Linda H. Kidder- PhD
- Business Development Manager at HORIBA
Linda H. Kidder
- PhD
- Business Development Manager at HORIBA
About
69
Publications
10,932
Reads
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1,769
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Introduction
I excel at utilizing novel approaches to solve problems in a variety of materials characterization, biological, biomedical, pharmaceutical and biopharmaceutical applications, and to transform technology into successful commercial products.
I mentor and develop those around me to create highly functional teams that perform well above expectation. I am highly collaborative, able to lead multidisciplinary teams spread across the globe.
Current institution
Additional affiliations
June 2016 - present
BrightSpec
Position
- Vice President, Market Development
Description
- Define customer requirements to drive product development and sales, planning and prioritization of product development. Responsible for sales and marketing strategy and implementation.
February 2016 - June 2016
BrightSpec
Position
- Managing Director
Description
- Responsible for sales and marketing for analytical instrumentation startup. Define product segmentation, develop market strategy.
January 2012 - January 2015
Position
- Senior Researcher
Description
- Lead multidisciplinary teams of engineers and scientists across the globe to bring entirely new products to fruition. Developed "fluency"in biopharmaceutical applications with no previous educational or professional experience in the field.
Education
September 1988 - October 1994
September 1984 - June 1988
Publications
Publications (69)
We have developed a new Fourier transform infrared chemical imaging technique ¹ which, when coupled with powerful multivariate data processing methods, allows the visualization of intrinsic chemical distributions in biological samples and other composite materials. Integrating spectroscopy with sample visualization and digital image processing is a...
Determination of the physicochemical properties of protein therapeutics and their aggregates is critical for developing formulations that enhance product efficacy, stability, safety and manufacturability. Analytical challenges are compounded for materials: (1) that are formulated at high concentration, (2) that are formulated with a variety of exci...
The purpose of this study was to assess the porosity variation of roller compacted ribbons made using different process parameters; in addition, the feasibility of using near-infrared chemical imaging (NIR-CI) to evaluate porosity variations was examined. Ribbons of neat microcrystalline cellulose were compacted using a range of roll pressures (RP)...
IntroductionMethods: Strengths and LimitationsApplicationsConclusion
References
IntroductionNear-Infrared SpectroscopyNear-Infrared Chemical ImagingInstrumentationOptimizing Experimental Success: Practical ConsiderationsConclusions
References
A thorough description of the instrumental design of instruments combining vibrational spectroscopy with light microscopy (microspectrometers) is presented in this article. Focus is made particularly on Raman and infrared microspectrometry and practical examples are given.
Scitation is the online home of leading journals and conference proceedings from AIP Publishing and AIP Member Societies
The PAT InitiativeThe Role of Near-infrared Chemical Imaging (NIR-CI) in the Pharmaceutical IndustryEvolution of NIR Imaging InstrumentationChemical Imaging PrinciplesPAT ApplicationsProcessing Case Study: Estimating ‘Abundance’ of Sample ComponentsProcessing Case Study: Determining Blend Homogeneity Through Statistical AnalysisFinal ThoughtsAcknow...
IntroductionData MeasurementSelection of Samples and Acquisition SchemesWhat, How Much and WhereData Analysis and the Underlying Structure of the DataImaging with Statistically Meaningful Spatial DimensionsChemical ContrastMeasure, Count and CompareCorrelating Data to Sample Performance and/or Behavior: the Value of NIRCI DataConclusions
References
The process analytical technology (PAT) initiativeThe role of near-infrared chemical imaging (NIR-CI) in the pharmaceutical industryThe development of imaging spectroscopyChemical imaging principlesPAT applicationsProcessing case study one: Estimating ‘abundance’ of sample componentsProcessing case study two: Determining blend homogeneity through s...
Background: single-point near-infrared spectroscopyDevelopment of NIR spectral imagingExamples of NIR spectral imaging capabilitiesConclusions
The United States FDA's Process Analytical Technology (PAT) initiative encourages the pharmaceutical industry to improve process efficiency by developing a thorough understanding of the manufacturing process and by using this knowledge to monitor what are identified as critical quality parameters. Currently, batches are processed according to estab...
Infrared (IR) spectroscopic imaging is the complete synthesis of IR spectroscopy with sample visualization and greatly extends the capabilities of conventional IR spectroscopy. The technique can be used to explore the heterogeneity of a single sample, or as a parallel spectroscopic technique to characterize multiple samples simultaneously. The hist...
Rapidity of data acquisition, high image fidelity and large field of view are of tremendous value when looking for chemical contaminants or for the proverbial "needle in the haystack" - in this case foreign inclusions in histologic sections of biopsy or autopsy tissues. Near infrared chemical imaging is one of three chemical imaging techniques (NIR...
We present the photoelectron (photodetacment) spectra of K
2−19− recorded using 2.540 eV photons. These spectra are highly structured, providing a wealth of information about the electronic structure of alkali metal clusters, including adiabatic electron affinities and electronic splittings for each size. Spectral assignments have been made with gu...
