Ling Liu

Objective Intestinal ischemia-reperfusion (IIR)-induced gut injury remains a challenge for critically ill patients despite the oxidative stress theory that has been elaborated. This study aimed to test whether Toll-like receptor 4 (TLR4) is involved in gut injury during IIR and whether somatostatin (SST) affects TLR4-nuclear factor-κB (NF-κB) cytok...

Anti-glycan antibody serologic markers may serve as a useful adjunct in the diagnosis/prognosis of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). This meta-analysis/systemic review aimed to evaluate the diagnostic value, as well as the association of anti-glycan biomarkers with IBD susceptible gene var...

Our previous study found that somatostatin (SST) inhibited the intestinal inflammatory injury in a macaque model of intestinal ischemia-reperfusion (IIR); however, the underlying mechanism was unclear. The present study was aimed to investigate the effects of SST on IFN-γ and the systemic inflammatory response after IIR. Fifteen macaques were rando...

Aim: To investigate inflammatory injury in the intestinal mucosa after intestinal ischemia-reperfusion (IIR) with Toll-like receptor (TLR)-mediated innate immunity. Methods: Ten macaques were randomized into control and IIR groups. The distribution and expression level of TLR2, TLR4, MD2, nuclear factor (NF)-κB p65 and interferon (IFN)-γ were me...

The effect of low‐FODMAPs diet on irritable bowel syndrome (IBS) in Western China has not been reported. We aimed to investigate the effect of low‐FODMAPs diet on IBS patients in the area and whether low‐FODMAPs diet‐induced alterations of microbiota could be improved through probiotics. IBS patients were randomized to the control group, low‐FODMAP...

The gut microbiome has been considered to play an important role in inflammatory bowel disease (IBD). Our previous study reported that tacrolimus-altered gut microbiota elicited immunoregulatory effects in both colonic mucosa and circulation, contributing to an increased allograft survival rate in mice. Here, we aimed to observe the changes in the...

Although previous studies reported that gut fungal microbiota was associated with Crohn’s disease (CD), only a few studies have focused on the correlation between gut fungi and clinical phenotypes of CD. Here, we aimed to analyze the association between intestinal fungi and the occurrence of CD, disease activity, biological behaviors, and perianal...

Duodenal dysbiosis may be potential infection risks in patients with severe acute pancreatitis (SAP). Acid-suppression drugs (ACDs) are widely used in SAP patients in Asian countries. However, the impact of ACDs on duodenal microbiota during the early phase of SAP is still unknown. This randomized controlled clinical trial evaluated the impacts of...

Background: It is common for high-risk, non-variceal upper gastrointestinal bleeding (NUGIB) patients coexisting anemia, but the role of anemia on the prognosis of endoscopic intervention is not clear. The aim of this study was to assess the impact of hemoglobin level on outcomes of endoscopic intervention in high-risk NUGIB patients. Methods: A re...

Background Endoscopic submucosal dissection (ESD) is effective for treating T1a early esophageal squamous cell carcinoma (ESCC). However, occasional recurrences are inevitable. This trial was designed to clarify the efficacy of combining ESD with additional radiotherapy in the treatment of T1a ESCC. Methods Between January 2015 and September 2018,...

Acute pancreatitis in pregnancy (APIP) varies in severity from a self-limiting mild condition to a severe life-threatening condition, and its severity is significantly correlated with higher risks of maternal and foetal death. This study evaluated the early predictive value of routine laboratory tests on the severity of APIP patients. We enrolled 1...

Approximately, 33.6% of nondiabetic solid organ transplantation recipients who received tacrolimus developed hyperglycemia. Whether the tacrolimus‐induced gut microbiota is involved in the regulation of hyperglycemia has not been reported. Hyperglycemia was observed in a tacrolimus‐treated mouse model, with reduction in taxonomic abundance of butyr...

Objectives: Severe acute pancreatitis (SAP) is still a big challenge. Accumulated data showed that overexpression of cyclooxygenase-2 (COX-2) in acute pancreatitis and experimental pancreatitis could be attenuated with COX-2 inhibitors. This study was aimed to evaluate whether the occurrence of SAP could be prevented by selective COX-2 inhibitors....

