Liliana Silva

Liliana Silva
University of Aveiro | UA · CICECO - Centre for Research in Ceramics and Composite Materials

Ph.D in Chemical Engineering

About

32
Publications
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Introduction
Liliana Silva currently works at the CICECO - Centre for Research in Ceramics and Composite Materials, University of Aveiro. Liliana does research in Chemical Engineering and Biomedical Engineering. Their most recent publication is 'Characterization and Modeling of the Liquid Phase of Deep Eutectic Solvents Based on Fatty Acids/Alcohols and Choline Chloride'.

Publications

Publications (32)
Article
Full-text available
The formation of deep eutectic solvents (DES) is tied to negative deviations to ideality caused by the establishment of stronger interactions in the mixture than in the pure DES precursors. This work tested thymol and menthol as hydrogen bond donors when combined with different flavonoids. Negative deviations from ideality were observed upon mixing...
Article
With the increasing number of applications being reported for protic ionic liquids (PILs), there is a demand for the development of thermodynamic models that can accurately describe their thermophysical properties and phase equilibria, with equations of state (EoS) derived from the Statistical Associating Fluid Theory (SAFT) being among the best. T...
Article
The differences on the impact of water on the intermolecular interactions present in the deep eutectic solvents betaine/urea and choline/urea are investigated in this work by measuring the solid–liquid phase diagrams of these mixtures with different amounts of added water. These data are analyzed in terms of ternary systems, rather than the usual p...
Article
Mixtures of carbohydrates are often reported in the literature as deep eutectic solvents yet, in most cases, their solid–liquid phase diagrams are poorly characterized and no evidence is available to validate this classification. In this work, the phase diagrams of the binary systems composed of the sugar alcohols mannitol or maltitol and meso-eryt...
Article
New experimental density data in a wide range of temperatures (283–363) K and pressures (0.1–95) MPa is here reported for five protic ILs based on the N,N-diethylethanolammonium ([DEEA]) cation, combined with the following anions: acetate ([Ace]), propanoate ([Prop]), butanoate ([But]), pentanoate ([Pent]) and hexanoate ([Hex]) in a 1:1 acid:base p...
Article
Dehydration technologies with low energy consumption using non-toxic materials are important in industrial, residential, and transport applications. Herein, nanocomposite polymeric hollow fibers with high dehydration capability were demonstrated with the incorporation of green amino acid-based ionic liquids. The ionic liquid was encapsulated in des...
Article
Aiming to contribute to drug pre-formulation, new eutectic mixtures were developed. Thymol, coumarin, or quaternary ammonium chlorides as excipients, were combined with the active pharmaceutical ingredients (APIs) acetylsalicylic acid, acetaminophen, ibuprofen, ketoprofen, or lidocaine. Their solid-liquid equilibrium (SLE) binary phase diagrams wer...
Article
Despite some promising potential applications of eutectic systems containing choline chloride ([Ch]Cl) and a polyalcohol, a detailed investigation of the thermodynamic behavior of these systems is still missing. In this work, the solid-liquid equilibria phase diagrams of binary systems containing [Ch]Cl and one from six different polyalcohols (ethy...
Article
The mechanism of formation of betaine‐based deep eutectic solvents (DES) is here presented for the first time. Due to its polarity unbalance, it is found that betaine displays strong negative deviations from ideality when mixed with a variety of different organic substances. These results pave the way for a comprehensive design of novel deep eutect...
Article
Ionic liquids have gathered special attention due to their potential for carbon dioxide capture, and their potential as solvents for climate changes mitigation. Following the scope of previous works, amino acid‐based ionic liquids encapsulated (ENILs) into carbonaceous submicrocapsules are here proposed as a novel material for CO 2 capture. The ENI...
Article
The criterion to distinguish a simple eutectic mixture from a deep eutectic solvent (DES) lies in the deviations to thermodynamic ideality presented by the components in the system. In this work, the current knowledge of the molecular interactions in types III and V DES is explored to liquefy a set of three fatty acids and three fatty alcohols, her...
Article
Full-text available
It was recently shown that tetramethylammonium chloride presented negative deviations to ideality when mixed with tetraethylammonium chloride or tetrapropylammonium chloride, leading to a strong decrease of the melting points of these salt mixtures, in a behavior akin to that observed in the formation of deep eutectic solvents. To better rationaliz...
Article
Deep eutectic solvents (DES) present interesting properties, mostly connected to their solvation ability, and have been subject to much research in the recent past. Currently, the discovery of new eutectic solvents is accomplished by experimentally measuring the eutectic point of random systems, often using choline chloride as a hydrogen bond accep...
Article
