Lígia Ribeiro Horta de Macedo

Lígia Ribeiro Horta de Macedo
University of São Paulo | USP · Departamento de Neurociências e Ciências do Comportamento (Ribeirão Preto)

PhD

About

9
Publications
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Introduction

Publications

Publications (9)
Article
Ayahuasca is an Amazonian botanical hallucinogenic brew which contains dimethyltryptamine, a 5-HT2A receptor agonist, and harmine, a monoamine-oxidase A inhibitor. Our group recently reported that ayahuasca administration was associated with fast-acting antidepressive effects in 6 depressive patients. The objective of the present work was to assess...
Article
Full-text available
Objective Characterize the social profile and the need of information from patients with refractory epilepsy. Method A semi-structured questionnaire was applied to 103 patients to investigate sociodemographic aspects, pharmacotherapy and any doubts about epilepsy. Results Patients were highly dependent on having a free and accessible supply of anti...
Article
Full-text available
Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Open-label trial co...
Article
The neuropeptide oxytocin improves the performance in facial emotion recognition tests in healthy volunteers and in individuals with schizophrenia. Different paradigms are used in emotion recognition tasks, engaging different neurobiological bases. To date, the effects of oxytocin in facial emotion matching tasks have not been studied. The objectiv...
Article
Oxytocin is an important centrally-synthesized neuropeptide with peripheral and central action. Centrally, oxytocin plays key roles in the regulation of complex social cognition and behavior, such as social exploration, attachment, aggression, anxiety and fear. Recently, oxytocin has been associated with social deficits and studies have shown that...
Article
Full-text available
Interactions between glutamatergic and endocannabinoid systems may contribute to schizophrenia, dissociative states, and other psychiatric conditions. Cannabidiol (CBD), a cannabinoid-1/2 (CB1/2) receptor weak partial agonist or antagonist, may play a role in the treatment of schizophrenia. This study tested the hypothesis that CBD would attenuate...

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