Liliana Rogozea

Universitatea Transilvania Brasov | unitbv · Departamentul de Discipline Fundamentale si profilactice

Background: Healthcare professionals had to face numerous challenges during the pandemic, their professional activity being influenced not only by the virus, but also by the spread of medical misinformation. In this regard, we aimed to analyze, from the perspective of medical staff, the way medical and non-medical information about the virus was c...

The coronavirus disease 2019 (COVID-19) pandemic is probably the most critical epidemiological situation that human civilization has faced in the last few decades. In this context, of all the professional categories involved in the management of patients with COVID-19 are the most likely to develop burnout syndrome. The main objective of this study...

Background: Advances in drug therapy for primary (or essential) arterial hypertension have contributed to a significant decrease in the frequency and severity of strokes, coronary artery disease and heart failure, and chronic renal insufficiency. Study question: What are the milestones of the changes in the expert approach to the pharmacological...

Background: Opioid use disorder continues to have a significant impact on public health morbidity and mortality throughout the United States and elsewhere. Managing opioid withdrawal is a critical treatment goal in individuals entering treatment with an active opioid use. Study question: What are the milestones of the changes in the expert appro...

Introduction: Vaccination is a procedure through which a community can become actively immunized by the administration of a vaccine. In recent years, in Romania, there has been an anti-immunization “movement” induced by several anti-vaccinists, who have alleged that vaccination might have a detrimental effect on the community. The purpose of the st...

Introduction: Medial errors in health care facilities from Romania are a crucial issue that affects the safety of medical services. Reporting medical errors is an important aspect of the patient safety culture that prevents future medical errors. However, only a small part of medical errors are reported in Romania. The main purpose of the study is...

The increasing occurrence of infections caused by pathogens found on objects of everyday use requires a variety of solutions for active disinfection. Using active materials that do not require daily maintenance has a potential advantage for their acceptance. In this contribution, transparent films, with silver as the main antimicrobial agent and a...

Introduction: Non-porous surfaces with antibacterial properties have begun to gain notoriety because strategies are being sought to prevent infections by methods that are as safe as possible for the human body. Objectives: Test methods can be variates, such as ISO 22196 standardized testing, inoculation testing with a sterile swab, bacteriological...

Introduction. The issue of sex education among young people is a major problem not only for civil society but also for medical staff, given that Romania ranks third in terms of unprotected sex in one year, according to the 'Emergency Contraception Study'. The realization of an education campaign among young people must be based on the knowledge of...

Background: Advances in drug therapy for atrial fibrillation (AF) have had a significant impact on the quality of life of a substantial majority of affected persons, which has contributed to a remarkable decrease in the frequency and severity of thromboembolic complications, hospitalizations, and mortality. Study question: What are the milestone...

Background: Advances in drug therapy for myasthenia gravis have had a significant impact on the quality of life and work potential of a substantial majority of affected persons and has contributed to a remarkable decrease in the frequency and severity of complications, hospitalizations, and mortality. Study question: What are the milestones of t...

The study aim was to evaluate the ultrasound (US) signs of the mammary lesions classified in the Breast Imaging-Reporting and Data System (BI-RADS) score category 3, 4, and 5, corresponding to US BI-RADS. It also followed the correlation between US changes of lesions suggestive for malignancy with the histopathological results and evaluated the pro...

Background: Advances in drug therapy for peptic ulcer have had a significant impact on quality of life and work potential of many millions of affected persons and have contributed to a remarkable decrease in the prevalence of the disease, frequency and severity of complications, hospitalizations, and mortality. Study question: What are the miles...

Background: Drug therapy for diabetes mellitus (DM) has had a significant impact on quality of life and work potential of affected persons and has contributed to a remarkable decrease in the frequency and severity of complications, hospitalizations, and mortality. The current approach is the result of incremental progress in using technological ad...

Background: The current pandemic has raised several ethical dilemmas, related to conducting real-time trials for new treatments or vaccines or with decisions such as accessibility to vaccines. Study question: Should there be a prioritization of access to the vaccine based on ethical and objective criteria or should the access be done at random?...

