Lindsey Otten

Lindsey Otten
Charité Universitätsmedizin Berlin | Charité · Research Group on Geriatrics

Master of Science

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46
Publications
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170
Citations

Publications

Publications (46)
Article
Background: Ageing is accompanied by a progressive decline of muscle mass and strength and also, higher levels of circulating cytokines such as growth differentiation factor 15 (GDF15). Studies evaluating the association of GDF15, muscle mass and strength are rare. In this analysis we investigated GDF15 concentrations and their relation to muscle...
Article
Full-text available
Although malnutrition is frequent in the old, little is known about its association with fatigue. We evaluated the relation of self-reported severe weight loss with fatigue and the predictors for fatigue in old patients at hospital discharge. Severe weight loss was defined according to involuntary weight loss ≥5% in the last three months. We determ...
Article
Objectives: sarcopenia is common especially in hospitalised older populations. The aim of this study was to assess the prevalence of sarcopenia, defined as low skeletal mass and muscle strength, and its impact on 1-year mortality in older patients with cancer. Methods: skeletal muscle mass was estimated using bioelectric impedance analysis and r...
Article
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The hormonal mediator fibroblast growth factor 21 (FGF21) is promptly induced by short fasting periods in animal models to regulate glucose and fat metabolism (Inagaki et al. 2007). Data on FGF21 in humans are controversial and FGF21 has not yet been investigated in geriatric patients with loss of appetite and ongoing weight loss. We aimed to explo...
Article
Full-text available
Chronic inflammation acts as a contributing factor in the development of age-related sarcopenia. Growth differentiation factor 15 (GDF15) is induced in various tissues due to inflammation and oxidative stress (Unsicker et al., 2013). The aim of the study was to evaluate the association between GDF15, sarcopenia and functional parameters in geriatri...
Article
Full-text available
Hospitalized, geriatric patients often have poor nutritional status, which is associated with increased complications and a reduction in quality of life. We evaluated functional limitations, frailty status and quality of life in geriatric patients with malnutrition or at nutritional risk at discharge from an acute geriatric clinic. Malnutrition scr...
Article
Objective: Fibroblast growth factor (FGF)21 is promptly induced by short fasting in animal models to regulate glucose and fat metabolism. Data on FGF21 in humans are inconsistent and FGF21 has not yet been investigated in old patients with cachexia, a complex syndrome characterized by inflammation and weight loss. The aim of this study was to expl...
Preprint
Background & aims: Low muscle mass is associated with increased falls, medical complications, length of hospital stay and loss of independence. An increasing number of studies has also shown the association between sarcopenia and health care expenditure. The following narrative review summarizes the current evidence on the economic relevance of lo...
Article
Objective: We analyzed the prevalence of sarcopenia among systemic sclerosis (SSc) patients with respect to quality of life, disability, organ involvement, and muscle function. Methods: A total of 129 patients who met the ACR/EULAR 2013 classification criteria were included. Body composition was measured using bioelectric impedance analysis. Sar...
Conference Paper
Introduction: Ein Großteil der geriatrischen Patienten wird mit einer Mangelernährung entlassen. Ein schlechter Ernährungszustand geht häufig mit funktionellen Beeinträchtigungen einher (1). Objectives: Wir untersuchten deshalb den funktionellen Zustand anhand verschiedener Methoden sowie Fragebögen und die Prävalenz von Frailty bei mangelernähr...
Conference Paper
Das Post-Hospital-Syndrom beschreibt eine Phase vorübergehender Anfälligkeit nach einer Krankenhausentlassung, u.a. aufgrund von verringerter Nahrungsaufnahme, Schlafmangel und psychischer Belastung während des Krankenhausaufenthalts, die mit einer höheren Wiederaufnahmerate korreliert (1). Objectives: Wir untersuchten die Einflussfaktoren auf di...
Article
Background/objectives: In obese subjects, reduced muscle mass and strength are associated with impaired functional and metabolic capacity. We therefore investigated the association between abdominal fat distribution, fat mass index and maximum muscle strength of upper and lower extremities in obese patients. Subjects/methods: One hundred and fif...
Article
Einleitung: Der bioelektrische Phasenwinkel (PhA) hat in mehreren Studien eine hohe prognostische Aussagekraft gezeigt. Daten bei geriatrischen Patienten sind hingegen limitiert. Wir untersuchten die Verteilung des PhA bei geriatrischen Patienten und den Zusammenhang mit Muskelparametern, Sturzhaufigkeit sowie Frailty Syndrom. Methoden: Stationare...
Article
Hintergrund: Vor allem fur altere Menschen stellt eine Mangelernahrung bei der Krankenhausentlassung ein haufiges Problem dar, das den post-stationaren Verlauf negativ beeinflussen kann. Im Rahmen einer Sekundaranalyse einer randomisierten, kontrollierten Interventionsstudie bei mangelernahrten alteren Patienten untersuchten wir Einflussfaktoren au...
Article
Hintergrund: Die krankheitsassoziierte Mangelernährung ist in Krankenhäusern immer noch ein häufiges Problem, das ein erhöhtes Risiko für medizinische Komplikationen bedingt und letztlich zur Verschlechterung der Lebensqualität und zu gesteigerten Behandlungskosten führt. Trotzdem bleibt die Mangelernährung aufgrund des mangelnden Problembewusstsei...
Article
Full-text available
Background: Selected nutrients or food groups have often been studied with regard to long-term mortality and cardiovascular disease, whereas the relation between diet quality and appendicular lean mass (ALM) has rarely been researched. Objective: The aim of this study was to explore the association between a Mediterranean-style diet and ALM in com...
Article
Full-text available
We present the scientific abstracts of the 3rd Annual Symposium of the German Society for Paleo Nutrition (Deutsche Gesellschaft für Paläoernährung e.V.) which was held on July 26th 2015 in Berlin, Germany. The focus of this year's symposium was on the future challenges of human society including topics such as nutritional sustainability, the paleo...
Article
Einleitung: Veranderungen der Korperzusammensetzung konnen insbesondere im hoheren Alter zu Einschrankungen in der Mobilitat und zu verminderter Kraft fuhren. Prado et al. [1] stellten kurzlich eine Einteilung der Korperzusammensetzung in vier Phanotypen anhand geschlechts-, alters-, und BMI-spezifischer Perzentilen der Fettmassen- und Skelettmuske...
Article
Einleitung: Prado et al. [1] stellten kurzlich eine Einteilung der Korperzusammensetzung in vier Phanotypen anhand geschlechts-, alters-, und BMI-spezifischer Perzentilen der Fettmassen- und Skelettmuskelmassenindices vor. Wir untersuchten diese hinsichtlich ausgewahlter inflammatorischer und metabolischer Parameter. Methodik: Untersucht wurden 142...
Poster
Bioelektrische Impedanz-Vektoranalyse (BIVA) zur frühen Ödemdetektion bei jugendlichen Patientinnen mit Anorexia Nervosa

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