Background and aims: Interleukin 6 (IL-6) or its receptor is currently a candidate for targeted biologic therapy of inflammatory bowel disease (IBD). Thus, a comprehensive understanding of the consequences of blocking IL-6 is imperative. We investigated these consequences by evaluating the effects of IL-6 deletion on the spontaneous colitis of IL-...

Abstract Obesity may aggravate acute pancreatitis (AP) through damaging the intestinal mucosal barrier (IMB). The underlying mechanism remains unclear. This study was aimed to provide further data to clarify the mechanism. 48 rats were divided into 4 groups: 1) normal control (NC), chow-fed rats with sham operation, 2) no-obese rats with AP (NAP),...

Objective: To evaluate the effect of proton pump inhibitors (PPIs) therapy on severe acute pancreatitis (SAP) patients. Methods: Forty five patients with SAP recruited in our center from October 2015 to October 2016,were randomly assigned into two groups: convention group (C group,n=21) and convention+esomeprazole group (C+E group,n=24). C+E gro...

This paper presents fractional order fixedtime nonsingular terminal sliding mode control for stabilization and synchronization of fractional order chaotic systems with uncertainties and disturbances. First, a novel fractional order terminal sliding mode surface is proposed to guarantee the fixed-time convergence of system states along the sliding s...

In this paper, a new class of fixed-time consensus protocols are proposed to further improve the existing fixed-time consensus protocols. Different from the existing fixed-time consensus protocols, both design parameters and the selected protocol function of the presented protocols determine the convergence rate and control input. Therefore, the pr...

Inflammasomes are large multimeric protein complexes that actively regulate cellular immunity and homeostasis through sensing and responding to either intracellular or extracellular stimuli. They are grouped on the basis of their sensor proteins, including nucleotide-binding domain (NBD) and leucine-rich repeat (LRR)-containing receptors (NLRs), ab...

This paper studies fixed-time leader-following lag consensus problem of second-order multi-agent systems with input delay. Using fixed-time distributed observer, we obtain the leader’s states for each followers. An extension of the Artstein’s reducing transformation is employed to transform the delayed error system into a second-order system withou...

Background and aims: NLRP3 inflammasome is known to be involved in inflammatory bowel diseases. However, it is controversial if it is pathogenic or beneficial. This study evaluated the roles of NLRP3-inflammasome in the pathogenesis of inflammatory bowel disease in IL-10-/- mice and humans. Methods: NLRP3 inflammasome in colonic mucosa, macropha...

In this paper, two simple 3D chaotic systems are constructed by introducing nonlinear functions into Sprott A system, which all have no equilibrium, and multi-scroll hidden attractors can be obtained. In the case of simple sine function without restricting its nonlinear dynamical range, the number of multi-scroll attractors has nothing to do with t...

In this paper, a fixed-time dynamic surface high-order sliding mode control approach is presented for chaos suppression and voltage stabilization in three-bus power system via design of current source converter-based static synchronous compensator controller. The proposed control strategy constructs two high-order sliding mode surfaces to achieve c...

In this paper, the threshold dynamics of Morris–Lecar neuron model is firstly analyzed by bifurcation diagram of interspike interval as a function of external forcing current, and then the discharge series, phase portraits and nullclines of the neuron under different conditions are investigated in a numerical way. The results show that the electric...

Background: Bacterial translocation (BT) plays a vital role in the development of liver cirrhosis (LC); however, little is known regarding the role of gut innate immunity in cirrhosis. Aims: To observe the influence of BT on multiple vital organs in LC and changes in the gut toll-like receptor-4 and nod-like receptor family pyrin domain containi...

This paper presents a novel chattering-free sliding mode control method for a class of disturbed nonlinear systems, which achieves fast and exact disturbance estimation, eliminates chattering, and recovers the performance of nominal system and nominal control input. The proposed approach combines time scale separation design and sliding mode contro...

This brief presents a novel control scheme to achieve fast fixed-time system stabilization. Based on fixed-time stability theory, a novel fixed-time stable system is presented. Using the proposed fixed-time stable system, a fast fixed-time non-singular terminal sliding mode control method is derived. Our control scheme achieves system stabilization...

A novel nonsingular fast terminal sliding mode (NNFTSM) control strategy based on the extended state observer (ESO) and the tracking differentiator (TD) is developed for the stabilization and tracking of the uncertain perturbed permanent magnet synchronous motor (PMSM) chaotic system. The proposed NNFTSM surface not only makes the system state rapi...

