Lilit Antonyan

The University of Calgary · Hotchkiss Brain Institute

While 1–2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13–38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings of OCS and its genetic relationship to OCD, we conducted the largest genome-wide association study (G...

Brain imaging and genomics are critical tools enabling characterization of the genetic basis of brain disorders. However, imaging large cohorts is expensive, and may be unavailable for legacy datasets used for genome-wide association studies (GWAS). Using an integrated feature selection/aggregation model, we developed Image-Mediated Association Stu...

While 1-2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~15-40%) experience subclinical obsessive-compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings of OCS and its genetic relationship to OCD, we conducted the largest genome-wide association study (G...

This chapter discusses the genetics of childhood and adolescent anxiety and obsessive-compulsive disorders. The chapter starts with a discussion of evidence from genetic epidemiological studies, followed by a detailed review of evidence from molecular genetic studies of anxiety and obsessive-compulsive disorder (OCD). Future directions are highligh...

We have performed a 50 ns molecular dynamics simulation of a hyperbranched polymer, i.e. polyethyleneimine (PEI), inside inverse micelles formed with zwitterionic surfactants 3-(N,N-dimethyl-dodecylammoniio)-propansulfonate (SB) in heptanol. The runs were performed using the GROMACS simulation package. During simulation time the PEI molecule underg...

We have performed a 50 ns molecular dynamics simulation of a hyperbranched polymer, i.e.polyethyleneimine (PEI), inside inverse micelles formed with zwitterionic surfactants 3-(N,N-dimethyl-dodecylammoniio)-propansulfonate (SB) in heptanol. The runs were performed using the GROMACSsimulation package. During simulation time the PEI molecule undergoe...

A series of long runs were performed on pentadecyl sulfonate/water systems using both atomic level and coarse-grained approaches. Surfactant micelle fusion was observed with coarse-grained approach; however, the atomic scale study did not reach the equilibrium even at long timescales. The shape of micellar aggregate appeared as to be prolate sphero...