Liliana Rogozea

• vicerector,professor,Medicine
• Transylvania University of Brașov

Background Vaccinology education forms a cornerstone of effective public health strategies, particularly in the face of global challenges such as vaccine hesitancy. This study investigates the current state of vaccinology education within Romanian medical universities, compares it against European standards, and identifies potential gaps in the cur...

Nurses face significant challenges, including long shifts and heavy workloads, which can negatively impact their mental health, contributing to depression, anxiety, burnout, and fatigue. These factors make nurses more vulnerable to mental health difficulties compared to the general population. We conducted a systematic review to assess the mental h...

Effective communication is crucial in pediatric palliative care and is essential to facilitate shared decision making between families and the health care team. This study explored the communication preferences of caregivers and health care specialists in Central-Eastern Europe, a region with unique cultural and health care dynamics. Through qualit...

Background: In the last decades, there has been a growing demand for outpatient services; understanding the factors influencing patient satisfaction is critical for improving healthcare quality. Objectives: This study evaluates patient satisfaction with nursing care and examines how satisfaction varies based on socio-demographic factors in ambulato...

Background Medications initially intended for diabetes treatment are now being used by other patients for weight loss. In the specialized literature, there are numerous meta-analyses investigating this aspect. Areas of Uncertainty The authors aimed to explore whether the application of scientometric methods for literature review within meta-analys...

The aim of this study was to report the translation into Romanian of the Seizure Severity Questionnaire (SSQ), an instrument for the evaluation of the frequency and severity of epileptic seizures, and the results of applying it to a group of patients with epilepsy evaluated at a hospital in Romania. Methods: Four translators were involved in obtain...

Background The promotion of the latest medicines produced by the pharmaceutical industry is an important issue both from an ethical point of view (the level of accessibility, the way research is carried out) and from the point of view of marketing and especially from the lobbying issues raised. Areas of Uncertainty The ethical dilemmas raised by t...

Background Artificial intelligence (AI) is considered the fourth industrial revolution that will change the evolution of humanity technically and relationally. Although the term has been around since 1956, it has only recently become apparent that AI can revolutionize technologies and has many applications in the medical field. Areas of Uncertaint...

Diabetes self-management education helps to improve health outcomes and qualities of life for diabetic patients. This systematic review examines the effectiveness of several types of diabetes self-management education for patients at the early stages of type 2 diabetes mellitus (T2DM). A review of studies that have researched the use and impacts of...

Background: The underutilization of primary care services is a possible factor influencing inappropriate emergency service presentations. The objective of this study was to evaluate the proportion and characteristics of patients inappropriately accessing emergency room services from the perspective of primary care underutilization. Methods: This cr...

Introduction: In the medical field, Artificial Intelligence (AI) has become increasingly influential, promising improvements in diagnostics, treatment, and patient management. A key aspect is the role of AI in developing treatment protocols, which could transform their personalization. However, its growth also involves significant ethical challenge...

Introduction: The time period immediately after stroke represents an important opportunity for primary palliative care. Stroke patients have a high prevalence of problems that can be ameliorated by integrating palliative care principles into stroke services. The inclusion of a target needs assessment is a useful first step in refining a generalist...

Background: The integration of Artificial Intelligence (AI) in drug development has revolutionized the pharmaceutical and medical landscape, enhancing drug discovery, clinical trials, and personalized medicine. This evolution, while beneficial, has introduced significant ethical challenges in data privacy, algorithmic bias, intellectual property ri...

Background The nocebo effect is often disregarded in medical practice and is certainly much less known than the placebo effect, although, in reality, both can influence therapeutic decision making and the quality of life of patients. However, the nocebo effect raises a number of issues not only of a practical nature related to clinical activity but...

Background: Vaccinology education forms a cornerstone of effective public health strategies, particularly in the face of global challenges such as vaccine hesitancy. This study investigates the current state of vaccinology education within Romanian medical universities, compares it against European standards, and identifies potential gaps in the cu...

Background: The objective of this study was to determine the effects of royal jelly and fermented soy extracts on menopausal symptoms and on quality of life in pre- and post-menopausal women. Materials and method: This prospective observational study was carried out in a Clinical Hospital of Brasov, Romania, during June 2020 and December 2021. Eigh...