In this paper, the problem of chaos suppression for a four-dimensional fundamental power system (FDFPS) model is considered via the design of a novel adaptive feedback controller. The period doubling bifurcation route to chaos and some dynamical behaviors of the power system are investigated in detail. Based on stability analysis using an energy-ty...

Aims: Intestinal ischemia-reperfusion has been taken as an important pathophysiological process for multiple organ dysfunctions in critical patients. Recent studies reported that dual expression programs of the B cells receptors and Toll-like receptors on B-lymphocytes permit these ubiquitous cells to integrate both adaptive and innate immune func...

Background Pancreatic enzyme replacement therapy (PERT) is widely applied to patients with exocrine pancreatic insufficiency (EPI), but its effect and safety has not been quantified. Therefore we performed a meta-analysis to determine the efficacy and tolerance of PERT on patients with EPI. Materials and Methods PubMed, Medline, Cochrane library d...

To explore the effects of somatostatin (SST) on macaque intestinal Peyer's patches (PP) in immune B cells and explore its mechanism. A total of 15 healthy adult macaques were randomized into control,MODS and MODS+SST groups.Surgical procedures of MODS in macaques: For MODS group, anesthesia was maintained with diazepam (0.16 ± 0.09) mg×kg(-1)×h(-1)...

In this paper a novel modular switched reluctance machine (SRM) with E-core stators and segmental rotors is presented. Unlike the conventional SRMs, there are hybrid radial and axial magnetic paths in the E-core stators due to the particular construction. An approximate and simplified 2D finite-element analysis (FEA) model is proposed to calculate...

This paper established the mathematical model of fractional-order BUCK converter firstly, and obtained that the model has chaotic characteristics under some certain conditions. Due to fractional calculus has widely development recently, fractional-order stability theory is applied to design the fractional-order PID controller in BUCK converter, and...

This paper proposes an near infrared spectroscopy quantitative analysis model based on incremental neural network with partial least squares. The proposed model adopts the typical three-layer back-propagation neural network (BPNN), and the absorbance of different wavelengths and the component concentration are the inputs and the outputs, respective...

This study presents a novel switched reluctance machine (SRM) with modular E-core stators and multi-layer common rotors for high reliability applications. The stator is composed of six independent modular E-cores with the windings wound around the yoke of the E-cores. The rotor consists of three magnetically independent common rotors which are plac...

A novel nonlinear four-dimensional hyperchaotic system and its fractional-order form are presented. Some dynamical behaviors of this system are further investigated, including Poincaré mapping, parameter phase portraits, equilibrium points, bifurcations, and calculated Lyapunov exponents. A simple fourth-channel block circuit diagram is designed fo...

This paper considers the design of adaptive sliding mode control approach for synchronization of a class of fractional-order arbitrary dimensional hyperchaotic systems with unknown bounded disturbances. This approach is based on the principle of sliding mode control and adaptive compensation term for solving the problem of synchronization of the un...

This paper analyzed the Lyapunov exponent characteristics of a novel fractional order hyperchaotic system with the asymmetric structure, analyzed the dynamic characteristics of the system, and then studied the adaptive projective synchronization control method. Through analyze the fractional order stability theory, a powerful synchronization scheme...

Adaptive pinning synchronization control is studied for a class of fractional-order complex network systems which are constructed depending on small-world network algorithm. Based on the fractional-order stability theory, the suitable adaptive control scheme is designed to guarantee global asymptotic stability of all the nodes in complex network sy...

This paper presents comparative studies of magnetic characteristics and dynamic performances for two mutually coupled dual-channel switched reluctance machines (DCSRMs) with the same properties and different winding connections. A 2D/3D finite element method (FEM) is used to analyze the magnetic field distributions and calculate the static inductan...

In this paper, a new five-dimensional hyperchaotic system by introducing two additional states feedback into a three-dimensional smooth chaotic system. With three nonlinearities, this system has more than one positive Lyapunov exponents. Based on the fractional derivative theory, the fractional-order form of this new hyperchaotic system has been in...

This study proposes an improved decoupled model of mutually coupled dual-channel switched reluctance machine (DCSRM) based on the equivalent inductance and flux linkage characteristics that consider magnetic saturation in dual-channel operation (DCO) mode. A three-dimensional finite-element analysis (FEA) is used to calculate the static phase equiv...

