inorganic nanomaterials provide a platform for a variety of applications. Chiral ligands are commonly used to induce chiroptical activity of nanoparticles through chiral transfer, while few materials have intrinsic chirality and the origins of their chirality are unclear as well. Here, several hexagonal copper sulfide (CuS) structures with a...

To address the challenge of highly sensitive and accurate detection of biomarkers in complex environments, a rational engineering strategy for designing electrochemical immunosensing platform is proposed. Herein, we develop a microsensor chip through the combination of multiplexed electrodes and microfluidic channels for the parallel detection of h...

Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for imaging guided sonodynamic therapy (SDT). It is challenging, however, to realize a single material that is simultaneously endowed with both NIR emitting and sonodynamic activities. Herein, we report the design of a class of NIR-emitting sono...

Chiral materials related to circularly polarized luminescence (CPL) are a rapidly developing new field that has broad application prospects in optoelectronic devices, selective recognition, biomedicine, and other fields. Biomolecules naturally chiral, and biofunctional chiral materials attracted increasing attention because of their unique biocompa...

Transition metal phosphides (TMPs) exhibit excellent competitiveness for electrochemical splitting water due to their high electrical conductivity and remarkable physicochemical stability. However, pure single-phase TMPs still possess some disadvantages, such as the limited number of active sites and difficulty in greatly accelerating mass/charge t...

Limited healthcare capacity highlights the needs of integrated sensing systems for personalized health-monitoring. However, only limited sensors can be employed for point-of-care applications, emphasizing the lack of a generalizable sensing platform. Here, we report a metal organic framework (MOF) ZIF-90-ZnO-MoS2 nanohybrid-based integrated electro...

It is of great challenge to design transition multimetallic carbonate hydroxides with delicate hollow features and defects for efficient electrolytic oxygen evolution reaction (OER). Here, a sequential self‐templating method to synthesize CoNiFe trimetallic carbonate hydroxide hierarchical hollow microflowers (CN‐xFe HMs) with oxygen vacancies (VO)...

A type I nitroreductase-mimicking nanocatalyst based on 2H–MoS2/Co3O4 nanohybrids for trace nitroaromatic compounds detection is reported in this work. For the preparation of nanocatalyst, ultrathin Co3O4 nanoflakes array was in-situ grown onto 2H–MoS2 nanosheets forming three-dimensional (3D) nanohybrid with large specific surface area as well as...

Signal amplification strategies increase the complexities of biosensors while improving the response signals. Herein, a novel electrochemical biosensor was developed based on a DNA hydrogel for sensitive analysis using microRNA-21 (miRNA-21) as a detection model. Poly C sequences combined with C-Ag(I)-C hydrogel formed a DNA hydrogel by the unique...

Correction for ‘Efficient and stable electrorheological fluids based on chestnut-like cobalt hydroxide coupled with surface-functionalized carbon dots’ by Yudai Liang et al. , Soft Matter , 2022, DOI: 10.1039/D2SM00176D.

Intrinsically polarized electrorheological fluids (ERFs) have better thermal stability than ERFs with polar molecules, so they have a broader application prospect. However, the electrorheological efficiency of the common intrinsically polarized ERF is still lower than 1500, which is related to the poor wettability between polarized materials and th...

A novel helix hydrogel with a G-quartet structure was synthesized by Guanosine (Gua) and its derivative 5'-guanosine monophosphate (5'-GMP) under a molecular crowding environment. The chirality of hydrogel is adjusted...

In recent years, two-dimensional layered material MXene has attracted extensive attention in the fields of sensors due to its large specific surface area and rich active sites. So, we employed multilayer Ti3C2TX and SnO2 microspheres to prepare SnO2/MXene composites for enhancing gas-sensing properties of pristine SnO2. The composite was brushed on...

The rational construction of highly efficient electrocatalysts comprising multiple components with distinctive bifunctionalities is still a challenge for the practical application due to their sluggish kinetics for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Here, a series of cobalt-molybdenum alloy nanorods encapsulated...

Limited healthcare capacity highlights the needs of integrated and simple sensing systems for personalized health monitoring. However, only a limited set of sensors can be employed for point-of-care applications, emphasizing the lack of a generalizable engineering strategy for sensor construction. Here, we report a de novo rational engineering stra...

Photogenerated carriers' transfer efficiency as one of the most important criteria determines the efficiency of a photoanode for photoelectrochemical (PEC) water splitting. Energy barrier-free charge transfer of photogenerated carriers is achieved in a core-shell heterostructure of Bi2S3/ZnS:Co/TiO2, in which the arrayed TiO2 nanorods are covered w...