Diabetes self-management education helps to improve health outcomes, quality of life and to reduce expenses for diabetic patients. This systematic review aimed to examine the effectiveness of diabetes self-management education used for newly diagnosed patients with type 2 diabetes (T2DM). A review of studies that have researched the use and the imp...

Background This study aims to evaluate the efficacy of transcranial magnetic stimulation (TMS) in patients with depression and whether concurrent psychotropic medication use negatively affects the treatment outcome of TMS. Patients' characteristics, predictors of treatment response, the relationship between demographics, and the selection of TMS as...

Background Cholera is a potentially lethal diarrheal disease produced by Vibrio cholerae serotypes O1 El Tor and O139. Known since antiquity, the condition causes epidemics in many areas, particularly in Asia, Africa, and South America. Left untreated, the mortality may reach 50%. The crucial therapeutic intervention is intravenous or oral rehydrat...

Background The history of medicine has flowed in the wake of knowledge and social perceptions about the body and corporeality. There is no idea of health without reference to the notion of body (although “health” can have other meanings, figuratively). Considering the same history, the body was the subject of numerous segregations and categorizatio...

Background: Complete bed rest has been a component of the management of acute myocardial infarction, which was first diagnosed in the United States in 1912. The prescribed duration of bed rest has been progressively shortened in the past century. Study question: What are the milestones of the changes in the expert approach to the duration of bed...

Background: Cardiovascular diseases are an important public health problem, the main cause of death in both men and women, with a continuous increasing prevalence and consequences upon morbidity in economic, physical, and psychological terms.The new technology have made possible the development of innovative devices, which have increased the possi...

Background: This study aimed to assess the influence of various clinical factors on the quality of life perception of patients with epilepsy over a follow-up period in current clinical practice. Methods: Thirty-five PWE evaluated via video-electro-encephalography in the Clinical Hospital of Psychiatry and Neurology in Brasov, Romania, were included...

Background: The COVID-19 pandemic has brought new ethical challenges to both health care professionals and the general public. Among the ethical problems amplified during this period were the making of medical decisions to quickly introduce some drugs into therapeutic practice with unproven or insufficiently proven effects (such as ivermectin), th...

Introduction: Placebo & Nocebo are two aspects of medical practice less known and evaluated, although the ethical implications are complex and should be a subject of systematic analysis and even systematic research both from the point of view of medical staff, regardless of his training, of people involved in medical ethics. The purpose of the stud...

Introduction: The perception of vaccines in the Romanian population has undergone a series of changes over time, leading to the reduction of the vaccination rate and even to the reappearance of some conditions, previously considered on the way to extinction. Like other countries, in Romania there is an anti-vaccine "movement", which intensified dur...

Background: Genetic engineering has allowed a major development of research in this field, with specialists attempting to edit the human genome, after the successful editing of the genomes of plants and animals. However, human gene editing technologies are at the center of ethical debates around the world. Areas of uncertainty: Ethical concerns...

Background Healthcare professionals had to face numerous challenges during the pandemic, their professional activity being influenced not only by the virus, but also by the spread of medical misinformation. In this regard, we aimed to analyze, from the perspective of medical staff, the way medical and non—medical information about the virus was com...

Background: Advances in drug therapy for pulmonary tuberculosis have had an extraordinary impact on the incidence of tuberculosis in the United States in the past century, which has decreased from 113/100,000 persons in 1920 to 2.2/100,000 in 2020. Modern treatments have contributed to a remarkable decrease in hospitalizations and mortality and ha...

This study investigates the impact of different clinical and demographic factors on the quality of life in people with epilepsy hospitalized at a health institution of Brasov County, Romania, using a QOLIE-31-P questionnaire and to reflect on the opportunities and limitations of incorporating such an instrument into the clinical practice. Methods:...

Background: Advances in drug therapy for inflammatory bowel disease (IBD) [Crohn disease and ulcerative colitis (UC)] have contributed to a decrease in the severity of these chronic and disabling conditions. Study question: What are the milestones of the changes in the expert approach to the pharmacological management of IBD in the past century?...