IL-10-/- mice spontaneously develop chronic colitis. Our study was to evaluate the role and regulation of NLRP3 inflammasome in colitis of IL-10-/- mice and Crohn’s disease (CD). Two major NLRP3 complex proteins, NLRP3 and ASC, were upregulated in colonic mucosa of both IL-10-/- mice and CD. Importantly, NLRP3 inflammasome in IL-10-/- mice was acti...

In this paper, an arbitrary-dimensional quantum cellular neural network (QCNN) model and its fractional-order form are presented by using the polarization of quantum-dot cell and fractional derivatives. Two classes of fractional-order QCNN equations, either two-cell or three-cell models with different value of fractional order α are taken into cons...

High-speed and high-power-density drives are attracting much interest in today's industry. This study presents the design, analysis and control of a high-speed switched reluctance machine (SRM) with conical magnetic bearings for aircraft application. The electromagnetic design and performance analysis of the SRM using finite element and indirect fi...

In this paper, a nonlinear state observer control strategy is developed for projective self-synchronization of the fractional-order chaotic attractors of a permanent magnet synchronous motor (PMSM) system. The mathematical model of PMSM system in a smooth fractional-order form is derived by using the fractional derivative theory. A state observer c...

In this paper, we consider an observer-based control approach for manipulating projective synchronization of nonlinear systems in high dimensional. Based on the stability theory of the fractional-order dynamical system, a nonlinear state observer is designed which can achieve projective synchronization in a class of high dimensional fractional-orde...

This article presents a new hyperchaotic system of four-dimensional quadratic autonomous ordinary differential equations, which has one equilibrium point and two quadratic nonlinearities. Some basic dynamical properties are further investigated by means of Poincaré mapping, parameter phase portraits, and calculated Lyapunov exponents and power spec...

This paper introduces a modified Chua's system which is a smooth four-dimensional continuous-time autonomous chaotic system with a cubic nonlinearity. Some dynamical behaviors of this 4-D Chua's system are further investigated by means of Poincaré mapping, parameter phase portraits, equilibrium points, bifurcations and calculated Lyapunov exponents...

This letter reports a novel three-dimensional autonomous chaotic system. Some basic dynamical properties, such as Lyapunov exponents, Poincare mapping, fractal dimension, continuous spectrum and chaotic behaviors of this new transverse butterfly attractor are studied. Furthermore, the forming mechanism of its compound structure obtained by merging...

This paper introduces a new four-dimensional (4D) hyperchaotic system, which has only two quadratic nonlinearity parameters but with a complex topological structure. Some complicated dynamical properties are then investigated in detail by using bifurcations, Poincaré mapping, LE spectra. Furthermore, a simple fourth-order electronic circuit is desi...

We construct a new four-dimensional autonomous hyperchaotic system. Theoretical numerical analysis has confirmed that this system only has one equilibrium point and possesses two positive Lyapunov exponents. Its dynamical behavior is further investigated in detail. Furthermore, a remarkable electronic oscillator circuit design of this hyperchaotic...

In this paper, a new chaotic system of three-dimensional quadratic autonomous differential equations is reported. Some basic dynamical properties, such as Lyapunov exponents, fractal dimension, Poincar$eA mapping, the continuous spectrum and chaotic behavior of this new transverse butterfly attractor are investigated. Furthermore, the complex chaot...

This paper reports a novel four-dimensional autonomous chaotic system, which has a canonical and many interesting complex structure. Furthermore, throughout the study of these dynamical behaviors of this chaotic system some basic dynamical properties, such as continuous spectrum, Lyapunov exponents, fractal dimensions, strange attractor and Poincar...

In this paper a new chaotic system is presented. Some basic dynamical properties are investigated. The oscillator circuit of a new chaotic system realized is simulated using EWB.

In this letter a modified Lorenz system is proposed. Continuous spectrum, Lyapunov exponents, fractal dimension and strange attractor of the new chaotic system are studied. Its chaotic dynamical behaviors and basic dynamical properties are proved by numerical simulation and theoretical analysis.

In this letter a new chaotic system is discussed. Some basic dynamical properties, such as Lyapunov exponents, Poincare mapping, fractal dimension, continuous spectrum and chaotic behaviors of this new butterfly attractor are studied. Furthermore, the forming mechanism of its compound structure obtained by merging together two simple attractors aft...