Semiconductor nanoparticles (NPs) with chiroptical activity are emerging candidates for photothermal agents that respond to circularly polarized light (CPL). Herein, CuS NPs capped with citrate (cit-CuS NPs) were prepared by a solution method. The chiral enantiomers l-CuS and d-CuS NPs were obtained by ligand exchange with cysteine (Cys). New mirro...

High efficient and durable catalysts are always needed to lower the kinetic barriers as well as prolong the service life associated with oxygen evolution reaction (OER). Herein, a sequential synthetic strategy is considered to prepare a hierarchical nanostructure, in which each component can be configured to achieve their full potential so that end...

Transition metal phosphides (TMP) show great potential to alternative noble metal based electrocatalysts for oxygen evolution reaction (OER) electrolysis but the still unsatisfactory catalytic activity hinders its practical application. Therefore, it is of much significance to rationally design TMP electrocatalysts for achieving high-efficiency OER...

A water-soluble and sensitive fluorescent probe N,N′-bis[tris-(2-aminoethyl)amine]-3,4,9,10-perylenetetracarboxylic diimide (PTRIS) was synthesized and, in combination with polydopamine (PDA), utilised in the detection of acetylcholinesterase (AChE) activity. PDA is spontaneously polymerized from dopamine (DA) in aerobic and alkaline solutions. The...

The formation of chirality of G-quartet materials has been of concern for a long time, however, the helix-handedness of G-quartet materials is still ambiguous, as well as the novel circularly polarized luminescence (CPL) properties. Here, we demonstrated that the handedness of G-quartet materials highly depends on their formation kinetics. By contr...

Prostate specific antigen (PSA) has become a potential biomarker for detecting prostate cancer (PCa) in the early stage. Herein, we report a target-induced resolution for the detection of PSA sensitively and specifically by amperometric electrochemical measurements. To meet a satisfactory performance, three conformations of pre-design DNA aptamers...

A label-free microRNAs (miRNAs) electrochemiluminescence sensor was developed based on the synergistically enhanced ECL signal using novel ECL nanomaterial assembled by tri-luminophores perylenetetracarboxylic acid (PTCA) graphite-like carbon nitride nanosheet (g-C3N4 NS) and graphene carbon quantum dots (GQDs). The ECL intensity of our proposed na...

The electrocatalytic water splitting into oxygen (O2) and hydrogen (H2) is one of promising technique for addressing the problem of energy shortage. Owing to the sluggish reaction kinetics for oxygen evolution reaction (OER), it is urgent to explore efficient and inexpensive OER electrocatalytic materials. Herein, a highly efficient three-dimension...

Serotonin is one of the important neurotransmitters in human nervous system and associated with central nervous system diseases. Herein, we have prepared a novel electrochemical aptasensor for rapid and sensitive detection of serotonin by using the pre-designed and prepared DNA aptamers. In the absence of serotonin, the electron transfer rate on th...

Herein, we present one three-way junction (TWJ) DNA based electrochemical biosensor for sensitive microRNAs detection with locked nucleic acid (LNA) as capture probe and enzyme-free redox cycling signal amplification strategy. LNA owns higher binding affinity and thermal stability compared to normal DNA sequence. In the presence of target microRNA...

Circularly polarized luminescence (CPL) as an intriguing luminescence phenomenon has attracted significant research interests for their chiroptical application, and CPL-active materials have been extensively explored in recent years. Herein, a highly chiroptical sensor was fabricated by the co-assembly of G-quartet nanofiber and gold-silver bimetall...

Chirality plays a key role in many fields ranging from life to natural sciences. For a long time, chiral materials have been developed and used to interact with chiral environments. In recent years, fluorescent carbon dots (CDots) are a new class of carbon nanomaterials exhibit excellent optical properties, good biocompatibility, excellent water so...

A ratiometric fluorescence system is reported based on fluorescence resonance energy transfer (FRET) between carbon quantum dots (CQDs) and gold nanoclusters (Au NCs) for sensitive detection of acetylcholinesterase (AChE) and organophosphorus pesticides (OPPs). The CQDs and Au NCs were synthesized by one‐pot approach, emitting at 420 nm (λex=320 nm...

β-lactoglobulin amyloid fibrils (BLGF) capped gold nanoclusters (Au NCs) with red, green and blue emissions were fabricated via pH dependent reduction strategy. The BLGF-Au NCs exhibit 3.2 times enhancement of fluorescence (λex=500 nm, λem=684 nm), a significant 42 nm red shift, a 11.57% quantum yield and a 1.4 µs decay time compared with native β-...

A reversible fluorescence probe for acetylcholinesterase activity detection was developed based on water soluble perylene derivative, N,N’-di(2-aspartic acid)-perylene-3,4,9,10-tetracarboxylic diimide (PASP). Based on the photo-induced electron transfer (PET), PASP fluorescence in aqueous is quenched after combining with copper ions (Cu²⁺). Acetylc...

