Liebert Parreiras Nogueira

Liebert Parreiras Nogueira
University of Oslo · Faculty of Dentistry

PhD

About

84
Publications
8,303
Reads
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261
Citations
Citations since 2017
48 Research Items
199 Citations
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080
Additional affiliations
December 2017 - present
University of Oslo
Position
  • Engineer
March 2012 - December 2017
Rio de Janeiro State University
Position
  • Professor
Education
March 2008 - December 2011
Federal University of Rio de Janeiro
Field of study
  • Applied Nuclear Physics

Publications

Publications (84)
Article
Full-text available
Experimental dental resin composites containing copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were developed to impart anti-bacterial properties. Increasing amounts of Cu-MBGN (0, 1, 5 and 10 wt%) were added to the BisGMA/TEGDMA resin matrix containing micro- and nano-fillers of inert glass, keeping the resin/filler ratio constant....
Article
In Pickering emulsions colloidal nanoparticles can efficiently stabilize water/oil mixtures and has been demonstrated for a wide range of applications. However the low mechanical properties of the final devices are limiting their adoption. Here we propose a strategy to use colloidal nanoparticle at hydrohobic polymer-water interface able to form bi...
Article
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Ecological conditions shape (adaptive) responses at the molecular, anatomical, and behavioral levels. Understanding these responses is key to predict the outcomes of intra- and inter-specific competitions and the evolutionary trajectory of populations. Recent technological advances have enabled large-scale molecular (e.g., RNAseq) and behavioral (e...
Article
Synchrotron radiation phase-contrast microtomography is sensitive to low attenuating tissues, giving an alternative visualisation of the sample and being useful for investigating microstructure inside biological specimens without staining them with a contrast medium. The phase-contrast technique has been widely used in the scientific community, as...
Article
Full-text available
Introduction The purpose of this study was to determine the degree of similarity between contralateral mandibular incisors utilising 3-dimensional (3D) models obtained from micro-computed tomographic (micro-CT) scans of extracted human teeth. The null hypothesis was that contralateral mandibular incisors do not exhibit matching symmetry. Methods S...
Preprint
Full-text available
Intra-portal islet transplantation is the method of choice for treatment of insulin dependent type 1 diabetes, but its outcome is hindered by limited islet survival due to the immunological and metabolic stress post transplantation. Adipose-derived stromal cells (ASCs) promise to improve significantly the islet micro-environment but an efficient lo...
Article
Bone is a vascularized organic-inorganic composite tissue that shows a heavily-mineralized extracellular matrix (ECM) on the nanoscale. Herein, the nucleation of calcium phosphates during the biomineralization process was mimicked using negatively-charged cellulose nanocrystals (CNCs). These mineralized-CNCs were combined with platelet lysate to pr...
Article
Full-text available
Background Superior mesenteric artery plexus (SMAP) injury is reported to cause postoperative intractable diarrhea after pancreatic/colonic surgery with extended lymphadenectomy. This study aims to describe the SMAP microanatomy and extent of injury after right colectomy with extended D3 mesenterectomy for cancer. Methods Three groups (I) anatomic...
Article
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The properties of composite materials are highly dependent on the fiber and matrix fraction and on the porosity resulting from micro voids. This paper addresses void content characterization and the constituent content of composite materials by resorting to a comparison of destructive and non-destructive methods. The work presents the detailed proc...
Article
The osteogenic differentiation potential of mesenchymal stromal cells (hMSCs) is an essential process for the haematopoiesis and the maintenance of haematopoietic stem cells (HSCs). Therefore, the aim of this work was to evaluate this potential in hMSCs from AML patients (hMSCs-AML) and whether it is associated with BMP4 expression. The results sho...
Article
Ceramic materials were applied to the area of bone defect treatment for a long time. The structure character and preparation method of ceramic scaffolds are of great importance to the satisfaction of defect repair. Among the myriads of forming methods, 3D printing technology allows to form porous and individualized ceramic scaffolds. Normally the e...
Article
Full-text available
Malignant bone tumors are usually treated by resection of tumor tissue followed by filling of the bone defect with bone graft substitutes. Polymethylmethacrylate (PMMA) cement is the most commonly used bone substitute in clinical orthopedics in view of its reliability. However, the dense nature of PMMA renders this biomaterial unsuitable for local...
