Linda Larson-PriorUniversity of Arkansas for Medical Sciences | UAMS · Psychiatric Research Institute
Linda Larson-Prior
Doctor of Philosophy
About
119
Publications
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Introduction
Publications
Publications (119)
The optimization of infant neuronal development through nutrition is an increasingly studied area. While human milk consumption during infancy is thought to give a slight cognitive advantage throughout early childhood in comparison to commercial formula, the biological underpinnings of this process are less well-known and debated in the literature....
OBJECTIVES/GOALS: This study explored whether gabapentin (GBN) differentially impacted heart rate variability (HRV) and whether HRV was associated with opioid withdrawal ratings among participants with opioid use disorder (OUD) undergoing a randomized, double blind placebo-controlled, trial (RCT) of GBN during a buprenorphine (BUP)-assisted taper....
Throughout infancy, the brain undergoes rapid changes in structure and function that are sensitive to environmental influences, such as diet. Breastfed (BF) infants score higher on cognitive tests throughout infancy and into adolescence than formula fed (FF) infants, and these differences in neurocognitive development are reflected in higher concen...
Introduction
Infancy is a stage characterized by multiple brain and cognitive changes. In a short time, infants must consolidate a new brain network and develop two important properties for speech comprehension: phonemic normalization and categorical perception. Recent studies have described diet as an essential factor in normal language developmen...
Almost 40% of US adults provide informal caregiving, yet research gaps remain around what burdens affect informal caregivers. This study uses a novel social media site, Reddit, to mine and better understand what online communities focus on as their caregiving burdens. These forums were accessed using an application programming interface, a machine...
Annual Meeting of the Society for Neuroscience
Effect of diet on brain development in infants
Preadolescence is an important period for the consolidation of certain arithmetic facts, and the development of problem-solving strategies. Obese subjects seem to have poorer academic performance in math than their normal-weight peers, suggesting a negative effect of obesity on math skills in critical developmental periods. To test this hypothesis,...
Progress in scientific disciplines is accompanied by standardization of terminology. Network neuroscience, at the level of macro-scale organization of the brain, is beginning to confront the challenges associated with developing a taxonomy of its fundamental explanatory constructs. The Workgroup for HArmonized Taxonomy of NETworks (WHATNET) was for...
Virtual reality has made numerous advancements in recent years and is used with increasing frequency for education, diversion, and distraction. Beginning several years ago as a device that produced an image with only a few pixels, virtual reality is now able to generate detailed, three-dimensional, and interactive images. Furthermore, these images...
Epilepsy, a neurological disorder characterized by recurrent seizures, is known to be associated with impaired sleep and memory. Although the specific mechanisms underlying these impairments are uncertain, the known role of sleep in memory consolidation suggests a potential relationship may exist between seizure activity, disrupted sleep, and memor...
Background
While the importance of adequate sleep duration to normal brain development is well known, more studies are needed to characterize how undiagnosed sleep disturbance other than suboptimal sleep duration may impact brain development. In this study we aim to understand the relationships between sleep disturbance measures and cortical morpho...
Neuroscience 2021, the 50 Annual Meeting of the Society for Neuroscience
As the global health crisis unfolded, many academic conferences moved online in 2020. This move has been hailed as a positive step towards inclusivity in its attenuation of economic, physical, and legal barriers and effectively enabled many individuals from groups that have traditionally been underrepresented to join and participate. A number of st...
Previous research shows that earlier age of onset of epilepsy and larger antiepileptic drug (AED) load are related to cognitive impairment and lower quality of life in patients with epilepsy. However, there has been a discrepancy in the specific cognitive domains that are affected and whether AED load is a significant contributor to the cognitive i...
Preadolescence is a period in which structural and functional changes occur in brain network reorganization that relate to the development of executive control functions, particularly in the areas of attention and cognitive inhibition. Obesity has been associated with a deficit in executive functions and behavioral and electrophysiological differen...
The move from in-person to online scientific conferences due to the global health crisis has been hailed as a positive step towards inclusivity in its attenuation of economic, physical and legal barriers. Yet pre-existing and new challenges to truly inclusive conference experiences remain unaddressed. While acknowledging the benefits of an online s...
Annual Meeting of the Cognitive Neuroscience Society, 2021
The University of Arkansas for Medical Sciences (UAMS), like many rural states, faces clinical and research obstacles to which digital innovation is seen as a promising solution. To implement digital technology, a mobile health interest group was established to lay the foundation for an enterprise-wide digital health innovation platform. To create...