Right (R)- and left (L)-handed helical G-quartet nanostructures were synthesized for the first time simultaneously via the self-assembly of 5'-guanosine monophosphate (GMP), the helical handedness of which is well regulated by metal ions. These g-nanostructures were further applied as circularly polarized luminescence (CPL) templates to realize ful...

Economic, efficient, and stable layered double hydroxides (LDHs) based oxygen evolution reaction (OER) electrocatalysts are recognized as promising substitutions of precious catalysts. While LDHs composites suffer from low intrinsic activity, which slightly impedes their wide utilization in energy conversion. Here, we demonstrate a kind of three-di...

In article number 2000307, Yuan Zhang and co‐workers present a self‐organized nanohybrid consisting of metal nanopillars in a semiconducting 2H‐MoS2 matrix for accurate analysis of prostate cancer biomarker, alpha‐methylacyl‐CoA racemase (AMACR) in complex human body fluids. The explored 2H‐MoS2‐based nanohybrid is employed for the fabrication of a...

Alpha‐methylacyl‐CoA racemase (AMACR) has been proven to be consistently overexpressed in prostate cancer epitheliums, and is expected to act as a positive biomarker for the diagnosis of prostate carcinoma in clinical practice. Here, a strategy for specific determination of AMACR in real human serum by using an electrochemical microsensor system is...

A label-free fluorescent nanoprobe for iodide ion (I−) detection was developed based on the direct fluorescence quenching of spermine-functionalized carbon dots (SC-dots), whether in complex biological fluids or living cells. The positively charged SC-dots were fabricated via one-step microwave synthesis and exhibited excellent optical properties....

Nanomaterials with enzyme-like characteristics (also called nanozymes) have attracted increasing attention in the area of analytical chemistry. Nevertheless, most of the nanozymes used for analytical applications are oxidoreductase mimics, and their enzyme-like activities are usually demonstrated by using chromogenic and/or fluorogenic substrates....

The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip. Through a combination of cell biology, engineering, and biomaterial technology, the microenvironment of the chip simulates that of the organ in terms of tissue interfaces and mechanical stimul...

Dihydronicotinamide adenine dinucleotide (NADH) is an important enzyme in all living cells, which is found to be abnormally expressed in cancer cells. Since it is redox-active, an electrochemical detection method would be suitable for monitoring its concentration in biological fluids. Here we present a strategy for specific determination of NADH in...

Gold nanoclusters (Au NCs) using fibrinogen (FBG) protein as template are fabricated via one-pot reduction strategy, and applied for fluorometric detections of cysteine (Cys) and mercury(II). The modified FBG-Au NCs exhibit red fluorescence, with excitation/emission maxima at 360/620 nm, a 7% quantum yield, and a 2.2 μs decay time. The fluorescence...

Circularly polarized luminescence (CPL) has recently attracted great interests due to the chiral optical applications; vaious materials are developed as templates for CPL readout. Here we demonstrate firstly CPL measurement from human telomeric G-quadruplex (Tel G4) and achiral fluorogenic dye (ThT) interaction, in which the chirality transferred f...

An inorganic titanium oxide (TiO) gel sensor was demonstrated for convenient detection of ascorbic acid (AA). It is composed of TiO (PI–TiO) functionalized with a perylene diimide derivative containing carboxylic groups as a new soft dopant material. A traditional solvothermal reaction is adopted to prepare the PI–TiO composite, which exhibits a di...

Cobalt oxides have been paid much attention in oxygen evolution reaction (OER). To enhance the catalysis reaction performance, here we reported Co3O4 nanocrystals anchored on phosphorous-doped carbon nitride (P-CN) sheets via Co-N bonds for highly efficient OER. By simple sintering the mixture of Co3O4 nanocrystals with P-CN sheets in tube furnace,...

As an important genetic material for life, DNA has been investigated widely in recent years, especially in interdisciplinary fields crossing nanomaterials and biomedical applications. It plays an important role because of its extraordinary molecular recognition capability and novel conformational polymorphism. DNA is also a powerful and versatile b...

Zeolitic imidazole frameworks (ZIFs) are a new class of functional porous materials with attractive characters, such as gas storage, selective separation, catalysis, and drug delivery. We report herein using nanoscale ZIF-90 crystals with free aldehyde group of imidazole-2-carboxaldehyde (ICA) ligand for the selective electrochemical detection of d...

Graphitic carbon nitride (g-C3N4) sheets have been assembled firstly with cobalt-meso-tetra-(4-carboxyphenyl)porphyrin (CoTCPP) (CoTCPP/g-C3N4) through noncovalent interaction (hydrogen bonding, electrostatic interaction and π-π stacking) and covalent interaction. The CoTCPP/g-C3N4 composites show high sensitivity to visible light irradiation and e...