Background: Drug therapy for heart failure influences quality of life and work potential of affected persons and has contributed to decrease in hospitalizations and cardiovascular mortality. The current approach is the result of incremental progress in understanding the pathophysiology of the syndrome, introduction of new molecules, and repurposin...

Mobile phones have become an essential "accessory" in modern society. Their use in hospitals can increase the quality of the medical act by allowing prompt communication between departments or the rapid search for data. Several studies demonstrate the possibility of microbial contamination of phones, mostly in the medical field, especially with spe...

This historical vignette displays an ex-libris dedicated to Doctor Mozes Karoly, created by the well-known Oradea artist Karoly Roman Radvany. This artwork displays the portrait of an old man with a beard examining a skull and surrounded by books. There is the vanitas theme influence in this between-wars artwork. Doctor Mozes Karoly contributed dec...

In Romania, users’ perceptions about availability of services in primary care have not been explored since 2009, when a national report was produced, and little is therefore known about the subject. The study aims to identify perceptions of primary healthcare service users regarding the availability of services in primary care. This research is a p...

Objective: We aimed to evaluate the association of risk factors such as smoking and professional status (students vs employed) as determinants of disparities in perceived wellness among Romanian individuals. Methods: We conducted a cross-sectional study in which 145 participants were enrolled from December 2017 to February 2018, in Brasov, Brasov C...

In 2020 we celebrate the bicentennial of the birth of Florence Nightingale and 110 years from her death (1820-1910). This gives us the opportunity to remember her life and her achievements. She is mainly known for her contribution to the foundation of modern nursing in the British Empire and subsequently to the world. Besides her personal engagemen...

Background: Pain and depression have a high impact on caring for the people who need palliative care, but both of these are neglected compared with the approach for other symptoms encountered by these patients. Areas of Uncertainty: There are few studies in humans that support the existence of common neural circuits between depression and pain t...

Obiectiv: Pacienții cu epilepsie pot fi ținte ale discriminării și se confruntă cu o calitate a vieții mai scăzută și în ciuda dezvoltării în ultimii douăzeci de ani a medicamentelor antiepileptice o parte dintre aceștia manifestă rezistență la tratament. Obiectivul acestei lucrări este de a corela conceptul de epilepsie farmacorezistentă, cu modal...

Purpose of review: Allergen immunotherapy (AIT) is a well-known disease-modifying intervention for allergic diseases. Its benefit in allergic asthma, ranging from prevention to facilitating asthma control, is yet to be clarified. Recent findings: In 2017, following several well-designed randomised controlled trials (RCTs) with house-dust mites (...

Background: Adjustment disorder requires therapeutic intervention because of its complications, which include a significant risk of suicide, but evidence-based therapeutic guidelines are not available. Areas of uncertainty: The main problem is related to answer to the following question: What is the optimal therapeutic approach to adjustment dis...

Background Currently considered an occupational disease, the burnout syndrome affects 13–27% of the active population in multiple occupational sectors of the modern world.Objectives Considering the burnout syndrome from the new perspective of the predictive, preventive, personalized medicine concept as a pathological entity with a predictable appea...

Background: Pain is one of the symptoms for which any man is willing not only to go to the doctor but also to resort to any means, including self-medication, to "get rid" of it. Self-medication is not only a current practice but also a public health problem, under the circumstances that it can influence the way in which a disease is diagnosed and/...

Purpose of review: Allergic diseases are prototypic examples for gene × environment-wide interactions. This review considers the current evidence for genetic and epigenetic mechanisms in allergic diseases and highlights barriers and facilitators for the implementation of these novel tools both for research and clinical practice. Recent findings:...

Improved understanding of the contribution of immune-inflammatory mechanisms in allergic diseases and asthma has encouraged development of biologicals and small molecules specifically targeting the innate and adaptive immune response. There are several critical points impacting the efficacy of this stratified approach, from the complexity of diseas...

With this Editorial, we want to present the Special Issue, “Advanced Analytical Methods in Clinical Diagnosis and Therapy”. The development of medicine is not possible without progress in the field of identifying different biomarkers or treatments using modern approaches, such as the analytical methods presented in articles that are part of this is...

Background and aim: Physiotherapy has a distinct feature in terms of patient relationship, regarding the level of communication, especially how physical therapy sessions take place throughout the rehabilitation process. One of the particularities encountered in Romanian physiotherapy practice is related to obtaining informed consent (IC), consider...

Background: Palliative care (PC) is the holistic care of patients with life-limiting illnesses focused on relief of suffering and maximizing quality of life for patients and their families. Patients with heart failure (HF) are the largest group eligible for PC services, but only a small percentage of them receive PC. Areas of uncertainty: The op...

Background: In patients with coronary artery disease, cardiovascular mortality and other acute events showed a clear correlation with risk factors and biomarkers including platelet activation. Study question of this research: Which was the incidence of low response to clopidogrel and its correlation with risk factors and biomarkers in coronary a...

Background Patients’ expectations and needs for healthcare services are changing. These changes are correlated with changes in disease profiles, a higher prevalence of chronic diseases, the introduction of new and innovative treatments and health technologies, and the emergence of new social and economic contexts. National health reports on Romania...

Background Patients’ expectations and needs for healthcare services are changing. These changes are correlated with changes in disease profiles, a higher prevalence of chronic diseases, the introduction of new and innovative treatments and health technologies, and the emergence of new social and economic contexts. National health reports on Romania...

Background National health reports on Romania show that decisions in healthcare planning are not correlated with the health needs of the population and that there is a high degree of unmet healthcare needs of the population (related to cost, distance and waiting times), especially for low-income populations. Family medicine is facing underfinancing...

Diabetic foot is a current public health problem and a late consequence of diabetes. Morbidity and mortality are significant, seriously affecting the patient's quality of life. Treatment of the diabetic foot is a long-lasting, highly resource-consumption process. Using negative pressure therapy leads to shorter hospitalization periods, better funct...

Introduction Physiotherapy has developed over the last century, and the physiotherapists' professional identity is growing. The heterogenity of physiotherapy studies in Europe, local government, and health policies have influenced the responsibilities and ethical reasoning of physiotherapists. Our study aims to explore the perceptions and differenc...

The effectiveness of pharmacological therapies is supported and guaranteed by medical protocols, which are the result of long-lasting experiments and scientific research, of course adapted to the level of competence and functional capacity of the healthcare provider. Besides pharmacological effectiveness, the therapeutic regimens should be evaluate...

Background: Anthracyclines remain the cornerstone of the treatment in many cancers including lymphomas, leukemia and sarcomas, and breast cancer. The cardiomyopathy that develops from anthracyclines can lead to heart failure and decreased survival. Multiple mechanisms are involved in the pathophysiology of anthracycline-induced heart failure. Stu...

Physiotherapists become responsible for the rehabilitation of patients in a wide range of conditions, but the bioethical questions have not been sufficiently assimilated to academic studies. A cross-sectional survey was applied to both physiotherapists and patients, related to informed consent (IC). A number of 148 physiotherapists and 397 patients...

Persistent organochlorine pollutants (POPs) are highly lipophilic and resistant to degradation, hence these substances are commonly found in the environment even decades after their prohibition. The aim of the present study was to determine human serum concentrations of POPs and polycyclic aromatic hydrocarbons (PAHs) in the Romanian population, in...

Antibiotherapy is the main determinant of Clostridium difficile infection due to the imbalance determined in the intestinal flora. Clostridium difficile infection can be considered a current public health problem, given the increased incidence, both as a nosocomial infection as well as at community level, by excessive, uncontrolled and unjustified...

Background The burnout syndrome is characterized by emotional exhaustion, depersonalization, and lack of personal accomplishment. It was identified in some professional categories, the most often being affected those in public health services. Objectives This study mainly aims to identify and analyze the value of the personality traits and work cha...

Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov...

Purpose of review: The precision medicine concept is both appealing and challenging. We review here the recent findings in the endotype-driven approach for major allergic diseases. Recent findings: Stratified medicine for different allergic diseases can identify patients who are more likely to benefit or experience an adverse reaction in respons...

The objective of this study was to evaluate the antioxidant effect of the vitamins A and E before and after intensive aerobic exercise effort and to provide pros and cons arguments on the use of both vitamins during the physical training. The research highlighted important adaptive changes of the functional parameters: PMA, VCEE, VO2max, of the oxi...

