Liliya Stoyko

I. Horbachevsky Ternopil National Medical University · Faculty of Pharmacy

BACKGROUND: At present, coughing can be regulated by medications such as dextromethorphan and codeine, which are associated with side effects, including drug drowsiness or dependency. Thus, there is an increasing demand for drugs that promote expectorant activities with fewer adverse effects. The root of Primula veris L. (Primulaceae) is an herbal...

The aim of this research was the comparative study of the content of the amino acids in the herb and tubers of Stachys sieboldii. The study of the amino acid composition of the raw materials was carried out using high-performance liquid chromatography (HPLC). The results obtained have shown that the aerial parts of plants investigated have higher a...

One of the tasks of pharmaceutical science is to find new sources of effective drugs. Such sources include plants such as Angelica archangelica L. and Angelica sylvestris L., which have been used for many years to treat various diseases in folk medicine. Because the chemical composition of these plants is poorly understood, the aim of our study was...

Chamaenerion angustifolium L. widely known as fireweed, has significant natural resources in Ukraine. It has long been used in folk medicine as a sedative, analgesic, astringent, antimicrobial, anti-inflammatory, antisclerotic, wound healing, and diaphoretic agent. These properties are the result of the availability of many groups of biologically a...

One of the promising areas for creating safe and effective anti-inflammatory drugs is herbal medicine. In recent years, interest in herbal medicines has grown. Given the above, a valuable medicinal plant earthnut (Cyperus esculentus L.) is of great interest today; chufa is a perennial herbaceous plant of Cyperaceae family, which is grown to produce...

The medicinal properties of Tropaeolum majus L. herb have been known since ancient times and are the result of the availability of different groups of biologically active compounds. The components of essential oil present in the herb of Tropaeolum majus L. were studied by GC/MS analysis. The results of the analysis showed that the Tropaeolum majus...

Crambe cordifolia and Crambe Koktebelica are promising but uncommon and understudied crops. Phytochemical studies have shown that they contain a number of important biologically active substances with different pharmacological properties. A mandatory characteristic of medicinal plant substances, along with high pharmacological activity, should be t...

Plants of the genus Stachys contain various secondary metabolites, including flavonoids, iridoids, fatty acids, phenolic acids, and essential oils, which are associated with anti-inflammatory, cytotoxic, antibacterial, and antioxidant activities. It is believed that the antibacterial effect of Stachys sieboldii is associated with the total content...

The method of random balance was used in the research process. The influence of six quantitative factors on the pharmaco-technological properties of powder masses and on the main indicators of tablet quality was studied. The optimal ratio of excipients in the composition of tablets was established. The study found that the flowability of the powder...

An important issue of modern nephrology is the treatment of disorders of general hemodynamics and water-electrolytic balance in the body. An elevated sodium level in the blood and intercellular space promotes the increase of osmotic pressure, water retention in the body tissues and formation of edemas [1]. Edemas are found with such diseases as art...

Medicines from plants are widely used in the complex treatment of many diseases. Therefore, theoretical and practical interest is the in-depth study of the herb of garden nasturtium. This plant has a long history of usage. Nasturtium is used as an antiscorbutic,

Gentiana cruciata L. herb is widespread in central Europe, Central and Western Asia, Kazakhstan and the Caucasus. Gentiana cruciata L. is known in most of the world. It is contains xanthones, polyphenols, iridoids, flavonoids, tannins, hydroxycinnamic acids, volatile components, organic and fatty acids, ascorbic acid, amino acids, chlorophylls and...

Diabetes mellitus is a medical and social problem caused by the rapid spread of the disease and the development of serious complications. One of the areas is using herbal remedies, either as monotherapy for the prevention of diabetes mellitus type 2 or in the mild stages of this disease. Of great interest in this regard is Cyperus esculentus L., ea...

Gentiana cruciata L. belongs to the Gentianaceae family and is a well-known plant, that has long been used in folk medicine in many countries of the world. The herb and roots of Gentiana cruciata L. are used for many diseases. The dry extract obtained of Gentiana cruciata L. herb was studied to antibacterial and antifungal properties. Phytochemical...

Primula denticulata Smith is a perennial herbaceous plant that has a thick spherical inflorescence of purple, purple-red, white, or blue, commonly known as primrose denticulate. The plant has widely been used in folk medicine. The medicinal properties of primrose denticulate have been known for many years. These properties are the result of the ava...

Pyrola rotundifolia L. is a perennial herbaceous plant, commonly known as round-leaved wintergreen. The medicinal properties of this plant have been known since ancient times. These properties are the result of the availability of many groups of biologically active compounds in Pyrola rotundifolia L. The tablets with dry extract of round-leaved win...

A detailed investigation on the anti-inflammatory activity of an ethanol extract of the herb of Stachys sieboldii was undertaken to find the pharmacological basis for the ethnomedical use of the plant. The study of anti-inflammatory action in the model of carrageenan edema in the foot of rats was performed on 30 white male rats weighing 180-220 g....

Pimpinella saxifraga L. known as burnet saxifrage, belongs to the family Apiaceae genus Pimpinella. Burnet saxifrage has many properties, including expectorant activity. This property is maybe a result of the presence of carbohydrates in plant. There is a lack of data about carbohydrates content of burnet saxifrage. Thus the aim of study was to det...

Centaurium erythraea Rafn. known as common centaury, belongs to the family Gentianaceae and is well-known all over the world. Common centaury herb is used for different diseases such as the illness of the liver, kidneys, biliary tract, diabetes, as well as to increase bile secretion and enhance the contraction of uterine muscles. The aim of our stu...

The prevalence of diabetes mellitus is becoming an epidemic. The variety of etiological factors contributes to the fact that types 2 of diabetes mellitus occur among different age groups and among different segments of the population. Particular attention deserves the different medicinal plants such will have more biologically active substances tha...

The aim of the work. Study of the influence of qualitative factors (excipients), such as fillers, disintegrants, sorbents, and lubricants on the pharmaco-technological performance of granular masses with plant extract having expectorant properties. Methods. Using one of the methods of mathematical planning, namely a four-factor plan based on the Gr...

Polymnia sonchifolia Poepp. & Endl., commonly known as yacon, belongs to the family Asteraceae. It has been introduced into a culture in many countries around the world. For a long time, yacon root tubers have been recommended for use in diseases that are associated with metabolic disorders. Therefore, our study aimed to establish the hypoglycemic...

One of the promising areas for creating safe and effective anti-inflammatory drugs is herbal medicine. In recent years, interest in herbal medicines has grown. Given the above, a valuable medicinal plant earthnut (Cyperus esculentus L.) is of great interest today; chufa is a perennial herbaceous plant of Cyperaceae family, which is grown to produce...

The medicinal properties of Tropaeolum majus L. herb have been known since ancient times and are the result of the availability of different groups of biologically active compounds. The components of essential oil present in the herb of Tropaeolum majus L. were studied by GC/MS analysis. The results of the analysis showed that the Tropaeolum majus...

Chamaenerion angustifolium L. (Epilobium angustifolium L.) is commonly known also as fireweed, belongs to the family Onagraceae. The medicinal properties of this plant have been known many year. These properties are the result of the availability of many groups of biologically active. The herb of this plant is used in various diseases. The lyophili...

Plant raw materials are widely used for the prevention and treatment providing of many diseases. The interest is the in-depth research of the flowers, leaves, and herb of Tagetes lucida . Therefore, the study aimed to determine the content of primary metabolites, namely amino acids in the raw materials of this plant. The amino acids composition and...

Objective: The aim of our study was to establish the content of some primary metabolites, such as amino acids in Crambe cordifolia and Crambe koktebelica. The lack of experimental data induced us to determine these compounds. Methods: Crambe cordifolia and Crambe koktebelica leaves were selected as the objects of the study. The amino acids in the r...

Medicines from plants are widely used in the complex treatment of different diseases every day. Therefore, theoretical and practical interest is the in-depth study of the herb of perspective plants like Centaurium erythraea Rafn. and Gentiana cruciata L. These plants have a long history of usage and interest of people. The aim of the study was to d...

The study was conducted with the aim to further use Pimpinella saxifraga L. rhizomes and roots not only in folk medicine used as an expectorant effect but in official medicine. Studies of acute toxicity of thick extracts from the rhizomes and roots of Pimpinella saxifraga L. were performed V. B. Prozorovskyi method. The expectorant effect of a thic...

Saponaria officinalis L. (common soapwort), usually named fuller's herb, is encountered in most of Europe, in Spain, France, Italy, for example, and also in Syria and North Africa. Saponaria officinalis L. is known in most of the world as an introduced species, often a weed, and sometimes as cultivated decorative plant. Saponaria officinalis contai...

Treatment using medicinal plants with a long history of use is of interest to our society. These plants include Saponaria officinalis L., as well commonly known as common soapwort belongs to the family Caryophyllaceae. The herb and roots of this plant used as a blood purifier, an expectorant in bronchitis, diaphoretic and diuretic, for skin diseases...

The tiger nut contains different active ingredients like oil, tannins, sterols, saponins, alkaloids, vitamins C and E, minerals, and resins. There is a lack of information about carbohydrates content of Cyperus esculentus L. Thus, the aim of this study was to determine the content of carbohydrates of tiger nut herb and tubers. The qualitative compo...

The Cyperus esculentus L. contains different biological active substances such as tannins, alkaloids, vitamins E and C, minerals, sterols, saponins and resins. There is a lack of information about fatty acids content of Cyperus esculentus L. herb and tubers Thus the aim of this research was to determine the content of fatty acids of Cyperus esculen...

Crambe cordifolia Steven is a perennial herb and contains many biologically active substances, including amino acids, quercetin and glycosides of kaempferol. In continuation of the investigation of these plant compounds, it is advisable to study the qualitative composition and quantitative contents of carboxylic acids. Using a HPLC method the quant...

Objective: Thus, the aim of our research was to determine the qualitative composition and quantitative content of carbohydrates in the studied plant material with the prospect of its application as a medicinal plant raw material. Methods: The carbohydrates of the herb of Gentiana cruciata L. determined by GC/MS method. Identification of monosacchar...

Throughout many years, plants using not only as a source of the meal but also in the fight against diseases. Among these plants are rock primrose (Primula saxatilis Коm.), Julia's primrose (Primula juliae Kusn.), and drumstick primrose (Primula denticulatа Smith.). The aim of our research was to determine the content of amino acids in these plants...

Medicinal plants have been considered as an important source for the prevention and treatment of various diseases. The genus Arnica L. is a genus of Asteraceae family, many species of which are used in traditional medicine. Arnica chamissonis Less. and Arnica foliosa Nutt., which belong to plants of the genus Arnica L., are successfully grown in th...

The present study was conducted with the aim to further use common cat's foot herb not only in folk medicine to treat liver diseases but in official medicine too. The research of the hepatoprotective activity of the common cat's foot herb dry extract was performed on a model of acute toxic hepatitis caused by tetrachloromethane (CCl4). The patholog...

Herbal medicines are widely used in the complex treatment of various diseases. Therefore, theoretical and practical interest is the in-depth study of drumstick primrose (Primula denticulata Smith). The study aimed to determine the optimal extraction mode of flavonoids and reducing compounds of drumstick primrose leaves. The concentration of ethanol...

The aim of the work ‒ determination of the qualitative composition and quantitative content of the individual components of tannins in the herb and tubers of the yellow nutgrass (chufa) (Cyperus esculentus L.) by the method of HPLC. Materials and Methods. Herb and tubers of the yellow nutgrass were objects for the research. The raw material was ha...

Diabetes mellitus is one of the global medical, social and economic problems of today.Therefore, it is important to develop a new mechanism of action with fewer side effects that can reduce glycemia and insulin resistance. The aim of the study was to determine the effect of phytocompositions on the basis of Galega officinalis L. and Galevit in the...

Вступ. Створення нових фітопрепаратів та вдосконалення технологій їх виробництва – важливий напрямок фармацевтичної науки і практики. Екстрагування сировини є складним фізико-хімічним процесом. На нього впливає багато чинників. Вагомим є вплив ступеня подрібнення рослинної сировини на інтенсифікування процесу екстрагування. Мета дослідження – визна...

An in-depth phytochemical study of Crambe cordifolia Steven and Crambe koktebelica (Junge) N. raw materials as sources of biologically active substances of phenolic nature is an urgent task of modern pharmacy. Therefore, the purpose of the research was to study the composition of phenolic compounds of the studied plant species. The qualitative comp...

The creation of new herbal products and the improvement of their production technologies is an important area of pharmaceutical science. A valuable source of biologically active substances is a representative of the Rose family (Rosaceae) common agrimony (Agrimonia eupatoria L.). Remedies on the basis of common agrimony are used to increase the sec...

Objective: The aim of the present study was to select excipients in an oral solid dosage form with a dry extract of round-leaved wintergreen (Pyrola rotundifolia L.) by using asymmetric, rotatable composite plan of the second-order (uniform plan No. 17). Methods: The tablets were prepared by using a direct compression method. The most important pha...

Objective: The purpose of our study was to determine sugars and amino acids content of Antennaria dioica Gaertn. herb. In continuation of the investigation of biologically active substances from Antennaria dioica Gaertn., it advisable to study the qualitative composition and quantitative contents of sugars and amino acids from the herb of this plan...

Вступ. Цінною сировиною для розробки фітопрепаратів є журавлини болотної плоди, які застосовують при лікуванні інфекцій сечовидільної системи, застудних та стоматологічних захворювань. Біологічно активні речовини, що містяться в цій сировині, здатні проявляти антимікробні властивості щодо головних уропатогенних штамів мікроорганізмів. При розробці...

Objective: The purpose of our study was to determine sugars and amino acids content of Antennaria dioica Gaertn. herb. In continuation of the investigation of biologically active substances from Antennaria dioica Gaertn., it advisable to study the qualitative composition and quantitative contents of sugars and amino acids from the herb of this plan...

Вступ. У світoвій флoрі рід Primula L. родини Primulaceae є одним із найчисленіших та oб’єднує понад 600 видів одно- і багаторічних рослин. На території України зростає 9 видів роду Примула. У джерелах літератури є інформація про цілющі властивості примули скельної (Primula saxatilis Коm.) та примули дрібнозубчастої (Primula denticulatа Smith.), як...

Introduction. Throughout the centuries, plants have been used not only as a source of nutrition, but also in the fight against diseases. The most interesting are medicinal plants being well tolerated by patients regardless of age. One of these plants is Centaurium erythraea Rafn. The aim of the study was to develop an optimal technology for obtaini...

Introduction. In the world flora Gentianaceae family comprises approximately 100 genera and over 1800 species, among which 24 species, belonging to 6 genera, grow on theterritory ofUkraine. The plants of the family are predominant in subtropical and temperate warm areas of each hemisphere, and also distribute in the mountainous regions of the tropi...