Since the Material Genome Initiative (MGI) was proposed, high-throughput based technology has been widely employed in various fields of materials science. As a theoretical guide, material informatics has been introduced based on machine learning and data mining and high-throughput computation has been employed for large scale search, narrowing down...

In this mini review, we will briefly introduce the rapid development of DNA conformational polymorphism in biosensing field, including canonical DNA duplex, triplex, quadruplex, DNA origami, as well as more functionalized DNAs (aptamer, DNAzyme etc.). Various DNA structures are adopted to play important roles in sensor construction, through working...

In this paper, we report a synthesised water soluble perylene derivative, N,N′-di(2-aspartic acid)-perylene-3,4,9,10-tetracarboxylic diimide (PASP), for highly sensitive and repeatable detection of copper (Cu²⁺) and aluminium ions (Al³⁺) and novel logic gate operation. In the presence of metal ions, a dramatic decrease in PASP optical intensity was...

DNA as life’s genetic material has been widely investigated around the world. In recent years, with the fiery researches on nanomaterials, it also plays an important role in the development of material science due to its extraordinary molecular recognition capability and prominent structural features. In this mini review, we mainly overview the rec...

Recently, microfluidic technologies have attracted an enormous amount of interest as potential new tools for a large range of applications including materials synthesis, chemical and biological detection, drug delivery and screening, point-of-care diagnostics, and in-the-field analysis. Their ability to handle extremely small volumes of fluids is a...

Mercury and its compounds are emitted during industrial processes and are extremely harmful for eco systems and human health. Therefore, the detection of mercury ions (Hg2+) in our living and working environment is of great importance for the society and especially for the health of human beings. Here we demonstrate a proof of concept nanoparticle...

The peroxidase-like catalytic activity of gold nanoclusters (NCs) is quite low around physiological pH, which greatly limits their biological applications. Herein, we found heparin can greatly accelerate the peroxidase-like activity of Au-NCs at neutral pH. The catalytic activity of Au-NCs toward the peroxidase substrate 3,3′,5,5′-tetramethylbenzid...

Over the past decade, the richness of electronic properties of graphene has attracted enormous interest for electrically detecting chemical and biological species using this two-dimensional material. However, the creation of practical graphene electronic sensors greatly depends on our ability to understand and maintain a low level of electronic noi...

Electrochemiluminescence (ECL) of metal nanoclusters and their application have been widely reported due to the good biocompatibility, fascinating electrocatalytic activity and so on. Using DNA as synthesis template opens new opportunities to modulate the physical properties of AgNCs. Triplex DNA has been reported for the site-specific, homogeneous...

Malaria infection remains a significant risk for much of the population of tropical and subtropical areas, particularly in developing countries. Therefore, it is of high importance to develop sensitive, accurate and inexpensive malaria diagnosis tests. Here, we present a novel aptamer-based electrochemical biosensor (aptasensor) for malaria detecti...

A rapid fabrication method of microgap electrodes using inkjet printing is described. In this approach, the lateral spacing between two printed electrode lines is precisely controlled down to 1 µm without any surface modification or substrate patterning. The strong confinement, well below typical resolution of inkjet printing, relies on complete so...

The vascular endothelial growth factor 165 (VEGF165) is widely used as an important biomarker in cancer- and neuron-related diseases. Herein, an aptamer-based biosensor is developed that features effective protein detection. A DNA aptamer is immobilized on a gold electrode surface as recognition element utilizing an electrochemically triggered clic...

In this communication, the ambipolar properties of an electrolyte-gated graphene field-effect transistor (GFET) have been explored to fabricate frequency-doubling biochemical sensor devices. By biasing the ambipolar GFETs in a common-source configuration, an input sinusoidal voltage at frequency f applied to the electrolyte gate can be rectified to...

Photoluminescent carbon dots (c-dots) have recently attracted growing interest as a new member of the carbon-nanomaterial family. Here, we report for the first time that c-dot-decorated TiO2 nanotube arrays (c-dot/TiNTs) exhibit highly enhanced abilities regarding photo/voltage-induced organic pollutant degradation and bacterial inactivation. By ap...

Conventional electronic circuits can perform multi-level logic operations; however, this capability is rarely realized by biological logic gates. In addition, the question of how to close the gap between biomolecular computation and silicon-based electrical circuitry is still a key issue in the bioelectronics field. Here we explore a novel split ap...

Konventionelle Elektronik kann mehrere Logikoperationen hintereinander ausführen; für bioelektronische Logikgatter wurde diese Fähigkeit bisher jedoch selten nachgewiesen. Zudem ist die Fragestellung, wie man die technologische Lücke zwischen biochemischen Prozessen und Silicium-basierten elektrischen Schaltungen schließt, eine Schlüsselproblematik...