Article
Fine aggregate matrix (FAM) has been regarded as a key constituent of asphalt mixtures. Several attempts focusing on the proper fabrication and characterization of FAM have been pursued in the last decades. However, there are still some limitations that require further investigations. One of those shortcomings is how to define the air void (AV) con...
Article
Full-text available
Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state form of the drug in the final product. The aim of this study was to investigate the influence of the drug load on printability and...
Preprint
Full-text available
Selection favour males that anticipate intraspecific competition levels and develop appropriate competitive traits. In holometabolous insects, larval density can act as an ecological cue of males future intraspecific competition levels while also limiting access to food allocated to sexually selected traits (e.g., testes). To date, however, most st...
Article
This study reports the reinforcement degree investigation of two types of rockwool fibers (F1 and F2), in nitrile rubber composites. The micro-computed tomography (micro-CT) 3D images showed that both fibers were well-dispersed in the NBR matrix, without a preferential orientation. The micro-CT analysis also allowed quantifying volume fraction, int...
Article
X-ray micro-computed tomography (micro-CT) is an advanced technique able to provide a comprehensive examination of the volumetric characteristics of asphalt mixtures. A key step for the air void (AV) quantification using micro-CT images is the segmentation, which is a stage of the digital image processing. The most common segmentation technique, th...
Article
Technological advancement in the treatment of cancer together with early detection and diagnosis have considerably improved the survival of breast cancer patients. On the other hand, the potential of patients developing side effects from cancer treatment are not negligible. Despite the progress that has been made in terms of early diagnosis, therap...
Article
Full-text available
Aim To introduce a methodology designed to simultaneously visualise dental ultrastructures, including cellular and soft tissue components, by utilising phosphotungstic acid (PTA) as a contrast‐enhancement agent. Methodology Sound third molars were collected from healthy human adults and fixed in 4% buffered paraformaldehyde. To evaluate the impact...
Article
In this work, we present a quantitative (statistical) 3D morphological characterization of optical fibers used in electric field sensing. The characterization technique employs propagation-based X-ray phase-contrast microcomputed tomography (micro-CT). Particularly, we investigate specialty optical fibers that contain microstructured holes that are...
Article
Rhodnius prolixus is the main triatomine insect vector of Chagas Disease, which affects between 6 and 8 million individuals, with approximately 12,000 deaths per year in Latin America. Azadirachtin is a drug that causes changes in several species of insects, including triatomines, thereby inhibiting their development. This work exploits Low-Energy...
Article
Full-text available
Bone defects resulting from trauma, surgery, congenital malformations, and other factors are among the most common health problems nowadays. Although current strategies such as autografts and allografts are recognized as the most successful treatments for stimulating bone regeneration, limitations such as graft source and complications still exist....
Article
3D printing technology has an important role at the study animal anatomy, and, for a long time, scientists have been searched for techniques that allow to create accurate 3D replicas of plants and animal specimens. In this work it was developed a methodology to print insects 3D replicas using X-Ray synchrotron microtomography. The insect chosen was...
Article
Full-text available
Amphibians are models for studying applied ecological issues such as habitat loss, pollution, disease, and global climate change due to their sensitivity and vulnerability to changes in the environment. Developmental series of amphibians are informative about their biology, and X-ray based 3D reconstruction holds promise for quantifying morphologic...
Article
Full-text available
Technological advances have made it possible to examine dental resin composites using 3D nanometer resolution. this investigation aims to characterize existing dental nano-hybrid and micro-hybrid resin composites through comparing and contrasting nano-computed tomography (nano-ct) with micro-ct and high-resolution SeM images. eight commercially ava...
Article
Objective Here we describe a novel formulation, based on quaternary ammonium (QA) and riboflavin (RF), which combines antimicrobial activities and protease inhibitory properties with collagen crosslinking without interference to bonding capabilities, was investigated. Methods Experimental adhesives modified with different fractions of dioctadecyld...
Article
Full-text available
Innovative strategies for periodontal regeneration have been the focus of research clusters across the globe for decades. In order to overcome the drawbacks of currently available options, investigators have suggested a novel concept of functionally graded membrane (FGM) templates with different structural and morphological gradients. Chitosan (CH)...
Article
Fine aggregate matrix (FAM) has been regarded as a key constituent of asphalt mixtures. Although several design methods have been recently proposed to prepare FAM specimens that represent the materials contained within the asphalt concretes, the volumetric characteristics of FAM may not be uniformly distributed within samples compacted using device...
Article
Full-text available
In vitro-expanded bone marrow stromal cells (BMSCs) have long been proposed for the treatment of complex bone-related injuries because of their inherent potential to differentiate into multiple skeletal cell types, modulate inflammatory responses, and support angiogenesis. Although a wide variety of methods have been used to expand BMSCs on a large...
Conference Paper
Fine aggregate matrix (FAM) is the primary phase of asphalt concrete (AC) in which important deformation-damage phenomena occur. Many studies have used laboratory testing on FAM to characterize mechanical behavior of asphalt mixtures and have also actively exploited FAM for microstructure modeling of AC mixture and predicting the fracture behavior...
Article
Full-text available
Urinary stone is a common clinical problem whose most frequent chemical compositions are calcium oxalate, calcium phosphate, uric acid and cystine. In this work we propose a new method for quantification of urinary stones using single-energy computed tomography (SECT). The results were validated with X-ray powder diffraction (XRPD). The proposed SE...
Conference Paper
This work uses Low-Energy X-Ray Microfluorescence to evaluate the distribution of Mg, Na, Al and Fe in the structures Rhodnius prolixus head, to understand the effects of Azadirachtin treatment on the development of the nervous system. This insect is the main insect vector of Chagas Disease, which affects between 6 and 8 million individuals, with a...
Conference Paper
Micro-CT is the most powerful 3D imaging technique to study morphology of the small animals, such as annelids, insects and amphibian embryos. Commercial lab-based X-ray micro-CT system is the most used to study anurans, however it presents some limitation when compared with synchrotron micro-CT techniques that offers significant advantages over suc...
Article
Microtomography has already shown to be a powerful tool for studying insects’ morphology yielding images with high resolution, in a non-destructive way and with fast data acquisition. Biological samples such as insects usually require the use of X-ray absorbing contrast agents in sample preparation, as there is a very little difference in the atten...
Article
In this work, in-line phase-contrast synchrotron microtomography was used in order to study the external and internal morphology of Thoropa miliaris tadpoles. Whole-specimens of T. miliaris in larval stages of development 28, 37 and 42, collected in the municipality of Mangaratiba (Rio de Janeiro, Brazil) were used for the study. The samples were s...
Article
Synchrotron radiation phase-contrast microtomography (SR-PHC-CT) has become an important tool in studies of insects, mainly Rhodinius prolixus, the insect vector of Chagas disease. A previous work has shown that SR-PHC-CT is an excellent technique in studies about the ecdysis process of R.prolixus head. The term ecdysis refers to the set of behavio...
Article
Full-text available
Purpose: In the present work, femur diaphysis of rats, treated with two different chemotherapy drugs, AC (doxorubicin + cyclophosphamide) and TC (docetaxel + cyclophosphamide) were evaluated by 3D morphological analysis using synchrotron radiation microtomography. Materials and Methods: Wistar rats were classified into three groups. One group recei...
Conference Paper
Full-text available
Chagas’ disease, also called American trypanosomiasis, is a human tropical disease, which is endemic in large areas of South and Central America. Rhodnius prolixus is the most important insect vector of Trypanosoma cruzi, the etiologic agent of Chagas’ disease. Studies have shown that microcomputed tomography (microCT) provides an excellent tool fo...
Article
Full-text available
Microtomography using synchrotron sources is a useful tool in biological imaging research since the phase coherence of synchrotron beams can be exploited to obtain images with high contrast resolution. This work is part of a series of works using phase contrast synchrotron microtomography in the study of Rhodnius prolixus head, the insect vector of...
Article
Full-text available
Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for the BC, including chemotherapy and/or radiotherapy, increased the survival rates for this type of cancer. One late complication induc...
Article
Full-text available
The recent years advancements in microtomography have increased the achievable resolution and contrast, making this relatively inexpensive and a widely available technology, potentially useful for studies of insect's internal morphology. Phase Contrast X-Ray Synchrotron Microtomography (SR-PhC-μCT) is a non-destructive technique that allows the mic...
Article
Full-text available
In recent years, new techniques have been developed for the analysis of bone matrix. Two of the most common technologies that make use of X-rays are X-ray microfluorescence (μXRF) and X-ray absorption microtomography (μCT). μXRF is a powerful analytical tool for the spectroscopic determination of almost all elements (Z > 13) present in a sample. μC...
Article
Full-text available
Recently some developments in a large number of investigative techniques have been made with the objective to obtain a micrometer spatial resolution imaging of elemental concentrations. The X-ray microfluorescence analysis (μXRF) is one of those techniques which is based on the localized excitation of a small area on the surface of sample, providin...
Article
Full-text available
Microporosities play important biologic and mechanical roles on health. One of the side effects caused by some chemotherapy drugs is the induction of amenorrhea, temporary or not, in premenopausal women, with a consequent decrease in estrogen production, which can lead to cortical bone changes. In the present work, the femur diaphysis of rats treat...
Conference Paper
Full-text available
Urolithiasis is a metabolic disease, which is characterized by formation of stones (calculi) in urinary tracts, affects a wide sector of population 4-15% approximately (depending on geographical area). The stones composition can be classified into two parts, an organic matrix and biominerals. Stones are often heterogeneous, containing mainly oxalat...
Conference Paper
Advancements in microtomography (μCT) have made possible fine resolution of internal morphology of very small insects. μCT has been used to quantify insect tracheal system dimensions, however has never been used to quantify Rhodnius prolixus structures, the most important insect vector of Trypanosoma cruzi, the etiologic agent of Chagas' disease. S...
Conference Paper
Full-text available
Microtomography using synchrotron sources is an useful tool in biological imaging research since the phase coherence of synchrotron beams can be exploited to obtain images with high contrast resolution. This work uses phase contrast synchrotron microtomography (µCT) in the study of Rhodnius prolixus head, the insect vector of Chagas' disease, which...
Article
Full-text available
Three-dimensional microtomography has the potential to examine complete bones of small laboratory animals with very high resolution in a non-invasive way. One of the side effects caused by some chemotherapy drugs is the induction of amenorrhea, temporary or not, in premenopausal women, with a consequent decrease in estrogen production, which can le...
Article
Full-text available
Phase Contrast X-Ray Synchroton Microtomography is a non-destructive technique that allows the microanatomical investigations of Rhodnius prolixus, one of the most important insect vectors of Trypanosoma cruzi. In this work complete series of virtual thin sections through the heads of selected Rhodnius prolixus were obtained. The sections of the he...
Article
Full-text available
We have used phase-contrast X-ray microtomography (PPC-mCT) to study the head of the blood-feeding bug, Rhodnius prolixus, which is one of the most important insect vector of Trypanosoma cruzi, ethiologic agent of Chagas disease in Latin America. Images reconstructed from phase-retrieved projections processed by ANKA phase are compared to those obt...
Article
Full-text available
It is well accepted that rat ovariectomy (OVX) is a model of estrogen deficiency. OVX played a very important role in the initiating and developing of osteoporosis and it has been shown to be a major risk factor for the development of postmenopausal osteoporosis in women. In this work we used synchrotron radiation computed microtomography to invest...
Article
Full-text available
The present work is the second one of a two- part publication on the use of Synchrotron Radiation Phase Contrast microtomography (SR-PhC-μCT) for the study of Rhodnius prolixus morphology. In previous paper the visualization of various detailed features were highlighted thanks to the edge enhancement effects typical of the phase contrast technique,...
Article
Full-text available
We have used phase-contrast X-ray microtomography (PPC-mCT) to study the head of the blood-feeding bug, Rhodniusprolixus, whichisoneofthemostimportantinsectvectorof Trypanosomacruzi, ethiologic agentofChagasdiseaseinLatinAmerica.Imagesreconstructedfromphase-retrievedprojections processedby ANKA phase are comparedtothoseobtainedthroughdirecttomograp...
Conference Paper
Full-text available
The most used treatment strategies for breast cancer (BC) are surgery, chemotherapy, and/or radiotherapy. Premenopausal women undergoing adjuvant chemotherapy BC treatment have significant bone loss from the first year after the treatment. This high bone mineral density loss can lead to an increased risk of fractures. Doxorubicin associated with Cy...