Background: Older adults with serious mental illness have a high prevalence of coronary artery and its major risk factors, that is, arterial hypertension, dyslipidemia, and diabetes mellitus. The prevalence and clinical control of these conditions have not been compared in geropsychiatric inpatients with dementia versus those with mood or psychoti...

Background: Innovations in drug therapy for obesity have had a limited impact on the body mass index, prevalence of medical complications, quality of life, and work potential of a substantial majority of affected persons. Study question: What are the milestones of the changes in the expert approach to the pharmacological management of obesity in...

The coronavirus disease 2019 (COVID-19) pandemic is probably the most critical epidemiological situation that human civilization has faced in the last few decades. In this context, of all the professional categories involved in the management of patients with COVID-19 are the most likely to develop burnout syndrome. The main objective of this study...

Background: Advances in drug therapy for primary (or essential) arterial hypertension have contributed to a significant decrease in the frequency and severity of strokes, coronary artery disease and heart failure, and chronic renal insufficiency. Study question: What are the milestones of the changes in the expert approach to the pharmacological...

Background: Opioid use disorder continues to have a significant impact on public health morbidity and mortality throughout the United States and elsewhere. Managing opioid withdrawal is a critical treatment goal in individuals entering treatment with an active opioid use. Study question: What are the milestones of the changes in the expert appro...

Introduction: Vaccination is a procedure through which a community can become actively immunized by the administration of a vaccine. In recent years, in Romania, there has been an anti-immunization “movement” induced by several anti-vaccinists, who have alleged that vaccination might have a detrimental effect on the community. The purpose of the st...

Introduction: Medial errors in health care facilities from Romania are a crucial issue that affects the safety of medical services. Reporting medical errors is an important aspect of the patient safety culture that prevents future medical errors. However, only a small part of medical errors are reported in Romania. The main purpose of the study is...

The increasing occurrence of infections caused by pathogens found on objects of everyday use requires a variety of solutions for active disinfection. Using active materials that do not require daily maintenance has a potential advantage for their acceptance. In this contribution, transparent films, with silver as the main antimicrobial agent and a...

Introduction: Non-porous surfaces with antibacterial properties have begun to gain notoriety because strategies are being sought to prevent infections by methods that are as safe as possible for the human body. Objectives: Test methods can be variates, such as ISO 22196 standardized testing, inoculation testing with a sterile swab, bacteriological...

Introduction. The issue of sex education among young people is a major problem not only for civil society but also for medical staff, given that Romania ranks third in terms of unprotected sex in one year, according to the 'Emergency Contraception Study'. The realization of an education campaign among young people must be based on the knowledge of...

Background: Advances in drug therapy for atrial fibrillation (AF) have had a significant impact on the quality of life of a substantial majority of affected persons, which has contributed to a remarkable decrease in the frequency and severity of thromboembolic complications, hospitalizations, and mortality. Study question: What are the milestone...

Background: Advances in drug therapy for myasthenia gravis have had a significant impact on the quality of life and work potential of a substantial majority of affected persons and has contributed to a remarkable decrease in the frequency and severity of complications, hospitalizations, and mortality. Study question: What are the milestones of t...

The study aim was to evaluate the ultrasound (US) signs of the mammary lesions classified in the Breast Imaging-Reporting and Data System (BI-RADS) score category 3, 4, and 5, corresponding to US BI-RADS. It also followed the correlation between US changes of lesions suggestive for malignancy with the histopathological results and evaluated the pro...

Background: Advances in drug therapy for peptic ulcer have had a significant impact on quality of life and work potential of many millions of affected persons and have contributed to a remarkable decrease in the prevalence of the disease, frequency and severity of complications, hospitalizations, and mortality. Study question: What are the miles...

Background: Drug therapy for diabetes mellitus (DM) has had a significant impact on quality of life and work potential of affected persons and has contributed to a remarkable decrease in the frequency and severity of complications, hospitalizations, and mortality. The current approach is the result of incremental progress in using technological ad...

Background: The current pandemic has raised several ethical dilemmas, related to conducting real-time trials for new treatments or vaccines or with decisions such as accessibility to vaccines. Study question: Should there be a prioritization of access to the vaccine based on ethical and objective criteria or should the access be done at random?...