Background: Behavioral and psychological symptoms in dementia significantly contribute to caregiver burden and impose patient hospitalization. The goal of treatment of admitted patients is the rapid remission of symptoms to allow their return to home as soon as possible. Intervention requires an intrusive approach with parenteral treatment and phy...

Purpose: The main purpose of the present paper is to analyze the rules for processing of special categories of personal data (genetic data, including biological samples, biometric and health data) in the light of the new General Data Protection Regulation (GDPR), thus contributing to overview the health status and the biomedical state of the data...

Purpose: International regulations regarding the protection of individuals concerning the processing of personal data and the free movement of such data highlight the need for their systematization and customization, depending on the purpose for which they are collected and used. Background: Medical legislation is structured so that the constitu...

Our study included a total of 259 patients with diabetes, who were admitted to the Department of Plastic Surgery and Reconstructive Microsurgery of the Emergency County Hospital of Piteşti, Romania, in 2016, with the diagnosis of “diabetic foot”. Of the 259 patients, 55 (21.23%) were diagnosed with type 1 diabetes, and the remaining 204 (78.77%) we...

Measurement of biomarkers has been incorporated within clinical research of asthma to characterize the population and to associate the disease with environmental and therapeutic effects. Regrettably, at present, there are no specific biomarkers, none is validated or qualified, and endotype-driven choices overlap. Biomarkers have not yet reached cli...

Palliative care nurses in Romania have a long history of collaborating with the End-of-Life Nursing Education Consortium (ELNEC) project, a national education initiative administered by the American Association of Colleges of Nursing (AACN) in Washington, DC, and the City of Hope National Medical Center in Duarte, California. Between January 2013 a...

In the last decade, Romanian hospitals have been facing a decline in autopsy rates. This has had a negative impact on medical education and the training of young doctors. Quite a number of caregivers strongly oppose the carrying out of autopsies on their deceased loved ones who have died in hospital. Hence, this study was designed to evaluate how a...

Background: The main objective of this cross sectional study was to assess the psychometric properties of a new research instrument. The secondary aim was to analyze patients' levels of dissatisfaction with the professionalism of medical staff. Methods: A social survey questionnaire was created and administered online. The instrument consisted o...

Clinical features: The term multiple drug intolerance (MDI) is attributed to patients who experience adverse drug reactions to more than 3 different classes of medication without a known immunological mechanism. A special attention should be given to multiple drug-intolerant hypertension (MDI-HTN) that is a cause of drop out from treatment and con...

Information and communication technologies exert considerable pressure on the educational environment. Students’ digital skills are less widely used in the educational process for creative purpose. Although access to electronic devices is high, the digital skills of Romanian ‘students are underdeveloped. The principal aim of this research is to inv...

Background: The management strategy for patients with atrial fibrillation (AF) is often very complex, electrical cardioversion (EC) being often used to restore sinus rhythm in those patients. The increased risk of thromboembolic complications was lowered using anticoagulation therapy. Usually, the anticoagulation was achieved using vitamin K antag...

Risk management is a major point of interest in the recent years. The current study aims to investigate the associations between motivation factors of employees, satisfaction, stress and risk management practice. Another aim is to assess the most significant predictors for risk management practice in health care system. The background of this study...

Purpose: The study proposes an analysis of the ethical aspects that occur in communicating bad news following histopathology laboratory tests in medical practice, in particular in the case of the anatomical pathology diagnosis confirming a medical condition of poor prognosis. Background: Over the last decades, the progress of science and technol...

Helicobacter pylori (HP) infection is one of the most frequent bacterial infections in humans. The studies performed in the last 30 years showed that this bacterium is the main cause of chronic gastritis and the main etiological agent of peptic ulcer and gastric cancer. We investigated the prevalence of HP infection in a group of 1525 patients who...

Objective: To evaluate the epidemiology, pathobiology, and management of benign ethnic neutropenia and determine the extent to which these factors should influence measures designed to avoid clozapine-induced agranulocytosis. Data sources: A structured MEDLINE search with no language limitation was performed from database inception until March 3...