Lima Patowary

Girijananda Chowdhury Institute of Pharmaceutical Science | GIPS · Department of Pharmaceutical Chemistry

Ellagic acid (EA) is an antiplasmodial polyphenol with reported in-vitro activity against Plasmodium falciparum. Studies have reported that EA acts in the late erythrocytic stages of P. falciparum (Pf) when DNA synthesis is taking place. Pf dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) is an important enzyme for DNA synthesis as its inhi...

Citation Barbhuyan, NU et al (2023) Design and screening of tetracycline antibiotics: an in-silico approach. Sciences of Phytochemistry. 2(1): 8-16. Abstract A prominent class of broad-spectrum antibiotics known as tetracycline works by inhibiting the synthesis of proteins, which prevents the development of bacteria. Tetracycline resistance is typi...

A prominent class of broad-spectrum antibiotics known as tetracycline works by inhibiting the synthesis of proteins, which prevents the development of bacteria. Tetracycline resistance is typically attributed to one or more of the following causes: ribosomal binding site mutations, acquisition of mobile genetic elements carrying tetracycline-specif...

In silico techniques reduce the need for rigorous animal experimentations. It is time-efficient, eco-friendly, sustainable, and also adheres to the principle of green chemistry. In silico techniques such as molecular docking, molecular dynamics, binding free energy calculations, quantitative structure-activity relationship, network pharmacology, de...

A versatile plant with many purposes, Bambusa vulgaris is primarily known for its industrial applications, but it is also becoming acknowledged as a possible source of bioactive substances and as a functional food. Every component of the bamboo plant, including the rhizome, culm shavings, leaves, roots, shoots, and seeds, has potential medical uses...

Background: The healthcare sector is facing an unprecedented amount of pressure due to antibiotic resistance. This problem mandates the need for newer molecules with higher efficacy and lower toxicity. Objective: In this study, we aim to virtually design and carry out in-silico studies to identify a potent quinolone derivative by targeting Staphylo...

Antibiotics kill bacteria by blocking essential metabolic processes which prevent them from reproducing thereby allowing the immune system to fight bacterial infections. However, the emergence and the quick spread of bacterial resistance against clinically approved antibiotics have become alarming. This necessitates the development of novel treatme...

SARS-CoV-2 is the pathogen responsible for the on-going COVID-19 pandemic. The two proteins namely, spike protein and papain-like protease are mainly responsible for the penetration and transmission of the virus, respectively. The objective of our study was to find the most promising phytoconstituents of Bridelia retusa that can inhibit both the pr...

BACKGROUND: Malaria is caused by five species of Plasmodium parasites. It is responsible for causing more than 200 million people malaria positive and kills more than 400,000 people every year. Toxicity, price, bioavailability issues and emergence of drug resistance have doubled down the suitability of the drugs. OBJECTIVE: To tackle these problems...

Background: The development of multidrug resistance in the strains of malaria parasites makes the discovery of new antimalarial drugs still relevant. Hence, the world is continuously looking for new antimalarial chemotherapeutic options. Objective: In this study, some new 4-aminoquinoline derivatives were designed and screened against the chloroqui...