Background: Drug therapy for heart failure influences quality of life and work potential of affected persons and has contributed to decrease in hospitalizations and cardiovascular mortality. The current approach is the result of incremental progress in understanding the pathophysiology of the syndrome, introduction of new molecules, and repurposin...

Mobile phones have become an essential "accessory" in modern society. Their use in hospitals can increase the quality of the medical act by allowing prompt communication between departments or the rapid search for data. Several studies demonstrate the possibility of microbial contamination of phones, mostly in the medical field, especially with spe...

This historical vignette displays an ex-libris dedicated to Doctor Mozes Karoly, created by the well-known Oradea artist Karoly Roman Radvany. This artwork displays the portrait of an old man with a beard examining a skull and surrounded by books. There is the vanitas theme influence in this between-wars artwork. Doctor Mozes Karoly contributed dec...

In Romania, users’ perceptions about availability of services in primary care have not been explored since 2009, when a national report was produced, and little is therefore known about the subject. The study aims to identify perceptions of primary healthcare service users regarding the availability of services in primary care. This research is a p...

Objective: We aimed to evaluate the association of risk factors such as smoking and professional status (students vs employed) as determinants of disparities in perceived wellness among Romanian individuals. Methods: We conducted a cross-sectional study in which 145 participants were enrolled from December 2017 to February 2018, in Brasov, Brasov C...

In 2020 we celebrate the bicentennial of the birth of Florence Nightingale and 110 years from her death (1820-1910). This gives us the opportunity to remember her life and her achievements. She is mainly known for her contribution to the foundation of modern nursing in the British Empire and subsequently to the world. Besides her personal engagemen...

Background: Pain and depression have a high impact on caring for the people who need palliative care, but both of these are neglected compared with the approach for other symptoms encountered by these patients. Areas of Uncertainty: There are few studies in humans that support the existence of common neural circuits between depression and pain t...

Obiectiv: Pacienții cu epilepsie pot fi ținte ale discriminării și se confruntă cu o calitate a vieții mai scăzută și în ciuda dezvoltării în ultimii douăzeci de ani a medicamentelor antiepileptice o parte dintre aceștia manifestă rezistență la tratament. Obiectivul acestei lucrări este de a corela conceptul de epilepsie farmacorezistentă, cu modal...

Purpose of review: Allergen immunotherapy (AIT) is a well-known disease-modifying intervention for allergic diseases. Its benefit in allergic asthma, ranging from prevention to facilitating asthma control, is yet to be clarified. Recent findings: In 2017, following several well-designed randomised controlled trials (RCTs) with house-dust mites (...

Background: Adjustment disorder requires therapeutic intervention because of its complications, which include a significant risk of suicide, but evidence-based therapeutic guidelines are not available. Areas of uncertainty: The main problem is related to answer to the following question: What is the optimal therapeutic approach to adjustment dis...

Background Currently considered an occupational disease, the burnout syndrome affects 13–27% of the active population in multiple occupational sectors of the modern world.Objectives Considering the burnout syndrome from the new perspective of the predictive, preventive, personalized medicine concept as a pathological entity with a predictable appea...

Background: Pain is one of the symptoms for which any man is willing not only to go to the doctor but also to resort to any means, including self-medication, to "get rid" of it. Self-medication is not only a current practice but also a public health problem, under the circumstances that it can influence the way in which a disease is diagnosed and/...

Purpose of review: Allergic diseases are prototypic examples for gene × environment-wide interactions. This review considers the current evidence for genetic and epigenetic mechanisms in allergic diseases and highlights barriers and facilitators for the implementation of these novel tools both for research and clinical practice. Recent findings:...

Improved understanding of the contribution of immune-inflammatory mechanisms in allergic diseases and asthma has encouraged development of biologicals and small molecules specifically targeting the innate and adaptive immune response. There are several critical points impacting the efficacy of this stratified approach, from the complexity of diseas...

With this Editorial, we want to present the Special Issue, “Advanced Analytical Methods in Clinical Diagnosis and Therapy”. The development of medicine is not possible without progress in the field of identifying different biomarkers or treatments using modern approaches, such as the analytical methods presented in articles that are part of this is...