Historically near-infrared (NIR) spectroscopy has enjoyed significant success as the industrial ‘cousin’ of the mid-infrared FTIR spectrometer. Most NIR spectrometers are significantly more rugged than their MIR counterparts, and are therefore suited for use as a QA/QC tool. Sample preparation is trivial or non-existent for most solid-state or liqu...
of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.
Extending the Detection Limit for Near Infrared Spectroscopic Measurements of Heterogeneous Solids Using Focal Plane Array Detectors - Volume 9 Issue S02 - E. Neil Lewis, Eunah Lee, Linda H. Kidder, Everett H. Jefferson, Christopher D. Ellison, Patrick J. Faustino, Robbe C. Lyon, Ajaz S. Hussain
Cluster analysis and artificial neural networks (ANNs) are applied to the automated assessment of disease state in Fourier transform infrared microscopic imaging measurements of normal and carcinomatous immortalized human breast cell lines. K-means clustering is used to implement an automated algorithm for the assignment of pixels in the image to c...
Chemical structure and conformation and physical property anisotropy at the microscopic level can have a major influence on the macroscopic performance characteristics of polymer products. Images based on infrared spectral differences and changes generated using FT-IR microscopy techniques are becoming increasingly used to highlight both chemical s...
Near Infrared Spectroscopic Imaging: A Paradigm Shift in Quantitative Analysis - Volume 8 Issue S02 - E. Neil Lewis, Linda H. Kidder, Eunah Lee
Industrial chemical imaging problems using near infrared (NIR) diffuse reflectance only are addressed. Using several examples, the unique features that chemical sensing with array detectors affords are highlighted. In these examples, quantitative analysis is applied.
A combination of Fourier transform infrared (FT-IR) spectroscopy and microscopy, FT-IR microspectroscopy, has been used to characterize sections of human colorectal adenocarcinoma. In this report, a database of 2601 high quality FT-IR point spectra from 26 patient samples and seven different histological structures was recorded and analyzed. The co...
Single point near-infrared (NIR) spectroscopy is used extensively for characterizing raw materials and finished products in a wide variety of industries: polymers, paper, film, pharmaceuticals, paintings and coatings, food and beverages, agricultural products. As advanced industrial materials become more complex, their functionality is often determ...
We have applied Fourier transform infrared (FTIR) spectroscopic imaging, coupling a mercury cadmium telluride (MCT) focal plane array detector (FPA) and a Michelson step scan interferometer, to the investigation of various states of malignant human prostate tissue. The MCT FPA used consists of 64x64 pixels, each 61 micrometers 2, and has a spectral...
Objective
To test the hypothesis that Fourier transform infrared (FTIR) spectral imaging, coupled with multivariate data processing techniques, can image the spatial distribution of matrix constituents in native and engineered cartilage samples.Methods
Tissue sections from native and trypsin-digested bovine nasal cartilage (BNC) and from engineered...
To test the hypothesis that Fourier transform infrared (FTIR) spectral imaging, coupled with multivariate data processing techniques, can image the spatial distribution of matrix constituents in native and engineered cartilage samples. Tissue sections from native and trypsin-digested bovine nasal cartilage (BNC) and from engineered cartilage, gener...
We have applied Fourier transform infrared (FTIR) spectroscopic imaging, coupling a mercury cadmium telluride (MCT) focal plane array detector (FPA) and a Michelson step scan interferometer, to the investigation of various states of malignant human prostate tissue. The MCT FPA used consists of 64x64 pixels, each 61 micrometers 2, and has a spectral...
FT-IR microspectrometry, particularly in combination with digital imaging techniques shows great promise for in-vivo and ex-vivo medical diagnosis. The statement is based on the knowledge that this method delivers information of the chemical structure and composition of a sample and the fact that any disease is linked to changes in the molecular an...
Optical microscopy has been the workhorse pathological technique, qualitatively differentiating tissue sections by characterizing morphological variations. Vibrational spectroscopic techniques provide quantitative as well as qualitative analytical information that reflects a sample’s biochemical composition and molecular structure. The utility of i...
We have applied Fourier transform infrared (IR) spectroscopic imaging to the investigation of the neuropathologic effects of a genetic lipid storage disease, Niemann-Pick type C (NPC). Tissue sections both from the cerebella of a strain of BALB/c mice that demonstrated morphology and pathology of the human disease and from control animals were used...
Conventional Fourier transform infrared (FTIR) spectroscopy is a workhorse analytical technique providing quantitative and qualitative information on a vast array of materials, ranging from semiconductors to biological samples. By coupling a Michelson interferometer and infrared (IR) microscope to an IR sensitive focal-plane array detector, we have...
