Lindokuhle Malibongwe Ngema- Doctor of Philosophy
- Research Scientist at University of the Witwatersrand
Lindokuhle Malibongwe Ngema
- Doctor of Philosophy
- Research Scientist at University of the Witwatersrand
Pharmaceutics | WITS Advanced Drug Delivery Platform | Fulbright Scholar | Johns Hopkins University - School of Medicine
About
23
Publications
1,382
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75
Citations
Introduction
Dr. Ngema is a skilled interdisciplinary researcher with research expertise in pharmaceutical and biomedical sciences. He holds a PhD in Pharmacy (Pharmaceutics), MMedSci (Pharmaceutical Chemistry) cum laude, and BSc Hons. (Biochemistry). Dr. Ngema's primary research interests are cancer nanomedicine (i.e., chemo, immuno, radio) and targeted drug delivery.
Current institution
Additional affiliations
January 2020 - October 2023
Position
- Doctor of Philosophy Candidate
Description
- Doctor of Philosophy candidate at Wits Advanced Drug Delivery Platform (WADDP)
September 2022 - June 2023
February 2021 - present
Position
- Academic Mentor and Tutor
Description
- Key Role(s): - Providing peer academic mentorship to BPharm and BNurs students. - Facilitating online tutorial sessions for Pharmaceutical Chemistry (BPharm III) and Microbiology (BNurs II).
Education
January 2020 - December 2022
Publications
Publications (23)
Developing wound dressings containing plant extracts is an innovative method of preparing wound dressings suitable for treating infected wounds. Different species of Capparis are known for their rich sources of antioxidants with wound‐healing effects. However, the Capparis sepiaria extracts have not been sufficiently explored for wound healing. Inf...
Background: The effectiveness of paclitaxel (PTX) in treating non-small-cell lung carcinoma (NSCLC) is restricted by its poor pharmacokinetic profile and side effects. This limitation stems from the lack of a suitable delivery vector to efficiently target cancer cells. Therefore, there is a critical need to develop an efficient carrier for the opti...
![(A) Showing the (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium...](publication/385994621/figure/fig4/AS:11431281397094578@1745498382886/A-Showing-the-3-4-5-dimethylthiazol-2-yl-2-5-diphenyl-tetrazolium-bromide-MTT_Q320.jpg)
Background/Objectives: To overcome the side effects of conventional cancer treatment, multifunctional nanoparticles with image-guidance properties are increasingly desired to obtain enhanced therapeutic efficacy without any toxicity of the treatment. Herein, we introduce the potential of Polydopamine Radioimmunotherapy with Image-guided Monitoring...
Aim: Using appropriate wound dressings is crucial when treating burn wounds to promote accelerated healing.Materials & methods: Sodium alginate (SA)-based gels containing Carboxymethyl cellulose (CMC) and Pluronic F127 were prepared. The formulations. SA/CMC/Carbopol and SA/CMC/PluronicF127 were loaded with aqueous root extract of Capparis sepiaria...
Gold nanoparticles (AuNPs) exhibit different physical properties compared to small molecules, bulk materials and other nanoparticles. Their synthesis using plant extracts, particularly polyflavonoids as phytoreductants, for the conversion of Au(iii) into Au(0) has been reported. In this study, AuNPs were synthesized with extracts, sterols and pure...
Background: Effective wound dressing is the key solution to combating the increased death rate and prolonged hospital stay common to patients with wounds. Methods: Sodium alginate-based single- and double-layer membranes incorporated with Capparis sepiaria root extract were designed using the solvent-casting method from a combination of polyvinyl a...
The design of targeted antiangiogenic nanovectors for the delivery of anticancer drugs presents a viable approach for effective management of nonsmall-cell lung carcinoma (NSCLC). Herein, we report on the fabrication of a targeted delivery nanosystem for paclitaxel (PTX) functionalized with a short antimatrix metalloproteinase 2 (MMP-2) CTT peptide...
Background
Brain metastases (BM) are a common complication in advanced cancer patients, and extremely challenging to treat. Consequently, whole brain radiotherapy (WBRT) remains the standard palliative intervention for patients with BM. The present study set to evaluate the clinical benefits of WBRT by assessing the quality of life (QoL) in WBRT-tr...
The use of an immunogenic smart radiotherapy biomaterial (iSRB) for the delivery of anti-CD40 is effective in treating different cancers in animal models. This study further characterizes the use of iSRBs to evaluate any associated toxicity in healthy C57BL6 mice. iSRBs were fabricated using a poly-lactic-co-glycolic-acid (PLGA) polymer mixed with...
Background
Brain metastases (BM) are a common complication in advanced cancer patients, and extremely challenging to treat. Consequently, whole brain radiotherapy (WBRT) remains the standard palliative intervention for patients with BM. The present study set to evaluate the clinical benefits of WBRT by assessing the quality of life (QoL) in WBRT-tr...
A design has been established for the surface decoration of superparamagnetic iron oxide nanoparticles (SPIONs) with anti-vascular endothelial growth factor peptide, HRH, to formulate a targeted paclitaxel (PTX) delivery nanosystem with notable tumor targetability and antiangiogenic activity. The design methodology included (i) tandem surface funct...
The actinium-225 (²²⁵Ac) radioisotope exhibits highly attractive nuclear properties for application in radionuclide therapy. However, the ²²⁵Ac radionuclide presents multiple daughter nuclides in its decay chain, which can escape the targeted site, circulate in plasma, and cause toxicity in areas such as kidneys and renal tissues. Several ameliorat...
The application of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as a nanomedicine for Non-Small Cell Lung Carcinoma (NSCLC) can provide effective delivery of anticancer drugs with minimal side-effects. SPIONs have the flexibility to be modified to achieve enhanced loading of hydrophobic anticancer drugs such as paclitaxel (PTX). The purpose...
The application of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as a nanomedicine for Non-Small Cell Lung Carcinoma (NSCLC) can provide effective delivery of anticancer drugs with minimal side-effects. SPIONs have the flexibility to be modified to achieve enhanced oading of hydrophobic anticancer drugs such as paclitaxel (PTX). The purpose o...
There are growing appeals for the design of efficacious treatment options for non-small-cell lung carcinoma (NSCLC) as it accrues to ∼ 85% cases of lung cancer. Although platinum-based doublet chemotherapy has been the main therapeutic intervention in NSCLC management, this leads to myriad of problems including intolerability to the doublet regimen...