Background and aim: Physiotherapy has a distinct feature in terms of patient relationship, regarding the level of communication, especially how physical therapy sessions take place throughout the rehabilitation process. One of the particularities encountered in Romanian physiotherapy practice is related to obtaining informed consent (IC), consider...

Background: Palliative care (PC) is the holistic care of patients with life-limiting illnesses focused on relief of suffering and maximizing quality of life for patients and their families. Patients with heart failure (HF) are the largest group eligible for PC services, but only a small percentage of them receive PC. Areas of uncertainty: The op...

Background: In patients with coronary artery disease, cardiovascular mortality and other acute events showed a clear correlation with risk factors and biomarkers including platelet activation. Study question of this research: Which was the incidence of low response to clopidogrel and its correlation with risk factors and biomarkers in coronary a...

Background Patients’ expectations and needs for healthcare services are changing. These changes are correlated with changes in disease profiles, a higher prevalence of chronic diseases, the introduction of new and innovative treatments and health technologies, and the emergence of new social and economic contexts. National health reports on Romania...

Background Patients’ expectations and needs for healthcare services are changing. These changes are correlated with changes in disease profiles, a higher prevalence of chronic diseases, the introduction of new and innovative treatments and health technologies, and the emergence of new social and economic contexts. National health reports on Romania...

Background National health reports on Romania show that decisions in healthcare planning are not correlated with the health needs of the population and that there is a high degree of unmet healthcare needs of the population (related to cost, distance and waiting times), especially for low-income populations. Family medicine is facing underfinancing...

Diabetic foot is a current public health problem and a late consequence of diabetes. Morbidity and mortality are significant, seriously affecting the patient's quality of life. Treatment of the diabetic foot is a long-lasting, highly resource-consumption process. Using negative pressure therapy leads to shorter hospitalization periods, better funct...

It is known that cigarette smoking is correlated with medical associated inquires. New electronic cigarettes are intensively advertised as an alternative to conventional smoking, but only a few studies demonstrate their harmful potential. A cross-sectional study was designed using 150 subjects from Brasov (Romania), divided into three groups: non-s...

Introduction Physiotherapy has developed over the last century, and the physiotherapists' professional identity is growing. The heterogenity of physiotherapy studies in Europe, local government, and health policies have influenced the responsibilities and ethical reasoning of physiotherapists. Our study aims to explore the perceptions and differenc...

The effectiveness of pharmacological therapies is supported and guaranteed by medical protocols, which are the result of long-lasting experiments and scientific research, of course adapted to the level of competence and functional capacity of the healthcare provider. Besides pharmacological effectiveness, the therapeutic regimens should be evaluate...

Background: Anthracyclines remain the cornerstone of the treatment in many cancers including lymphomas, leukemia and sarcomas, and breast cancer. The cardiomyopathy that develops from anthracyclines can lead to heart failure and decreased survival. Multiple mechanisms are involved in the pathophysiology of anthracycline-induced heart failure. Stu...

Physiotherapists become responsible for the rehabilitation of patients in a wide range of conditions, but the bioethical questions have not been sufficiently assimilated to academic studies. A cross-sectional survey was applied to both physiotherapists and patients, related to informed consent (IC). A number of 148 physiotherapists and 397 patients...

Persistent organochlorine pollutants (POPs) are highly lipophilic and resistant to degradation, hence these substances are commonly found in the environment even decades after their prohibition. The aim of the present study was to determine human serum concentrations of POPs and polycyclic aromatic hydrocarbons (PAHs) in the Romanian population, in...

Antibiotherapy is the main determinant of Clostridium difficile infection due to the imbalance determined in the intestinal flora. Clostridium difficile infection can be considered a current public health problem, given the increased incidence, both as a nosocomial infection as well as at community level, by excessive, uncontrolled and unjustified...

Background The burnout syndrome is characterized by emotional exhaustion, depersonalization, and lack of personal accomplishment. It was identified in some professional categories, the most often being affected those in public health services. Objectives This study mainly aims to identify and analyze the value of the personality traits and work cha...

Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov...