Lillian Horin

Harvard University | Harvard · FAS Center for Systems Biology

Background The mechanisms that regulate platelet biogenesis remain unclear; factors that trigger megakaryocytes (MKs) to initiate platelet production are poorly understood. Platelet formation begins with proplatelets which are cellular extensions originating from the MK cell body. Objectives Proplatelet formation is an asynchronous and dynamic pro...

Thyroid hormones (TH) regulate metabolism, but are typically suppressed during times of stressful physiological conditions, including fasting. Interestingly, prolonged fasting in northern elephant seal pups is associated with reliance on a lipid-based metabolism and increased levels of circulating thyroid hormones that are partially attributed to a...

Prolonged‐food deprivation in mammals is associated with the suppression of metabolism via the down‐regulation of cellular thyroid hormone (TH)‐mediated components, insulin, and glucose concentrations. However, during a 2–3 month prolonged‐fast, northern elephant seal (NES) pups experience an up‐regulation of cellular TH‐mediated components and adi...