The coupling of imaging modalities with spectroscopic techniques adds additional dimensions to sample analysis in both the spectroscopic and spatial domains. The particular ability of infrared (IR) imaging to explore the spatial distribution of chemically distinct species on length scales ranging from microns to kilometers demonstrates the versatil...
Conventional Fourier transform IR spectroscopy has proven to be an
invaluable research and diagnostic approach for the study of a wide
range of biomedical problems. In this article we describe a new
biomedical imaging method which integrates high-resolution IR
spectroscopy with high- definition digital imaging. The continuing
development and commer...
Conventionally, the diagnosis of neuropathology in a subject requires the identification of a behavioral modification, which provides direction for appropriate histological analyses. However, since the ultimate diagnosis of the pathology largely depends on the initial choice of histological tests, the opportunity exists for inaccurate or insensitiv...
Vibrational spectroscopic imaging has already demonstrated enormous potential for studying a variety of chemical and biological systems at both the microscopic and macroscopic level. However, these spectral images are large and complicated, typically consisting of tens of thousands of pixels, each with an associated high-resolution vibrational spec...
Infrared spectroscopy has been used to probe a variety of biological systems including for example, the determination of diseased states and the investigation of foreign inclusions in biologicals. The technique generates qualitative and quantitative information on the structure and dynamics of samples, including lipids, proteins, and non-biological...
By combining step-scan Fourier-transform Michelson interferometry, an infrared microscope, and mercury cadmium telluride focal-plane array image detection we have constructed a mid-infrared spectroscopic imaging system that simultaneously records high-fidelity images and spectra of materials from 3500 to 900 cm - 1 (2.8 to 11 µ m ) at a variety of...
An instrument is described that simultaneously records images and spectra of materials in the infrared fingerprint region using a longwavelength infrared focal-plane array detector, a step-scan Michelson interferometer, and an infrared microscope. With the combination of step-scan Fourier transform (FT) Michelson interferometry and arsenic-doped si...
Between 1 and 2 million women in the United States have silicone breast implants. Complications include capsular contracture and calcification and possibly connective tissue diseases such as scleroderma and rheumatoid arthritis, a subject of some controversy. In order to accurately assess the role of silicone in any histopathologic change, it is ne...
Infrared imaging spectroscopy has been used to investigate several
biological systems. The imaging instrument is comprised of IR sensitive
array detectors coupled with a step-scan interferometer and microscope.
Each pixel on the array simultaneously measures an IR spectrum in
frequency ranges that depend only on the type of array employed. As
image...
We describe a Raman imaging microscope that produces high-fidelity, large format Raman images and Raman spectra from samples as small as 1 micron in size. Laser illumination is delivered to the object by means of an infinity corrected microscope objective, either by a galvanometer scanning system or a widefield fibre optic. Wavelength selection of...
We have developed a new Fourier transform infrared chemical imaging technique which, when coupled with powerful multivariate data processing techniques, allows the visualization of complex intrinsic chemical distributions in biological materials with the potential for performing rapid histological examinations. Integrating spectroscopy with sample...
We describe a Raman imaging microscope that produces high-fidelity, large format Raman images and Raman spectra at close to diffraction-limited spatial resolution. A silicon charge- coupled device is used as a high sensitivity array detector. Wavelength selection of Raman scattered emission is achieved by an acousto-optic tunable filter, which main...
Infrared microspectroscopic imaging has the capabilities of generating spatial information as well as the standard spectroscopy. By taking advantage of the vibrational spectral signatures of biological components, such as lipids and proteins, one has have the capability of obtaining images of the intrinsic distribution of these molecules. The autho...
We present the photoelectron spectra of negatively charged cesium iodide nanocrystals recorded using 2.540 eV photons. The species examined were produced using an inert gas condensation cluster ion source, and they ranged in size from (CsI)−n=13 to nanocrystal anions comprised of 330 atoms. Nanocrystals showing two distinct types of photoemission b...
We present preliminary evidence for catalytic activity by unsupported mixed metal oxide nanocrystalline materials. The results of this study show that a nanophase form of Li-MgO has begun to exhibit catalytic activity by 300 C. This is at least 200 degrees below the temperature at which conventional Li-MgO catalysts exhibit comparable activity. Fur...
We report on the further development of an ion source for producing intense, continuous beams of large positive and negative cluster ions comprised of high temperature materials. This device, the Smoke-Ion Source, is the result of combining inert gas condensation methods with techniques for injecting electrons directly into expanding jets. We demon...
The alkali metals are the simplest of metals. We have recorded the photoeiectron spectra of $Na^{-}_{n=2-5} K^{-}_{N=2-8}, Rb^{-}_{n=2-4}$. and $Ca^{-}_{n=2,3}$ using 2.540 eV photons. These highly structured spectra chart both the electron affinities vs. cluster size for those cluster anions studied thus fat and the electronic state splittings of...
Thesis (Ph. D.)--Johns Hopkins University, 1995. Vita. U.M.I. no. 9533277. Includes bibliographical references. Microfilm.