Natural products can be the basis for the development of green solvents, relevant for the advancement of new, more sustainable, processes and products. In this work, ten binary mixtures constituted by terpenes are prepared and characterized. Their solid-liquid phase diagrams show that room temperature solvents can be prepared from solid terpenes in...
Article
Mixtures of non-ionic compounds have been reported as DES but most are just ideal mixtures. In the thymol–menthol system, an abnormal strong interaction was identified stemming from the acidity difference of the phenolic and aliphatic hydroxyl groups. This type of interaction is found to be the key to prepare non-ionic DES, that may be classified a...
Article
There is a lack of fundamental knowledge on deep eutectic solvents, even for the most extensively studied mixtures, such as the mixture of cholinium chloride and urea, that prevents a judicious choice of components to prepare new solvents. The objective of this work is to study and understand the fundamental interactions between cholinium chloride...
Article
Given the recent boom of applications for deep eutectic solvents (DES), there is a need for robust and accurate thermodynamic models that are able to describe them. Recent works have used molecular-based equations of state, derived from the Statistical Associating Fluid Theory (SAFT), to model DES due to their ability to explicitly account for hydr...
Article
Full-text available
Given the recent boom of applications for deep eutectic solvents (DES), there is a need for robust and accurate thermodynamic models able to describe them. Recent works have used molecular-based equations of state, derived from the Statistical Associating Fluid Theory (SAFT), to model DES due to their ability to explicitly account for hydrogen bond...
Article
The high melting point of a large number of organic salts with potential ionic liquid-like properties, hinders their applicability as solvents. Considering the success of cholinium chloride on lowering the melting temperature of several substances and its success on forming deep eutectic solvents, this work studies its mixing with organic chlorides...
Article
The solubilities of gallic, protocatechuic, gentisic or α-resorcylic acids were measured in nine pure solvents (water, methanol, ethanol, 1-propanol, 2-propanol, 2-butanone, ethyl acetate, acetonitrile and dimethylformamide) at 298.15 K and 313.15 K, using the analytical isothermal shake-flask method. Additionally, solid phase studies of the select...
Article
Aiming at providing an extensive characterization of the solid-liquid equilibria (SLE) of deep eutectic solvents (DESs), the phase diagrams of nine eutectic mixtures composed by choline chloride ([Ch]Cl) and (poly)carboxylic acids, commonly reported in the literature as DESs, were measured experimentally. Contrarily to the behavior reported for eut...
Article
Full-text available
Inspired by the lack of characterization of natural eutectic and deep eutectic (DES) systems, we studied the solid-liquid equilibria (SLE) of binary and ternary mixtures involving choline chloride and sugars. The densities, viscosities and solvatochromic parameters for the binary systems containing choline chloride, [Ch]Cl, were measured at the eut...
Article
Full-text available
Recently some works reported claims that hydrophobic deep eutectic solvents could be prepared based on menthol and monocarboxylic acids. Despite of some promising potential applications these systems were poorly understood and this work addresses this issue. Here the characterization of eutectic solvents composed by the terpenes thymol or L(–)-ment...
Article
The solid-liquid equilibria phase diagrams of eight eutectic systems formed by choline chloride and fatty acids, or fatty alcohols, were measured to characterize the non-ideality of the liquid phase of these deep eutectic solvents (DES), and to evaluate the best modelling approaches to their description. Most of these systems are shown to present o...
Presentation
Deep eutectic solvents (DES) are a new class of solvents with green properties that have attracted the researcher’s attention over the last years. Among their unique properties, stand their easy formulation and low melting points due to hydrogen complexation of their constituents, a hydrogen bond donor and a hydrogen bond acceptor. Owing to their p...
Article
Terpenes and terpenoids belong to the largest and most diverse class of natural products. Due to the increasing importance of their applications and the emerging perception of their impact on the environment, the available physico-chemical characterization is insufficient. In this work the water solubility of geraniol, linalool, dl-citronellol, thy...
Article
In this study the solid-liquid equilibria (SLE) of 15 binary mixtures composed of one of three different symmetrical quaternary ammonium chlorides and one of five different fatty acids were measured. The experimental data obtained showed extreme negative deviations to ideality causing large melting-temperature depressions (up to 300 K) that are cha...
Article
The temperature and enthalpy of fusion of choline chloride -[Ch]Cl- are not directly measurable since this compound decomposes upon melting. Yet, given the wide use of this compound in the preparation of deep eutectic solvents (DES), its thermophysical fusion properties are very important for a better understanding of these mixtures and the thermod...

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