Lina Harfouche

Lina Harfouche
Université de Rouen | UR · Sciences et Méthodes Séparatives SMS EA 3233

PhD
Materials Scientist

About

5
Publications
276
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32
Citations
Introduction
I am an ambitious Researcher in the field of Materials Science. I have experience in the field of crystallization, specifically with chiral pharmaceutical compounds. I am skilled in techniques for materials characterization and testing. I am adaptable and driven by a strong work ethic.

Publications

Publications (5)
Article
Full-text available
Nucleation of DL- and L-histidine is examined using induction time measurements and their nucleation rates have been deduced. Results indicate a much slower nucleation for the racemic form compared to...
Thesis
Many active pharmaceutical ingredients are chiral compounds. The two enantiomers of the corresponding molecules exhibit identical chemical and physical properties, but the desired biological activity is often provided by only one enantiomer. The strict regulations forced the pharmaceutical industry to develop new ways to produce pure enantiomers. A...
Article
A cocrystal screening of the chiral drug “proxyphylline” (PXL) and achiral coformers was performed using dry or solvent as-sisted grinding and evaporation methods, yielding 10 different original solid forms with a 1:1 stoichiometry. Among them three anhydrous cocrystals and a monohydrated conglomerate forming system have been identified with salicy...
Article
The monohydrated co‐crystal composed of the chiral active pharmaceutical ingredient proxyphyline, of salicylic acid and of water, was successfully resolved by preferential crystallization (PC) from a water/ethanol mixture. To the best of our knowledge, this is the first report of PC applied to such system and the results highlight unusually high en...
Article
The preparative resolution by preferential crystallization (PC) of proxyphylline has been achieved despite the existence of a stable racemic compound. This is enabled through the careful selection of a solvent in which both the racemic compound and the metastable conglomerate possess a low nucleation rate. Induction time measurements in isobutyl al...

Network

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Projects

Projects (2)
Project
CORE is a Horizon2020 Marie Skłodowska-Curie Innovative Training Network on Continuous Resolution and Deracemization of Chiral Compounds by Crystallization to start on the 1st of October 2016. CORE brings together 8 academic and 7 industrial partners from 6 European countries resulting in an unparalleled combination of chirality, synthesis and crystallization training and research covering the areas of Chemical Engineering, Chemistry and Applied Physics. Methods: Towards Continuous Resolution, Hybrid Resolution Processes, Enabling Resolution Date: 1 October 2016 - 30 September 2020
Project
CORE is a Horizon2020 Marie Skłodowska-Curie Innovative Training Network on Continuous Resolution and Deracemization of Chiral Compounds by Crystallization to start on the 1st of October 2016. CORE brings together 8 academic and 7 industrial partners from 6 European countries resulting in an unparalleled combination of chirality, synthesis and crystallization training and research covering the areas of Chemical Engineering, Chemistry and Applied Physics.