The Arkansas Image Enterprise System (ARIES) is an instantiation of the Platform for Imaging in Precision Medicine (PRISM). PRISM containerizes The Cancer Image Archive (TCIA) technology stack, streamlining its deployment, and incorporating new tools to organize and analyze data. Its adoption improves TCIA's ability to manage and analyze integrated...
Background:
Neurodegenerative diseases increase in incidence with age. Prior studies using differing populations and gait paradigms have reported various parameters changing with age, some of which correlate with falls and mortality. Here we use three different paradigms to evaluate gait and balance in healthy non-fallers.
Research question:
Wha...
Introduction:
Freezing of gait (FOG) is a debilitating, late motor complication of Parkinson's disease (PD) that occurs in 50-80% of patients. Gait freezing significantly worsens quality of life by decreasing mobility and increasing falls. Studies have shown that patients with episodic freezing episodes also have deficits in continuous gait. We ev...
While a clear definition of the ‘healthy aged gut’ remains elusive, age-related spatio-temporal variations in the gut microbiota such as a decrease in Bifidobacteria and Firmicutes together with a decrease in overall microbiota diversity are commonly reported [61,73,74]. Age-related disruption of the gut microbiome plays an important role in pathol...
This paper develops object-oriented data analysis (OODA) statistical methods that are novel and complementary to existing methods of analysis of human brain scan connectomes, defined as graphs representing brain anatomical or functional connectivity. OODA is an emerging field where classical statistical approaches (e.g., hypothesis testing, regress...
Subcortical circuits mediating sleep–wake functions have been well characterized in animal models, and corroborated by more recent human studies. Disruptions in these circuits have been identified in hypersomnia disorders (HDs) such as narcolepsy and Kleine–Levin Syndrome, as well as in neurodegenerative disorders expressing excessive daytime sleep...
Introduction
REM sleep behavior disorder (RBD) has a strong association with synucleinopathies. Prior studies of psychometrics have demonstrated subtle abnormalities of task-switching and visuospatial tasks in iRBD, similar to deficits in synucleinopathies. In this study, we used resting state functional connectivity MRI to assess the strength of b...
The model of the brain—particularly the human brain—as a computer is widespread in the modern age. In keeping with most analogies by which complex systems behavior has been understood, this model has provided some useful conceptualizations of brain processing while leaving unanswered the emergent property of the mind. This chapter will explore the...
Scale-free properties of ECoG Movie.AVI. Animation of PSD plots across 120 min of consecutive data during with separated into 5 min sections from start (S00) to finish (S24) during which subject 1 falls asleep (awake to several epochs of SWS illustrated in Figure 10). Colors in PSD data show frequency ranges linked to plot on right showing the segm...
"100 S/s (uniform)". Auditory stimuli (Dau-chirps) at 100 S/s at a uniform rate.
MovieC. This is a QuickTime presentation of the dots of Fig. 20, at a high rate.
"2 S/s (uniform)". Auditory stimuli (Dau-chirps) at 2 S/s at a uniform rate.
"2 S/s (jitter)". Auditory stimuli (Dau-chirps) at 2 S/s with a 12% jitter.
"100 S/s (jitter)". Auditory stimuli (Dau-chirps) at 100 S/s with a 12% jitter.
CONVOLVED DATA of Fig. 6. This is a collection of the convolved, averaged data from which the deconvolved waveforms of some of the figures were derived. Note that there is often a prominent 10 Hz appearance to these waveforms. The QSD-sequence must have Q-magnitudes greater than unity in the passband [14] This has the consequence that the convoluti...
CONVOLVED DATA of Fig. 8. This is a collection of the convolved, averaged data from which the deconvolved waveforms of some of the figures were derived. Note that there is often a prominent 10 Hz appearance to these waveforms. The QSD-sequence must have Q-magnitudes greater than unity in the passband [14] This has the consequence that the convoluti...
CONVOLVED DATA of Fig. 4. This is a collection of the convolved, averaged data from which the deconvolved waveforms of some of the figures were derived. Note that there is often a prominent 10 Hz appearance to these waveforms. The QSD-sequence must have Q-magnitudes greater than unity in the passband [14] This has the consequence that the convoluti...
MovieB. This is a QuickTime presentation of the dots of Fig. 20, at a slow rate.
"Table 1" Table of q-sequences used to obtain the data in the Figures.
Note: If you wish to see an analysis of a q-sequence, you can click on the appropriate "Additional file" in this legend. The name in this list shows the repetition rate and the associated Figure numbers in which the sequence was used, in the following format: rate_Fig#. Each q-s...
40persec_dau; "No jitter – uniform".
q-sequence: 16persec_fig4_6_8_9_10_17
q-sequence: 20persec_fig4_6